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1. 发明申请

US20120225053A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CONDITIONS ASSOCIATED WITH INFLAMATION 审中-公开
标题翻译：预防和治疗与炎症有关的病症的组合物和方法
公开(公告)号：US20120225053A1
公开(公告)日：2012-09-06
申请号：US11920973
申请日：2006-05-24
申请人： Slavik Dushenkov , Patricia Lucas-Schnarre , Julie Beth Hirsch , David Evans , Kitty Evans
发明人： Slavik Dushenkov , Patricia Lucas-Schnarre , Julie Beth Hirsch , David Evans , Kitty Evans
IPC分类号： A61K31/353 , A61P11/06 , A61P25/00 , A61P1/00 , A61P11/00 , A61P37/08 , A61P31/00 , A61P19/02 , A61P17/06 , A61K31/7008 , A61K38/48 , A61K36/287 , A61K31/715 , A61K38/39 , A61K35/60 , A61K36/906 , A61K36/16 , A61K36/258 , A61K36/87 , A61K36/76 , A61K36/736 , A61K36/81 , A61P29/00
CPC分类号： A61K36/82 , A23L33/11 , A23L33/175 , A61K36/16 , A61K36/185 , A61K36/258 , A61K36/28 , A61K36/324 , A61K36/73 , A61K36/752 , A61K36/76 , A61K36/87 , A61K36/9066 , A61K36/9068 , A61K38/39 , A61K2300/00
摘要： The present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need thereof an effective amount of a theaflavin composition and an effective amount of one or more therapies other than such a theaflavin composition. In particular, the present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need thereof an effective amount of a theaflavin composition, an effective amount of a glucosamine composition, and optionally one or more other therapies.
摘要翻译：本发明提供了用于预防，治疗，控制和/或改善与炎症（例如，炎症性疾病）或其症状相关的病症的方法，所述方法包括向有需要的受试者施用有效量的茶黄素组合物和有效量的除了这种茶黄素组合物之外的一种或多种疗法。特别地，本发明提供了用于预防，治疗，控制和/或改善与炎症（例如，炎症性疾病）或其症状相关的病症的方法，所述方法包括向有需要的受试者施用有效量的茶黄素组合物，有效量的葡糖胺组合物，以及任选的一种或多种其它疗法。

2. 发明申请

US20070088078A1 Methods for managing adipocyte fat accumulation 审中-公开
标题翻译：脂肪细胞脂肪积累的方法
公开(公告)号：US20070088078A1
公开(公告)日：2007-04-19
申请号：US11508587
申请日：2006-08-22
申请人： Slavik Dushenkov , David Evans , Kitty Evans
发明人： Slavik Dushenkov , David Evans , Kitty Evans
IPC分类号： A61K31/353
CPC分类号： A61K36/752 , A61K31/352 , A61K31/353
摘要： The present invention provides methods for management fat accumulation in an adipocyte using compositions comprising a polymethoxylated flavone fraction of at least one of 5,6,7,3′,4′-pentamethoxyflavone (sinensetin); 5,6,7,8,3′,4′-hexamethoxyflavone (nobiletin); 5,6,7,8,4′-pentamethoxyflavone (tangeretin); 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone (auranetin); 5-hydroxy-7,8,3′,4′-tetramethoxyflavone; 5,7-dihydroxy-6,8,3′,4′-tetramethoxyflavone; 5,7,8,3′,4′-pentamethoxyflavone; 5,7,8,4′-tetramethoxyflavone; 3,5,6,7,8,3′,4′-heptamethoxyflavone; 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone; 5-hydroxy-6,7,8,4′-tetramethoxyflavone; 5,6,7,4′-tetramethoxyflavone; 7-hydroxy-3,5,6,8,3′,4′-hexamethoxyflavone; or 7-hydroxy-3,5,6,3′,4′-pentamethoxyflavone. In certain embodiments, methods for preventing rebound weight gain in a subject who has experienced weight loss are provided.
摘要翻译：本发明提供了使用包含5,6,7,3'，4'-五甲氧基黄酮（维生素）中的至少一种的多甲氧基化黄酮部分的组合物来管理脂肪细胞中的脂肪蓄积的方法; 5,6,7,8,3'，4'-六甲氧基黄酮（nobiletin）; 5,6,7,8,4'-五甲氧基黄酮（tangeretin）; 5-羟基-6,7,8,3'，4'-五甲氧基黄酮（auranetin）; 5-羟基-7,8,3'，4'-四甲氧基黄酮; 5,7-二羟基-6,8,3'，4'-四甲氧基黄酮; 5,7,8,3'，4'-五甲氧基黄酮; 5,7,8,4'-四甲氧基黄酮; 3,5,6,7,8,3'，4'-七甲氧基黄酮; 5-羟基-3,6,7,8,3'，4'-六甲氧基黄酮; 5-羟基-6,7,8,4'-四甲氧基黄酮; 5,6,7,4'-四甲氧基黄酮 7-羟基-3,5,6,8,3'，4'-六甲氧基黄酮; 或7-羟基-3,5,6,3'，4'-五甲氧基黄酮。在某些实施方案中，提供了防止体重减轻的个体中的回弹体重增加的方法。

3. 发明申请

US20080138481A1 Methods of reducing reactive carbonyl species 审中-公开
标题翻译：还原反应性羰基的方法
公开(公告)号：US20080138481A1
公开(公告)日：2008-06-12
申请号：US11636013
申请日：2006-12-07
申请人： Chi-Tang Ho , Chih-Yu Lo , Di Tan , Yu Wang , Slavik Dushenkov
发明人： Chi-Tang Ho , Chih-Yu Lo , Di Tan , Yu Wang , Slavik Dushenkov
IPC分类号： A23L3/34
CPC分类号： A23L3/3472 , A23L2/44 , A23L5/27 , A23L33/105
摘要： Methods for reducing the concentration of reactive carbonyl species, for example, in thermally processed foods, including beverages, are provided herein.
摘要翻译：本文提供了用于降低反应性羰基物质浓度的方法，例如在热加工食品（包括饮料）中。

