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    • 3. 发明授权
    • Shampoo compositions with silicone and cationic organic polymeric
conditioning agents
    • 具有硅氧烷和阳离子有机聚合物调理剂的洗发剂组合物
    • US5573709A
    • 1996-11-12
    • US388120
    • 1995-02-13
    • Robert L. Wells
    • Robert L. Wells
    • A61K8/00A61K8/40A61K8/44A61K8/46A61K8/81A61K8/89A61K8/891A61Q5/02A61Q5/12C08L83/04C11D1/65C11D1/62C11D1/82C11D3/37
    • A61K8/8182A61K8/463A61K8/891A61Q5/02A61Q5/12A61K2800/5422A61K2800/5426A61K2800/594
    • Disclosed are hair conditioning shampoo compositions comprisingA liquid hair conditioning shampoo composition comprising:(a) from about 5% to about 50%, by weight, of an anionic surfactant component;(b) from about 0.1% to about 10%, by weight, of a dispersed, insoluble, nonvolatile, nonionic silicone hair conditioning agent;(c) from about 0.05% to about 10%, by weight, of soluble, organic, polymeric cationic hair conditioning agent, said polymeric, cationic hair conditioning agent consisting essentially of one or more cationic, hair conditioning polymers, said cationic hair conditioning polymers having quaternary ammonium or cationic amino moieties, or a mixture thereof, an open chain backbone, and a charge density of about +3.0 meq/gram or less; andThe shampoo compositions hereof can provide excellent overall hair conditioning benefits, in conjunction with excellent cleaning performance, to a variety of hair types including treated hair such as permed and color-treated hair, as well as undamaged hair.
    • 公开了包含A液体毛发调理洗发剂组合物的头发调理洗发剂组合物,其包含:(a)约5重量%至约50重量%的阴离子表面活性剂组分; (b)约0.1%至约10%重量的分散的不溶性非挥发性非离子型硅氧烷护发剂; (c)约0.05重量%至约10重量%的可溶性有机聚合物阳离子头发调理剂,所述聚合物阳离子头发调理剂基本上由一种或多种阳离子毛发调理聚合物组成,所述阳离子头发调理聚合物 具有季铵或阳离子氨基部分,或其混合物,开链主链和约+ 3.0meq /克或更小的电荷密度; 并且本发明的洗发剂组合物可以提供优异的整体头发调理效果,以及优异的清洁性能,适用于多种头发类型,包括处理的头发,如烫发和彩色处理的头发,以及未损坏的头发。
    • 5. 发明授权
    • Noninvasive electrocardiographic method of real time signal processing
for obtaining and displaying instantaneous fetal heart rate and fetal
heart rate beat-to-beat variability
    • 实时信号处理的无创心电图方法,用于获取和显示瞬时胎儿心率和胎心率心率差异变异
    • US5042499A
    • 1991-08-27
    • US561575
    • 1990-08-02
    • Thomas H. FrankRichard K. GibbsRobert L. Wells
    • Thomas H. FrankRichard K. GibbsRobert L. Wells
    • A61B5/024A61B5/0428A61B5/0444G06F17/00
    • A61B5/0444A61B5/02411A61B5/04282A61B5/4362
    • A fetal heart rate monitor monitors weak fetal electrocardiogram signals in the presence of strong interfering material ECG complexes, general random background muscle noise, and 60 Hz power line noise. An electrocardiographic adaptive cancellation process to cancel the maternal ECG component from an abdominal ECG signal recorded from a pregnant subject's abdomen signal is processed using computer software. A set of easily movable maternal abdominal and thoracic ECG electrodes is used. An operator views the ECG data in an oscilloscope and optimally places the set of thoracic electrodes to adaptively cancel the maternal ECG signal from the signal separately derived from a movable abdominal electrocardiographic lead. The invention noninvasively obtains from the abdomen of a pregnant subject the fetal ECG signal, fetal heart rate, and accurate beat-to-beat fetal heart rate variability. Computer software provides cancellation of the maternal ECG component derived from a maternal abdominal ECG lead using a separate set of maternal thoracic ECG leads. A starting fetal ECG signal is obtained from an electrocardiographic digital signal processing normalized correlation automatic start-up procedure. Ensuing fetal ECG complexes are matched with the starting complex for detecting ensuing ECG signals. Fetal heart rate and FHR variability are accurately and reliably measured and reported from the signals in an instantaneous or beat-to-beat fashion.
