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1. 发明授权

US07781442B2 Compounds and uses thereof in modulating amyloid beta 有权
标题翻译：调节淀粉样蛋白β的化合物及其用途
公开(公告)号：US07781442B2
公开(公告)日：2010-08-24
申请号：US11779249
申请日：2007-07-17
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： A61K31/505
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。调节方法水平和治疗与异常A＆Bgr相关的疾病的方法; 还提供了水平。

2. 发明申请

US20100331551A1 ALPHA-HALOKETONE DERIVATIVES OF IMIDAZOLYL-SUBSTITUTED AROMATIC COMPOUNDS AND COMPOUNDS PREPARED THEREFROM 失效
标题翻译：咪唑啉取代芳族化合物的ALPHA-HONOKETONE衍生物及其制备的化合物
公开(公告)号：US20100331551A1
公开(公告)日：2010-12-30
申请号：US12875935
申请日：2010-09-03
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： C07D233/64 , C07D233/66
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。调节方法水平和治疗与异常A＆Bgr相关的疾病的方法; 还提供了水平。

3. 发明授权

US08017629B2 Compounds and uses thereof in modulating amyloid β 有权
标题翻译：调节淀粉样蛋白的化合物及其用途
公开(公告)号：US08017629B2
公开(公告)日：2011-09-13
申请号：US12861782
申请日：2010-08-23
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： A61K31/44 , C07D417/00
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。调节方法水平和治疗与异常A＆Bgr相关的疾病的方法; 还提供了水平。

4. 发明申请

US20100324032A1 COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA 有权
标题翻译：化合物及其在调节AMYLOID BETA中的用途
公开(公告)号：US20100324032A1
公开(公告)日：2010-12-23
申请号：US12861782
申请日：2010-08-23
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： A61K31/541 , C07D417/10 , C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/454 , A61K31/5377 , A61P25/28
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。调节方法水平和治疗与异常A＆Bgr相关的疾病的方法; 还提供了水平。

5. 发明授权

US07799808B2 α-Haloketone derivatives of imidazolyl-substituted aromatic compounds and compounds prepared therefrom 有权
标题翻译：咪唑基取代的芳族化合物的α-卤代酮衍生物和由其制备的化合物
公开(公告)号：US07799808B2
公开(公告)日：2010-09-21
申请号：US11765397
申请日：2007-06-19
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。调节方法水平和治疗与异常A＆Bgr相关的疾病的方法; 还提供了水平。

6. 发明授权

US07244739B2 Compounds and uses thereof in modulating amyloid beta 有权
标题翻译：调节淀粉样蛋白β的化合物及其用途
公开(公告)号：US07244739B2
公开(公告)日：2007-07-17
申请号：US10846941
申请日：2004-05-14
申请人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
发明人： Soan Cheng , Daniel D. Comer , Long Mao , Guity P. Balow , David Pleynet
IPC分类号： A61K31/505 , C07D277/20
CPC分类号： C07D417/10 , C07D277/42 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
摘要翻译：提供了新的化合物，组合物和试剂盒。还提供了调节Abeta水平的方法和治疗与异常Abeta水平相关的疾病的方法。

7. 发明授权

US6093807A Sugar-modified 7-deaza-7-substituted oligonucleotides 失效
标题翻译：糖修饰的7-脱氮-7-取代的寡核苷酸
公开(公告)号：US6093807A
公开(公告)日：2000-07-25
申请号：US272977
申请日：1999-03-19
申请人： Guity P. Balow , Oscar L. Acevedo , Phillip Dan Cook
发明人： Guity P. Balow , Oscar L. Acevedo , Phillip Dan Cook
IPC分类号： C07H19/14 , C07H19/16 , C07H21/02
CPC分类号： C07H19/16 , C07H19/14
摘要： Functionalized nucleomonomers and oligonucleotides are provided which have increased nuclease resistance and enhanced binding affinity to target DNA or RNA molecules. The oligonucleotides of the present invention comprise at least one 7-deaza-7-iodo-2'-substituted purine, herein referred to as a functionalized nucleomonomer. A preferred 2' substituent on the sugar moiety is a 2'-O-alkoxy alkyl group. More preferably, the 2'-substituent is 2'--O--CH.sub.2 --CH.sub.2 --O--CH.sub.3 (or 2'-methoxyethoxy). Such oligonucleotides are useful as therapeutics for modulating protein expression in organisms and treating disease states susceptible to oligonucleotide therapeutics. Such oligonucleotides are also useful as diagnostics for the diagnosis and detection of disease states, and as research reagents.
摘要翻译：提供功能化的核小体单体和寡核苷酸，其具有增加的核酸酶抗性并增强与靶DNA或RNA分子的结合亲和力。本发明的寡核苷酸包含至少一种7-脱氮-7-碘-2'-取代嘌呤，在本文中称为官能化核小体单体。糖部分上优选的2'取代基是2'-O-烷氧基烷基。更优选地，2'-取代基是2'-O-CH 2 -CH 2 -O-CH 3（或2'-甲氧基乙氧基）。这样的寡核苷酸可用作调节生物体中的蛋白质表达并治疗对寡核苷酸治疗敏感的疾病状态的治疗剂。这样的寡核苷酸也可用作诊断和检测疾病状态以及作为研究试剂。

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