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1. 发明申请

US20090264724A1 SERUM SAMPLING APPARATUS AND CATHETER 审中-公开
标题翻译：血清采样装置和导管
公开(公告)号：US20090264724A1
公开(公告)日：2009-10-22
申请号：US12105210
申请日：2008-04-17
申请人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
发明人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
IPC分类号： A61B5/153 , A61B5/1473
CPC分类号： A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150389 , A61B5/150511 , A61B5/153 , A61B5/155 , A61B5/157 , A61B2560/0223
摘要： In a serum measurement device, an analyte concentration measurement apparatus facilitates sampling and analysis of analytes in body fluid and includes an implantable serum sampling catheter comprising a biocompatible tubing enclosing a vacuum release lumen and a serum lumen that are interconnected by a port. The serum lumen is separated from the sampling catheter exterior by a membrane barrier. The sampling catheter is configured for drawing a serum sample from a body fluid compartment by creation of suction in the serum lumen.
摘要翻译：在血清测量装置中，分析物浓度测量装置便于对体液中的分析物进行取样和分析，并且包括可植入的血清取样导管，其包括封闭真空释放腔的生物相容管和由端口相互连接的血清腔。通过膜屏障将血清内腔与取样导管外部分离。采样导管被配置为通过在血清管腔中产生吸力来从体液隔室中抽取血清样品。

2. 发明授权

US06690958B1 Ultrasound-guided near infrared spectrophotometer 失效
标题翻译：超声波引导近红外分光光度计
公开(公告)号：US06690958B1
公开(公告)日：2004-02-10
申请号：US10143248
申请日：2002-05-07
申请人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers
发明人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers
IPC分类号： A61B500
CPC分类号： A61B5/1464 , A61B5/14542 , A61B5/6853 , A61B8/0808 , A61B8/0866 , A61B8/12 , A61B8/4416 , A61B8/445 , A61B2562/0233 , A61B2562/0242 , A61B2562/043
摘要： A diagnostic apparatus includes a near infrared spectrophotometer (NIRS) and an ultrasound transducer that operate in combination to improve diagnostic measurements. The diagnostic apparatus includes a near infrared spectrophotometer that measures an analyte, for example tissue oxygenation, in an optical sample volume and an ultrasound imager to accurately position the optical sample volume in biological tissue or vessels. In one example, the diagnostic apparatus includes an optical source, a linear array of ultrasound transducers, and an optical photodetector arranged in the same plane so that the ultrasound sample volume interrogated by the ultrasound transducers intersects the optical sample volume formed by the optical source and detector.
摘要翻译：诊断装置包括近红外分光光度计（NIRS）和超声波换能器，其组合操作以改善诊断测量。诊断装置包括近红外分光光度计，其测量光学样本体积中的分析物例如组织氧合，以及超声波成像器，以将光学样本体积精确地定位在生物组织或血管中。在一个示例中，诊断装置包括光源，超声波换能器的线性阵列和布置在同一平面中的光学检测器，使得由超声波换能器询问的超声波样品体积与由光源形成的光学样本体积相交，探测器。

