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1. 发明授权

US08101823B2 Method of controlling a cellular process in a multi-cellular organism 失效
标题翻译：控制多细胞生物体中的细胞过程的方法
公开(公告)号：US08101823B2
公开(公告)日：2012-01-24
申请号：US10535763
申请日：2003-11-20
申请人： Stefan Werner , Sylvestre Marillonnet , Yurii Dorokhov , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Yurii Dorokhov , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/29 , C12N15/00 , A01H5/00
CPC分类号： C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/8217
摘要： A method of controlling a genetically-modified multi-cellular organism or a part thereof, comprising the following steps: (a) providing a multi-cellular organism or a part thereof, whereby cells of said multi-cellular organism or said part contain a heterologous nucleic acid, (b) causing expression of a I protein from said heterologous nucleic acid in at least some of said cells, wherein said protein is capable of (i) leaving a cell and entering other cells of said multi-cellular organism or a part thereof, (ii) causing expression of said protein in cells containing said heterologous nucleic acid, and optionally (iii) controlling a cellular process of interest.
摘要翻译：一种控制遗传修饰的多细胞生物体或其一部分的方法，包括以下步骤：（a）提供多细胞生物体或其一部分，由此所述多细胞生物体或所述部分的细胞含有异源核酸，（b）在至少一些所述细胞中引起来自所述异源核酸的I蛋白的表达，其中所述蛋白质能够（i）离开细胞并进入所述多细胞生物体的其它细胞或部分（ii）引起所述蛋白质在含有所述异源核酸的细胞中的表达，以及任选地（iii）控制感兴趣的细胞过程。

2. 发明申请

US20060075524A1 Method of controlling a cellular process in a multi-cellular organism 失效
标题翻译：控制多细胞生物体中的细胞过程的方法
公开(公告)号：US20060075524A1
公开(公告)日：2006-04-06
申请号：US10535763
申请日：2003-11-20
申请人： Stefan Werner , Sylvestre Marillonnet , Yurii Dorokhov , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Yurii Dorokhov , Victor Klimyuk , Yuri Gleba
IPC分类号： A01H1/00 , C12N1/20 , C12N15/82
CPC分类号： C12N15/63 , C12N15/67 , C12N15/8216 , C12N15/8217
摘要： A method of controlling a genetically-modified multi-cellular organism or a part thereof, comprising the following steps: (a) providing a multi-cellular organism or a part thereof, whereby cells of said multi-cellular organism or said part contain a heterologous nucleic acid, (b) causing expression of a I protein from said heterologous nucleic acid in at least some of said cells, wherein said protein is capable of (i) leaving a cell and entering other cells of said multi-cellular organism or a part thereof, (ii) causing expression of said protein in cells containing said heterologous nucleic acid, and optionally (iii) controlling a cellular process of interest.
摘要翻译：一种控制遗传修饰的多细胞生物体或其一部分的方法，包括以下步骤：（a）提供多细胞生物体或其一部分，由此所述多细胞生物体或所述部分的细胞含有异源核酸，（b）在至少一些所述细胞中引起来自所述异源核酸的I蛋白的表达，其中所述蛋白质能够（i）离开细胞并进入所述多细胞生物体的其它细胞或部分（ii）引起所述蛋白质在含有所述异源核酸的细胞中的表达，和任选地（iii）控制感兴趣的细胞过程。