    • 胎心率监测器在强干扰物质心电复合物,一般随机背景肌肉噪声和60Hz电力线噪声的存在下监测弱胎儿心电图信号。 使用计算机软件处理从怀孕对象的腹部信号记录的腹部ECG信号中消除母体ECG分量的心电自适应消除处理。 使用一套容易移动的母体腹部和胸部ECG电极。 操作员在示波器中观察ECG数据,并最佳地放置该组胸部电极,以自动地从从可移动的腹部心电图导出的信号中消除母体ECG信号。 本发明从怀孕对象的腹部非侵入性地获得胎儿心电图信号,胎儿心率,以及准确的心跳节拍胎心率变异性。 计算机软件提供使用母体胸部ECG导联的母体腹部ECG导联产生的母体ECG成分的取消。 从心电图数字信号处理归一化相关自动启动程序获得起始胎儿ECG信号。 将胎儿心电图复合物与起始复合物匹配,以检测随后的ECG信号。 胎心率和FHR变异性可以准确可靠地以瞬时或搏动到搏动的方式从信号中测量和报告。
    • 7. 发明授权
    • Isokinetic testing machine
    • 等动力试验机
    • US06561990B1
    • 2003-05-13
    • US09471874
    • 1999-12-23
    • Thomas B. GilliamRobert L. Wells
    • Thomas B. GilliamRobert L. Wells
    • A61B5103
    • A61B5/4528A61B5/103A61B5/224A61B5/6895Y10S482/908
    • An isokinetic testing machine which includes an adjustable seat which is capable of being positioned to accommodate individuals of different sizes for various isokinetic tests of the legs, arms and/or back and a moveable dynamometer which is capable of being positioned to measure left knee strength, right knee strength, left elbow strength, right elbow strength and/or trunk movement. In one preferred embodiment of the present invention, the isokinetic machine is fabricated in two (2) independent sections which are capable of being readily disassembled for transportation and reassembled at remote locations for on-site isokinetic testing.
    • 一种等动力试验机,其包括可调节的座椅,该座椅能够定位成适应不同尺寸的个人,用于腿部,手臂和/或背部的各种等动力学测试,以及可移动测力计,其能够被定位成测量左膝盖强度, 右膝强度,左肘强度,右肘强度和/或躯干运动。 在本发明的一个优选实施例中,等动力机器制造在两(2)个独立部分中,其能够容易地拆卸运输并在远程位置重新组装用于现场等动力学测试。
    • 10. 发明申请
    • NOVEL SECRETED PROTEINS OF ADIPOCYTES FOR DIAGNOSTIC PURPOSES
    • 用于诊断用途的新药分泌蛋白
    • US20100190686A1
    • 2010-07-29
    • US12452061
    • 2008-06-23
    • Robert L. WellsJae-min LinDorothy Hausman
    • Robert L. WellsJae-min LinDorothy Hausman
    • C12Q1/34C12Q1/02G01N33/53A61K31/175A61K31/155A61K31/4439A61K31/7034A61K31/45A61K31/195A61K31/4985A61K38/22A61K38/28A61P3/10
    • G01N33/5023G01N2800/042G01N2800/54
    • The present invention relates to the discovery of polypeptide biomarkers excreted into the blood stream (serum or plasma) and/or urine from adipocytes and their use to determine the existence of metabolic syndrome (prediabetic) and/or diabetic conditions (including type 2 diabetes) including insulin resistance and/or glucose intolerance, their use to monitor the state of metabolic syndrome or diabetes toward a state of control and/or cure of the disease state or condition and their use to monitor the long-term health of the patient by determining the existence of metabolic syndrome (prediabetic conditions insulin resistance and/or glucose intolerance) or the existence of type 2 diabetes and to identify potential antidiabetes agents. Methods of identifying potential agents to be used in the treatment of metabolic syndrome and/or type2 diabetes and assays for assisting in the diagnosis of metabolic syndrome and/or type 2 diabetes are additional aspects of the invention. Lipoprotein lipase; Quiescin Q6; Cathepsin B; Complement Component 6; Hippocampal Cholinergic Neurostimulating Protein (HCNP); Serine Protease Inhibitor 2C; Adiponectin; Angiotensinogen (angiotensin); Cyclophilin A; Laminin B1 subunit 1; cartilage glycoprotein 39; complement factor MASP-3 (MASP-3); Niemann-Pick disease, type C2, isoform CRA b (NPC2); Tetranectin; tissue inhibitor of metalloproteinase 2 (TIMP2); Superoxide dismutase secreted; and Spondin 1
    • 本发明涉及从脂肪细胞分泌到血流(血清或血浆)和/或尿中的多肽生物标志物的发现及其用于确定代谢综合征(糖尿病前期)和/或糖尿病状况(包括2型糖尿病)的存在的用途, 包括胰岛素抵抗和/或葡萄糖不耐受,其用于监测代谢综合征状态或糖尿病状态的控制和/或治愈疾病状态或状况,以及其用于通过确定患者的长期健康来监测患者的长期健康 代谢综合征(糖尿病前期胰岛素抵抗和/或葡萄糖不耐受)的存在或2型糖尿病的存在并鉴定潜在的抗糖尿病药物。 识别用于治疗代谢综合征和/或2型糖尿病的潜在药物的方法和用于辅助诊断代谢综合征和/或2型糖尿病的测定法是本发明的另外的方面。 脂蛋白脂肪酶; Quiescin Q6; 组织蛋白酶B 补体组分6; 海马胆碱能神经刺激蛋白(HCNP); 丝氨酸蛋白酶抑制剂2C; 脂联素 血管紧张素原(血管紧张素); 环丙沙星A; 层粘连蛋白B1亚基1; 软骨糖蛋白39; 补体因子MASP-3(MASP-3); 尼曼 - 皮克病,C2型,同种型CRA b(NPC2); 紫杉醇; 金属蛋白酶2组织抑制剂(TIMP2); 分泌超氧化物歧化酶 和Spondin 1