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1. 发明申请

US20120134924A1 Micro-Vesicles Providing Contrast To Target Tissue Electrical Property Gradients 审中-公开
标题翻译：提供与目标组织电性能梯度对比的微囊泡
公开(公告)号：US20120134924A1
公开(公告)日：2012-05-31
申请号：US12956519
申请日：2010-11-30
申请人： Stephen Anthony Cerwin , Jane F. Emerson , David B. Chang , Martin Fessenmaier , Nicholas J. Witchey
发明人： Stephen Anthony Cerwin , Jane F. Emerson , David B. Chang , Martin Fessenmaier , Nicholas J. Witchey
IPC分类号： A61K49/00
CPC分类号： A61K41/0028
摘要： Micro-vesicles that become acoustically sensitive in the presence of a Radio Frequency (RF) Electromagnetic (EM) field are presented. The micro-vesicles can comprise a main body having one or more affinity ligands configured to preferentially bind to a target tissue. Once bound, the micro-vesicles and the target tissue can be bathed in an RF EM field, which induces the target tissue or micro-vesicles to generate an acoustic signal. The micro-vesicles can also become receptive to acoustic energy. An acoustic therapeutic signal can be directed toward the target tissue and micro-vesicles, which causes therapeutic excitation of the micro-vesicles. The therapeutic excitation can include heating the target tissue, releasing a drug formulation, or other excitation. The disclosed techniques can be used with a high degree of precision to activate micro-vesicles local to the target tissue.
摘要翻译：提出了在存在射频（RF）电磁场的情况下变得声学敏感的微囊泡。微囊泡可以包含具有配体优先结合靶组织的一种或多种亲和配体的主体。一旦结合，微囊泡和目标组织可以沐浴在RF EM场中，其诱导靶组织或微囊泡产生声信号。微囊泡也可以接受声能。声学治疗信号可以被引向目标组织和微泡，这引起微泡的治疗激发。治疗激发可以包括加热靶组织，释放药物制剂或其它激发。可以高度精确地使用所公开的技术以激活靶组织局部的微小囊泡。

2. 发明申请

US20110288411A1 Multi-Mode Induced Acoustic Imaging Systems And Methods 审中-公开
标题翻译：多模感应声学成像系统及方法
公开(公告)号：US20110288411A1
公开(公告)日：2011-11-24
申请号：US12913586
申请日：2010-10-27
申请人： Stephen Anthony Cerwin , David B. Chang , Jane F. Emerson
发明人： Stephen Anthony Cerwin , David B. Chang , Jane F. Emerson
IPC分类号： A61B18/18 , A61B8/00
CPC分类号： A61B8/08 , A61B8/4472 , A61B8/463 , A61B8/466 , A61B8/483 , A61B8/5223
摘要： A multi-mode Electro-Magnetic Acoustic Imaging (EMAI) system is disclosed. The EMAI system utilizes an electromagnetic energy source to induce multiple acoustic signals in surrounding objects including a target tissue area or a transducer. The induced acoustic signals can be collected and converted to imaging data, which can be used to display a tissue area image. The collected acoustic signals can be filtered or isolated based on one or more signal proprieties including frequency. A signal's frequency can indicate a property of the target tissue including the tissue's conductivity or its density.
摘要翻译：公开了一种多模式电磁成像（EMAI）系统。 EMAI系统利用电磁能量来引导包括目标组织区域或换能器在内的周围物体中的多个声学信号。感应的声信号可以被收集并转换成成像数据，其可用于显示组织区域图像。所收集的声信号可以基于包括频率在内的一个或多个信号特性进行滤波或隔离。信号的频率可以指示包括组织的电导率或其密度的目标组织的性质。

3. 发明授权

US06974415B2 Electromagnetic-acoustic imaging 失效
标题翻译：电声成像
公开(公告)号：US06974415B2
公开(公告)日：2005-12-13
申请号：US10444202
申请日：2003-05-22
申请人： Stephen Anthony Cerwin , David B. Chang , James E. Drummond , Jane F. Emerson , Stuart McNaughton
发明人： Stephen Anthony Cerwin , David B. Chang , James E. Drummond , Jane F. Emerson , Stuart McNaughton
IPC分类号： A61B5/00 , A61B8/13 , A61B8/00 , A61B5/04
CPC分类号： A61B5/416 , A61B5/0073 , A61B5/0095 , A61B8/13
摘要： Ultrasound induced by RF irradiation within FDA exposure limits is produced with sufficient signal-to-noise ratio to allow acquisition of sub-millimeter resolution images within practical time frames.
摘要翻译：在FDA暴露极限内通过RF照射引起的超声波产生具有足够的信噪比，以允许在实际时间范围内采集亚毫米分辨率图像。

