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1. 发明授权

US07456001B2 Lipoxygenase 失效
标题翻译：脂氧合酶
公开(公告)号：US07456001B2
公开(公告)日：2008-11-25
申请号：US10362776
申请日：2001-09-05
申请人： Soren Christensen , Akiko Sugio , Shinobu Takagi , Lars Ostergaard , Ernst Oliw
发明人： Soren Christensen , Akiko Sugio , Shinobu Takagi , Lars Ostergaard , Ernst Oliw
IPC分类号： C12N9/02 , C12N15/00 , C12N1/20 , C12P21/04 , A21D10/00 , C11D3/02 , C07H21/04 , C12Q1/00 , C12Q1/68
CPC分类号： C12N9/0069
摘要： The invention provides sequence information of a microbial protein having lipoxy-genase activity and a method of producing the protein by recombinant DNA technology. More specifically, the inventors have isolated a gene encoding a lipoxygenase from Gaeu-mannomyces graminis, cloned it into an E. coli strain and sequenced it. A comparison shows less than 25% identity to known lipoxygenase sequences, the closest being human 15S li-poxygenase. The inventors have expressed the lipoxygenase recombinantly and found that the recombinant lipoxygenase is glycosylated.
摘要翻译：本发明提供具有脂氧合酶活性的微生物蛋白质的序列信息和通过重组DNA技术生产该蛋白质的方法。更具体地说，本发明人已经分离出来自禾谷镰刀菌的编码脂氧合酶的基因，将其克隆到大肠杆菌菌株中并对其进行测序。比较显示与已知的脂氧合酶序列具有小于25％的同一性，最接近的是人15S li-加氧酶。本发明人重组表达了脂氧合酶，发现重组脂氧合酶被糖基化。

2. 发明授权

US08366388B2 Multi-stage centrifugal pump (axial face seal) 有权
标题翻译：多级离心泵（轴面密封）
公开(公告)号：US08366388B2
公开(公告)日：2013-02-05
申请号：US12720735
申请日：2010-03-10
申请人： Aage Bruhn , Lars Ostergaard
发明人： Aage Bruhn , Lars Ostergaard
IPC分类号： F04D29/12
CPC分类号： F04D29/126
摘要： An axial face seal (13), which seals a pump housing in the region of the pump shaft (12), is constructed in an axially compact manner. Spring holders (24, 25), which transmit the required pressing force of a compression spring (23), are connected to one another with a positive fit in a rotation direction, and hold a rotating axial face seal ring (19) in a rotationally fixed manner to the pump shaft (12). The spring holders (24, 25) are compact and enclose an abutment ring (33) for pump impellers as well as the compression spring (23). A motor-side spring (24) engages over the rotating axial face seal ring (19), by which an axially extremely short constructional length is achieved.
摘要翻译：在泵轴（12）的区域中密封泵壳体的轴向面密封件（13）以轴向紧凑的方式构造。传递压缩弹簧（23）所需的按压力的弹簧保持器（24,25）在旋转方向上以正配合彼此连接，并且旋转地保持旋转的轴向面密封环（19）固定到泵轴（12）。弹簧保持器（24,25）是紧凑的并且包围用于泵叶轮以及压缩弹簧（23）的抵接环（33）。电动机侧弹簧（24）接合在旋转的轴向面密封环（19）上方，由此实现轴向极短的结构长度。

3. 发明授权

US08740569B2 Impeller for a centrifugal pump 有权
标题翻译：离心泵叶轮
公开(公告)号：US08740569B2
公开(公告)日：2014-06-03
申请号：US12714626
申请日：2010-03-01
申请人： Aage Bruhn , Lars Ostergaard
发明人： Aage Bruhn , Lars Ostergaard
IPC分类号： F04D29/22
CPC分类号： F04D29/2222 , F04D29/242
摘要： The impeller for a centrifugal pump includes a carrier disk and possibly a shroud. The blades of the impeller are identical, but are arranged in pairs such that impellers of different hydraulic characteristics are formed with blades of the same shape.
摘要翻译：用于离心泵的叶轮包括托盘和可能的护罩。叶轮的叶片是相同的，但成对布置，使得具有相同形状的叶片形成不同液压特性的叶轮。

4. 发明申请

US20120052088A1 PNEUMOCOCCAL VACCINE AND USES THEREOF 审中-公开
标题翻译：肺癌疫苗及其用途
公开(公告)号：US20120052088A1
公开(公告)日：2012-03-01
申请号：US13266846
申请日：2010-03-17
申请人： Heather Lynn Davis , Arthur Mertz Krieg , Nicolai Lohse , Lars Ostergaard , Henrik Carl Schonheyder , Ole Schmeltz Sogaard
发明人： Heather Lynn Davis , Arthur Mertz Krieg , Nicolai Lohse , Lars Ostergaard , Henrik Carl Schonheyder , Ole Schmeltz Sogaard
IPC分类号： A61K39/385 , A61P31/04 , A61P31/12 , A61P35/00 , A61P3/00 , A61P31/18 , A61P9/00 , A61P11/00 , A61P9/04 , A61P3/10 , A61P1/16 , A61P25/32 , A61P25/00 , A61P11/08 , A61P1/00 , A61P7/00 , A61P35/02 , A61P13/12 , A61P11/06 , A61K39/39 , A61K39/09
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/55561 , A61K2039/6037
摘要： The present invention relates to new pneumococcal vaccines. The invention also relates to vaccination of subjects, in particular immunocompromised subjects, against pneumococcal infections using said novel pneumococcal vaccines.
摘要翻译：本发明涉及新型肺炎球菌疫苗。本发明还涉及使用所述新型肺炎球菌疫苗接种受试者，特别是免疫受损的受试者针对肺炎球菌感染。

