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1. 发明授权

US6166072A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US6166072A
公开(公告)日：2000-12-26
申请号：US342492
申请日：1999-06-29
申请人： Stanley Charles Bell , Michael De Vivo , Allen Hopper , Methvin Isaac , Anne O'Brien , Vassil Ilya Ognyanov , Richard Schumacher
发明人： Stanley Charles Bell , Michael De Vivo , Allen Hopper , Methvin Isaac , Anne O'Brien , Vassil Ilya Ognyanov , Richard Schumacher
IPC分类号： C07C323/60 , A61K31/21
CPC分类号： C07C323/60
摘要： Described herein are compounds having the general formula: ##STR1## wherein: Ar.sup.1 and Ar.sup.2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, alkanoyl, aralkyl, aralkyloxy, halo, NO.sub.2, Ph, CF.sub.3, CN, OH, methylenedioxy, ethylenedioxy, SO.sub.2 NRR', NRR', CO.sub.2 R (where R and R' are independently selected from the group consisting of H and alkyl) and a second aryl group, which may be substituted as above;wherein any cycloalkyl or aryl substituent is linked to Ar.sup.1 or Ar.sup.2 by a bridging element which may be a single bond, a vinylene group, an ethynylene group, a Z group, a --Z--(CH.sub.2).sub.n -- group, a --(CH.sub.2).sub.n --Z-- group, or a --Z--(CH.sub.2).sub.n --Z-- group, where Z represents an O atom, a S atom, an NH group or an N-alkyl group, and n is an integer from 1 to 4;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;wherein Ar.sup.1 and Ar.sup.2 may be attached to the central atom to which they are connected by a single bond, an alkylene, alkenylene or alkynylene group;R.sup.3 is selected from the group consisting of H and aryl, which may be substituted as for Ar.sup.1 ;R.sup.4 and R.sup.5 are independently selected from the group consisting of H, alkyl, alkanoyl, benzoyl and benzyl.
摘要翻译：本文描述的是具有以下通式的化合物：其中：Ar 1和Ar 2是独立选择的芳基，任选地被选自烷基，环烷基，烷氧基，烷酰基，芳烷基，芳烷氧基，卤素，NO 2，Ph，CF 3， CN，OH，亚甲二氧基，亚乙二氧基，SO 2 NRR'，NRR'，CO 2 R（其中R和R'独立地选自H和烷基）和可如上所述被取代的第二芳基; 其中任何环烷基或芳基取代基通过可以是单键的桥连元件连接到Ar 1或Ar 2上，亚乙烯基，亚乙炔基，Z基，-Z-（CH 2）n - 基， - （CH 2））nZ-基或-Z-（CH2）nZ-基，其中Z表示O原子，S原子，NH基或N-烷基，n是1至4的整数; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; 其中Ar1和Ar2可以通过单键连接到它们连接的中心原子上，亚烷基，亚烯基或亚炔基; R 3选自H和芳基，其可以被取代为Ar 1; R 4和R 5独立地选自H，烷基，烷酰基，苯甲酰基和苄基。

2. 发明申请

US20110046146A9 Phosphodiesterase 4 inhibitors 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20110046146A9
公开(公告)日：2011-02-24
申请号：US11602283
申请日：2006-11-21
申请人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号： A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号： C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物具有式I：其中R 1，R 2，R 3和R 4如本文所定义。

3. 发明申请

US20070078139A1 Phosphodiesterase 4 inhibitors 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20070078139A1
公开(公告)日：2007-04-05
申请号：US11602283
申请日：2006-11-21
申请人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号： A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号： C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物是式I的化合物：其中R 1，R 2，R 3和R 4， >如本文所定义。

4. 发明申请

US20070123570A1 Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs 失效
标题翻译：磷酸二酯酶4抑制剂，包括氨基吲唑和氨基苯并呋喃类似物
公开(公告)号：US20070123570A1
公开(公告)日：2007-05-31
申请号：US11642592
申请日：2006-12-21
申请人： Richard Schumacher , Allen Hopper , Ashok Tehim
发明人： Richard Schumacher , Allen Hopper , Ashok Tehim
IPC分类号： A61K31/4439 , A61K31/4433 , C07D405/02 , C07D403/02
CPC分类号： A61K31/343 , A61K31/416 , C07D231/56 , C07D401/12 , C07D405/12 , C07D405/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs, The compounds of the present invention are of Formulas I and II: wherein R1, R2, R3, R4, R7 and R8 are as defined herein.
摘要翻译： PDE4抑制是通过新的化合物，例如氨基吲唑和氨基苯并呋喃类似物来实现的。本发明化合物具有式I和II：其中R 1，R 2，R 2， R 4，R 4，R 8和R 8如本文所定义。

5. 发明申请

US20060211865A1 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20060211865A1
公开(公告)日：2006-09-21
申请号：US11378615
申请日：2006-03-20
申请人： Richard Schumacher , Elizabeth Graham , Allen Hopper , Ashok Tehim
发明人： Richard Schumacher , Elizabeth Graham , Allen Hopper , Ashok Tehim
IPC分类号： A61K31/4439 , C07D405/02 , C07D403/02 , C07D213/26
CPC分类号： C07D213/89 , C07D401/06 , C07D401/12 , C07D405/12
摘要： PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R1, R2, R3, R7, R8, R9, R10 and R6 are as defined herein.
摘要翻译：通过新的硝基氧化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4抑制。本发明的化合物是式I-III的化合物：其中A，B，D，R 1，R 2，R 3， R 7，R 8，R 9，R 10和R 6均为如本文所定义。

