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1. 发明申请

US20050125077A1 Viable tissue repair implants and methods of use 有权
标题翻译：活组织修复植入物和使用方法
公开(公告)号：US20050125077A1
公开(公告)日：2005-06-09
申请号：US10729046
申请日：2003-12-05
申请人： Alexander Harmon , Stephanie Kladakis , Julia Hwang
发明人： Alexander Harmon , Stephanie Kladakis , Julia Hwang
IPC分类号： A61L27/00 , A61F2/08 , A61F2/28 , A61L27/38 , A61F2/02 , C12N5/08
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译：提供生物相容性组织植入物用于修复组织损伤或缺损。组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。还提供了使用组织植入物修复组织损伤或缺陷的方法。

2. 发明申请

US20070179474A1 Syringe activated-valve for flushing a catheter and methods thereof 失效
标题翻译：用于冲洗导管的注射器活化阀及其方法
公开(公告)号：US20070179474A1
公开(公告)日：2007-08-02
申请号：US11646847
申请日：2006-12-28
申请人： Ryan Cahill , Stephanie Kladakis
发明人： Ryan Cahill , Stephanie Kladakis
IPC分类号： A61M39/00 , A61M39/10 , A61M25/00 , A61M25/18 , A61M25/16
CPC分类号： A61M39/02 , A61M25/0097 , A61M39/045 , A61M39/225 , A61M39/26 , A61M2039/0205
摘要： This invention relates to a syringe-activated valve for flushing a catheter for delivering an implant to an anatomical site, such as a patent foramen ovale in a patient and method thereof. In one embodiment, a catheter includes a proximal end, a distal end, a “Y” connector at the proximal end, the “Y” connector having a guide wire port and a connector port, a syringe activated valve having a first end and a second end, the second end of syringe-activated valve connecting to the connector port of the “Y” connector, and a syringe connecting to the first end of the syringe-activated valve. Saline is injected by the syringe through the syringe-activated valve into the proximal end of the catheter, thereby flushing air from the catheter lumen out of the distal end of the catheter.
摘要翻译：本发明涉及一种用于冲洗用于将植入物递送到解剖部位的导管的注射器启动阀，例如患者中的卵孔卵孔及其方法。在一个实施例中，导管包括近端，远端，在近端处的“Y”连接器，“Y”连接器具有导丝端口和连接器端口，注射器启动阀，其具有第一端和第二端，连接到“Y”连接器的连接器端口的注射器启动阀的第二端和连接到注射器启动阀的第一端的注射器。盐水通过注射器通过注射器激活的阀注射到导管的近端中，从而将导管腔中的空气从导管的远端冲出。

3. 发明申请

US20080091234A1 Method for modifying a medical implant surface for promoting tissue growth 审中-公开
标题翻译：修改用于促进组织生长的医用植入物表面的方法
公开(公告)号：US20080091234A1
公开(公告)日：2008-04-17
申请号：US11904482
申请日：2007-09-26
申请人： Stephanie Kladakis
发明人： Stephanie Kladakis
IPC分类号： A61B17/03 , B29C59/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00243 , A61L27/18 , A61L27/34 , A61L27/50 , B29C59/14 , C08L67/04 , C08L89/06 , C08L5/10
摘要： Disclosed is an occluder for closing an intracardiac defect, such as a patent foramen ovale (PFO), and a method for making the same. The occluder includes a frame and at least one scaffold which are formed from a bioabsorbable polymer, such as poly-4-hydroxybutyrate. The surface of the frame and scaffold are textured to promote cell attachment. Texturing of the surface can be achieved by any number of mechanical or chemical procedures. The device is coated with collagen and heparin which are covalently bound to the surface of the device. The occluder provides improved defect closure compared to other septal occluders known in the art. In particular, the occluder described is specifically designed to improve host cell attachment to and tissue ingrowth over the device when implanted in a patient as compared to the level of host cell attachment and tissue ingrowth achieved with other implantable devices made of bioabsorbable polymers.
摘要翻译：公开了用于闭合心内缺损的封堵器，例如卵圆孔卵孔（PFO）及其制造方法。闭塞器包括由生物可吸收聚合物如聚-4-羟基丁酸酯形成的框架和至少一个支架。框架和支架的表面被纹理化以促进细胞附着。表面的纹理可以通过任何数量的机械或化学程序来实现。该装置涂覆有共价结合到装置表面的胶原和肝素。与本领域已知的其它间隔闭塞器相比，封堵器提供改善的缺陷闭合。特别地，所描述的闭塞器特别设计成与植入患者体内的装置相比，与由其他可生物吸收聚合物制成的可植入装置实现的宿主细胞附着和组织向内生长相比，改善宿主细胞与组织向内生长。