5. 发明申请

US20110123375A1 ROTATIONAL DIRECTION INDICATOR 有权
标题翻译：旋转方向指示器
公开(公告)号：US20110123375A1
公开(公告)日：2011-05-26
申请号：US12994549
申请日：2009-04-27
申请人： Lars Ostergaard , Carsten Norgard
发明人： Lars Ostergaard , Carsten Norgard
IPC分类号： F04D29/58 , H02K9/06 , G01D13/00
CPC分类号： F04D29/584 , F04B2205/05 , G01F1/28 , H02K9/06 , H02K11/21
摘要： The inventive rotational direction indicator for an electric motor having a cooling fan has a baffle element which can be moved between two positions and which can be arranged on an electric motor with a cooling fan in such a way that the baffle element is positioned in an airstream of the cooling fan whose direction depends on the rotational direction of the electric motor, and said baffle element is respectively moved into one of its two positions by said electric motor as a function of the direction of the airstream. The rotational direction indicator has a display unit which is designed to visually indicate the position of the baffle element and can be arranged on an outer side of the electric motor. In addition, the rotational direction indicator has a display actuating unit which connects the display unit and baffle element to one another, and transmits the position of the baffle element to the display unit.
摘要翻译：具有冷却风扇的电动机的本发明旋转方向指示器具有挡板元件，该挡板元件可以在两个位置之间移动，并且其可以布置在具有冷却风扇的电动机上，使得挡板元件位于气流中所述冷却风扇的方向取决于所述电动机的旋转方向，并且所述挡板元件根据所述气流的方向被所述电动机分别移动到其两个位置中的一个位置。旋转方向指示器具有显示单元，该显示单元设计成可视地指示挡板元件的位置，并且可以布置在电动机的外侧。此外，旋转方向指示器具有显示致动单元，其将显示单元和挡板元件彼此连接，并且将挡板元件的位置传递到显示单元。

6. 发明申请

US20090324553A1 Chimeric Viral Envelopes 失效
标题翻译：嵌合病毒信封
公开(公告)号：US20090324553A1
公开(公告)日：2009-12-31
申请号：US12225268
申请日：2007-03-16
申请人： Finn Skou Pedersen , Shervin Bahrami , Mogens Ryttergaard Duch , Lars Ostergaard , Martin Tolstrup
发明人： Finn Skou Pedersen , Shervin Bahrami , Mogens Ryttergaard Duch , Lars Ostergaard , Martin Tolstrup
IPC分类号： A61K38/16 , C07K14/005 , C07H21/04 , C12N15/63 , C12N5/10 , A01K67/027 , A61K31/7088 , A61K35/76 , C07K16/00 , C12Q1/70 , A61P31/12
CPC分类号： C07K14/005 , C07K2319/33 , C07K2319/74 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2740/16222 , C12N2810/6054 , C12N2810/6072
摘要： The invention relates to chimeric polytropic viral envelope polypeptides and uses thereof, as well as to polynucleotides encoding said chimeric polypeptides and constructs comprising said polypeptides and/or polynucleotides. The invention also relates to chimeric retroviral envelope polypeptides, polynucleotides and vectors encoding said chimeric retroviral envelope polypeptides, virus particles and cells harbouring said chimeric envelope polypeptides. Said chimeric polypeptide comprise an envelope polypeptide, or fragment thereof, and a polypeptide sequence of a receptor binding region, ligand or polypeptide sequence of a ligand binding region, and optionally a linker sequence. The invention include methods of targeting receptors, methods of treatment and methods for delivery of agents using said chimeric retroviral envelope polypeptides. The invention is applicable for directed targeting and controlled fusion of virus particles with other cellular membranes.
摘要翻译：本发明涉及嵌合多皮病毒包膜多肽及其用途，以及编码所述嵌合多肽的多核苷酸和包含所述多肽和/或多核苷酸的构建体。本发明还涉及嵌合逆转录病毒包膜多肽，多核苷酸和编码所述嵌合逆转录病毒包膜多肽的载体，病毒颗粒和携带所述嵌合包膜多肽的细胞。所述嵌合多肽包含包膜多肽或其片段，以及配体结合区的受体结合区，配体或多肽序列和任选的接头序列的多肽序列。本发明包括靶向受体的方法，治疗方法和使用所述嵌合逆转录病毒包膜多肽递送药物的方法。本发明适用于病毒颗粒与其他细胞膜的定向靶向和受控融合。

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