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1. 发明授权

US5945509A Glutamate receptor compositions and method 失效
标题翻译：谷氨酸受体组成和方法
公开(公告)号：US5945509A
公开(公告)日：1999-08-31
申请号：US486269
申请日：1995-06-06
申请人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan Egebejerg Jensen
发明人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan Egebejerg Jensen
IPC分类号： C07K14/705 , C07K16/28 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/70571 , C07K16/2869 , C12Q1/6876 , C12Q2600/158
摘要： The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR4 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.
摘要翻译：本发明公开了编码具有谷氨酸受体特征的电生理和药理特性的蛋白质的新型DNA。谷氨酸受体的例子是由代表性的cDNA克隆GluR1，GluR2，GluR3，GluR4，GluR5，GluR6和GluR7及其片段以及这些谷氨酸受体蛋白和/或片段的功能组合编码的蛋白质。用于GluR1，GluR2，GluR3，GluR4和GluR5的cDNA克隆的DNA序列特别可用作探针，因此使得本领域技术人员能够在没有过度实验的情况下鉴定L-谷氨酸受体家族的其它成员。

2. 发明授权

US5739291A Glutamate receptor antibodies 失效
标题翻译：谷氨酸受体抗体
公开(公告)号：US5739291A
公开(公告)日：1998-04-14
申请号：US481206
申请日：1995-06-06
申请人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan Egebejerg Jensen
发明人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan Egebejerg Jensen
IPC分类号： C07K14/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/94
CPC分类号： G01N33/94 , C07K14/70571 , C07K16/2869 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR5 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.
摘要翻译：本发明公开了编码具有谷氨酸受体特征的电生理和药理特性的蛋白质的新型DNA。谷氨酸受体的例子是由代表性的cDNA克隆GluR1，GluR2，GluR3，GluR4，GluR5，GluR6和GluR7及其片段以及这些谷氨酸受体蛋白和/或片段的功能组合编码的蛋白质。用于GluR1，GluR2，GluR3，GluR5和GluR5的cDNA克隆的DNA序列特别可用作探针，因此使得本领域技术人员能够在没有过度实验的情况下鉴定L-谷氨酸受体家族的其它成员。

3. 发明授权

US5202257A Isolated nucleic acids encoding glutamate receptor protein 失效
标题翻译：分离核酸编码谷氨酸受体蛋白
公开(公告)号：US5202257A
公开(公告)日：1993-04-13
申请号：US718575
申请日：1991-06-21
申请人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan E. Jensen
发明人： Stephen F. Heinemann , James R. Boulter , Michael Hollmann , Bernhard Bettler , Jan E. Jensen
IPC分类号： C07K14/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/94
CPC分类号： G01N33/94 , C07K14/70571 , C07K16/2869 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR5 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.
摘要翻译：本发明公开了编码具有谷氨酸受体特征的电生理和药理特性的蛋白质的新型DNA。谷氨酸受体的例子是由代表性的cDNA克隆GluR1，GluR2，GluR3，GluR4，GluR5，GluR6和GluR7及其片段以及这些谷氨酸受体蛋白和/或片段的功能组合编码的蛋白质。用于GluR1，GluR2，GluR3，GluR5和GluR5的cDNA克隆的DNA序列特别可用作探针，因此使得本领域技术人员能够在没有过度实验的情况下鉴定L-谷氨酸受体家族的其它成员。

4. 发明授权

US5591590A Neuronal nicotinic acetylcholine receptor assay 失效
标题翻译：神经元烟碱乙酰胆碱受体测定
公开(公告)号：US5591590A
公开(公告)日：1997-01-07
申请号：US472989
申请日：1995-06-06
申请人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman
发明人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566 , G01N33/53
CPC分类号： C07K14/70571 , G01N33/944 , G01N2500/04
摘要： The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明涉及由神经元激动剂和非激动剂结合亚基组成的神经元烟碱乙酰胆碱受体家族，以及编码这种亚基的DNA序列。这些新型神经元烟碱乙酰胆碱受体亚基包括激动剂结合亚基α2，α3，α4和α5，加上非激动剂结合亚单位β2，β3和β4。含有本发明的DNA序列的代表性cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