3. 发明授权

US08193410B2 Transgenic plants with controlled distribution of a trait to progeny 有权
标题翻译：具有受控分布特征的后代的转基因植物
公开(公告)号：US08193410B2
公开(公告)日：2012-06-05
申请号：US12621765
申请日：2009-11-19
申请人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/83 , C12N15/84 , C12N15/31 , C12N15/62 , A01H1/02 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8274 , C12N15/8213 , C12N15/8216 , C12N15/8231 , C12N15/8265 , C12N15/8289
摘要： A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said first heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide sequence. Further, the invention provides a process of producing hybrid seeds for agriculture.
摘要翻译：一种生产表达感兴趣性状的转基因多细胞植物或其部分的方法，所述性状具有所述性状受控于后代的分布，其中所述方法包括（i）产生第一种植物或其细胞，其具有第一种核染色体的位点是包含编码所述目的性状的核苷酸序列的第一片段的第一异源核苷酸序列，（ii）产生第二种植物或细胞，所述第二种植物或细胞在与所述核染色体同源的核染色体的第二位点中具有步骤（i），第二异源核苷酸序列，其包含编码所述感兴趣性状的核苷酸序列的第二片段，和（iii）将所述第一和第二植物或细胞杂交以产生由于结合而表现出所述目的功能性状的后代在由所述第一异源核苷酸序列编码的蛋白质或多肽与由所述第二异源核苷酸编码的蛋白质或多肽之间异源核苷酸序列。此外，本发明提供了一种生产用于农业的杂种种子的方法。

4. 发明授权

US08053632B2 Method of controlling cellular processes in plants 有权
标题翻译：控制植物细胞过程的方法
公开(公告)号：US08053632B2
公开(公告)日：2011-11-08
申请号：US10535780
申请日：2003-11-20
申请人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/00 , C12N15/09 , C12N15/33
CPC分类号： C12N15/8216 , C12N15/8217 , C12N15/8237
摘要： A method of controlling a genetically-modified plant, comprising (a) providing a genetically-modified plant, whereby cells of said genetically-modified plant contain a heterologous nucleic acid and whereby said genetically-modified plant is inactive with regard to a cellular process of interest, (b) switching on said cellular process of interest by directly introducing a polypeptide from a cell-free composition into cells containing said heterologous nucleic acid wherein said polypeptide and said heterologous nucleic acid are mutually adapted such that said polypeptide is capable of switching on said cellular process of interest.
摘要翻译：一种控制遗传修饰植物的方法，包括（a）提供经遗传修饰的植物，其中所述经遗传修饰的植物的细胞含有异源核酸，由此所述遗传修饰的植物在细胞过程中是无活性的兴趣，（b）通过将多肽从无细胞组合物直接引入到含有所述异源核酸的细胞中，其中所述多肽和所述异源核酸相互适应使得所述多肽能够导通，从而切换所述感兴趣的细胞过程所述细胞过程是感兴趣的。

5. 发明授权

US07718848B2 Safe production of a product of interest in hybrid seeds 有权
标题翻译：安全生产杂交种子感兴趣的产品
公开(公告)号：US07718848B2
公开(公告)日：2010-05-18
申请号：US10559430
申请日：2004-06-04
申请人： Stefan Werner , Romy Kandzia , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Romy Kandzia , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/34 , A01H1/02
CPC分类号： C12N15/8216 , C12N15/8217 , C12N15/8242 , C12N15/8257
摘要： A process of the production of a product of interest in an F1 seed obtained by a hybridization of a first and a second transgenic parental plant, said hybridization generating a genetic endowment in said F1 seed for said production by combining in said F1 seed first and second partial genetic endowments of said first and second transgenic parental plants, followed by isolating said product of interest from said F1 seed or a seedling thereof.
摘要翻译：通过第一和第二转基因亲本植物的杂交获得的F1种子中感兴趣的产品的生产过程，所述杂交通过在所述F1种子中组合产生用于所述生产的所述F1种子中的遗传禀赋，第一和第二所述第一和第二转基因亲本植物的部分遗传禀赋，然后从所述F1种子或其幼苗中分离所述目的产物。

