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1. 发明申请

US20050250707A1 HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 审中-公开
公开(公告)号：US20050250707A1
公开(公告)日：2005-11-10
申请号：US11155568
申请日：2005-06-20
申请人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
发明人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
IPC分类号： C07D277/04 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/472 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K38/04 , A61K45/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/02 , A61P43/00 , C07D207/09 , C07D207/16 , C07D207/24 , C07D209/52 , C07D213/38 , C07D217/26 , C07D231/12 , C07D263/04 , C07D263/06 , C07D277/00 , C07D277/06 , C07D277/20 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/60 , C07D295/13 , C07D307/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08 , C07K5/04
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

2. 发明申请

US20070021354A1 HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 审中-公开
标题翻译： HIV蛋白酶抑制剂，含有它们的组合物，它们的药物用途和用于合成的材料
公开(公告)号：US20070021354A1
公开(公告)日：2007-01-25
申请号：US11450943
申请日：2006-06-09
申请人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
发明人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
IPC分类号： A61K38/04 , A61K31/4025 , A61K31/401 , C07K5/04 , C07D403/02
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译：公开了下式的化合物：其中式变量如本文所定义，其有利地抑制或阻断HIV蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物可用于治疗感染HIV病毒的患者或宿主。还描述了制备这些化合物的中间体和合成方法。

3. 发明授权

US06953858B2 HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 失效
标题翻译： HIV蛋白酶抑制剂，含有它们的组合物，它们的药物用途和用于合成的材料
公开(公告)号：US06953858B2
公开(公告)日：2005-10-11
申请号：US10166957
申请日：2002-06-11
申请人： Stacie S. Canan Koch , Therese N. Alexander , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Benjamin J. Burke , Tod Holler , Tanya M. Jewell , Vara Prasad Josyula , David J. Kucera , Maria Angelica Linton , Jeffrey J. Machak , Lennert J. Mitchell, Jr. , Sean T. Murphy , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Michael Melnick
发明人： Stacie S. Canan Koch , Therese N. Alexander , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Benjamin J. Burke , Tod Holler , Tanya M. Jewell , Vara Prasad Josyula , David J. Kucera , Maria Angelica Linton , Jeffrey J. Machak , Lennert J. Mitchell, Jr. , Sean T. Murphy , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Michael Melnick
IPC分类号： C07D277/04 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/472 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K38/04 , A61K45/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/02 , A61P43/00 , C07D207/09 , C07D207/16 , C07D207/24 , C07D209/52 , C07D213/38 , C07D217/26 , C07D231/12 , C07D263/04 , C07D263/06 , C07D277/00 , C07D277/06 , C07D277/20 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/60 , C07D295/13 , C07D307/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08 , C07K5/04
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译：公开了下式的化合物：其中式变量如本文所定义，其有利地抑制或阻断HIV蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物可用于治疗感染HIV病毒的患者或宿主。还描述了制备这些化合物的中间体和合成方法。

4. 发明授权

US07179918B2 HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 失效
公开(公告)号：US07179918B2
公开(公告)日：2007-02-20
申请号：US10166979
申请日：2002-06-11
申请人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
发明人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
IPC分类号： C07D207/16 , C07D221/02
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

5. 发明申请

US20080287479A1 INHIBITORS OF SERINE PALMITOYLTRANSFERASE 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂的抑制剂
公开(公告)号：US20080287479A1
公开(公告)日：2008-11-20
申请号：US11945452
申请日：2007-11-27
申请人： Richard Hutchings , William Park , Gary Bolton , Chad Van Huis , Jeff Kohrt
发明人： Richard Hutchings , William Park , Gary Bolton , Chad Van Huis , Jeff Kohrt
IPC分类号： A61K31/438 , C07D401/14 , A61K31/454 , A61K31/439
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention provides compounds of the formula: useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).
摘要翻译：本发明提供下式的化合物：可用于抑制或调节丝氨酸棕榈酰转移酶及其在治疗或改善2型糖尿病，1型糖尿病，胰岛素抵抗，肥胖症，代谢综合征（有时称为作为综合征X），葡萄糖耐量减低，库欣氏病，心血管疾病，血栓形成状况，心肌梗死，高血压，充血性心力衰竭，心肌病，动脉粥样硬化，血脂异常，败血症，肝损伤，视网膜退行性疾病，恶病质，肺气肿，丙型肝炎感染， HIV感染和炎症性疾病，并且可用于在哺乳动物中提高HDL血浆水平的方法。本发明的化合物也可用于防止胰岛β细胞的损伤或损失（例如在胰腺β细胞凋亡的情况下，包括与胰岛素依赖性糖尿病相关的细胞凋亡）。