4. 发明申请

US20070055229A1 In tunnel electrode for sealing intracardiac defects 审中-公开
标题翻译：用于密封心内缺陷的隧道电极
公开(公告)号：US20070055229A1
公开(公告)日：2007-03-08
申请号：US11516315
申请日：2006-09-06
申请人： Stephanie Kladakis , James Scutti , Carol Devellian , Helen Liu
发明人： Stephanie Kladakis , James Scutti , Carol Devellian , Helen Liu
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B17/12022 , A61B17/12122 , A61B2017/00243 , A61B2017/00575 , A61B2018/00291 , A61B2018/00351 , A61B2018/143 , A61B2018/1432 , A61B2018/1475
摘要： The present invention provides methods and devices for sealing intracardiac defects, such as a patent foramen ovale (PFO) utilizing an electrode positioned in the lumen of the defect such as the tunnel of a PFO.
摘要翻译：本发明提供了用于密封心内缺陷的方法和装置，例如利用位于诸如PFO的隧道的缺陷管腔中的电极的卵孔卵泡（PFO）。

5. 发明申请

US20060280768A1 Meniscal repair device and method 审中-公开
标题翻译： Meniscal修复装置及方法
公开(公告)号：US20060280768A1
公开(公告)日：2006-12-14
申请号：US11151615
申请日：2005-06-13
申请人： Julia Hwang , Stephanie Kladakis , Sudhakar Kadiyala , Steven Bowman
发明人： Julia Hwang , Stephanie Kladakis , Sudhakar Kadiyala , Steven Bowman
IPC分类号： A61F2/00
CPC分类号： A61F2/3872 , A61B17/064 , A61B2017/0646 , A61B2017/0647 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30092 , A61F2002/30125 , A61F2002/30131 , A61F2002/30153 , A61F2002/30156 , A61F2002/30166 , A61F2002/30171 , A61F2002/30179 , A61F2002/30306 , A61F2002/30761 , A61F2210/0004 , A61F2210/0014 , A61F2230/0008 , A61F2230/0013 , A61F2230/0019 , A61F2230/0023 , A61F2230/0028 , A61F2230/005 , A61F2230/0058 , A61F2230/0097 , A61F2250/0014 , A61L31/005 , A61L31/06 , A61L2430/06 , C08L67/04
摘要： Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a stent. The tissue repair device is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth through contact with vascularized portions of the meniscus or as a conduit for introduction of exogenous healing therapies.
摘要翻译：公开了用于治疗半月板组织损伤的方法和装置，包括包括支架的生物相容性半月板修复装置。组织修复装置适于放置成与弯液面中的缺陷接触，并且可以优选地提供用于支撑半月板组织和/或通过与弯月面的血管部分接触或作为用于引入外源愈合的导管来促进组织生长的结构疗法。

6. 发明申请

US20070167981A1 Catch members for occluder devices 审中-公开
标题翻译：抓住闭塞器装置的成员
公开(公告)号：US20070167981A1
公开(公告)日：2007-07-19
申请号：US11644373
申请日：2006-12-21
申请人： Steven Opolski , Sean Forde , Stephanie Kladakis , David Callaghan
发明人： Steven Opolski , Sean Forde , Stephanie Kladakis , David Callaghan
IPC分类号： A61B17/08
CPC分类号： A61B17/1215 , A61B17/0057 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： Devices and techniques for modifying and maintaining a configuration of an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices and techniques relate particularly to, but are not limited to, modifying and maintaining a configuration of a PFO occluder made from a polymer tube. The proximal portion of a catch member may be provided with one or more protrusions, or arms, or bump or other raised element for securing the occluder in a partial or fully deployed configuration, either temporarily or permanently.
摘要翻译：描述了用于修改和保持用于闭合物理异常的闭塞装置的构造的装置和技术，例如房间隔缺损，卵圆孔卵孔（PFO）以及其它间隔和血管缺陷。所述装置和技术特别涉及但不限于修改和维持由聚合物管制成的PFO封堵器的构造。捕获构件的近侧部分可以设置有一个或多个突起，或臂或凸起或其它凸起元件，用于将闭塞器临时或永久地部分地或完全展开的构造固定。

