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1. 发明专利

JP2011235106A Reactive surgical implant 审中-公开
标题翻译：反应性外科植入物
公开(公告)号：JP2011235106A
公开(公告)日：2011-11-24
申请号：JP2011106734
申请日：2011-05-11
申请人： Sofradim Production Sa , Tyco Healthcare Group Lp , ソフラディムプロダクションソシエテアノニム , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , STOPEK JOSHUA , LADET SEBASTIEN , GRAVAGNA PHILIPPE , ELACHCHABI AMIN
IPC分类号： A61F2/30 , A61L27/00
CPC分类号： A61L27/50
摘要： PROBLEM TO BE SOLVED: To prepare a surgical implant that is porous and matched to an issue structure and delivered in a manner with minimum invasiveness in accordance with its prescription.SOLUTION: The atomizable surgical implant includes: a first component including microparticulates having a size of about 10 μm to about 500 μm; and a second component including at least one cross-linking reagent. The second component includes the microparticulates whose surface is modified with at least one of the cross-linking reagent.
摘要翻译：要解决的问题：准备多孔的外科植入物，并与发病结构匹配，并按照其处方以最小的侵入性递送。解决方案：可雾化手术植入物包括：第一组分，其包含具有约10μm至约500μm尺寸的微粒; 和包含至少一种交联试剂的第二组分。第二组分包括其表面用至少一种交联剂修饰的微粒。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2012090954A Applicator tip having mixing ball 审中-公开
标题翻译：适用人员提供混合球
公开(公告)号：JP2012090954A
公开(公告)日：2012-05-17
申请号：JP2011179556
申请日：2011-08-19
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , DESAI ARPAN , STOPEK JOSHUA
IPC分类号： A61M39/00 , A61M5/142
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M35/00
摘要： PROBLEM TO BE SOLVED: To provide an applicator tip for use with a fluid applicator device.SOLUTION: The applicator tip in accordance with the present disclosure includes a body portion and a dispensing tip. The body portion includes a proximal end having an inlet adapted for fluid communication with a fluid source, a distal end including an opening, and a mixing chamber disposed therebetween. The mixing chamber includes at least one mixing ball and at least one biologically active agent disposed therein. The dispensing tip defines a lumen therethrough. The lumen is in fluid communication with the opening of the distal end of the body portion and includes an outlet for passage of a fluid flowing therethrough.
摘要翻译：要解决的问题：提供一种用于流体涂抹器装置的施用器尖端。解决方案：根据本公开的施用器尖端包括主体部分和分配尖端。主体部分包括具有适于与流体源流体连通的入口的近端，包括开口的远端和设置在其间的混合室。混合室包括至少一个混合球和设置在其中的至少一种生物活性剂。分配尖端限定通过其中的内腔。管腔与主体部分的远端的开口处于流体连通状态，并且包括用于通过流过其中的流体的出口。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2011245288A Tissue adhesive and sealant and method for their use 审中-公开
标题翻译：组织粘合剂及密封剂及其使用方法
公开(公告)号：JP2011245288A
公开(公告)日：2011-12-08
申请号：JP2011104793
申请日：2011-05-09
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , STOPEK JOSHUA , HADBA AHMAD R
IPC分类号： A61L24/00
CPC分类号： A61L27/227 , A61L24/0031 , A61L24/108 , A61L27/50 , A61L31/047 , A61L31/14 , C09J189/00
摘要： PROBLEM TO BE SOLVED: To provide a biological adhesive and/or sealant that is fully synthetic and therefore highly consistent in its properties without the concern of viral transmission.SOLUTION: A biocompatible composition includes: an implant including a substrate; a first component including a tissue binding end group and a functional group such as biotin and avidin; and a second component including a substrate binding end group and a functional group such as biotin and avidin. The functional group of the first component is different from the functional group of the second component, and one of the first and second components adheres to a tissue surface and the other of the first and second components adheres to the implant.
