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1. 发明授权

US08021866B2 Therapeutic use of ADPase enhanced apyrases 有权
标题翻译：治疗性使用ADPase增强的apyrases
公开(公告)号：US08021866B2
公开(公告)日：2011-09-20
申请号：US12145394
申请日：2008-06-24
申请人： Soon Seog Jeong , Ridong Chen , Timothy A. Mitsky
发明人： Soon Seog Jeong , Ridong Chen , Timothy A. Mitsky
IPC分类号： C12N9/02 , C12N1/20 , C07H21/04
CPC分类号： C12N9/14 , A61K48/00 , C12Y306/01005
摘要： The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.
摘要翻译：本发明提供了用于预防和逆转血小板聚集和募集用于治疗和预防哺乳动物血管疾病的ADP酶增强多肽，药物组合物和方法的设计和治疗应用。

2. 发明申请

US20130142775A1 THERAPEUTIC APYRASE CONSTRUCTS, APYRASE AGENTS, AND PRODUCTION METHODS 有权
标题翻译：治疗APYRASE建议，APYRASE代理和生产方法
公开(公告)号：US20130142775A1
公开(公告)日：2013-06-06
申请号：US13522311
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： C12N9/14 , C12N15/85 , A61K38/46 , C12N5/10
CPC分类号： C12N9/14 , C07K14/70596
摘要： This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.
摘要翻译：本发明提供了一类具有优异的药代动力学，药效学和药物化学性质的增强的apyrases（EN-apyrases），并且可以使用简化的程序纯化。本发明进一步提供了用于转化细胞以产生这些EN-磷酸酶的构建体。 EN-脱酰酶构建体包含编码信号序列，接头和可溶性apyrase的序列。还提供了apyrases的制剂和在培养细胞中产生apyrase的方法和其纯化。

3. 发明申请

US20130028880A1 APYRASE THERAPY FOR BLEEDING CONDITIONS 有权
标题翻译：用于治疗条件的APYRASE治疗
公开(公告)号：US20130028880A1
公开(公告)日：2013-01-31
申请号：US13522310
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46 , A61P7/04
CPC分类号： A61K38/46 , C12Y306/01005
摘要： This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are patho-physiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
摘要翻译：本发明提供了治疗由于血管损伤而出现或有出血风险的受试者，特别是微血管和/或血小板脱敏的新方法。由apyrase试剂有效治疗的损伤的实例是病理生理学条件，缺血再灌注损伤，药理学试剂如抗凝血剂，抗血小板剂，抗血栓药，溶血栓剂和/或免疫抑制剂的损伤以及由移植引起的损伤。当所述器官移植到同种异体受体中时，阿魏酸酶剂也可用于维持器官功能。

4. 发明申请

US20110053221A1 RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS 有权
标题翻译：使用人体细胞表达系统重新产生认可人类蛋白质
公开(公告)号：US20110053221A1
公开(公告)日：2011-03-03
申请号：US12922293
申请日：2009-03-12
申请人： Ridong Chen , Soon Seog Jeong , Hui Feng
发明人： Ridong Chen , Soon Seog Jeong , Hui Feng
IPC分类号： C12P21/00 , C12N15/63 , C12N9/12 , C07K14/54 , C07K16/24 , C12N5/10 , C07K14/555 , C07K14/61 , C07K16/40 , C07K16/26
CPC分类号： C12N15/85 , A61K38/18 , A61K38/1816 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/193 , A61K38/20 , A61K38/2026 , A61K45/06 , C07K14/4716 , C07K14/495 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/75 , C07K14/765 , C12N2800/107 , C12N2840/60
摘要： The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.
摘要翻译：本发明涉及用于从新型人类细胞系的稳定培养物，由其产生的真实重组蛋白质以及针对这些真实的重组蛋白产生的抗体有效地产生真正的重组人蛋白质的新型表达盒和载体。

5. 发明授权

US07217865B2 Transgenic high tryptophan plants 有权
标题翻译：转基因高色氨酸植物
公开(公告)号：US07217865B2
公开(公告)日：2007-05-15
申请号：US10138927
申请日：2002-05-03
申请人： Lisa M Weaver , Jihong Liang , Ridong Chen , Soon Seog Jeong , Timothy Mitsky , Steven Slater , William Rapp
发明人： Lisa M Weaver , Jihong Liang , Ridong Chen , Soon Seog Jeong , Timothy Mitsky , Steven Slater , William Rapp
IPC分类号： C12N15/12 , C12N15/31 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8254 , C12N9/88
摘要： The present invention provides transgenic plants transformed with an isolated DNA encoding a monomeric anthranilate synthase. The present invention also provides an isolated DNA encoding a monomeric anthranilate synthase from Agrobacterium tumefaciens. Transformation vectors and transformed plants containing the isolated DNA and seeds derived therefrom, are also provided.
摘要翻译：本发明提供用编码单体邻氨基苯甲酸合酶的分离的DNA转化的转基因植物。本发明还提供了编码来自根癌农杆菌的单体邻氨基苯甲酸合酶的分离的DNA。还提供了转化载体和含有分离的DNA和从其衍生的种子的转化植物。

