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1. 发明授权

US07929122B2 Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
标题翻译：利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的红细胞指数的方法和装置
公开(公告)号：US07929122B2
公开(公告)日：2011-04-19
申请号：US12946503
申请日：2010-11-15
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G01N33/48
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

2. 发明申请

US20090238438A1 METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置
公开(公告)号：US20090238438A1
公开(公告)日：2009-09-24
申请号：US12408357
申请日：2009-03-20
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

3. 发明授权

US08310658B2 Method and apparatus for identifying reticulocytes within a blood sample 有权
标题翻译：用于鉴定血液样品内的网织红细胞的方法和装置
公开(公告)号：US08310658B2
公开(公告)日：2012-11-13
申请号：US13039453
申请日：2011-03-03
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G01N33/48
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.
摘要翻译：提供了一种用于鉴定血液样本内的网织红细胞的方法和装置。该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，并且室具有在面板的内表面之间延伸的已知或可确定的高度，其高度使得至少一个样品内的红血细胞或红细胞聚集体接触两个内表面; b）将supravital染料与样品混合，该染料可操作以在由一种或多种预定波长的光激发时使网状蛋白发荧光; c）使用包括导致网状蛋白发荧光的一个或多个预定波长的光成像样品; d）使用被血红蛋白吸收的光进行成像，以产生基于每个图像单位的光密度值; 以及e）使用由导致染色的网状蛋白发荧光的光产生的样品的图像来识别样品内的网织红细胞，并且使用每个图像单位的光密度值。

4. 发明申请

US20110149061A1 METHOD AND APPARATUS FOR IDENTIFYING RETICULOCYTES WITHIN A BLOOD SAMPLE 有权
标题翻译：用于在血液样品中鉴定细胞因子的方法和装置
公开(公告)号：US20110149061A1
公开(公告)日：2011-06-23
申请号：US13039453
申请日：2011-03-03
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method and apparatus for identifying reticulocytes within a blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, and the chamber has a known or determinable height extending between the interior surfaces of panels, which height is such that at least one red blood cell, or an aggregate of red blood cells, within the sample contacts both of the interior surfaces; b) admixing a supravital dye with the sample, which dye is operable to cause reticulin to fluoresce when excited by light of one or more predetermined wavelengths; c) imaging the sample using light that includes the one or more predetermined wavelengths that cause reticulin to fluoresce; d) imaging the sample using light that is absorbed by hemoglobin to produce values of optical density on a per image unit basis; and e) identifying reticulocytes within the sample using the image of the sample created with light that causes the dyed reticulin to fluoresce, and using the per image unit optical density values.
摘要翻译：提供了一种用于鉴定血液样本内的网织红细胞的方法和装置。该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，并且室具有在面板的内表面之间延伸的已知或可确定的高度，其高度使得至少一个样品内的红血细胞或红细胞聚集体接触两个内表面; b）将supravital染料与样品混合，该染料可操作以在由一种或多种预定波长的光激发时使网状蛋白发荧光; c）使用包括导致网状蛋白发荧光的一个或多个预定波长的光成像样品; d）使用被血红蛋白吸收的光进行成像，以产生基于每个图像单位的光密度值; 以及e）使用由导致染色的网状蛋白发荧光的光产生的样品的图像，以及使用每个图像单位的光密度值来鉴定样品内的网织红细胞。

5. 发明申请

US20110059481A1 METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置
公开(公告)号：US20110059481A1
公开(公告)日：2011-03-10
申请号：US12946503
申请日：2010-11-15
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

6. 发明授权

US07903241B2 Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
公开(公告)号：US07903241B2
公开(公告)日：2011-03-08
申请号：US12408357
申请日：2009-03-20
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G01N33/48
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.

7. 发明授权

US09873118B2 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion 有权
公开(公告)号：US09873118B2
公开(公告)日：2018-01-23
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： A61J1/06 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

8. 发明申请

US20130029373A1 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 有权
标题翻译：使用荧光猝灭和/或漂白分析个体细胞或颗粒物的方法和装置
公开(公告)号：US20130029373A1
公开(公告)日：2013-01-31
申请号：US13645075
申请日：2012-10-04
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

9. 发明申请

US20110230740A1 METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的HEMATOCRIT的方法和装置
公开(公告)号：US20110230740A1
公开(公告)日：2011-09-22
申请号：US13116837
申请日：2011-05-26
申请人： Robert A. Levine , Stephen C. Wardlaw , Darryn W. Unfricht , Niten V. Lalpuria
发明人： Robert A. Levine , Stephen C. Wardlaw , Darryn W. Unfricht , Niten V. Lalpuria
IPC分类号： A61B5/1455
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

10. 发明授权

US08994930B2 Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching 有权
标题翻译：使用荧光猝灭和/或漂白分析单个细胞或微粒的方法和装置
公开(公告)号：US08994930B2
公开(公告)日：2015-03-31
申请号：US13959294
申请日：2013-08-05
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N33/48 , G01N33/50 , G01N15/14 , G01N21/64 , G01N15/00
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

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