5. 发明授权

US5371188A Neuronal nicotinic acetylcholine receptor compositions 失效
标题翻译：神经元烟碱乙酰胆碱受体组成
公开(公告)号：US5371188A
公开(公告)日：1994-12-06
申请号：US898185
申请日：1992-06-12
申请人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann
发明人： Stephen F. Heinemann , James W. Patrick , James R. Boulter , Evan S. Deneris , Keiji Wada , Marc C. Ballivet , Daniel J. Goldman , John G. Connolly , Robert M. Duvoisin , Eden D. Heinemann
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566 , C07K13/00
CPC分类号： C07K14/70571 , G01N33/944 , G01N2500/04
摘要： The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明涉及由神经元激动剂和非激动剂结合亚基组成的神经元烟碱乙酰胆碱受体家族，以及编码这种亚基的DNA序列。这些新型神经元烟碱乙酰胆碱受体亚基包括激动剂结合亚基α2，α3，α4和α5，加上非激动剂结合亚单位β2，β3和β4。含有本发明的DNA序列的代表性cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

6. 发明授权

US4652629A Synthetic peptide-based anti-rabies compositions and methods 失效
标题翻译：基于合成肽的抗狂犬病药物组合物和方法
公开(公告)号：US4652629A
公开(公告)日：1987-03-24
申请号：US752222
申请日：1985-07-03
申请人： James W. Patrick , Stephen F. Heinemann , Barbara D. Boss , W. Maxwell Cowan
发明人： James W. Patrick , Stephen F. Heinemann , Barbara D. Boss , W. Maxwell Cowan
IPC分类号： C12N15/02 , A61K39/205 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/145 , C07K14/705 , C07K16/00 , C07K16/10 , C07K19/00 , C12N5/10 , C12P21/08 , C12R1/91
CPC分类号： C07K14/005 , C07K16/10 , A61K2039/6081 , C12N2760/20122
摘要： A sequence in the coat glycoprotein of rabies virus is identified as the molecular basis for an essential step in the pathogenesis of the virus, the binding of virus to acetylcholine receptor at neuromuscular junctions prior to virus uptake into peripheral nerves. Based on this discovery, synthetic peptide-based, anti-rabies vaccines are prepared. The active ingredient of such vaccines is a synthetic protein, which is a conjugate with an immunogenic carrier protein of a synthetic peptide with a sequence which includes a sequence which is substantially the same as a substantial portion of the sequence of the acetylcholine receptor-binding segment of the rabies virus coat protein. Anti-rabies antisera, and anti-rabies antibodies, are prepared by injecting a mammal with a synthetic protein of the invention in a manner that induces an immune response in the mammal against the synthetic protein. Hybridomas which secrete anti-rabies antibodies, which bind to specific epitopes on or near the acetylcholine receptor binding segment on the rabies virus coat glycoprotein, are prepared with B cells immunized in vitro with a synthetic peptide or synthetic protein of the invention or taken from a mammal inoculated with such a peptide or protein. The anti-rabies vaccines of the invention avoid risks associated with currently available anti-rabies vaccines. The antisera and antibodies of the invention are useful therapeutically to induce passive anti-rabies immunity in a mammal that has been exposed to rabies virus. The antisera and antibodies are also useful for diagnosing whether a mammal is rabid and whether a mammal has been exposed to live rabies virus.
摘要翻译：鉴定狂犬病病毒外壳糖蛋白中的序列是病毒发病机理中必不可少的步骤的分子基础，在病毒摄入到外周神经之前，病毒与神经肌肉接头处的乙酰胆碱受体结合。基于这一发现，制备合成的基于肽的抗狂犬病疫苗。这种疫苗的活性成分是合成蛋白质，其是具有合成肽的免疫原性载体蛋白的缀合物，其具有序列，其包含与乙酰胆碱受体结合区段的大部分基本相同的序列的狂犬病病毒外壳蛋白。抗狂犬病抗血清和抗狂犬病抗体通过以对哺乳动物诱导针对合成蛋白质的免疫应答的方式向哺乳动物注射本发明的合成蛋白质来制备。使用与本发明的合成肽或合成蛋白质体外免疫的B细胞一起制备分泌抗狂犬病抗体的杂交瘤，其与狂犬病病毒外壳糖蛋白上的乙酰胆碱受体结合片段上或附近的特异性表位结合，用这种肽或蛋白质接种的哺乳动物。本发明的抗狂犬病疫苗避免了与目前可用的抗狂犬病疫苗相关的风险。本发明的抗血清和抗体可用于在暴露于狂犬病病毒的哺乳动物中诱导被动抗狂犬病免疫。抗血清和抗体也可用于诊断哺乳动物是否狂犬病以及哺乳动物是否已经暴露于活狂犬病毒。

