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    • 2. 发明申请
    • METHOD FOR NAVIGATING AN UNDERSEA VEHICLE
    • 用于航行下车的方法
    • US20100106349A1
    • 2010-04-29
    • US12531834
    • 2008-02-07
    • Dirk RathjenArmin SchmiegelRobert Engel
    • Dirk RathjenArmin SchmiegelRobert Engel
    • G05D1/04G01C21/00G01S5/18
    • G01S15/025G01C21/00G01S5/186
    • In a method for navigating an undersea vehicle (12), navigation data about position, orientation, and absolute vehicle speed of the undersea vehicle (12) are determined from measurement data delivered by navigation sensors (17) via a navigation filter (18) which incorporates the measurement values of a Doppler log (14). To achieve a highly accurate tracking of the course taken by the undersea vehicle (12), particularly during submerging and surfacing phases, the stretch of water (10) traversed by the undersea vehicle (12) is divided into regions (13) which at least in the vertically oriented z-axis have a finite dimension within a Cartesian coordinate system (11). During the voyage of the undersea vehicle (12), the flow rates in the stretch of water (10) in relation to the individual spatial layers (13) are determined and stored from the relative vehicle speeds measured by the Doppler log (14) in successive measurement processes, and from the absolute vehicle speeds issued continuously by the navigation filter (18). The stored flow rates are input into the navigation filter (18) (FIG. 1) in accordance with the respective spatial layer (13) reached by the undersea vehicle (12).
    • 在用于导航水下车辆(12)的方法中,从由导航传感器(17)经由导航过滤器(18)传送的测量数据确定关于水下车辆(12)的位置,方向和绝对车辆速度的导航数据,导航过滤器(18) 并入多普勒日志的测量值(14)。 为了实现对海底车辆(12)所采取的过程的高度精确跟踪,特别是在浸没和铺面阶段期间,由水下车辆(12)穿过的水(10)的伸展被分成至少至少 在垂直取向的z轴中,在笛卡尔坐标系(11)内具有有限的尺寸。 在海底车辆(12)的航行期间,根据多普勒日志(14)测量的相对车辆速度来确定和存储相对于各个空间层(13)的水(10)的流速 连续的测量过程,以及由导航过滤器(18)连续发出的绝对车辆速度。 存储的流量根据由水下车辆(12)到达的相应的空间层(13)被输入到导航过滤器(18)(图1)中。
    • 4. 发明授权
    • Method of producing nanoparticle suspensions
    • 制备纳米颗粒悬浮液的方法
    • US09296685B2
    • 2016-03-29
    • US13583536
    • 2011-03-07
    • Robert EngelWolfgang GerlingerStefan BraeseThierry MullerChristina BelenkiHeike P. SchuchmannMarion Gedrat
    • Robert EngelWolfgang GerlingerStefan BraeseThierry MullerChristina BelenkiHeike P. SchuchmannMarion Gedrat
    • C07C69/36C07C271/08B01F17/00C07C69/38C07C233/56
    • C07C271/08B01F17/0007B01F17/0021C07C69/36C07C69/38C07C233/56
    • Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.
    • 制备纳米颗粒悬浮液的方法,步骤(i)制备分散极性相的乳液,其中水相包含一种或多种形成纳米颗粒的前体物质,在连续的有机相中,在稳定乳液的乳化剂存在下 ,(ii)将一种或多种前体物质转化为分散水相中的纳米颗粒,(iii)破乳和相分离,其中纳米颗粒悬浮液作为一相获得,(iv)将纳米颗粒悬浮液分离 ,(v)任选地从纳米颗粒悬浮液中分离纳米颗粒,其中所述乳化剂选自X为O,NH,Y为C(O),NH,R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基,R 1是氢或C 1 -C 4 - 烷基,R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子,优选6至30个碳原子的二烷基,R 3是C 1 -C 4 - 烷基,n是0或1,并且通过分裂乳化剂来实现乳液的断裂。
    • 5. 发明申请
    • METHOD OF PRODUCING NANOPARTICLE SUSPENSIONS
    • 制备纳米悬浮液的方法
    • US20120329888A1
    • 2012-12-27
    • US13583536
    • 2011-03-07
    • Robert EngelWolfgang GerlingerStefan BraeseThierry MullerChristina BelenkiHeike P. SchuchmannMarion Gedrat
    • Robert EngelWolfgang GerlingerStefan BraeseThierry MullerChristina BelenkiHeike P. SchuchmannMarion Gedrat
    • B01J13/00C07C69/36C07C69/38C07C233/56C07C271/12
    • C07C271/08B01F17/0007B01F17/0021C07C69/36C07C69/38C07C233/56
    • Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.