7. 发明申请

US20070118176A1 Radiopaque bioabsorbable occluder 审中-公开
标题翻译：不透射线生物吸收性封堵器
公开(公告)号：US20070118176A1
公开(公告)日：2007-05-24
申请号：US11585395
申请日：2006-10-24
申请人： Steven Opolski , Stephanie Kladakis
发明人： Steven Opolski , Stephanie Kladakis
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B90/39 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00862 , A61B2017/1205
摘要： The present invention provides an occluder for a biological defect, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder is at least partially formed of a radiopaque, bioabsorbable material. In some embodiments, the occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The radiopaque, bioabsorbable material is a blend of a biocompatible radiopaque material with a bioabsorbable material. In some embodiments, the radiopaque material may have a mass attenuation coefficient greater than about 1.2 cm2/gm and/or a linear attenuation coefficient greater than about 9 cm−1. In some embodiments, the radiopaque material is tungsten. In some embodiments, the bioabsorbable material may have a molecular weight greater than about 300,000. In some embodiments, the bioabsorbable material is a polymer.
摘要翻译：本发明提供了一种用于生物缺陷的闭塞器，例如房间隔缺损（ASD）或卵圆孔卵孔（PFO）。封堵器至少部分地由不透射线的生物可吸收材料形成。在一些实施例中，封堵器由管子形成，管子被切割以在每一侧产生支柱。施加力时，支柱变形成环。不透射线的生物可吸收材料是生物相容性不透射线材料与生物可吸收材料的混合物。在一些实施例中，不透射线材料可以具有大于约1.2cm 2 / gm的质量衰减系数和/或大于约9cm -1的线性衰减系数。在一些实施例中，不透射线材料是钨。在一些实施方案中，生物可吸收材料可具有大于约300,000的分子量。在一些实施方案中，生物可吸收材料是聚合物。

8. 发明申请

US20070031470A1 NONWOVEN TISSUE SCAFFOLD 有权
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20070031470A1
公开(公告)日：2007-02-08
申请号：US11427477
申请日：2006-06-29
申请人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

9. 发明申请

US20050234549A1 Meniscal repair scaffold 有权
标题翻译： Meniscal修复脚手架
公开(公告)号：US20050234549A1
公开(公告)日：2005-10-20
申请号：US10828841
申请日：2004-04-20
申请人： Stephanie Kladakis , Steven Bowman , Robert Steckel
发明人： Stephanie Kladakis , Steven Bowman , Robert Steckel
IPC分类号： A61B17/58 , A61F2/38 , A61L27/00 , A61L27/14 , A61L27/18 , A61L27/44 , A61L27/56 , A61F2/30
CPC分类号： A61F2/3872 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a biocompatible tissue repair scaffold and a cell growth conduit flap. The tissue repair scaffold is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth. The cell growth conduit flap, which is attached to the tissue repair scaffold, allows communication between the synovium and the tissue repair scaffold.
摘要翻译：公开了用于治疗半月板组织损伤的方法和装置，包括生物相容性半月板修复装置，其包括生物相容性组织修复支架和细胞生长导管瓣。组织修复支架适于与弯液面中的缺陷接触，并且可以优选地提供用于支撑半月板组织和/或促进组织生长的结构。连接到组织修复支架的细胞生长导管瓣允许滑膜和组织修复支架之间的连通。

10. 发明申请

US20080077180A1 Scaffold for tubular septal occluder device and techniques for attachment 审中-公开
标题翻译：用于管状隔膜闭塞器装置的支架和附接技术
公开(公告)号：US20080077180A1
公开(公告)日：2008-03-27
申请号：US11904137
申请日：2007-09-26
申请人： Stephanie Kladakis , David Marchesiello , Carol Devellian
发明人： Stephanie Kladakis , David Marchesiello , Carol Devellian
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00893 , A61B2017/00986
摘要： The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. A tissue scaffold material is disposed on the occluder. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one side of the occluder includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.
摘要翻译：本发明提供一种用于闭塞解剖孔的装置，例如房间隔缺损（ASD）或卵圆孔卵孔（PFO）。封堵器包括通过中心管连接的两侧。组织支架材料设置在闭塞器上。封堵器由管子形成，其被切割以在每一侧产生支柱。施加力时，支柱变形成环。环可以是各种形状，尺寸和构造，并且在至少一些实施例中，环具有圆形的周边。在一些实施例中，封堵器的至少一侧包括组织支架。闭塞器还包括在体内维持其部署状态的捕获系统。当闭塞器部署在体内时，两侧设置在围绕孔的间隔组织的相对侧上，并且捕获系统被展开，使得封堵器对隔膜组织施加压缩力并闭合孔。

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