摘要翻译：要解决的问题：提供完全合成的生物粘合剂和/或密封剂，因此其性能高度一致，而不需要病毒传播。解决方案：生物相容性组合物包括：包含基底的植入物; 包括组织结合端基和诸如生物素和抗生物素蛋白的官能团的第一组分; 以及包含底物结合端基和诸如生物素和抗生物素蛋白的官能团的第二组分。第一组分的官能团不同于第二组分的官能团，第一组分和第二组分中的一个组分粘附到组织表面，并且第一和第二组分中的另一个粘附到植入物。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2011104356A Wound closure devices 审中-公开
标题翻译：封闭装置
公开(公告)号：JP2011104356A
公开(公告)日：2011-06-02
申请号：JP2010228000
申请日：2010-10-07
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY
IPC分类号： A61F2/02 , A61B17/00 , A61L15/16
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065 , A61L31/145 , A61L31/146
摘要： PROBLEM TO BE SOLVED: To provide an implant which provides a wound with closure, especially, a wound closure device for restoring and sealing the perforation of the tissue of a laparoscope port part and so on. SOLUTION: A wound closure device 1 includes an elongated body 12 which has a proximal end and a distal end, a tissue opposing surface 16 which is connected to the distal end of the elongated body pivotally, and a plug member 14 which has a second surface on the side opposite to the tissue opposing surface. The tissue opposing surface includes an electrophilic component. Additionally, the second surface on the side opposite to the tissue opposing surface includes a nucleophilic component. This disclosure provides the wound closing device, a method to produce this device, and the method to use this device. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种提供闭合的伤口的植入物，特别是用于恢复和密封腹腔镜部件的组织穿孔等的伤口闭合装置。伤口闭合装置1包括具有近端和远端的细长主体12，枢转地连接到细长主体的远端的组织相对表面16和具有在与组织相对表面相对的一侧上的第二表面。组织相对表面包括亲电子组分。此外，与组织相对表面相反一侧的第二表面包括亲核成分。本公开提供了伤口闭合装置，制造该装置的方法以及使用该装置的方法。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2011078764A Composition for surgical operation 有权
标题翻译：外科手术组成
公开(公告)号：JP2011078764A
公开(公告)日：2011-04-21
申请号：JP2010224398
申请日：2010-10-01
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , STOPEK JOSHUA
IPC分类号： A61L27/00
CPC分类号： A61L27/52 , A61L27/20 , A61L27/222 , A61L27/24 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/64 , C08L5/08
摘要： PROBLEM TO BE SOLVED: To provide biocompatible polymers which may be used as tissue scaffolds capable of providing cells with growth and development components. SOLUTION: The tissue scaffolds are provided with: a first hydrogel precursor including a natural component selected from among collagen, serum, gelatin, hyaluronic acid, and combinations thereof; and a second hydrogel precursor including an electrophilic functional group selected from among N-hydroxysuccinimides, succinimidyl succinates, succinimidyl propionates, sulfosuccinimides, isocyanates, thiocyanates, carbodiimides, benzotriazole carbonates, and combinations thereof. The first hydrogel precursor and the second hydrogel precursor react to form the tissue scaffold. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可用作能够向细胞提供生长和发育成分的组织支架的生物相容性聚合物。组织支架设置有：第一水凝胶前体，其包含选自胶原，血清，明胶，透明质酸及其组合的天然成分; 和包含选自N-羟基琥珀酰亚胺，琥珀酰亚胺基琥珀酸酯，琥珀酰亚胺基丙酸酯，磺基琥珀酰亚胺，异氰酸酯，硫氰酸酯，碳二亚胺，苯并三唑碳酸酯及其组合的亲电官能团的第二水凝胶前体。第一水凝胶前体和第二水凝胶前体反应形成组织支架。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2011235095A In situ forming biphasic osteochondral plug 审中-公开
标题翻译：在现代形成双重OSTEOCHONDRAL插头
公开(公告)号：JP2011235095A
公开(公告)日：2011-11-24
申请号：JP2011098764
申请日：2011-04-26
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： DESAI ARPAN , SARGEANT TIMOTHY , AGAWU ATU , STOPEK JOSHUA
IPC分类号： A61L27/00
CPC分类号： A61L27/50 , A61B17/00491 , A61B2017/3419 , A61L27/14 , A61L27/54 , A61L27/56
摘要： PROBLEM TO BE SOLVED: To provide a biphasic or multiphasic plug adjusted to the specific tissue types by customizing the physical properties of each phase to accommodate the biomechanical properties of each tissue type and optimizing the biochemical compatibility of each phase to its respective tissue type to growth and repair of the tissues.SOLUTION: There is provided an osteochondral plug including: a first scaffold which is a solid scaffold containing one or more pendant reactive functional groups; and a second scaffold capable of reacting with the one or more pendant reactive functional groups of the first scaffold.