    • 制备纳米颗粒悬浮液的方法,步骤(i)制备分散极性相的乳液,其中水相包含一种或多种形成纳米颗粒的前体物质,在连续的有机相中,在稳定乳液的乳化剂存在下 ,(ii)将一种或多种前体物质转化为分散水相中的纳米颗粒,(iii)破乳和相分离,其中纳米颗粒悬浮液作为一相获得,(iv)将纳米颗粒悬浮液分离 ,(v)任选地从纳米颗粒悬浮液中分离纳米颗粒,其中所述乳化剂选自X为O,NH,Y为C(O),NH,R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基,R 1是氢或C 1 -C 4 - 烷基,R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子,优选6至30个碳原子的二烷基,R 3是C 1 -C 4 - 烷基,n是0或1,并且通过分裂乳化剂来实现乳液的断裂。
    • 6. 发明申请
    • QUATERNARY AMMONIUM FUNCTIONALIZED GLYCODENDRIMERS, METHODS FOR THE PRODUCTION AND USE THEREOF
    • 季铵盐功能性糖苷,其生产方法及其用途
    • US20090196847A1
    • 2009-08-06
    • US12282496
    • 2007-03-12
    • Mary CloningerRobert Engel
    • Mary CloningerRobert Engel
    • A01N33/12C08G69/48C08G65/48C08G77/00A01P1/00A61P29/00A61K31/785A61P17/00
    • A61K31/787Y02A50/473
    • The present invention provides novel antimicrobial agents that are quaternary ammonium functionalized glycodendrimers. In one embodiment, the quaternary ammonium functionalized glycodendrimers are compounds of Formula (I): (Q+−-S-L)z-DnX− wherein: D is a dendrimer; n is the generation number of the functionalized dendrimer; z is an integer less than or equal to 2(n+2); L is a linking group; Q+ represents a quaternary ammonium moiety; and S represents a carbohydrate moiety. The present invention further provides formulations containing the antimicrobial agents of the invention, methods of making the agents and formulations of the invention, and methods of using the same as effective and/or broad spectrum antimicrobial agents. The agents and formulations of the invention find use in medicine, for the treatment of various inflammatory conditions or diseases, for example, and have numerous industrial applications. (Q+−-S-L)z-DnX−  (I)
    • 本发明提供了新颖的抗菌剂,它们是季铵官能化的缔结缔合体。 在一个实施方案中,季铵官能化的甘氨酸衍生物是式(I)的化合物:(Q + -S-L)z-DnX-其中:D是树枝状大分子; n是官能化树枝状聚合物的代数; z是小于或等于2(n + 2)的整数; L是连接基团; Q +表示季铵部分; S表示碳水化合物部分。 本发明还提供了含有本发明的抗微生物剂,制备本发明的试剂和制剂的方法的制剂,以及将其用作有效和/或广谱抗微生物剂的方法。 本发明的药剂和制剂可用于医药,例如用于治疗各种炎性病症或疾病,并具有许多工业应用。 (Q + -SL)z-DnX-(I)<?in-line-formula description =“In-line formula”end =“lead”? end =“tail”?>