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1. 发明申请

US20060004093A1 Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto 审中-公开
标题翻译：腺嘌呤核苷酸转位酶（ANT）的配体及其相关的组合物和方法
公开(公告)号：US20060004093A1
公开(公告)日：2006-01-05
申请号：US11146933
申请日：2005-06-07
申请人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
发明人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
IPC分类号： A61K31/277 , C07C255/41
CPC分类号： C07D263/57 , A61K31/185 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/94 , C07D277/66 , C07D307/80 , C07D333/16 , C07D333/24 , C07D333/56 , C07D333/60
摘要： Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
摘要翻译：可用于治疗与改变的线粒体功能相关的病症的化合物。所述化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， >，R 4，R 5和R 6如本文所定义。还公开了含有结构（I）化合物的药物组合物以及与其用途有关的方法。

2. 发明申请

US20060194825A1 Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto 审中-公开
标题翻译：腺嘌呤核苷酸转位酶（蚂蚁）的配体及其相关的组合物和方法
公开(公告)号：US20060194825A1
公开(公告)日：2006-08-31
申请号：US10539539
申请日：2003-12-19
申请人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
发明人： Soumitra Ghosh , Yazhong Pei , Xiao-Qing Tang , Spiros Liras , Michael Ahlijanian
IPC分类号： A61K31/44 , A61K31/40 , A61K31/277 , A61K31/235 , A61K31/192 , A61K31/195
CPC分类号： C07D263/57 , A61K31/185 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/94 , C07D277/66 , C07D307/80 , C07D333/16 , C07D333/24 , C07D333/56 , C07D333/60
摘要： Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
摘要翻译：可用于治疗与改变的线粒体功能相关的病症的化合物。具有结构（I）的化合物，包括立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， R 4，R 5和R 6如本文所定义。还公开了含有结构（I）化合物的药物组合物，以及与其使用有关的方法。

3. 发明申请

US20050003352A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 失效
公开(公告)号：US20050003352A1
公开(公告)日：2005-01-06
申请号：US09809827
申请日：2001-03-16
申请人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/10
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

4. 发明申请

US20050064530A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 失效
公开(公告)号：US20050064530A1
公开(公告)日：2005-03-24
申请号：US09811132
申请日：2001-03-14
申请人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12Q1/48 , C07J17/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

5. 发明申请

US20060004062A1 Compounds for inhibiting insulin secretion and methods related thereto 审中-公开
标题翻译：用于抑制胰岛素分泌的化合物及其相关方法
公开(公告)号：US20060004062A1
公开(公告)日：2006-01-05
申请号：US11140368
申请日：2005-09-13
申请人： Yazhong Pei , Soumitra Ghosh , Ian James
发明人： Yazhong Pei , Soumitra Ghosh , Ian James
IPC分类号： C07D213/26 , A61K31/44
CPC分类号： C07D207/335 , C07C45/46 , C07C45/673 , C07C205/56 , C07C211/29 , C07C229/34 , C07C233/11 , C07C237/10 , C07C237/14 , C07C317/44 , C07C323/29 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/49 , C07C323/52 , C07C323/60 , C07C335/18 , C07C2601/02 , C07C2601/14 , C07D211/24 , C07D211/96 , C07D213/38 , C07D213/70 , C07D213/73 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/20 , C07D233/64 , C07D271/06 , C07D277/28 , C07D277/64 , C07D295/185 , C07D413/12 , C07C49/83
摘要： Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following struture (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
摘要翻译：用于改变胰岛素分泌的化合物，组合物和方法，特别是在治疗具有或怀疑患有糖尿病风险的受试者的情况下。所述化合物具有以下结构（I）：包括立体异构体，前药和药学上可接受的盐，其中W 1，W 2，X，R 1， R 2，R 2，R 3，R 4，m和n在本文中定义。

6. 发明申请

US20050019835A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 失效
公开(公告)号：US20050019835A1
公开(公告)日：2005-01-27
申请号：US09811131
申请日：2001-03-14
申请人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/554 , G01N33/567 , G01N33/569
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

7. 发明申请

US20050003353A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 失效
标题翻译：腺嘌呤转运蛋白（ANT）的生产，新型配体和筛选测定
公开(公告)号：US20050003353A1
公开(公告)日：2005-01-06
申请号：US09809889
申请日：2001-03-16
申请人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
发明人： Christen Anderson , Robert Davis , William Clevenger , Sandra Wiley , Scott Miller , Tomas Szabo , Soumitra Ghosh , Walter Moos , Yazhong Pei
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/10
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要翻译：提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

