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1. 发明申请

US20050020832A1 Pyridone, pyridazone and triazone derivatives as lp-pla2 inhibitors 审中-公开
标题翻译：吡啶酮，哒嗪酮和三嗪衍生物作为lp-pla2抑制剂
公开(公告)号：US20050020832A1
公开(公告)日：2005-01-27
申请号：US10495022
申请日：2002-11-08
申请人： Stephen Fell , Deirdre Hickey , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith
发明人： Stephen Fell , Deirdre Hickey , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith
IPC分类号： A61K31/501 , A61P9/10 , A61P17/06 , A61P29/00 , C07D401/12 , C07D401/14 , C07D237/02 , C07D241/02
CPC分类号： C07D401/12 , C07D401/14
摘要： Compounds of the formula (I) are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译：式（I）的化合物是Lp-PLA2酶的抑制剂，并且在治疗中尤其用于治疗动脉粥样硬化。

2. 发明申请

US20050014793A1 Pyridinone derivatives for treatment of atherosclerosis 有权
标题翻译：用于治疗动脉粥样硬化的吡啶酮衍生物
公开(公告)号：US20050014793A1
公开(公告)日：2005-01-20
申请号：US10900489
申请日：2004-07-28
申请人： Deirdre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
发明人： Deirdre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号： C07D215/20 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61P3/10 , A61P9/00 , A61P9/10 , A61P19/02 , A61P29/00 , C07D211/74 , C07D215/36 , C07D221/04 , C07D401/12 , C07D471/04 , C07D495/04 , C07D513/04 , A61K31/4439 , C07
CPC分类号： C07D221/04 , C04B35/632 , C07D211/74 , C07D215/36 , C07D401/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译：式（I）化合物：是Lp-PLA2酶的抑制剂，可用于治疗，特别是治疗动脉粥样硬化。式（I）化合物：是Lp-PLA2酶的抑制剂，可用于治疗，特别是治疗动脉粥样硬化。

3. 发明申请

US20070123549A1 Pyrimidine compounds 有权
标题翻译：嘧啶化合物
公开(公告)号：US20070123549A1
公开(公告)日：2007-05-31
申请号：US11561926
申请日：2006-11-21
申请人： Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
发明人： Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号： A61K31/513 , C07D239/47
CPC分类号： C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要： Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
摘要翻译：式（I）的嘧啶酮化合物：是Lp-PLA 2酶的抑制剂，可用于治疗动脉粥样硬化。

4. 发明申请

US20060241126A1 Pyrimidinone Derivatives and Their Use in the Treatment of Atherosclerosis 失效
标题翻译：嘧啶酮衍生物及其在治疗动脉粥样硬化中的应用
公开(公告)号：US20060241126A1
公开(公告)日：2006-10-26
申请号：US11456129
申请日：2006-07-07
申请人： Richard Elliott , Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith
发明人： Richard Elliott , Deirdre Hickey , Robert Ife , Colin Leach , Ivan Pinto , Stephen Smith
IPC分类号： A61K31/519 , C07D239/70
CPC分类号： C07D239/36 , C07D239/70 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译：式（I）化合物：是Lp-PLA 2酶的抑制剂，可用于治疗，特别是用于治疗动脉粥样硬化。

5. 发明申请

US20050043335A1 Heterocyclic derivatives of glycinamide and their medical use 审中-公开
标题翻译：甘氨酰胺的杂环衍生物及其用途
公开(公告)号：US20050043335A1
公开(公告)日：2005-02-24
申请号：US10494509
申请日：2002-11-08
申请人： Richard Elliott , Deidre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
发明人： Richard Elliott , Deidre Hickey , Robert Ife , Colin Leach , John Liddle , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号： C07D215/22 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P43/00 , C07D215/06 , C07D215/233 , C07D401/12 , C07D413/12 , C07D471/02 , A61K31/517 , A61K31/519
CPC分类号： C07D215/233
摘要： Compounds of the formula (I) are inhibitors of the enzyme Lp-PLA2? and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译：式（I）的化合物是酶抑制剂Lp-PLA 2？并且用于治疗，特别是用于治疗动脉粥样硬化。

6. 发明申请

US20050033052A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20050033052A1
公开(公告)日：2005-02-10
申请号：US10495025
申请日：2002-11-08
申请人： Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
发明人： Colin Leach , Ivan Pinto , Stephen Smith , Steven Stanway
IPC分类号： A61K31/519 , A61P3/10 , A61P9/10 , A61P9/12 , C07D495/04 , C07D213/69 , C07D239/02
CPC分类号： C07D495/04
摘要： Pyrimidone and pyridone compounds of the formula: are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
摘要翻译：下式的嘧啶酮和吡啶酮化合物是Lp-PLA2酶的抑制剂，可用于治疗，特别是用于治疗动脉粥样硬化。