摘要翻译：要解决的问题：通过定制每个相的物理性质以适应每种组织类型的生物力学性质并优化各相与其各自组织的生物化学相容性来提供调整到特定组织类型的双相或多相插塞类型为组织的生长和修复。提供了一种骨软骨塞，包括：第一支架，其是含有一个或多个侧链反应性官能团的固体支架; 和能够与第一支架的一个或多个侧链反应性官能团反应的第二支架。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011074075A Multi-mechanism surgical composition 审中-公开
标题翻译：多机械手术组合物
公开(公告)号：JP2011074075A
公开(公告)日：2011-04-14
申请号：JP2010223973
申请日：2010-10-01
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , STOPEK JOSHUA
IPC分类号： A61K9/06 , A61K38/00 , A61K38/23 , A61K38/27 , A61K47/12 , A61K47/16 , A61K47/20 , A61K47/22 , A61K47/42 , A61P43/00
CPC分类号： A61L24/0031 , A61L27/52 , A61L2300/00
摘要： PROBLEM TO BE SOLVED: To provide a multi-mechanism surgical composition. SOLUTION: The composition includes: at least one hydrogel precursor containing a functional group selected from the group consisting of an electrophilic group, a nucleophilic group, and these combinations; and at least one self-assembling peptide, wherein this self-assembling peptide forms a self-assembled macromer, and also this hydrogel precursor forms a hydrogel composition. In one embodiment, the self-assembling peptide is an amphiphilic peptide. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供多机构手术组合物。该组合物包括：至少一种含有选自亲电子基团，亲核基团和这些组合的官能团的水凝胶前体; 和至少一种自组装肽，其中该自组装肽形成自组装大分子单体，并且该水凝胶前体也形成水凝胶组合物。在一个实施方案中，自组装肽是两亲肽。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2012090955A Applicator tip 审中-公开
标题翻译：申请人提示
公开(公告)号：JP2012090955A
公开(公告)日：2012-05-17
申请号：JP2011179869
申请日：2011-08-19
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： SARGEANT TIMOTHY , DESAI ARPAN , STOPEK JOSHUA
IPC分类号： A61B17/11 , A61B17/00 , B05C5/00 , B05C17/005
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/00951
摘要： PROBLEM TO BE SOLVED: To provide an applicator tip configured and dimensioned for use with various fluid applicators.SOLUTION: The applicator tip for use with a fluid applicator includes a base configured for releasable engagement with a fluid applicator at a proximal end of the base. The base includes a chamber defined therein configured for retaining a mixing component therein. One or more penetrable members are disposed within the base to at least partially enclose the chamber to retain the mixing component therein. A shaft extends distally from the base and defines a longitudinal axis. The shaft has a lumen extending therethrough configured for passage of a fluid therethrough. Upon penetration of the penetrable member, the fluid from the fluid applicator flows into the chamber such that the fluid and the mixing component form a mixture to be applied.
