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    • 1. 发明授权
    • Methods of forming acid particle based packers for wellbores
    • 形成用于井筒的基于酸性颗粒的包装机的方法
    • US08230936B2
    • 2012-07-31
    • US11424676
    • 2006-06-16
    • Stephen DaviesFrank EspinosaJohn W. StillJean-Louis Pessin
    • Stephen DaviesFrank EspinosaJohn W. StillJean-Louis Pessin
    • E21B33/12
    • E21B33/1208C09K8/516
    • Methods for creating packers at a desired location or locations within a wellbore for use in specific wellbore applications. A slurry of fluid medium and hydrolysable particulate matter is flowed to a downhole position and dehydrated. At this location, the particulate matter is released from the fluid medium and accumulated. The continual accumulation of the slurry and consequent deposition of particulate matter creates a degradable packer at the desired location within the wellbore. The particulate matter may be formed of an acid particle which may be removable, degradable, or hydrolysable under certain conditions of temperature, time, hydration, pH, and/or pressure. Either simultaneous with or subsequent to a wellbore activity, the packer is partially or completely removed from the wellbore.
    • 在井眼中的期望位置或位置处创建包装器以用于特定井眼应用的方法。 流体介质和可水解颗粒物质的浆液流入井下位置并脱水。 在这个位置,颗粒物质从流体介质中释放并积聚。 浆料的持续积累和随之而来的颗粒物质的沉积在井眼内的所需位置产生可降解的封隔器。 颗粒物质可以由在特定温度,时间,水合,pH和/或压力条件下可去除,可降解或可水解的酸性颗粒形成。 与井眼活动同时或之后,封隔器部分或完全从井筒中移除。
    • 2. 发明申请
    • Methods of Forming Acid Particle Based Packers for Wellbores
    • 形成用于井筒的酸性粒子包装机的方法
    • US20070044966A1
    • 2007-03-01
    • US11424676
    • 2006-06-16
    • Stephen DaviesFrank EspinosaJohn StillJean-Louis Pessin
    • Stephen DaviesFrank EspinosaJohn StillJean-Louis Pessin
    • E21B33/12
    • E21B33/1208C09K8/516
    • Methods for creating packers at a desired location or locations within a wellbore for use in specific wellbore applications. A slurry of fluid medium and hydrolysable particulate matter is flowed to a downhole position and dehydrated. At this location, the particulate matter is released from the fluid medium and accumulated. The continual accumulation of the slurry and consequent deposition of particulate matter creates a degradable packer at the desired location within the wellbore. The particulate matter may be formed of an acid particle which may be removable, degradable, or hydrolysable under certain conditions of temperature, time, hydration, pH, and/or pressure. Either simultaneous with or subsequent to a wellbore activity, the packer is partially or completely removed from the wellbore.
    • 在井眼中的期望位置或位置处创建包装器以用于特定井眼应用的方法。 流体介质和可水解颗粒物质的浆液流入井下位置并脱水。 在这个位置,颗粒物质从流体介质中释放并积聚。 浆料的持续积累和随之而来的颗粒物质的沉积在井眼内的所需位置产生可降解的封隔器。 颗粒物质可以由在特定温度,时间,水合,pH和/或压力条件下可去除,可降解或可水解的酸性颗粒形成。 与井眼活动同时或之后,封隔器部分或完全从井筒中移除。
    • 3. 发明申请
    • P38 Map Kinase Inhibitors
    • P38图激酶抑制剂
    • US20090099185A1
    • 2009-04-16
    • US12299333
    • 2007-05-01
    • David Charles Festus MoffatStephane PintatStephen Davies
    • David Charles Festus MoffatStephane PintatStephen Davies
    • A61K31/4412C07D211/76C12N9/99C07D413/12A61K31/5377A61P1/00A61P17/06A61P11/06A61P3/10A61P19/02A61P37/00A61P37/06
    • C07D213/73
    • Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2), —X1-L1-Y—NH—CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid.