8. 发明授权

US07928060B2 Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them 失效
标题翻译：胰岛淀粉样多肽多肽-6（AFP-6）类似物及其制备和使用方法
公开(公告)号：US07928060B2
公开(公告)日：2011-04-19
申请号：US11664750
申请日：2005-10-11
申请人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew Young , Richard Pittner , Soumitra Ghosh
发明人： Mary Erickson , Ved Srivastava , Sarah McQuaid , Andrew Young , Richard Pittner , Soumitra Ghosh
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.
摘要翻译：本发明涉及淀粉蛋白家族多肽-6（AFP-6）类似物，其包括衍生物和片段，相关核酸，表达构建体，宿主细胞和用于重组生产AFP-6类似物的方法。本发明的AFP-6类似物包括一个或多个氨基酸序列修饰。此外，公开了治疗和预防诸如代谢和心血管疾病如肥胖症，糖尿病，代谢综合征，心肌缺血和增加的心血管风险的病症的方法和组合物。

9. 发明申请

US20050148768A1 Cobalt-porphyrin complexes and use thereof as an anti-obesity agent 审中-公开
标题翻译：钴 - 卟啉络合物及其作为抗肥胖剂的用途
公开(公告)号：US20050148768A1
公开(公告)日：2005-07-07
申请号：US10984557
申请日：2004-11-08
申请人： Tomas Szabo , Soumitra Ghosh , Robert Davis
发明人： Tomas Szabo , Soumitra Ghosh , Robert Davis
IPC分类号： A61K31/409 , A61K33/24 , A61P3/04 , C07D487/22 , C07F15/06
CPC分类号： C07D487/22
摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
摘要翻译：用作抗肥胖剂的钴卟啉（Co-P）络合物，以及与其相关的组合物和方法。 Co-P配合物与钴中卟啉（Co-MP）和钴原卟啉（Co-PP）相比显示出降低的氧化还原活性，其减轻了与施用与氧化应激相关的Co-P相关的有害作用，特别是在注射的情况下现场毒性。

10. 发明授权

US5210203A Sulfonamide-derivative compounds for tagging nucleic acid probes 失效
标题翻译：用于标记核酸探针的磺酰胺衍生化合物
公开(公告)号：US5210203A
公开(公告)日：1993-05-11
申请号：US879593
申请日：1992-05-07
申请人： Gary F. Musso , Soumitra Ghosh , Emil T. Kaiser
发明人： Gary F. Musso , Soumitra Ghosh , Emil T. Kaiser
IPC分类号： C07F7/18 , C07H21/00 , C12Q1/68
CPC分类号： C07H21/00 , C07F7/1852 , C07F7/1856 , C12Q1/6816
摘要： Nucleic acid hybridization probes are provided which comprise an N.sup.4 -(substituted amino)cytosine moiety, wherein the substituted amino group comprises a tag moiety, whereby the probe is detected. Methods of preparing probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in hybridization assays are also provided. Typical tag moieties employed with the probes of the invention are biotinyl, aminothiadiazole and fluorescein derivatives, connected to N.sup.4 -amino groups of modified cytosines of the probe through linker moieties. Probes tagged with biotin are typically detected by binding to the biotinyl moieties, through a streptavidin or avidin molecule, a reporter group which includes streptavidin or avidin and then detecting a signal due to the reporter group. Probes tagged with aminothiadiazole derivatives are typically detected by essentially the same method as those tagged with biotinyl but employing as reporter group one which binds to the derivative through a carbonic anhydrase molecule. Probes tagged with fluorescein derivatives are detected by a fluorescence spectroscopic method without binding of a reporter group to the tag.
摘要翻译：提供了包含N4-（取代氨基）胞嘧啶部分的核酸杂交探针，其中取代的氨基包括标签部分，由此检测探针。还提供了制备本发明的探针的方法，在这些方法中使用的中间体以及在杂交测定中使用本发明的探针的方法。与本发明的探针一起使用的典型标签部分是通过接头部分连接到探针的修饰胞嘧啶的N4-氨基的生物素，氨基噻二唑和荧光素衍生物。用生物素标记的探针通常通过结合生物素部分，通过链霉抗生物素蛋白或抗生物素蛋白分子，包括链霉抗生物素蛋白或抗生物素蛋白的报道基团检测，然后检测由于报告基团引起的信号。用氨基噻二唑衍生物标记的探针通常用与生物素标记的那些基本上相同的方法来检测，但采用作为通过碳酸酐酶分子与衍生物结合的报告基团。用荧光素衍生物标记的探针通过荧光光谱法检测，而不将报道基团与标签结合。

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