4. 发明授权

US07122008B2 Blood pressure diagnostic aid 失效
公开(公告)号：US07122008B2
公开(公告)日：2006-10-17
申请号：US10934843
申请日：2004-09-03
申请人： David B. Chang , James E. Drummond , Jane F. Emerson
发明人： David B. Chang , James E. Drummond , Jane F. Emerson
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/022 , A61B5/024
摘要： A medical diagnostic method using systolic and diastolic blood pressures, and pulse frequency of a patient is provided to compute a normalized diastolic distensibility value and a normalized peripheral resistance value, and to automatically compute the product of the normalized diastolic distensibility value and the normalized peripheral resistance value to generate a first product value. The first product value is compared to a stored distribution of normalized diastolic distensibility and a normalized peripheral resistance values for comparable individuals to determine if the first product value is equivalent to a value determined to indicate an abnormal condition. Particular values of the computed parameters aid in determining the etiology of hypertension and direct selection of pharmacotherapy.

5. 发明申请

US20110166438A1 RF FIELD SHAPING AND ATTENUATION FOR EMAI INDUCTION ELEMENTS 审中-公开
标题翻译： EMAI感应元件的射频场形成和衰减
公开(公告)号：US20110166438A1
公开(公告)日：2011-07-07
申请号：US12896733
申请日：2010-10-01
申请人： Jane F. Emerson , David B. Chang , Stephen A. Cerwin , James E. Drummond , Joy Drummond
发明人： Jane F. Emerson , David B. Chang , Stephen A. Cerwin , James E. Drummond , Joy Drummond
IPC分类号： A61B8/13 , A61B8/00 , A61B5/055
CPC分类号： A61B5/0051 , G01R33/4814
摘要： An Electro-Magnetic Imaging (EMAI) System is presented. EMAI systems can include induction elements (e.g., an induction coil) configured to induce a target tissue to generate internally sourced ultrasounds. The induction elements can be shielded by one or more shielding elements to shape, or otherwise alter, an imaging field while attenuating radiated fields in a far zone. EMAI systems can further include a shield tuner to adjust shield parameters to achieved desired imaging or radiated field properties. A shielding element can be placed approximately one induction coil radius away from the coil to achieve suitably strong imaging field magnitudes while also achieving suitably weak radiated field magnitudes in a far zone. In some embodiments, acoustic sensors lack substantial shielding from the fields generated by the induction elements.
摘要翻译：介绍了电磁成像（EMAI）系统。 EMAI系统可以包括被配置为诱导靶组织以产生内部来源的超声波的感应元件（例如感应线圈）。感应元件可以被一个或多个屏蔽元件屏蔽，以形成或以其它方式改变成像场，同时衰减远区中的辐射场。 EMAI系统还可以包括屏蔽调谐器来调节屏蔽参数以实现期望的成像或辐射场特性。屏蔽元件可以放置在大约一个感应线圈半径远离线圈，以实现适当强的成像磁场强度，同时在远区域也实现适当的弱辐射场强。在一些实施例中，声传感器缺少与感应元件产生的场的实质屏蔽。

6. 发明授权

US06535625B1 Magneto-acoustic imaging 失效
标题翻译：磁声成像
公开(公告)号：US06535625B1
公开(公告)日：2003-03-18
申请号：US09405236
申请日：1999-09-24
申请人： David B. Chang , James E. Drummond , Jane F. Emerson
发明人： David B. Chang , James E. Drummond , Jane F. Emerson
IPC分类号： G06K900
CPC分类号： A61B5/416 , A61B5/05 , A61B5/0536 , A61B8/08 , G01R33/56308 , G01S7/52017 , G01S7/52034
摘要： An apparatus having a coil of wire, energized by a repetitively pulsed radio frequency (RF) power source to provide electromagnetic fields to a region within a body. A scanning, directional hydrophone acoustically connected to the body, samples ultrasonic radiation generated by the RF fields at the RF frequency or twice the RF frequency induced from conductive spots. Signals from the hydrophone are analyzed with regard to their time of arrival relative to the RF pulses and with respect to their direction of arrival. These collected data are recorded and displayed as images of the spots within the region.
摘要翻译：一种具有线圈的装置，其由重复脉冲射频（RF）电源激励，以向身体内的区域提供电磁场。声学连接到身体的扫描定向水听器采样RF频率产生的超声波辐射，或从导电点引起的RF频率的两倍。关于来自水听器的信号关于它们相对于RF脉冲的到达时间以及相对于它们的到达方向进行分析。这些收集的数据被记录并显示为该区域内的斑点的图像。