6. 发明申请

US20050119225A1 Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs 失效
标题翻译：磷酸二酯酶4抑制剂，包括N-取代苯胺和二苯胺类似物
公开(公告)号：US20050119225A1
公开(公告)日：2005-06-02
申请号：US10622833
申请日：2003-07-21
申请人： Richard Schumacher , Allen Hopper , Ashok Tehim , Hans-Jurgen Hess , Axel Unterbeck , Erik Kuester , William Brubaker , Robert Dunn
发明人： Richard Schumacher , Allen Hopper , Ashok Tehim , Hans-Jurgen Hess , Axel Unterbeck , Erik Kuester , William Brubaker , Robert Dunn
IPC分类号： A61K31/135 , A61K31/36 , A61K31/40 , A61K31/41 , A61K31/695 , A61P25/00 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/92 , C07C229/60 , C07D213/38 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D215/12 , C07D215/14 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/14 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/20 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
CPC分类号： C07D241/12 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/92 , C07C229/60 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D215/12 , C07D215/14 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D261/08 , C07D261/14 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/20 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物是式I的化合物：其中R 1，R 2，R 3和R 4， >如本文所定义。

7. 发明申请

US20090118270A1 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20090118270A1
公开(公告)日：2009-05-07
申请号：US12329214
申请日：2008-12-05
申请人： Francisco Xavier Talamas , Joan Marie Caroon , Robert Dunn , Allen Hopper , Erik Kuester , Richard Schumacher , Ashok Tehim
发明人： Francisco Xavier Talamas , Joan Marie Caroon , Robert Dunn , Allen Hopper , Erik Kuester , Richard Schumacher , Ashok Tehim
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/4439 , A61K31/506 , A61P25/18 , A61P25/24 , C07D401/12 , C07D413/02
CPC分类号： C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.
摘要翻译： PDE4抑制通过新化合物，例如N-取代的二芳基胺类似物来实现。本发明化合物是式I-III：其中A，B，D，E，G，J，K，R1，R2，R3，R4，R11，R12，R13，R14，R21，R22，R23和 R 24如本文所定义。

8. 发明申请

US20070049611A1 Phosphodiesterase 4 inhibitors 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20070049611A1
公开(公告)日：2007-03-01
申请号：US11449868
申请日：2006-06-09
申请人： Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
发明人： Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4545 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.
摘要翻译： PDE4抑制通过新化合物，例如N-取代的二芳基胺类似物来实现。本发明的化合物为式I-III：其中A，B，D，E，G，J，K，R 1，R 2， R 3，R 4，R 11，R 12，R 13，R 13， SEQ ID NO：14，R 21，R 22，R 23和R 24定义如上这里。

9. 发明申请

US20050222207A1 Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs 审中-公开
标题翻译：磷酸二酯酶4抑制剂，包括N-取代的二芳基胺类似物
公开(公告)号：US20050222207A1
公开(公告)日：2005-10-06
申请号：US11008775
申请日：2004-12-10
申请人： Richard Schumacher , Allen Hopper , Robert Dunn , Erik Kuester , Ashok Tehim , Thomas Renau , Joan Caroon , Francisco Talamas , Sharada Labadie
发明人： Richard Schumacher , Allen Hopper , Robert Dunn , Erik Kuester , Ashok Tehim , Thomas Renau , Joan Caroon , Francisco Talamas , Sharada Labadie
IPC分类号： A61K31/444 , A61K31/4545 , C07D213/74 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14 , C07D41/14
CPC分类号： C07D213/74 , A61K31/444 , A61K31/4545 , C07C229/60 , C07D213/36 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formula I: wherein A, B, D, R1, R2, R3 and R4 are as defined herein.
摘要翻译： PDE4抑制通过新化合物，例如N-取代的二芳基胺类似物来实现。本发明的化合物具有式I：其中A，B，D，R 1，R 2，R 3和R 3， SUP> 4 如本文所定义。

10. 发明授权

US08372464B2 Methods for producing partially hydrated and cooked bean products 有权
标题翻译：生产部分水合和煮熟的豆制品的方法
公开(公告)号：US08372464B2
公开(公告)日：2013-02-12
申请号：US12530733
申请日：2008-03-12
申请人： Mark Dierking , Richard Schumacher , Jerry Hopkins
发明人： Mark Dierking , Richard Schumacher , Jerry Hopkins
IPC分类号： A23L1/20
CPC分类号： A23L11/10 , A23L5/13 , A23L11/05 , A23P30/20
摘要： Methods for producing a partially hydrated bean paste are disclosed. The methods include inputting a quantity of uncooked whole beans or split beans into an extruder comprising an inlet, one or more temperature zones in series downstream of the inlet, and a die downstream of the one or more temperature zones; rotating a screw assembly of the extruder to extrude the beans and force the beans through the one or more temperature zones, wherein a quantity of steam and a quantity of water is added to the beans as the beans are forced through each temperature zone; and forcing the beans exiting the final temperature zone of said one or more temperature zones in series through the die to produce a bean paste. The partially hydrated bean paste produced by the methods of the disclosure comprises a water content of at least about 45% by weight. The partially hydrated bean paste can be further processed into partially hydrated bean products, such as refried beans.
摘要翻译：公开了生产部分水合豆酱的方法。所述方法包括将一批未煮熟的全豆或分裂豆输入到挤出机中，所述挤出机包括入口，在入口下游的串联的一个或多个温度区域和在所述一个或多个温度区域下游的模具; 旋转挤出机的螺杆组件以挤出豆子并迫使豆子通过一个或多个温度区域，其中当豆被强制通过每个温度区域时，将一定量的蒸汽和一定量的水加入到豆中; 并迫使通过模具串联的所述一个或多个温度区域的最终温度区域离开出来的豆以产生豆浆。通过本公开的方法制备的部分水合的豆酱包含至少约45重量％的水含量。部分水合的豆酱可以进一步加工成部分水合的豆制品，例如重烧豆。

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