6. 发明授权

US07642404B2 Transgenic plants with controlled distribution of a trait to progeny 有权
标题翻译：具有受控分布特征的后代的转基因植物
公开(公告)号：US07642404B2
公开(公告)日：2010-01-05
申请号：US10514905
申请日：2003-03-21
申请人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/83 , C12N15/84 , A01H5/00 , A01H5/10 , A01H1/02 , C12N15/31 , C12N15/62
CPC分类号： C12N15/8274 , C12N15/8213 , C12N15/8216 , C12N15/8231 , C12N15/8265 , C12N15/8289
摘要： A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said first heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide sequence. Further, the invention provides a process of producing hybrid seeds for agriculture.
摘要翻译：一种生产表达感兴趣性状的转基因多细胞植物或其部分的方法，所述性状具有所述性状受控于后代的分布，其中所述方法包括（i）产生第一种植物或其细胞，其具有第一种核染色体的位点是包含编码所述目的性状的核苷酸序列的第一片段的第一异源核苷酸序列，（ii）产生第二种植物或细胞，所述第二种植物或细胞在与所述核染色体同源的核染色体的第二位点中具有步骤（i），第二异源核苷酸序列，其包含编码所述感兴趣性状的核苷酸序列的第二片段，和（iii）将所述第一和第二植物或细胞杂交以产生由于结合而表现出所述目的功能性状的后代在由所述第一异源核苷酸序列编码的蛋白质或多肽与由所述第二异源核苷酸编码的蛋白质或多肽之间异源核苷酸序列。此外，本发明提供了一种生产用于农业的杂种种子的方法。

7. 发明授权

US07632981B2 Process of producing environmentally safe transgenic organisms 有权
标题翻译：生产环境安全的转基因生物的方法
公开(公告)号：US07632981B2
公开(公告)日：2009-12-15
申请号：US10512879
申请日：2002-04-29
申请人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/84 , C12N15/83 , C12N15/62 , A01H5/00 , A01H1/00
CPC分类号： C12N15/8286 , A01K2217/05 , A01K2217/20 , A01K2227/10 , C12N15/8263 , C12N15/8265 , C12N15/8271 , C12N15/8273 , C12N15/8277 , C12N15/85 , C12N15/8509 , C12N2800/30 , C12N2800/40 , C12N2840/10 , C12N2840/445 , Y02A40/162
摘要： A process of producing a transgenic multi-cellular plant or animal organism expressing a trait of interest and having a controlled distribution of said trait to progeny, wherein said process comprises hybridising a first multi-cellular organism or a cell thereof having a first heterologous DNA sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest and a second multi-cellular organism or a cell thereof having a second heterologous DNA sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, whereby said first and said second heterologous sequences are designed such that said trait of interest arises due to RNA trans-splicing after said hybridation.
摘要翻译：一种产生表达感兴趣的性状并且具有所述性状受控分布的后代的转基因多细胞植物或动物生物的方法，其中所述方法包括使具有第一异源DNA序列的第一多细胞生物体或其细胞杂交其包含编码所述感兴趣性状的核苷酸序列的第一片段和具有第二异源DNA序列的第二多细胞生物体或其细胞，所述第二异源DNA序列包含编码所述感兴趣性状的核苷酸序列的第二片段，由此所述第一和第二设计异源序列使得所述感兴趣的性状由于所述杂交后的RNA转拼而产生。

8. 发明申请

US20060026718A1 Method of controlling cellular processes in plants 有权
标题翻译：控制植物细胞过程的方法
公开(公告)号：US20060026718A1
公开(公告)日：2006-02-02
申请号：US10535780
申请日：2003-11-20
申请人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： A01H1/00 , C12N15/82
CPC分类号： C12N15/8216 , C12N15/8217 , C12N15/8237
摘要： A method of controlling a genetically-modified plant, comprising (a) providing a genetically-modified plant, whereby cells of said genetically-modified plant contain a heterologous nucleic acid and whereby said genetically-modified plant is inactive with regard to a cellular process of interest, (b) switching on said cellular process of interest by directly introducing a polypeptide from a cell-free composition into cells containing said heterologous nucleic acid wherein said polypeptide and said heterologous nucleic acid are mutually adapted such that said polypeptide is capable of switching on said cellular process of interest.
摘要翻译：一种控制遗传修饰植物的方法，包括（a）提供经遗传修饰的植物，其中所述经遗传修饰的植物的细胞含有异源核酸，由此所述遗传修饰的植物在细胞过程中是无活性的兴趣，（b）通过将多肽从无细胞组合物直接引入到含有所述异源核酸的细胞中，其中所述多肽和所述异源核酸相互适应使得所述多肽能够导通，从而切换所述感兴趣的细胞过程所述细胞过程是感兴趣的。