    • 式(I)化合物是p38MAP激酶的抑制剂,因此可用于治疗特别是炎性病症,包括类风湿性关节炎和COPD:其中:G是-N-或-CH-; D是任选取代的具有5-13个环成员的二价单环或双环芳基或杂芳基; R6是氢或任选取代的C 1 -C 3烷基; P表示氢,U表示式(IA)的基团; 或U表示氢,P表示式-A-(CH2),-X1-L1-Y-NH-CHR1R2的基团,其中A表示任选取代的具有5-13个环成员的二价单环或双环碳环或杂环基; z,Y,L1和X1如说明书中所定义; R 1是羧酸基团(-COOH)或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R2是天然或非天然α氨基酸的侧链。
    • 6. 发明申请
    • Genetic circuit inverting amplifier
    • 遗传电路反相放大器
    • US20050112615A1
    • 2005-05-26
    • US10861415
    • 2004-06-07
    • Stephen DaviesGianna DeRubertis
    • Stephen DaviesGianna DeRubertis
    • H03F99/00C12Q1/68H03F21/00
    • H03F21/00
    • We describe methods and compositions for setting the level of gene expression in a cell. The instant invention is of an amplifier, an analog circuit. It is directly analogous to the inverting amplifier commonly used in electronics. This circuit produces an output wherein an increase in the input signal leads to a proportional decrease in the output. Similarly, a decrease in the input leads to an increase in the output signal. Here the inputs and outputs may be concentrations of intracellular molecular species. The circuit is implemented as nucleic acid constructs. By analogy with the similar circuit found in analog electronics, such a circuit is expected to have improved signal to noise ratio, improved stability, and increased accuracy. It should aid in the development of intracellular instrumentation and hence the diagnosis and treatment of disease.
    • 我们描述了设置细胞中基因表达水平的方法和组合物。 本发明是放大器,模拟电路。 它直接类似于电子学中通常使用的反相放大器。 该电路产生输出,其中输入信号的增加导致输出的比例减小。 类似地,输入的减小导致输出信号的增加。 这里的输入和输出可以是细胞内分子种类的浓度。 电路实现为核酸构建体。 通过与模拟电子学中类似的电路类似,预计这种电路具有改善的信噪比,改进的稳定性和增加的精度。 它应该有助于细胞内仪器的发展,从而有助于疾病的诊断和治疗。
    • 7. 发明授权
    • Security system
    • 保安系统
    • US5710540A
    • 1998-01-20
    • US284585
    • 1996-02-20
    • Richard Marc ClementStephen Davies
    • Richard Marc ClementStephen Davies
    • G07G1/00G07G3/00G08B13/24G08B13/187
    • G08B13/246G07G1/0054G07G3/003G08B13/2474
    • Unauthorized removal of articles e.g. from a retail store, each article carrying a read/write tag, is detected by a security system having at least one point-of-sale apparatus (30) arranged to write specific data into (or erase specific data from) the tag to indicate that the article has been paid for, and a detector apparatus (40) for the or each exit of the store and arranged to read each tag to determine if the specific data has been written into (or erased from) the tag, and otherwise to initiate an alarm. The system also includes a refunds/returns detector apparatus (50) to read the tag of each article presented to it, to determine if the specific data has been written into (or erased from) the tag, and to erase (or write in) that data so that the article can be returned to stock.
    • PCT No.PCT / GB93 / 00287 Sec。 371日期1996年2月20日 102(e)日期1996年2月20日PCT提交1993年2月11日PCT公布。 出版物WO93 / 17404 日期:1993年9月2日 每个物品携带读/写标签由具有至少一个销售点设备(30)的安全系统检测到,所述销售点设备被设置为将特定数据写入(或从其中删除特定数据)以指示 以及用于商店的每个出口的检测器装置(40),并被布置成读取每个标签以确定特定数据是否已被写入(或从该标签中删除),否则为 发起警报 该系统还包括一个退回/退回检测器装置(50),用于读取呈现给它的每个物品的标签,以确定该特定数据是否已被写入(或从该标签中删除),以及擦除(或写入) 该数据使文章可以退回库存。
    • 8. 发明授权
    • System and method for voice networking
    • US10904179B2
    • 2021-01-26
    • US16191344
    • 2018-11-14
    • Stephen Davies
    • Stephen Davies
    • H04L12/58H04M3/42H04M3/533H04W4/12G10L15/26G10L17/00
    • A system and method for voice based social networking is disclosed. The system receives a voice message (and frequently an image) and ultimately delivers it to one or multiple users, placing it within an ongoing context of conversations. The voice and image may be recorded by various devices and the data transmitted in a variety of formats. An alternative implementation places some system functionality in a mobile device such as a smartphone or wearable device, with the remaining functionality resident in system servers attached to the internet. The system can apply rules to select and limit the voice data flowing to each user; rules prioritize the messages using context information such as user interest and user state. An image is fused to the voice message to form a comment. Additional image or voice annotation (or both) identifying the sender may be attached to the comment. Fused image(s) and voice annotation allow the user to quickly deduce the context of the comment. The system provides the means to deliver a seamless flow of a conversation without requiring user interaction to hear individual comments. Multiple conversations or parts of conversations (or both) are blended into the users acoustic channel without requiring user interaction at the level of individual comments. Advertising may also be integrated. The resulting information flow is translated into formats acceptable to the user's receiving device.