3. 发明申请

US20090047177A1 LACTATE CONCENTRATION MEASUREMENT DEVICE 审中-公开
标题翻译： LACTATE浓度测量装置
公开(公告)号：US20090047177A1
公开(公告)日：2009-02-19
申请号：US11840528
申请日：2007-08-17
申请人： Stephen D. Walker , Devon J. Dallmann , Charles W. Henry , Peter E. Nelson , R. Dale Zellers , John E. Repine
发明人： Stephen D. Walker , Devon J. Dallmann , Charles W. Henry , Peter E. Nelson , R. Dale Zellers , John E. Repine
IPC分类号： G01N21/00 , G01N33/48
CPC分类号： G01N21/314 , G01N21/35 , G01N2021/3166
摘要： A lactate concentration measurement apparatus comprising a housing enclosing a sample chamber configured for holding a body fluid sample and measurement photo-optics that generate light and monitor light intensity along a plurality of optical paths in the sample chamber. The apparatus further comprises a plurality of optical filters aligned in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by lactate and water and a second optical filter with light absorption to water alone. A logic determines lactate concentration based on a ratio of intensities detected at a first detector in an optical path intersected by the first optical filter and detected at a second detector in an optical path intersected by the second optical filter.
摘要翻译：一种乳酸盐浓度测量装置，包括：壳体，其包围被构造成用于保持体液样本的样本室，以及测量光学光学器件，其产生光并沿着样本室中的多个光路监测光强度。该装置还包括多个光学滤光器，该多个光学滤光器在光路的各个光路中排列成多个，至少包括具有乳酸和水的光吸收的第一滤光器以及仅对水单独吸收光的第二滤光器。逻辑根据在与第一滤光器相交的光路中的第一检测器检测到的强度的比值确定乳酸浓度，并且在与第二滤光器相交的光路中的第二检测器处检测。

4. 发明申请

US20090018416A1 Analyte Concentration Measurement Device 审中-公开
标题翻译：分析物浓度测定装置
公开(公告)号：US20090018416A1
公开(公告)日：2009-01-15
申请号：US11777940
申请日：2007-07-13
申请人： Stephen D. Walker , Devon J. Dallmann , Charles W. Henry , Peter E. Nelson , R. Dale Zellers , John E. Repine
发明人： Stephen D. Walker , Devon J. Dallmann , Charles W. Henry , Peter E. Nelson , R. Dale Zellers , John E. Repine
IPC分类号： A61B5/00
CPC分类号： G01N21/314 , A61B5/14532 , G01N21/35
摘要： A method for measuring concentration of an analyte in body fluid comprises acquiring a body fluid sample, emitting light into the body fluid sample, and detecting emitted light intensity on a plurality of optical paths through the body fluid sample. A plurality of optical filters are arranged in respective optical paths of the optical path plurality comprising at least a first optical filter with light absorption by an analyte and water and a second optical filter with light absorption to water alone. Light intensity passed through the first optical filter and passed through the second optical filter is measured and analyte concentration is determined based on a ratio of intensities detected at a detector in an optical path intersected by the first optical filter and detected at a detector in an optical path intersected by the second optical filter.
摘要翻译：用于测量体液中分析物浓度的方法包括获取体液样品，将光发射到体液样品中，以及检测通过体液样品的多条光路上的发射光强度。多个光学滤光器被布置在包括至少一个具有被分析物和水的光吸收的第一滤光器的光路的多个光路中，以及仅对水单独吸收光的第二滤光器。测量通过第一滤光器并通过第二滤光器的光强度，并且基于在由第一滤光器相交的光路中的检测器处检测到的强度的比率确定分析物浓度，并在光学检测器中检测路径与第二光学滤波器相交。

5. 发明申请

US20080004513A1 VCSEL Tissue Spectrometer 审中-公开
标题翻译： VCSEL组织光谱仪
公开(公告)号：US20080004513A1
公开(公告)日：2008-01-03
申请号：US11428217
申请日：2006-06-30
申请人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
发明人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/412 , A61B2562/0233 , A61B2562/043
摘要： In a tissue sensor, a plurality of emitters are configured to emit narrowband light into biological tissue at a plurality of selected wavelengths including one or more wavelengths indicative of a profile for one or more selected analytes and a reference wavelength at which absorbance for the selected analyte is negligible. The sensor further comprises a photo detector configured to detect light at wavelengths that emerge from the biological tissue.
摘要翻译：在组织传感器中，多个发射器被配置为以多个选定的波长将窄带光发射到生物组织中，所述多个选定波长包括一个或多个波长，其指示一个或多个所选分析物的分布，以及所选分析物的吸光度是微不足道的传感器还包括被配置为检测从生物组织出现的波长处的光的光检测器。