6. 发明授权

US08535662B2 Apyrase therapy for bleeding conditions 有权
标题翻译： Apyrase治疗出血情况
公开(公告)号：US08535662B2
公开(公告)日：2013-09-17
申请号：US13522310
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46
CPC分类号： A61K38/46 , C12Y306/01005
摘要： This invention provides new methods of treating subjects experiencing or at risk of bleeding due to vascular injury, especially to the microvasculature and/or platelet desensitization. Examples of injury usefully treated by apyrase agents are pathophysiological conditions, ischemia reperfusion injury, injury from pharmacologic agents such as anticoagulants, antiplatelet agents, antithrombotics, thrombolytics, and/or immunosuppressants, and injury resulting from transplantation. Apyrase agents are also useful to maintain organ function when said organs are transplanted into an allogeneic recipient.
摘要翻译：本发明提供了治疗由于血管损伤而出现或有出血风险的受试者，特别是微血管和/或血小板脱敏的新方法。由apyrase试剂有效治疗的损伤的实例是病理生理学条件，缺血再灌注损伤，药理学试剂如抗凝血剂，抗血小板剂，抗血栓药，溶栓剂和/或免疫抑制剂的损伤以及由移植引起的损伤。当所述器官移植到同种异体受体中时，阿魏酸酶剂也可用于维持器官功能。

7. 发明申请

US20130095062A1 RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS 审中-公开
公开(公告)号：US20130095062A1
公开(公告)日：2013-04-18
申请号：US13552284
申请日：2012-07-18
申请人： Ridong Chen , Soon Seog Jeong , Hui Feng
发明人： Ridong Chen , Soon Seog Jeong , Hui Feng
IPC分类号： C07K14/52 , A61K45/06 , A61K38/20 , A61K38/19 , A61K38/18
CPC分类号： C12N15/85 , A61K38/18 , A61K38/1816 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/193 , A61K38/20 , A61K38/2026 , A61K45/06 , C07K14/4716 , C07K14/495 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/75 , C07K14/765 , C12N2800/107 , C12N2840/60
摘要： The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.

8. 发明申请

US20150099295A1 RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS 审中-公开
标题翻译：使用人体细胞表达系统重新产生认可人类蛋白质
公开(公告)号：US20150099295A1
公开(公告)日：2015-04-09
申请号：US14506217
申请日：2014-10-03
申请人： Ridong Chen , Soon Seog Jeong , Hui Feng
发明人： Ridong Chen , Soon Seog Jeong , Hui Feng
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K38/18 , A61K38/1816 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/193 , A61K38/20 , A61K38/2026 , A61K45/06 , C07K14/4716 , C07K14/495 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/75 , C07K14/765 , C12N2800/107 , C12N2840/60
摘要： The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.
摘要翻译：本发明涉及用于从新型人类细胞系的稳定培养物，由其产生的真实重组蛋白质以及针对这些真实的重组蛋白产生的抗体有效地产生真正的重组人蛋白质的新型表达盒和载体。

9. 发明授权

US08771683B2 Therapeutic apyrase constructs, apyrase agents, and production methods 有权
标题翻译：治疗性apyrase构建体，apyrase试剂和生产方法
公开(公告)号：US08771683B2
公开(公告)日：2014-07-08
申请号：US13522311
申请日：2011-01-13
申请人： Ridong Chen , Soon Seog Jeong
发明人： Ridong Chen , Soon Seog Jeong
IPC分类号： A61K38/46
CPC分类号： C12N9/14 , C07K14/70596
摘要： This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.
摘要翻译：本发明提供了一类具有优异的药代动力学，药效学和药物化学性质的增强的apyrases（EN-apyrases），并且可以使用简化的程序纯化。本发明进一步提供了用于转化细胞以产生这些EN-磷酸酶的构建体。 EN-脱酰酶构建体包含编码信号序列，接头和可溶性apyrase的序列。还提供了apyrases的制剂和在培养细胞中产生apyrase的方法及其纯化。

10. 发明授权

US08236527B2 Recombinant production of authentic human proteins using human cell expression systems 有权
标题翻译：使用人类细胞表达系统重组生产真实的人类蛋白质
公开(公告)号：US08236527B2
公开(公告)日：2012-08-07
申请号：US12922293
申请日：2009-03-12
申请人： Ridong Chen , Soon Seog Jeong , Hui Feng
发明人： Ridong Chen , Soon Seog Jeong , Hui Feng
IPC分类号： C12P1/00 , C12N15/64 , C12N15/00 , C12N15/74 , C12N5/02 , C12N5/10 , C12N5/071 , C12N5/00
CPC分类号： C12N15/85 , A61K38/18 , A61K38/1816 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/193 , A61K38/20 , A61K38/2026 , A61K45/06 , C07K14/4716 , C07K14/495 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/75 , C07K14/765 , C12N2800/107 , C12N2840/60
摘要： The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.
摘要翻译：本发明涉及用于从新型人类细胞系的稳定培养物，由其产生的真实重组蛋白质以及针对这些真实的重组蛋白产生的抗体有效地产生真正的重组人蛋白质的新型表达盒和载体。

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