7. 发明授权

US5476017A Unit dose bulk material sampling apparatus 失效
标题翻译：单位剂量散装材料采样仪
公开(公告)号：US5476017A
公开(公告)日：1995-12-19
申请号：US136139
申请日：1993-10-15
申请人： Ivan Pinto , Gerardo Perez , William P. Wallace
发明人： Ivan Pinto , Gerardo Perez , William P. Wallace
IPC分类号： G01N1/08 , G01N1/10 , G01N1/28 , G01N1/04
CPC分类号： G01N1/08 , G01N2001/1006
摘要： Apparatus for removing a sample of granular or powder materials from a vat in which such materials are mixed in bulk, including an elongated probe having a sample receiving cavity at one end which may be adjusted to a predetermined volume. The probe is inserted in the bulk mixture to a predetermined depth, the cavity loaded with material from the bulk and after closing the cavity, the probe is removed from the bulk removing therefrom a sample of a desired predetermined quantity representative of the bulk mixture at the insertion point. A backing plate is also provided in the probe to compact the sample in the cavity to facilitate handling of the sample.
摘要翻译：用于从其中大量混合这种材料的槽中除去颗粒或粉末材料样品的装置，包括在一端具有可以调节到预定体积的样品接收腔的细长探针。将探针插入大体积混合物中至预定的深度，空腔中装有来自本体的材料，并且在封闭空腔之后，将探针从体内移除，从而将探针从其中去除，代表在插入点还在探针中提供背板以压缩空腔中的样品以便于处理样品。

8. 发明申请

US20050059726A1 Pyrrolidine-2-ones as factor xa inhibitors 审中-公开
标题翻译：吡咯烷-2-酮作为因子xa抑制剂
公开(公告)号：US20050059726A1
公开(公告)日：2005-03-17
申请号：US10499529
申请日：2002-12-20
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
IPC分类号： A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4365 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/546 , A61P3/00 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/404 , C07D43/02 , C07D45/02 , C07D49/02
CPC分类号： C07D207/273 , C07D401/12 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04
摘要： The present invention relates to novel compounds and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and to the use of compounds in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及新化合物及其药学上可接受的衍生物。本发明还涉及制备化合物的方法，含有该化合物的药物组合物，以及化合物在医药中的用途，特别是在改善指定因子Xa抑制剂的临床病症中。

9. 发明申请

US20070191378A1 Anthranilic acid derivatives and their use as activators of the hm74a receptor 审中-公开
标题翻译：邻氨基苯甲酸衍生物及其作为hm74a受体激活剂的用途
公开(公告)号：US20070191378A1
公开(公告)日：2007-08-16
申请号：US10568029
申请日：2004-08-13
申请人： Matthew Campbell , Richard Hatley , Jag Heer , Andrew Mason , Ivan Pinto , Shahzad Rahman , Ian Smith
发明人： Matthew Campbell , Richard Hatley , Jag Heer , Andrew Mason , Ivan Pinto , Shahzad Rahman , Ian Smith
IPC分类号： A61K31/498 , A61K31/47 , A61K31/195 , C07D217/12 , C07D215/08
CPC分类号： C07D209/18 , C07C233/55 , C07C235/24 , C07C235/38 , C07C237/22 , C07C2602/08 , C07C2602/10 , C07D217/12 , C07D217/24 , C07D317/60 , C07D333/60
摘要： Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
摘要翻译：式（I）的治疗活性邻氨基苯甲酸衍生物，所述衍生物的制备方法，含有该化合物的药物制剂以及该化合物在治疗中的用途，特别是用于治疗HM74A受体活化不足的疾病所述疾病或所述受体的活化将是有益的。

10. 发明申请

US20070135456A1 Medicaments with hm74a receptor activity 有权
标题翻译：具有hm74a受体活性的药物
公开(公告)号：US20070135456A1
公开(公告)日：2007-06-14
申请号：US10589474
申请日：2005-02-10
申请人： Ivan Pinto , Shahzad Rahman , Harlow Essex Nicholson
发明人： Ivan Pinto , Shahzad Rahman , Harlow Essex Nicholson
IPC分类号： A61K31/522 , C07D473/02
CPC分类号： C07D473/06 , C07D473/04
摘要： The present invention provides therapeutically active compounds which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, particularly in the treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial, having the formula (II): wherein R1 is selected from: hydrogen and C1-4 alkyl which may be optionally substituted with one or more groups selected from CN and CF3, R2 is selected from: C2-10 unsubstituted alkyl, C1-10 alkyl substituted with one or more groups selected from fluorine and CN, C5 alkenyl, unbranched C4 alkenyl, and C1-4 alkyl substituted with cycloalkyl, and R3 is selected from halogen and CN.
摘要翻译：本发明提供治疗活性化合物，其为黄嘌呤衍生物，制备所述衍生物的方法，含有活性化合物的药物制剂以及该化合物在治疗中的用途，特别是用于治疗HM74A受体活化不足的疾病具有式（II）：其中R 1选自：氢和C 1-4烷基，其可以是该受体的活化或有利的活化，其可以是任选被一个或多个选自CN和CF 3的基团取代，R 2选自：C 2-10未取代的烷基，C 被一个或多个选自氟和CN，C 5链烯基，未分支的C 4 - 4链烯基和C

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