6. 发明授权

US07251516B2 Noninvasive glucose sensor 失效
标题翻译：无创葡萄糖传感器
公开(公告)号：US07251516B2
公开(公告)日：2007-07-31
申请号：US10844230
申请日：2004-05-11
申请人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
发明人： Stephen D. Walker , Peter E. Nelson , R. Dale Zellers , Charles W. Henry , John E. Repine
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61K31/405
摘要： Glucose concentration is noninvasively measured by measuring a plurality of absorption values using at least one emitter operating at a corresponding plurality of emission wavelengths through a common optical sample volume and deriving glucose concentration from the absorption measurement values.
摘要翻译：通过使用至少一个发射体以相应的多个发射波长通过共同的光学样本体积测量多个吸收值并从吸收测量值导出葡萄糖浓度来非葡萄糖浓度。

7. 发明授权

US06802812B1 Noninvasive optical sensor for measuring near infrared light absorbing analytes 失效
标题翻译：用于测量近红外光吸收分析物的无创光学传感器
公开(公告)号：US06802812B1
公开(公告)日：2004-10-12
申请号：US09917414
申请日：2001-07-27
申请人： Stephen D. Walker , John E. Repine , Charles W. Henry , Harry L. Valenta, Jr. , Peter E. Nelson , R. Dale Zellers
发明人： Stephen D. Walker , John E. Repine , Charles W. Henry , Harry L. Valenta, Jr. , Peter E. Nelson , R. Dale Zellers
IPC分类号： A61B500
CPC分类号： A61B5/412 , A61B5/02028 , A61B5/0261 , A61B5/14553 , A61B5/413 , A61B5/7275 , A61B2562/028
摘要： An optical sensor includes an optical source capable of being positioned on a tissue and emitting near infrared light into the tissue at a plurality of selected wavelengths, and a photodetector capable of detecting reflected light from the tissue. The photodetector being positioned on the tissue removed from the optical source but sufficiently close in proximity to the optical source to contact the same general tissue. The optical sensor further includes an oscillator coupled to the optical source and capable of activating the optical source to emit the near infrared light, and a modulator coupled to the oscillator and capable of controlling radio frequency modulation of the optical source to emit a radio frequency component that is used to measure the optical path length and absorbance of an analyte of interest within the tissue.
摘要翻译：光学传感器包括能够定位在组织上并以多个选定波长将近红外光发射到组织中的光源，以及能够检测来自组织的反射光的光电检测器。光电检测器定位在从光源移除的组织上，但是在光源附近充分接近以接触相同的一般组织。光学传感器还包括耦合到光源并且能够激活光源以发射近红外光的振荡器，以及耦合到振荡器并且能够控制光源的射频调制以发射射频分量的振荡器其用于测量组织内感兴趣的分析物的光程长度和吸光度。

8. 发明申请

US20090018483A1 Infrared Sample Chamber 审中-公开
标题翻译：红外样品室
公开(公告)号：US20090018483A1
公开(公告)日：2009-01-15
申请号：US11777961
申请日：2007-07-13
申请人： Stephen D. Walker , Charles W. Henry , Peter E. Nelson , John E. Repine
发明人： Stephen D. Walker , Charles W. Henry , Peter E. Nelson , John E. Repine
IPC分类号： A61M37/00
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14557
摘要： A body fluid analysis apparatus comprises a unitary housing containing a single-celled chamber and having an entry portal for communicating body fluid between a patient body and the chamber. A barrier coupled at the entry portal prevents selected components of the body fluid from entering the chamber.
摘要翻译：体液分析装置包括一体式壳体，其包含单细胞室并且具有用于在患者体和腔室之间连通体液的入口入口。在入口处连接的屏障阻止体液的选定部件进入腔室。

