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    • 9. 发明申请
    • CHELANTS AS CONTRAST ENHANCING AGENTS
    • 作为对比增强剂的CHELANTS
    • WO1995007270A1
    • 1995-03-16
    • PCT/GB1994001931
    • 1994-09-06
    • NYCOMED SALUTAR, INC.COCKBAIN, JulianGARRITY, MarthaCROFTS, Shaun, PaulCARVALHO, JoanSTRANDE, PerDUGSTAD, Harald
    • NYCOMED SALUTAR, INC.COCKBAIN, Julian
    • C07D257/02
    • A61K49/0002C07D257/02Y10S514/836
    • The present invention provides a polychelant compound of formula (VII), (wherein each X which may be the same or different is NZ, O or S, at least two Xs being NZ; B is (CR Y) or -N(CR 2Y)-; each Z is a group R or a group CR 2Y, at least one Z being a group CR 2Y; each Y is a group CO2H, PO3H, SO3H, CONR 2, CON(OR )R , CNS or CONR NR 2; m is 0 or 1 or 2; each n is 2 or 3; q is 0 or 1 when B is (CR Y) and 2 when B is N(CR 2Y); p is an integer having a value of at least 2; each R which may be the same or different is a hydrogen atom or an alkyl, aryl or aralkyl group optionally substituted by one or more hydroxy or alkoxy groups, or two R groups on ring atoms or in Z groups together represent a linker group L; each L which may be the same or different represents a bond or an organic linker group having a molecular weight of less than 1000 and salts and chelates thereof. These compounds, especially the di- and trichelates with paramagnetic or heavy metal ions are especially useful as diagnostic imaging contrast agents.
    • 本发明提供一种式(Ⅶ)的聚合物化合物,其中每个X可以相同或不同,为NZ,O或S,至少两个X为NZ; B为(CR 1 Y)或-N (CR 1 2Y) - ;每个Z是基团R 1或基团CR 1Y 2,至少一个Z是基团CR 2Y;每个Y是基团CO 2 H,PO 3 H,SO 3 H ,CONR 1,CON(OR 1)R 1,CNS或CONR 1 NR 12,m为0或1或2;每个n为2或3; q为0或 1,当B为(CR 1)Y)时为2,B为N时为2(CR 1 2Y); p为值至少为2的整数;每个R 1可以相同或不同 任选被一个或多个羟基或烷氧基取代的烷基,芳基或芳烷基或环原子上或Z基团中的两个R 1一起表示连接基团L;每个L可以相同 或不同的表示分子量小于1000的键或有机连接基团及其盐和螯合物,这些化合物,特别是具有顺磁或重金属离子的二 - 和三 - s作为诊断成像造影剂是特别有用的。
    • 10. 发明申请
    • MARKER COMPOSITIONS
    • 标记组成
    • WO1998010797A2
    • 1998-03-19
    • PCT/GB1997002509
    • 1997-09-12
    • NYCOMED IMAGING ASCOCKBAIN, JulianBRILEY-SÆBO, Karen, CatherinKELLAR, Kenneth, EdmundLADD, David, LeeHOLLISTER, Kenneth, RobertBJORNERUD, Atle
    • NYCOMED IMAGING ASCOCKBAIN, Julian
    • A61K49/00
    • A61K49/128A61K49/18A61K49/1803
    • This invention relates to a set of aqueous marker compositions, each composition having a selected 1/Ti value which is substantially invariant over an at least 10 DEG C temperature range between 15 and 40 DEG C and preferably over an at least +/- 2 % magnetic field strength range about a selected field strength value between 0.01 and 5T and comprising an aqueous matrix material having a non-zero 1/Ti temperature dependence within said temperature range with distributed therein a first paramagnetic material having a Ti relaxivity which is substantially invariant within said range(s) and/or a second paramagnetic material having within said range(s) a Ti relaxivity which has a non-zero temperature dependence of opposite polarity to the temperature dependence of 1/Ti of said matrix material, said set containing a plurality of said compositions with different selected 1/Ti values preferably encompassing at least the range 1.0 to 2.5 s , said set preferably comprising at least one said composition containing said second paramagnetic material and at least one said composition containing said first paramagnetic material, where i in Ti is 1 or 2.
    • 本发明涉及一组水性标记组合物,每种组合物具有选择的1 / Ti值,其在15至40℃之间的至少10℃温度范围内基本上不变,优选至少为+/- 2% 磁场强度范围大约在0.01和5T之间的选定的场强值,并且包括在所述温度范围内具有非零1 / Ti温度依赖性的水基质材料,其中分布有第一顺​​磁性材料,其具有基本上不变的Ti弛豫度 所述范围和/或第二顺磁材料具有在所述范围内的Ti弛豫度,其具有与所述基体材料的1 / Ti的温度依赖性相反极性的非零温度依赖性,所述组包含 具有不同选择的1 / Ti值的多个所述组合物优选包含至少1.0至2.5s -1的范围,所述组优选包含至少一个所述共 包含所述第二顺磁性材料和至少一种含有所述第一顺磁性材料的组合物,其中i在Ti中为1或2。