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1. 发明授权

US5158969A Indole derivatives as potassium channel blockers 失效
标题翻译：吲哚衍生物作为钾通道阻滞剂
公开(公告)号：US5158969A
公开(公告)日：1992-10-27
申请号：US748050
申请日：1991-08-21
申请人： Soren-Peter Olesen , Leif H. Jensen , Peter Moldt , Mikkel Thaning
发明人： Soren-Peter Olesen , Leif H. Jensen , Peter Moldt , Mikkel Thaning
IPC分类号： A61K31/40
CPC分类号： A61K31/40
摘要： A method of treating a disease in a mammal, including a human, responsive to blockade of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.11, R.sup.12, R.sup.13, R.sup.14 and R.sup.15 independently of each other are hydrogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy or phenyl; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, C.sub.1-6 -alkyl, NO.sub.2, NH.sub.2, OH or C.sub.1-6 -alkoxy,and a method as above wherein 1-(4-methoxyphenyl)-indole is employed,and a method as above wherein depression, memory disorders, Alzheimers disease and diabetes 2 is treated,and further a method as above wherein the active ingredient is administered in the form of a pharmaceutical composition thereof, in which it is present together with a pharmaceutically-acceptable carrier or diluent.

2. 发明授权

US5475015A Benzimidazole derivatives, their preparation and pharmaceutical use 失效
标题翻译：苯并咪唑衍生物，其制备和药物用途
公开(公告)号：US5475015A
公开(公告)日：1995-12-12
申请号：US206506
申请日：1994-03-04
申请人： Soren-Peter Olesen , Leif H. Jensen , Peter Moldt
发明人： Soren-Peter Olesen , Leif H. Jensen , Peter Moldt
IPC分类号： A61K31/415 , A61K31/4184 , A61P1/00 , A61P1/12 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/06 , A61P13/10 , A61P25/00 , A61P25/08 , C07D235/26 , C07D235/28 , C07D235/04 , C07D487/00
CPC分类号： C07D235/28 , C07D235/26
摘要： A compound having the formula ##STR1## wherein X is O, SR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, or CF.sub.3 ;R' is hydrogen or NO.sub.2 ; andfurther a method of treating a disorder or disease of a living animal body, including a human, which is responsive to opening of potassium channels, which comprises administering to a living animal body, including a human, in need thereof an effective amount of a compound as above.
摘要翻译：具有式“IMAGE”的化合物，其中X为O，S R4，R5，R6和R7彼此独立地为氢，卤素或CF3; R'是氢或NO 2; 以及进一步治疗对钾通道开放有响应的活体动物体（包括人）的病症或疾病的方法，其包括对有需要的活体动物体（包括人）施用有效量的化合物如上。

3. 发明授权

US5314903A Benzimidazole compounds useful as calcium channel blockers 失效
标题翻译：可用作钙通道阻断剂的苯并咪唑化合物
公开(公告)号：US5314903A
公开(公告)日：1994-05-24
申请号：US978131
申请日：1992-11-18
申请人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
发明人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
IPC分类号： A61K31/415 , A61K31/4184 , A61P3/00 , A61P3/14 , A61P9/10 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07D235/30
CPC分类号： C07D235/30
摘要： The present invention discloses compounds of the formula ##STR1## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain;n is 1 or 2;R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino; andR.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy; or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
摘要翻译：本发明公开了式“IMAGE”的化合物，其中R'和R“彼此独立地是氢或烷基，或者R'和R”一起形成3至6元亚烷基链; n为1或2; R 1是可以被卤素，CF 3，烷氧基，烷基或氨基取代一次或多次的苯基; R 4，R 5，R 6和R 7彼此独立地是氢，卤素，氨基，CF 3，烷基或烷氧基; 或其药学上可接受的加成盐。这些化合物可用作药物，例如用于治疗缺血，缺氧，偏头痛和精神病。