摘要翻译：要解决的问题：提供一种构造和尺寸设计用于各种流体施加器的施用器尖端。解决方案：用于与流体施用器一起使用的施用器尖端包括被配置为与基部的近端处的流体施加器可释放地接合的基座。底座包括限定在其中的腔室，其被配置为将混合部件保持在其中。一个或多个可穿透构件设置在基座内以至少部分地包围室以将混合部件保持在其中。轴从基部向远侧延伸并且限定纵向轴线。轴具有延伸穿过其构造成用于通过其中的流体的内腔。在可穿透构件穿透时，来自流体施加器的流体流入腔室，使得流体和混合构件形成要施加的混合物。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2011245311A Hydrogel implants with varying degrees of crosslinking 审中-公开
标题翻译： HYDROGEL植入物具有不同程度的交联
公开(公告)号：JP2011245311A
公开(公告)日：2011-12-08
申请号：JP2011119717
申请日：2011-05-27
申请人： Confluent Surgical Inc , Tyco Healthcare Group Lp , コンフルエントサージカル, インコーポレイテッド , タイコヘルスケアグループリミテッドパートナーシップ
发明人： BENNETT STEVEN , MAST NATHANIEL , LAVIGNE KEVIN , SKALLA WALTER , BANERJEE SAUMYA , SARGEANT TIMOTHY , STOPEK JOSHUA
IPC分类号： A61L27/00 , A61K9/06
CPC分类号： A61L27/16 , A61K9/06 , A61K31/00 , A61K47/08 , A61K47/18 , A61K47/32 , A61K47/34 , A61L27/18 , A61L27/52 , A61L27/54 , A61L31/145 , A61L2430/38
摘要： PROBLEM TO BE SOLVED: To provide hydrogel and a method of making and using the same.SOLUTION: Implants including the hydrogel are provided. The implant includes the hydrogel, and the hydrogel includes: a first reactive precursor including multi-arm polyether possessing electrophilic groups; a second reactive precursor including nucleophilic groups; and at least one initiated precursor including at least one vinyl group. The first reactive precursor includes a core selected from a group consisting of polyethylene glycol, polyethylene oxide, polyethylene oxide-co-polypropylene oxide, co-polyethylene oxide block copolymers, co-polyethylene oxide random copolymers, and the combination.
摘要翻译：要解决的问题：提供水凝胶及其制备和使用方法。提供了包括水凝胶在内的植入物。所述植入物包括所述水凝胶，并且所述水凝胶包括：包含具有亲电子基团的多臂聚醚的第一反应性前体; 包括亲核基团的第二反应性前体; 和至少一种引发的前体，其包括至少一个乙烯基。第一反应性前体包括选自聚乙二醇，聚环氧乙烷，聚氧化乙烯 - 共聚 - 丙烯氧化物，共聚 - 聚氧化乙烯嵌段共聚物，共聚 - 聚氧化乙烯无规共聚物，以及该组合的核心。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2011120879A Wound closure devices 审中-公开
标题翻译：封闭装置
公开(公告)号：JP2011120879A
公开(公告)日：2011-06-23
申请号：JP2010228001
申请日：2010-10-07
申请人： Tyco Healthcare Group Lp , タイコヘルスケアグループリミテッドパートナーシップ
发明人： STOPEK JOSHUA , SARGEANT TIMOTHY , OKONIEWSKI GREGORY , FISCHVOGT GREGORY , BETTUCHI MICHAEL
IPC分类号： A61B17/12 , A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/00641 , A61B2017/0065
摘要： PROBLEM TO BE SOLVED: To provide a wound closure device desired to be improved. SOLUTION: The wound closure device includes an elongate body 12 having a proximal end and a distal end, and a tissue facing plug member 14 coupled to the distal end of the elongate body 12, the plug member 14 includes hydrogel, wherein the elongate body 12, the plug member 14, or both, includes at least one reactive group. COPYRIGHT: (C)2011,JPO&INPIT

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