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1. 发明授权

US5962027A Retinal cell transplant 失效
标题翻译：视网膜细胞移植
公开(公告)号：US5962027A
公开(公告)日：1999-10-05
申请号：US322735
申请日：1994-10-13
申请人： Stephen E. Hughes
发明人： Stephen E. Hughes
IPC分类号： A61B17/00 , A61B19/00 , A61F2/14 , A61F9/007 , A61K35/44 , A61L27/38 , C12N5/08
CPC分类号： A61L27/3683 , A61B90/00 , A61F2/14 , A61F9/0017 , A61F9/007 , A61K35/44 , A61L27/3604 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/383 , A61L27/3839 , A61L27/3891 , A61B2017/00969 , A61L2430/16 , A61M2025/0042
摘要： Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.
摘要翻译：提供外科手术器械，外科手术技术，移植物，细胞和组织分离技术以及在其正常构型中移植视网膜细胞，包括光感受器，视网膜色素上皮和睫状体的方法，或共同移植手术中的所有三种组织。

2. 发明授权

US06955809B2 Retinal cell grafts 失效
标题翻译：视网膜细胞移植
公开(公告)号：US06955809B2
公开(公告)日：2005-10-18
申请号：US10323958
申请日：2002-12-17
申请人： Stephen E. Hughes
发明人： Stephen E. Hughes
IPC分类号： A61B17/00 , A61B19/00 , A61F2/14 , A61F9/007 , A61K35/44 , A61L27/38 , C12N5/08
CPC分类号： A61L27/3683 , A61B19/00 , A61B90/00 , A61B2017/00969 , A61F2/14 , A61F9/0017 , A61F9/007 , A61K35/44 , A61L27/3604 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/383 , A61L27/3839 , A61L27/3891 , A61L2430/16 , A61M2025/0042
摘要： Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.
摘要翻译：提供外科手术器械，外科手术技术，移植物，细胞和组织分离技术以及在其正常构型中移植视网膜细胞，包括光感受器，视网膜色素上皮和睫状体的方法，或共同移植手术中的所有三种组织。

3. 发明授权

US06579256B2 Instrument for subretinal implantation 失效
标题翻译：视网膜下植入仪器
公开(公告)号：US06579256B2
公开(公告)日：2003-06-17
申请号：US09411122
申请日：1999-10-04
申请人： Stephen E. Hughes
发明人： Stephen E. Hughes
IPC分类号： A61M3100
CPC分类号： A61L27/3683 , A61B19/00 , A61B90/00 , A61B2017/00969 , A61F2/14 , A61F9/0017 , A61F9/007 , A61K35/44 , A61L27/3604 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/383 , A61L27/3839 , A61L27/3891 , A61L2430/16 , A61M2025/0042
摘要： An instrument for subretinal implantation comprising an elongate tube having a distal end and a proximal end, the tube having a lumen passing from the proximal end to the distal end, the distal end having a distal tip, wherein the lumen forms an opening in the tip, the instrument further including a plunger, the plunger being capable of sliding motion within and with respect to the tube, wherein the outer diameter of the distal end of the elongate tube is sufficiently small to be inserted through the pars plana area of an eye and the length of the distal end of the elongate tube is sufficient long to permit the opening in said tip to thereafter be inserted beneath the retina through an opening therein, wherein the plunger can express material within the lumen therefrom through the opening in the tip into the subretinal space of an eye into which the tip is inserted.
摘要翻译：一种用于视网膜下植入的器械，包括具有远端和近端的细长管，所述管具有从所述近端到所述远端的内腔，所述远端具有远端尖端，其中所述内腔在所述尖端中形成开口该仪器还包括柱塞，所述柱塞能够在管内并相对于所述管滑动运动，其中所述细长管的远端的外径足够小以穿过眼睛的平面平面区域，并且细长管的远端的长度足够长以允许所述尖端中的开口在此之后通过其中的开口插入到视网膜下方，其中柱塞可以将内腔中的材料从顶端中的开口表达进入将眼尖插入其中的眼睛的视网膜下空间。

4. 发明授权

US06514238B1 Method for preparation and transplantation of volute grafts and surgical instrument therefor 失效
标题翻译：蜗牛移植物及其手术器械的制备和移植方法
公开(公告)号：US06514238B1
公开(公告)日：2003-02-04
申请号：US08464054
申请日：1995-06-05
申请人： Stephen E. Hughes
发明人： Stephen E. Hughes
IPC分类号： A61B1700
CPC分类号： A61L27/3604 , A61B90/00 , A61B2017/00969 , A61F2/14 , A61F2/148 , A61F9/007 , A61F9/00736 , A61L27/3641 , A61L27/38 , A61L27/3804 , A61L27/3839 , A61L2430/16 , A61M2025/0042
摘要： A method of transplanting a graft in the subretinal area of a host eye comprises preparing the graft by harvesting from the donor tissue a population of cells in a manner that maintains the population of cells in the same organization and cellular polarity as is present in normal tissue of that type. The population of cells are of a sheet-like form and are assembled with a relatively thin flexible pliable carrier composed of a non-toxic flexible composition which substantially dissolves at body temperature to form a graft. The graft is sufficiently flexible and pliable to be coiled to form a volute without disturbing the organization and polarity of the cells. The method further comprises coiling the graft to form a volute with the convolutions of the volute free of one another for subsequent uncoiling of the graft substantially to its original sheet-like form. An incision is made in the host eye for insertion of the volute. The incision in the eye is smaller than the incision that would be required for insertion of the graft in its uncoiled sheet-like form. The volute is inserted one end first into the host eye through the incision and transported to a position between the retina and the underlying tissue. The volute uncoils after its insertion to lie in sheet-like form between the retina and the underlying tissue of the host eye. The incision is then closed.
摘要翻译：在宿主眼睛的视网膜下区域移植移植物的方法包括通过从供体组织收获细胞群来制备移植物，其方式是使细胞群维持在与正常组织中相同的组织和细胞极性的那种。细胞群体是片状形式，并且组装有由无毒的柔性组合物组成的相对薄的柔性柔韧载体，其基本上在体温下溶解以形成移植物。移植物具有足够的柔韧性和柔韧性，可卷起形成蜗壳，而不会干扰细胞的组织和极性。所述方法还包括将所述移植物卷绕以形成蜗壳，所述蜗壳的旋转体彼此不相互旋转，用于随后将所述移植物开卷大致其原始的片状形式。在宿主眼中进行切口以插入蜗壳。眼睛中的切口小于将未接种的片状形式的移植物插入所需的切口。蜗壳通过切口首先插入宿主眼睛，并运送到视网膜和下面的组织之间的位置。蜗壳在其插入之后，在视网膜和宿主眼睛的下面的组织之间以片状形式展开。然后关闭切口。

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