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1. 发明授权

US06716624B2 GSK3 polypeptides 失效
标题翻译： GSK3多肽
公开(公告)号：US06716624B2
公开(公告)日：2004-04-06
申请号：US10211412
申请日：2002-07-31
申请人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
发明人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
IPC分类号： C12N912
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3&agr; and GSK3&bgr; polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK3多肽，包括GSK3α和GSK3β多肽，以及使用这些多肽来鉴定和优化GSK3抑制剂。还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病（包括阿尔茨海默病，2型糖尿病和炎症）的化合物的方法。

2. 发明申请

US20080182313A1 GSK3 polypeptides 失效
标题翻译： GSK3多肽
公开(公告)号：US20080182313A1
公开(公告)日：2008-07-31
申请号：US12074543
申请日：2008-03-03
申请人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
发明人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
IPC分类号： C12N9/12 , C07H21/04 , C12N15/00
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK 3多肽，包括GSK3α和GSK3β多肽，以及这些多肽用于鉴定和优化GSK 3抑制剂的用途。还提供了具有与野生型GSK 3不同的至少一个取代的氨基酸的GSK 3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK 3活性（包括阿尔茨海默病，2型糖尿病和炎症）介导的疾病的化合物的方法。

3. 发明授权

US07361484B2 GSK3 polypeptides 失效
标题翻译： GSK3多肽
公开(公告)号：US07361484B2
公开(公告)日：2008-04-22
申请号：US11704724
申请日：2007-02-08
申请人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
发明人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
IPC分类号： C12Q1/48 , G01N33/53 , G01N33/00 , G01N33/563 , C12P21/06 , C12P21/08 , C12N9/12 , C12N5/02 , C12N5/06 , C12N15/00 , C07K14/00
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK3多肽，包括GSK3α和GSK3β多肽，以及使用这些多肽来鉴定和优化GSK3抑制剂。还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病（包括阿尔茨海默病，2型糖尿病和炎症）的化合物的方法。

4. 发明授权

US06465231B2 GSK3 polypeptides 有权
标题翻译： GSK3多肽
公开(公告)号：US06465231B2
公开(公告)日：2002-10-15
申请号：US09916109
申请日：2001-07-25
申请人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
发明人： Stephen D. Harrison , John A. Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Y. Fang , Doris G. Coit , Steve H. Nguyen , Angelica Medina-Selby
IPC分类号： C12N912
CPC分类号： C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要： The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3&agr; and GSK3&bgr; polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译：本发明提供能够结晶的截短的GSK3多肽，包括GSK3α和GSK3β多肽，以及使用这些多肽来鉴定和优化GSK3抑制剂。还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽，其中取代的氨基酸不能被磷酸化。本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病（包括阿尔茨海默病，2型糖尿病和炎症）的化合物的方法。

5. 外观设计

USD686628S1 Electronics device holder 有权
标题翻译：电子设备座
公开(公告)号：USD686628S1
公开(公告)日：2013-07-23
申请号：US29419798
申请日：2012-05-02
申请人： John A. Hall
设计人： John A. Hall

6. 发明申请

US20100318371A1 COMPREHENSIVE HAZARD EVALUATION SYSTEM AND METHOD FOR CHEMICALS AND PRODUCTS 审中-公开
标题翻译：综合危害评估系统及化学品及其制品方法
公开(公告)号：US20100318371A1
公开(公告)日：2010-12-16
申请号：US12483071
申请日：2009-06-11
申请人： Johnny R. Sanders, JR. , Denise A. Tuck , Patrick J. Finley , Cliff Paterson , John A. Hall
发明人： Johnny R. Sanders, JR. , Denise A. Tuck , Patrick J. Finley , Cliff Paterson , John A. Hall
IPC分类号： G06Q99/00 , G06F17/30 , G06F17/00
CPC分类号： G06Q30/0282 , G16H50/30 , G16H50/80
摘要： A comprehensive hazard evaluation system and method for chemicals and products. The system includes a memory and a processor. The memory stores the component make-up for each of a number of products. The memory also stores an environmental hazard score, an environmental health hazard score, and a physical hazard score for each component. A product hazard score is determined and stored based on the environmental hazard score, the environmental health hazard score, and the physical hazard score. The processor is operable to process user request and to display the product hazard score for at least one product on a display.
摘要翻译：化学品和产品的综合危害评估系统和方法。该系统包括一个存储器和一个处理器。内存存储各种产品的组件组成。记忆还存储每个组分的环境危害分数，环境健康危害分数和物理危害分数。根据环境危害分数，环境健康危害分数和身体危害分数确定并存储产品危害分数。处理器可操作以处理用户请求并且在显示器上显示至少一种产品的产品危害分数。