9. 发明授权

US08391956B2 Medical device location systems, devices and methods 有权
标题翻译：医疗设备定位系统，设备和方法
公开(公告)号：US08391956B2
公开(公告)日：2013-03-05
申请号：US12949663
申请日：2010-11-18
申请人： Robert D. Zellers , Peter E. Nelson , Charles W. Henry
发明人： Robert D. Zellers , Peter E. Nelson , Charles W. Henry
IPC分类号： A61B5/05
CPC分类号： A61B5/062
摘要： Methods, devices and systems for one or both of two- or three-dimensional location of the disposition of a sensor coil in a subject including: an array of electromagnetic drive coil sets, each set having two or three dimensionally oriented drive coils; a sensor coil being electromagnetically communicative with the array of electromagnetic drive coil sets; and, a system controller communicative with and adapted to energize one or more of the electromagnetic coils in the array of electromagnetic drive coil sets, the energizing of the one or more of the electromagnetic coils including one or more of energizing the coils singly, or in pairs of x-y and y-z or x-z coils, or in triplets of x-y-z coils while measuring the response of the sensor coil; whereby the system uses the measurements of the responses of the sensor coil to calculate the location and orientation of the sensor coil relative to said drive coil sets.
摘要翻译：传感器线圈在被摄体中的二维或三维位置的一个或两个位置的方法，装置和系统，包括：电磁驱动线圈组阵列，每组具有二维或三维定向的驱动线圈; 传感器线圈与电磁驱动线圈组阵列电磁连接; 以及与电磁驱动线圈组阵列中的一个或多个电磁线圈通电且适于对电磁驱动线圈组的电磁线圈通电的系统控制器，一个或多个电磁线圈的激励包括单独激励线圈中的一个或多个，或者一对xy和yz或xz线圈，或在xyz线圈的三元组中，同时测量传感器线圈的响应; 由此系统使用传感器线圈的响应的测量来计算传感器线圈相对于所述驱动线圈组的位置和取向。

10. 发明申请

US20120130229A1 Medical Device Location Systems, Devices and Methods 有权
标题翻译：医疗器械定位系统，设备和方法
公开(公告)号：US20120130229A1
公开(公告)日：2012-05-24
申请号：US12949671
申请日：2010-11-18
申请人： Robert D. Zellers , Peter E. Nelson , Charles W. Henry
发明人： Robert D. Zellers , Peter E. Nelson , Charles W. Henry
IPC分类号： A61B5/05
CPC分类号： A61B5/062
摘要： Methods, devices and systems for one or both of two- or three-dimensional location of the disposition of a sensor coil in a subject including: an array of electromagnetic drive coil sets, each set having two or three dimensionally oriented drive coils; a sensor coil being electromagnetically communicative with the array of electromagnetic drive coil sets; and, a system controller communicative with and adapted to energize one or more of the electromagnetic coils in the array of electromagnetic drive coil sets, the energizing of the one or more of the electromagnetic coils including one or more of energizing the coils singly, or in pairs of x-y and y-z or x-z coils, or in triplets of x-y-z coils while measuring the response of the sensor coil; whereby the system uses the measurements of the responses of the sensor coil to calculate the location and orientation of the sensor coil relative to said drive coil sets.
摘要翻译：传感器线圈在被摄体中的二维或三维位置的一个或两个位置的方法，装置和系统，包括：电磁驱动线圈组阵列，每组具有二维或三维定向的驱动线圈; 传感器线圈与电磁驱动线圈组阵列电磁连接; 以及与电磁驱动线圈组阵列中的一个或多个电磁线圈通电且适于对电磁驱动线圈组的电磁线圈通电的系统控制器，一个或多个电磁线圈的激励包括单独激励线圈中的一个或多个，或者一对xy和yz或xz线圈，或在xyz线圈的三元组中，同时测量传感器线圈的响应; 由此系统使用传感器线圈的响应的测量来计算传感器线圈相对于所述驱动线圈组的位置和取向。

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