专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070026508A1 Enzymatic method of making 1,2-diol derivatives and their esters 审中-公开
标题翻译：制备1,2-二醇衍生物及其酯的酶法
公开(公告)号：US20070026508A1
公开(公告)日：2007-02-01
申请号：US10554962
申请日：2004-04-30
申请人： Soon Hwang , Do Kim , Hye Ryu
发明人： Soon Hwang , Do Kim , Hye Ryu
IPC分类号： C12P7/62 , C12P7/20
CPC分类号： C12P7/02 , C12P7/62 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 by enzymatic method from racemic alcohols represented by the general formula 1 in scheme 1. In more details, this invention relates to a process for producing optically active alcohols and their esters which are used as pharmaceutical intermediates from alcohols represented by the general formula 1 by stereospecific transesterification of secondary hydroxyl group using lipases as catalyst with acyl donors in organic solvent or with acyl donors only without using organic solvent. According to this invention, optically active alcohols and esters of high optical purity in high yield can be produced by transforming the primary hydroxyl group of 1,2-diols by tosyl group and transesterifying the secondary hydroxyl group stereospecifically by lipase.
摘要翻译：本发明涉及由方案1中通式1表示的外消旋醇通过酶法由制备由通式2表示的光学活性醇及其由通式3表示的酯的新方法。更具体地，本发明涉及一种用于制备光学活性醇及其酯的方法，其通过使用脂肪酶作为催化剂的有机溶剂中的酰基供体的催化剂或仅与酰基供体的立体特异性酯交换作为由通式1表示的醇用作药物中间体不使用有机溶剂。根据本发明，可以通过将1,2-二醇的伯羟基转化成甲苯磺酰基并通过脂肪酶立体特异性酯交换酯化，可以制备高产率的高光学纯度的光学活性醇和酯。

IPRDB

热门服务

关于我们

友情链接

联系方式