7. 发明授权

US5449606A DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit 失效
标题翻译：编码含有β4亚基的神经元烟碱乙酰胆碱受体组合物的DNA
公开(公告)号：US5449606A
公开(公告)日：1995-09-12
申请号：US59502
申请日：1993-05-06
申请人： Stephen F. Heinemann , Robert M. Duvoisin , Evan S. Deneris , James W. Patrick
发明人： Stephen F. Heinemann , Robert M. Duvoisin , Evan S. Deneris , James W. Patrick
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K14/70571
摘要： The present invention discloses a new neuronal nicotinic acetylcholine receptor subunit, .beta.4. The new subunit can form functional combinations with other neuronal nicotinic acetylcholine receptor subunits, including, but not limited to, alpha2, alpha3, alpha4 and beta2. A cDNA clone containing the DNA sequences that encode the novel receptor subunit of the invention has been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明公开了一种新的神经元烟碱乙酰胆碱受体亚单位β4。新亚基可以与其它神经元烟碱乙酰胆碱受体亚基形成功能性组合，包括但不限于α2，α3，α4和β2。包含编码本发明的新受体亚单位的DNA序列的cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

8. 发明授权

US06664055B2 Kainate receptor subunit GLUR7 polymorphisms for determining predispositions to recurrent unipolar and bipolar II depressive disorders 失效
标题翻译：用于确定复发单极和双相II抑郁障碍倾向的红藻氨酸受体亚基GLUR7多态性
公开(公告)号：US06664055B2
公开(公告)日：2003-12-16
申请号：US09854140
申请日：2001-05-11
申请人： Hans H. Schiffer , Stephen F. Heinemann
发明人： Hans H. Schiffer , Stephen F. Heinemann
IPC分类号： C12Q168
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Provided are methods for determining the predisposition of a subject to a mood disorder by determining in a biological sample of a subject, the presence of a kainate receptor subunit GluR7 allelic genotype or allelic phenotype associated with predisposition to a mood disorder. The allelic genotype is homozygosity for a thymine containing nucleotide at position 928 (928T/T) or homozygosity for a guanine containing nucleotide position 928 (928G/G). In addition, a predominant expression of one GluR7 allele over the other allele in a heterozygous individuals also predicts predisposition to a mood disorder. The present invention also includes a method of treating or preventing a mood disorder and methods for identifying a compound useful for treatment. Transgenic non-human animals that express only a particular human GluR7 allele at nucleotide position 928 also are provided as a model of a human mood disorder.
摘要翻译：提供了通过在受试者的生物学样品中确定与心境障碍倾向相关的红藻氨酸受体亚基GluR7等位基因型或等位基因型的存在来确定受试者对情绪障碍的倾向的方法。等位基因基因型是含有胸腺嘧啶核苷酸的位置928（928T / T）或含有核苷酸位置928（928G / G）的鸟嘌呤的纯合性）的纯合性。另外，在杂合子中，一个GluR7等位基因在其他等位基因中的主要表达也预示着情绪障碍的倾向。本发明还包括治疗或预防情绪障碍的方法以及用于鉴定可用于治疗的化合物的方法。在核苷酸位置928处仅表达特定人GluR7等位基因的转基因非人动物也作为人类情绪障碍的模型提供。

9. 发明授权

US5529898A Methods of detecting disorders of the central nervous system by detecting autoantibodies which specifically bind ionotropic glutamate receptors 失效
标题翻译：通过检测特异性结合离子型谷氨酸受体的自身抗体来检测中枢神经系统疾病的方法
公开(公告)号：US5529898A
公开(公告)日：1996-06-25
申请号：US109234
申请日：1993-08-19
申请人： Scott W. Rogers , James O. McNamara, Sr. , Stephen F. Heinemann
发明人： Scott W. Rogers , James O. McNamara, Sr. , Stephen F. Heinemann
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P25/00 , A61P37/00 , C07K16/42 , G01N33/564 , G01N33/68
CPC分类号： C07K16/4258 , G01N33/564 , G01N33/6896 , A61K38/00 , G01N2800/24 , Y10S436/811
摘要： A method of screening a subject for a central nervous system disorder caused by autoimmune disease (e.g., an inflammatory seizure disorder) comprises a sample from the subject and then detecting the presence or absence of anti-glutamate receptor autoantibodies (e.g., anti-GluR3 glutamate receptor autoantibodies) in the biological sample. The presence of such autoantibodies indicates the subject is afflicted with a central nervous system disorder caused by autoimmune disease. Methods of treating such disease by reducing the number of autoantibodies available to bind to glutamate receptors in the subject are also disclosed.
摘要翻译：由自身免疫性疾病（例如炎症性发作障碍）引起的中枢神经系统疾病筛选受试者的方法包括来自受试者的样品，然后检测抗谷氨酸受体自身抗体的存在或不存在（例如，抗GluR3谷氨酸受体自身抗体）。这种自身抗体的存在表明受试者患有由自身免疫疾病引起的中枢神经系统疾病。还公开了通过减少可用于结合受试者中的谷氨酸受体的自身抗体的数量来治疗这种疾病的方法。