4. 发明授权

US5210091A Imidazole compounds and their use 失效
标题翻译：咪唑化合物及其用途
公开(公告)号：US5210091A
公开(公告)日：1993-05-11
申请号：US888036
申请日：1992-05-22
申请人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
发明人： Oskar Axelsson , Mikkel Thaning , Peter Moldt
IPC分类号： C07D235/30
CPC分类号： C07D235/30
摘要： The application discloses benzimidazole derivatives, pharmaceutical preparations comprised the compounds, their preparation and use in the treatment of disorders of the Central Nervous System such as ischemia, migraine, epilepsia, psychosis, Parkinsonism and depression.
摘要翻译：该申请公开了苯并咪唑衍生物，药物制剂包括化合物，其制备和用于治疗中枢神经系统疾病如缺血，偏头痛，癫痫，精神病，帕金森综合征和抑郁症。

5. 发明授权

US5554626A Substituted heterocyclic compounds as dopamine-reuptake inhibitors 失效
标题翻译：取代的杂环化合物作为多巴胺再摄取抑制剂
公开(公告)号：US5554626A
公开(公告)日：1996-09-10
申请号：US93184
申请日：1993-07-16
申请人： Peter Moldt , J.o slashed.rgen Scheel-Kr uger , Leif H. Jensen
发明人： Peter Moldt , J.o slashed.rgen Scheel-Kr uger , Leif H. Jensen
IPC分类号： A61K31/46 , C07D451/02 , C07D413/04
CPC分类号： C07D451/02 , A61K31/46
摘要： The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sub.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
摘要翻译：本发明公开了下式的化合物：其任何混合物，或其药学上可接受的盐; 其中R，R 3和R 4各自具有说明书中阐述的含义。该化合物具有有价值的药物性质作为多巴胺再摄取抑制剂。

6. 发明授权

US5374636A 2,3-trans-disubstituted tropane compounds which have useful pharmaceutical utility 失效
标题翻译：具有有用的药物效用的2,3-反式二取代的托烷化合物
公开(公告)号：US5374636A
公开(公告)日：1994-12-20
申请号：US93182
申请日：1993-07-16
申请人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
发明人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02 , A61K31/46
摘要： The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sup.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
摘要翻译：本发明公开了下式的化合物：其任何混合物，或其药学上可接受的盐; 其中R，R 3和R 4各自具有说明书中阐述的含义。该化合物具有有价值的药物性质作为多巴胺再摄取抑制剂。

7. 发明授权

US5369113A Certain 2,3-diphenyl-2-(1,2,4-oxadiazol-5-yl)tropanes useful as dopamide reuptake inhibitors 失效
标题翻译：某些用作多巴胺再摄取抑制剂的2,3-二苯基-2-（1,2,4-恶二唑-5-基）托烷
公开(公告)号：US5369113A
公开(公告)日：1994-11-29
申请号：US93183
申请日：1993-07-16
申请人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
发明人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
IPC分类号： A61K31/46 , C07D451/02 , A61K31/44
CPC分类号： C07D451/02 , A61K31/46
摘要： The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sup.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
摘要翻译：本发明公开了下式的化合物：其任何混合物，或其药学上可接受的盐; 其中R，R 3和R 4各自具有说明书中阐述的含义。该化合物具有有价值的药物性质作为多巴胺再摄取抑制剂。

8. 发明授权

US5444070A Phenyl substituted heterocyclic compounds 失效
标题翻译：苯基取代的杂环化合物
公开(公告)号：US5444070A
公开(公告)日：1995-08-22
申请号：US93181
申请日：1993-07-16
申请人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
发明人： Peter Moldt , Jorgen Scheel-Kruger , Leif H. Jensen
IPC分类号： A61K31/46 , C07D451/02 , C07D413/04 , A61K31/44 , C07D401/04
CPC分类号： C07D451/02 , A61K31/46
摘要： The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sub.3, and R.sup.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
摘要翻译：本发明公开了下式的化合物：其任何混合物，或其药学上可接受的盐; 其中R，R 3和R 4各自具有说明书中阐述的含义。该化合物具有有价值的药物性质作为多巴胺再摄取抑制剂。