7. 发明申请

US20110287959A1 PAN-ANTIBODY ASSAYS - PRINCIPLES, METHODS, AND DEVICES 审中-公开
标题翻译： PAN抗体测定 - 原理，方法和设备
公开(公告)号：US20110287959A1
公开(公告)日：2011-11-24
申请号：US13112754
申请日：2011-05-20
申请人： Jane F. Emerson , Emil P. Kartalov
发明人： Jane F. Emerson , Emil P. Kartalov
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N33/6845 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , C40B60/12
摘要： The present invention includes methods, assays, and devices for assaying a sample to detect the presence, absence, or level of at least one analyte in a biological sample using a pan-antibody panel or multiplexed immunoassay, wherein at least one analyte is detected by two or more antibodies. Certain embodiments include the use of a microfluidic device in the immunoassay. Further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is determined for a diagnostic or a scientific purpose. Still further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is indicative of a condition or disease. Yet further embodiments of the invention include incorporating additional diagnostic techniques (e.g., PCR, RT-PCR, and DNA hybridization arrays) to the assays, device, and methods.
摘要翻译：本发明包括用于分析样品以使用泛抗体面板或多重免疫测定来检测生物样品中至少一种分析物的存在，不存在或水平的方法，测定和装置，其中至少一种分析物被两种或更多种抗体。某些实施方案包括在免疫测定中使用微流体装置。本发明的其它实施方案包括用于检测为诊断或科学目的确定的至少一种分析物的存在，不存在或水平的测定，方法和装置。本发明的另外的实施方案包括检测指示病症或疾病的至少一种分析物的存在，不存在或水平的测定，方法和装置。本发明的另外的实施方案包括将其它诊断技术（例如，PCR，RT-PCR和DNA杂交阵列）结合到测定，装置和方法中。

8. 发明申请

US20100314335A1 PHOTOPOLYMER SERUM SEPARATOR 有权
标题翻译：光电子分离器
公开(公告)号：US20100314335A1
公开(公告)日：2010-12-16
申请号：US12861401
申请日：2010-08-23
申请人： Jane F. Emerson
发明人： Jane F. Emerson
IPC分类号： B01D21/26 , B01D17/038
CPC分类号： B01L3/50215 , B01L2300/12 , G01N15/042 , G01N15/05
摘要： Contemplated whole blood separators tubes include a curable composition with a density intermediate to the density of serum and the cell-containing fraction. After centrifugation, the curable composition is located between the serum and the cell-containing fraction and preferably irradiated with UV light to initiate a curing reaction in which the curable composition solidifies to a barrier that is immobilized and resistant to breakdown at freezing temperatures and extended storage.
摘要翻译：考虑的全血分离器管包括密度介于血清密度和含细胞分数之间的可固化组合物。离心后，可固化组合物位于血清和含细胞部分之间，优选用UV光照射以引发固化反应，其中可固化组合物固化成固定的屏障，并且在冷冻温度下耐受破坏并延长储存。

9. 发明申请

US20100108619A1 PHOTOPOLYMER SERUM SEPARATOR 有权
公开(公告)号：US20100108619A1
公开(公告)日：2010-05-06
申请号：US12691670
申请日：2010-01-21
申请人： Jane F. Emerson
发明人： Jane F. Emerson
IPC分类号： B01D21/26 , B01D15/32 , B01L3/14
CPC分类号： B01L3/50215 , B01L2300/12 , G01N15/042 , G01N15/05
摘要： Contemplated whole blood separators tubes include a curable composition with a density intermediate to the density of serum and the cell-containing fraction. After centrifugation, the curable composition is located between the serum and the cell-containing fraction and preferably irradiated with UV light to initiate a curing reaction in which the curable composition solidifies to a barrier that is immobilized and resistant to breakdown at freezing temperatures and extended storage.

10. 发明授权

US07674388B2 Photopolymer serum separator 有权
标题翻译：光聚合物血清分离器
公开(公告)号：US07674388B2
公开(公告)日：2010-03-09
申请号：US11499436
申请日：2006-08-04
申请人： Jane F. Emerson
发明人： Jane F. Emerson
IPC分类号： B01D21/26 , B01D12/00
CPC分类号： B01L3/50215 , B01L2300/12 , G01N15/042 , G01N15/05
摘要： Contemplated whole blood separators tubes include a curable composition with a density intermediate to the density of serum and the cell-containing fraction. After centrifugation, the curable composition is located between the serum and the cell-containing fraction and preferably irradiated with UV light to initiate a curing reaction in which the curable composition solidifies to a barrier that is immobilized and resistant to breakdown at freezing temperatures and extended storage.
摘要翻译：考虑的全血分离器管包括密度介于血清密度和含细胞分数之间的可固化组合物。离心后，可固化组合物位于血清和含细胞部分之间，优选用UV光照射以引发固化反应，其中可固化组合物固化成固定的屏障，并且在冷冻温度下耐受破坏并延长储存。

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