10. 发明授权

US5066593A Synthetic peptide-based anti-rabies compositions and methods 失效
标题翻译：基于合成肽的抗狂犬病药物组合物和方法
公开(公告)号：US5066593A
公开(公告)日：1991-11-19
申请号：US91509
申请日：1987-08-31
申请人： James W. Patrick , Stephen F. Heinemann , Barbara D. Boss , W. Maxwell Cowan
发明人： James W. Patrick , Stephen F. Heinemann , Barbara D. Boss , W. Maxwell Cowan
IPC分类号： A61K35/58 , A61K39/00 , A61K39/205 , A61K39/395 , A61K39/42 , C07K14/145 , C07K16/10 , G01N33/569
CPC分类号： C07K14/005 , A61K35/58 , A61K39/12 , A61K39/205 , A61K39/395 , A61K39/42 , C07K16/10 , G01N33/56983 , A61K2039/55566 , A61K2039/6081 , C12N2760/20122 , C12N2760/20134
摘要： A sequence in the coat glycoprotein of rabies virus is identified as the molecular basis for an essential step in the pathogenesis of the virus, the binding of virus to acetylcholine receptor at neuromuscular junctions prior to virus uptake into peripheral nerves. Based on this discovery, synthetic peptide-based, anti-rabies vaccines are prepared. The active ingredient of such vaccines is a synthetic protein, which is a conjugate with an immunogenic carrier protein of a synthetic peptide with a sequence which includes a sequence which is substantially the same as a substantial portion of the sequence of the acetylcholine receptor-binding segment of the rabies virus coat protein. Anti-rabies antisera, and anti-rabies antibodies, are prepared by injecting a mammal with a synthetic protein of the invention in a manner that induces an immune response in the mammal against the synthetic protein. Hybridomas which secrete anti-rabies antibodies, which bind to specific epitopes on or near the acetylcholine receptor binding segment on the rabies virus coat glycoprotein, are prepared with B cells immunized in vitro with a synthetic peptide or synthetic protein of the invention or taken from a mammal inoculated with such a peptide or protein. The anti-rabies vaccines of the invention avoid risks associated with currently available anti-rabies vaccines. The antisera and antibodies of the invention are useful therapeutically to induce passive anti-rabies immunity in a mammal that has been exposed to rabies virus. The antisera and antibodies are also useful for diagnosing whether a mammal is rabid and whether a mammal has been exposed to live rabies virus.
摘要翻译：鉴定狂犬病病毒外壳糖蛋白中的序列是病毒发病机理中必不可少的步骤的分子基础，在病毒摄入到外周神经之前，病毒与神经肌肉接头处的乙酰胆碱受体结合。基于这一发现，制备合成的基于肽的抗狂犬病疫苗。这种疫苗的活性成分是合成蛋白质，其是具有合成肽的免疫原性载体蛋白的缀合物，其具有序列，其包含与乙酰胆碱受体结合区段的大部分基本相同的序列的狂犬病病毒外壳蛋白。抗狂犬病抗血清和抗狂犬病抗体通过以对哺乳动物诱导针对合成蛋白质的免疫应答的方式向哺乳动物注射本发明的合成蛋白质来制备。使用与本发明的合成肽或合成蛋白质体外免疫的B细胞一起制备分泌抗狂犬病抗体的杂交瘤，其与狂犬病病毒外壳糖蛋白上的乙酰胆碱受体结合片段上或附近的特异性表位结合，用这种肽或蛋白质接种的哺乳动物。本发明的抗狂犬病疫苗避免了与目前可用的抗狂犬病疫苗相关的风险。本发明的抗血清和抗体可用于在暴露于狂犬病病毒的哺乳动物中诱导被动抗狂犬病免疫。抗血清和抗体也可用于诊断哺乳动物是否狂犬病以及哺乳动物是否已经暴露于活狂犬病毒。

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