9. 发明申请

US20100056561A1 HYDROCHLORIDE SALT OF AN AZABICYCLO[3.2.1]OCTANE DERIVATIVE 有权
标题翻译：亚硫酸氢盐的盐酸盐[3.2.1]月桂衍生物
公开(公告)号：US20100056561A1
公开(公告)日：2010-03-04
申请号：US12529502
申请日：2008-02-28
申请人： Trevor John Grinter , Peter Moldt , Frank Watjen
发明人： Trevor John Grinter , Peter Moldt , Frank Watjen
IPC分类号： A61K31/46 , C07D451/02 , A61P25/00
CPC分类号： C07D451/02
摘要： The invention relates to a hydrochloride salt of (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-[(methyloxy)methyl]-8-azabicyclo[3.2.1]octane, uses of the salt as a medicament in the treatment inter alia of disorders of the central nervous system and pharmaceutical compositions and dosage forms comprising the salt.
摘要翻译：本发明涉及（1R，2R，3S，5S）-3-（3,4-二氯苯基）-2 - [（甲氧基）甲基] -8-氮杂双环[3.2.1]辛烷的盐酸盐，盐作为治疗特别是中枢神经系统病症的药物以及包含该盐的药物组合物和剂型。

10. 发明授权

US5296493A 1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells 失效
标题翻译： 1-取代-2-（N-苯基-N-（苯甲基）甲胺）-4,5-二氢咪唑及其相关化合物及其在脑细胞中治疗钙超载中的应用
公开(公告)号：US5296493A
公开(公告)日：1994-03-22
申请号：US704469
申请日：1991-05-23
申请人： Peter Moldt , Elsebet O. Nielsen
发明人： Peter Moldt , Elsebet O. Nielsen
IPC分类号： C07D233/24 , C07D233/54 , C07D233/60 , C07D235/14 , C07D401/12 , C07D403/06 , C07D405/12 , A61K31/415 , A61K31/44 , C07D233/61 , C07D401/06
CPC分类号： C07D233/64 , C07D233/24 , C07D235/14 , C07D401/12 , C07D403/06 , C07D405/12
摘要： The present patent application discloses compounds of the formula ##STR1## wherein R.sup.1 is C.sub.1-10 saturated or unsaturated alkyl; or ##STR2## wherein R'" is H or ##STR3## R.sup.2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; or cyclohexyl;R.sup.3 phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl; pyridyl; C.sub.1-6 unsaturated alkyl; furanyl;R.sup.4 is H, C.sub.1-6 -alkyl, or benzyl; or ##STR4## together form ##STR5## R' and R" are each hydrogen or together form an extra benzo ring; and wherein the dotted line represents an optional extra bond between the two carbon atoms designated .alpha. and .beta.,or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells.
摘要翻译：本专利申请公开了式IMA的化合物，其中R 1是C 1-10饱和或不饱和的烷基; 或者其中R“'为H或R 2是未被取代或被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代或被取代的苯基。可以被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代一次或多次的苄基; 吡啶基或环己基; R 3苯基，其未被取代或被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6烷基，甲基取代一次或多次; 可以被卤素，CF 3，C 1-6 - 烷氧基，NO 2，CO 2 -C 1-6 - 烷基，甲基取代一次或多次的萘基; 吡啶基 C 1-6不饱和烷基; 呋喃基 R4是H，C1-6烷基或苄基; 或一起形成 R'和R“各自为氢或一起形成额外的苯并环; 并且其中虚线表示指定为α和β的两个碳原子之间的任选的额外键或其药学上可接受的加成盐。这些化合物可用作药物，例如用于治疗脑细胞中的Ca超载。

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