7. 发明授权

US06274148B1 Hepatitis C virus asialoglycoproteins 失效
标题翻译：丙型肝炎病毒脱唾液酸糖蛋白
公开(公告)号：US06274148B1
公开(公告)日：2001-08-14
申请号：US08249843
申请日：1994-05-26
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： A61K3929
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
摘要翻译：两种丙型肝炎病毒包膜蛋白（E1和E2）不表达唾液酸化。这些蛋白质在低等真核生物或其末端糖基化被阻断的哺乳动物细胞中的重组表达导致与天然HCV糖蛋白更相似的重组蛋白质。当通过GNA凝集素亲和力分离时，E1和E2蛋白聚集成病毒样颗粒。

8. 发明授权

US6074852A Hepatitis C virus asialoglycoproteins 失效
公开(公告)号：US6074852A
公开(公告)日：2000-06-13
申请号：US443900
申请日：1995-05-17
申请人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
发明人： Robert O. Ralston , Frank Marcus , Kent B. Thudium , Barbara A. Gervase , John A. Hall , Kim M. Berger , Qui-Lim Choo , Michael Houghton , George Kuo
IPC分类号： G01N33/576 , A61K35/16 , A61K38/00 , A61K38/10 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/12 , C07K14/18 , C12N1/19 , C12N5/10 , C12N15/09 , C12N15/51 , C12P21/02 , C12P21/04 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S530/82 , Y10S530/826 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/915 , Y10S977/918
摘要： Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

9. 发明授权

US08333260B1 Deep insertion vented earpiece system 有权
标题翻译：深插入式耳机系统
公开(公告)号：US08333260B1
公开(公告)日：2012-12-18
申请号：US12796078
申请日：2010-06-08
申请人： John A. Hall , Karl Cartwright , Kris Cartwright
发明人： John A. Hall , Karl Cartwright , Kris Cartwright
IPC分类号： H04R25/02 , H04R25/00
CPC分类号： H04R1/1016
摘要： A deep insertion vented earpiece system is described including resilient earpieces shaped to a wearer's ear canal for a conformal fit. A receptacle is provided within the outer surface of each earpiece for releasably receiving an audio plug. The audio plugs include a miniature loudspeaker and a pair of external ribs for mating with a corresponding pair of grooves formed along the periphery of the receptacle. This rib and groove feature provides for a secure retention of the audio plugs while enabling a simple removal operation. Each earpiece includes an audio passage to conduct the audio signal from the loudspeaker and a vent passage to enable continuous venting of the wearer's ear to atmosphere.
摘要翻译：描述了深插入式耳塞系统，其包括成形为佩戴者的耳道的适形配合的弹性耳机。插座设置在每个耳机的外表面内，用于可释放地接收音频插头。音频插头包括微型扬声器和一对外部肋条，用于与沿插座周边形成的相应的一对凹槽配合。这种肋和凹槽功能提供了音频插头的安全保持，同时实现简单的移除操作。每个听筒包括用于传导来自扬声器的音频信号的音频通道和一个排气通道，以使佩戴者的耳朵能连续排放到大气中。

10. 发明授权

US06715813B2 Over-center spring control 有权
标题翻译：超中心弹簧控制
公开(公告)号：US06715813B2
公开(公告)日：2004-04-06
申请号：US10224223
申请日：2002-08-20
申请人： Joseph M. Thompson , Paul C. Schutter , John A. Hall
发明人： Joseph M. Thompson , Paul C. Schutter , John A. Hall
IPC分类号： B60N302
CPC分类号： B60N3/023 , Y10T16/50 , Y10T16/515
摘要： An arcuate spring is coupled between a fixed vehicle member and a movable vehicle member with a pivot connection between the members interposed between the ends of the spring such that, as the movable member is moved from a first position, the axis of the pivot connection is located outside of a line intersecting the ends of the spring, thereby holding the movable member in a first position. When the movable member is moved to a second position, the pivot connection lies between the spring and a line connecting the end points of the spring to provide a bias force which holds the movable member in a second position. In one embodiment, the over-center spring is integrated with a grab handle for holding the grab handle in a deployed or retracted position. In another embodiment, the spring is associated with a vehicle panel.
摘要翻译：弧形弹簧联接在固定车辆构件和可移动车辆构件之间，其间插入在弹簧的端部之间的构件之间的枢转连接，使得当可动构件从第一位置移动时，枢转连接的轴线为位于与弹簧的端部相交的线的外侧，从而将可动构件保持在第一位置。当可移动部件移动到第二位置时，枢转连接位于弹簧与连接弹簧的端点的线之间，以提供将可动件保持在第二位置的偏压力。在一个实施例中，过中心弹簧与抓握手柄集成，用于将抓握手柄保持在展开或缩回位置。在另一个实施例中，弹簧与车辆面板相关联。

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