9. 发明授权

US08624080B2 Plant virus-based inducible expression system 有权
标题翻译：植物病毒诱导表达系统
公开(公告)号：US08624080B2
公开(公告)日：2014-01-07
申请号：US12301156
申请日：2007-05-25
申请人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/40 , C12N15/79 , C12N15/83 , C12N7/01 , A01H5/00
CPC分类号： C12N15/8238
摘要： A process of producing one or more than one protein of interest, comprising: (a) providing a plant or plant cells comprising a first heterologous nucleotide sequence comprising a nucleotide sequence encoding an RNA replicon, and a first inducible promoter operably linked to said nucleotide sequence encoding said RNA replicon; said RNA replicon not encoding a protein providing for cell-to-cell movement of said RNA replicon in said plant; said RNA replicon encoding a polymerase and said one or more than one protein of interest, said polymerase being adapted for replicating said RNA replicon; and (b) inducing, in said plant or plant cells of step (a), said inducible promoter, thereby producing said one or more than one protein of interest in said plant or plant cells.
摘要翻译：一种产生一种或多于一种感兴趣的蛋白质的方法，包括：（a）提供包含第一异源核苷酸序列的植物或植物细胞，所述第一异源核苷酸序列包含编码RNA复制子的核苷酸序列，和与所述核苷酸序列可操作地连接的第一诱导型启动子编码所述RNA复制子; 所述RNA复制子不编码提供所述植物中所述RNA复制子的细胞与细胞运动的蛋白质; 所述RNA复制子编码聚合酶和所述一种或多种感兴趣的蛋白质，所述聚合酶适于复制所述RNA复制子; 和（b）在所述植物或植物细胞中诱导所述诱导型启动子，从而在所述植物或植物细胞中产生所述一种或多种感兴趣的蛋白质。

10. 发明授权

US08604281B2 Transgenic plants with controlled distribution of a trait to progeny 有权
标题翻译：具有受控分布特征的后代的转基因植物
公开(公告)号：US08604281B2
公开(公告)日：2013-12-10
申请号：US13470812
申请日：2012-05-14
申请人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Anatoly Giritch , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/31 , C12N15/62 , C12N9/22 , A01H1/02 , A01H1/04 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8274 , C12N15/8213 , C12N15/8216 , C12N15/8231 , C12N15/8265 , C12N15/8289
摘要： A process of producing transgenic multi-cellular plants or parts thereof expressing a trait of interest that has a controlled distribution of said trait to progeny, comprising (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plants or cells thereof to generate progeny exhibiting said functional trait of interest. Also disclosed is a process of producing hybrid seeds for agriculture.
摘要翻译：一种生产转基因多细胞植物或其部分表达感兴趣的性状的方法，所述转基因多细胞植物或其部分具有所述性状受控于后代的分布，其包括（i）产生在核染色体的第一位点具有的第一植物或其细胞第一异源核苷酸序列，其包含编码所述感兴趣性状的核苷酸序列的第一片段，（ii）产生具有与步骤（i）的所述核染色体同源的核染色体的第二位点的第二植物或其细胞，第二异源核苷酸序列，其包含编码所述感兴趣性状的核苷酸序列的第二片段，和（iii）使所述第一和第二植物或细胞杂交以产生表现出所述目的功能性状的后代。还公开了一种生产用于农业的杂种种子的方法。

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