6. 发明授权

US09227678B2 Locking wheel rim cover 有权
标题翻译：锁边轮盖
公开(公告)号：US09227678B2
公开(公告)日：2016-01-05
申请号：US13851263
申请日：2013-03-27
申请人： Gary Bolton
发明人： Gary Bolton
IPC分类号： B62D43/00
CPC分类号： B62D43/007
摘要： A locking wheel rim cover is described for attachment to the outer face of a spare wheel rim having a given diameter, an outer face and log openings. The cover includes a circular rim plate having a diameter substantial the same as the diameter of the wheel rim, an inner face and an outer face; a locking member extending inwardly from the inner face of the rim plate; a first attachment member extending inwardly from the inner face of the rim plate; and an attachment bracket mountable on the outer face of the wheel rim, the bracket including a locking member opening to receive the locking member, a second attachment member connectable with the first attachment member and inwardly extending adapters sized for insertion into the wheel lug openings.
摘要翻译：描述了锁定轮缘盖，用于附接到具有给定直径，外表面和对数开口的备用轮缘的外表面。该盖包括圆形边框板，其直径与轮缘的直径基本相同，内表面和外表面; 从所述边缘板的内表面向内延伸的锁定件; 从所述边缘板的内表面向内延伸的第一附接构件; 以及可安装在所述轮缘的外表面上的附接支架，所述支架包括用于接收所述锁定构件的锁定构件开口，与所述第一附接构件连接的第二附接构件和尺寸适于插入到所述轮突起开口中的向内延伸的适配器。

7. 发明申请

US20140077583A1 LOCKING WHEEL RIM COVER 有权
标题翻译：锁定轮RIM盖
公开(公告)号：US20140077583A1
公开(公告)日：2014-03-20
申请号：US13851263
申请日：2013-03-27
申请人： Gary Bolton
发明人： Gary Bolton
IPC分类号： B62D43/00
CPC分类号： B62D43/007
摘要： A locking wheel rim cover is described for attachment to the outer face of a spare wheel rim having a given diameter, an outer face and log openings. The cover includes a circular rim plate having a diameter substantial the same as the diameter of the wheel rim, an inner face and an outer face; a locking member extending inwardly from the inner face of the rim plate; a first attachment member extending inwardly from the inner face of the rim plate; and an attachment bracket mountable on the outer face of the wheel rim, the bracket including a locking member opening to receive the locking member, a second attachment member connectable with the first attachment member and inwardly extending adapters sized for insertion into the wheel lug openings.
摘要翻译：描述了锁定轮缘盖，用于附接到具有给定直径，外表面和对数开口的备用轮缘的外表面。该盖包括圆形边框板，其直径与轮缘的直径基本相同，内表面和外表面; 从所述边缘板的内表面向内延伸的锁定件; 从所述边缘板的内表面向内延伸的第一附接构件; 以及可安装在所述轮缘的外表面上的附接支架，所述支架包括用于接收所述锁定构件的锁定构件开口，与所述第一附接构件连接的第二附接构件和尺寸适于插入到所述轮突起开口中的向内延伸的适配器。

8. 发明申请

US20060287378A1 Novel pyrroles and imidazoles 审中-公开
标题翻译：新颖的吡咯和咪唑
公开(公告)号：US20060287378A1
公开(公告)日：2006-12-21
申请号：US11389664
申请日：2006-03-24
申请人： Gary Bolton , Daniel Bowles , David Boyles , Walter Howard , Richard Hutchings , Robert Kennedy , William Park , Yuntao Song , Bharat Trivedi
发明人： Gary Bolton , Daniel Bowles , David Boyles , Walter Howard , Richard Hutchings , Robert Kennedy , William Park , Yuntao Song , Bharat Trivedi
IPC分类号： A61K31/4178 , A61K31/4172 , C07D405/02 , C07D233/54
CPC分类号： C07D413/14 , A61K31/4172 , A61K31/4178 , A61K45/06 , C07D207/34 , C07D207/36 , C07D233/64 , C07D233/66 , C07D233/84 , C07D233/90 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/12 , A61K2300/00
摘要： Novel imidazoles and novel pyrroles are provided. Also provided are pharmaceutical compositions, methods of making and methods of using the compounds.
摘要翻译：提供了新颖的咪唑和新颖的吡咯。还提供了药物组合物，制备方法和使用该化合物的方法。

9. 发明申请

US20050239857A1 Novel imidazoles 审中-公开
标题翻译：新型咪唑
公开(公告)号：US20050239857A1
公开(公告)日：2005-10-27
申请号：US11105288
申请日：2005-04-13
申请人： Gary Bolton , Daniel Bowles , David Boyles , Walter Howard , Richard Hutchings , Robert Kennedy , William Park , Toni-Jo Poel , Yuntao Song
发明人： Gary Bolton , Daniel Bowles , David Boyles , Walter Howard , Richard Hutchings , Robert Kennedy , William Park , Toni-Jo Poel , Yuntao Song
IPC分类号： A61K31/4172 , A61K31/4178 , A61K45/06 , C07D233/54 , C07D233/66 , C07D233/84 , C07D233/90 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/12 , C07D413/14 , C07D43/02
CPC分类号： C07D413/14 , A61K31/4172 , A61K31/4178 , A61K45/06 , C07D207/34 , C07D207/36 , C07D233/64 , C07D233/66 , C07D233/84 , C07D233/90 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/12 , A61K2300/00
摘要： Novel imidazoles are provided. The compounds are useful as HMGCo-A Reductase Inhibitor. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
摘要翻译：提供新的咪唑。该化合物可用作HMGCo-A还原酶抑制剂。还提供了化合物的药物组合物。还提供了制备方法和使用该化合物的方法。

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