4. 发明授权

US07351739B2 Bioactive compounds and methods of uses thereof 失效
标题翻译：生物活性化合物及其使用方法
公开(公告)号：US07351739B2
公开(公告)日：2008-04-01
申请号：US11118915
申请日：2005-04-29
申请人： Chi-Tang Ho , Naisheng Bai , Zigang Dong , Ann M. Bode , Slavik Dushenkov
发明人： Chi-Tang Ho , Naisheng Bai , Zigang Dong , Ann M. Bode , Slavik Dushenkov
IPC分类号： A01N43/20 , A01N43/24 , A61K31/335 , C07D303/00 , C07D305/14
CPC分类号： C07D493/20 , A61K36/53
摘要： In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.
摘要翻译：在一个方面，本发明提供具有如下所示的式I或IV的化合物：如本文进一步定义。在另外的方面，本发明提供了包含本发明化合物的组合物和试剂盒及其用于预防或治疗癌症的方法。

5. 发明申请

US20140039044A1 Hydroxylated Polymethoxyflavone Compositions 审中-公开
标题翻译：羟基化聚甲氧基黄酮组合物
公开(公告)号：US20140039044A1
公开(公告)日：2014-02-06
申请号：US13935991
申请日：2013-07-05
申请人： Chi-Tang Ho , Shiming Li , Min-Hsiung Pan , Chih-Yu Lo , Slavik Dushenkov
发明人： Chi-Tang Ho , Shiming Li , Min-Hsiung Pan , Chih-Yu Lo , Slavik Dushenkov
IPC分类号： A61K31/352 , A23L1/30 , A61K8/49
CPC分类号： A61K31/352 , A61K8/498 , A61K8/97 , A61K36/752 , A61Q19/00
摘要： Provided herein are compositions enriched in polyhydroxylated polymethoxyflavones useful as dietary supplements, food additives, pharmaceutical compositions, nutraceutical compositions and cosmetic compositions.
摘要翻译：本文提供富含多羟基化聚甲氧基黄酮的组合物，其用作膳食补充剂，食品添加剂，药物组合物，营养药物组合物和化妆品组合物。

6. 发明授权

US5917117A Inducing hyperaccumulation of metals in plant shoots 失效
标题翻译：诱导植物芽中金属的超积累
公开(公告)号：US5917117A
公开(公告)日：1999-06-29
申请号：US621138
申请日：1996-03-21
申请人： Burt D. Ensley , Michael J. Blaylock , Slavik Dushenkov , Nanda P.B.A. Kumar , Yoram Kapulnik
发明人： Burt D. Ensley , Michael J. Blaylock , Slavik Dushenkov , Nanda P.B.A. Kumar , Yoram Kapulnik
IPC分类号： B09C1/10 , C02F3/32 , C22B3/24
CPC分类号： C02F3/327 , B09C1/105 , Y02W10/18
摘要： The present invention provides methods by which hyperaccumulation of metals in plant shoots is induced by exposure to inducing agents. Hyperaccumulation occurs as part of a two-step process in which metals are first accumulated into plant roots; subsequent transport to plant shoots is induced by exposure to the agent. In preferred embodiments, manipulations that increase availability of metals to the plant are employed prior to application of the inducing agent. Effective inducing agents include conditions of low pH, chelators, herbicides, and high levels of heavy metals. Other phytotoxic agents are also useful. Application of multiple inducing agents results in synergistic effects.
摘要翻译：本发明提供了通过暴露于诱导剂诱导植物芽中金属的超积累的方法。超累积是作为金属首次积累到植物根中的两步过程的一部分发生的。随后运送到植物芽是通过暴露于试剂诱导的。在优选的实施方案中，在施用诱导剂之前使用增加金属对植物的可利用性的操作。有效的诱导剂包括低pH，螯合剂，除草剂和高水平重金属的条件。其他植物毒素也是有用的。多种诱导剂的应用导致协同效应。

7. 发明申请

US20070275106A1 Hydroxylated polymethoxyflavone compositions 审中-公开
标题翻译：羟基化聚甲氧基黄酮组合物
公开(公告)号：US20070275106A1
公开(公告)日：2007-11-29
申请号：US11724558
申请日：2007-03-14
申请人： Chi-Tang Ho , Shiming Li , Min-Hsiung Pan , Chih-Yu Lo , Slavik Dushenkov
发明人： Chi-Tang Ho , Shiming Li , Min-Hsiung Pan , Chih-Yu Lo , Slavik Dushenkov
IPC分类号： A61K31/352 , A61K36/00 , A61K36/752 , A61P35/00 , C07D311/30
CPC分类号： A61K31/352 , A61K8/498 , A61K8/97 , A61K36/752 , A61Q19/00
摘要： Provided herein are compositions enriched in polyhydroxylated polymethoxyflavones useful as dietary supplements, food additives, pharmaceutical compositions, nutraceutical compositions and cosmetic compositions.
摘要翻译：本文提供富含多羟基化聚甲氧基黄酮的组合物，其用作膳食补充剂，食品添加剂，药物组合物，营养药物组合物和化妆品组合物。

8. 发明申请

US20060241154A1 Benzotropolone derivatives and modulation of inflammatory response 失效
公开(公告)号：US20060241154A1
公开(公告)日：2006-10-26
申请号：US11473821
申请日：2006-06-23
申请人： Chi-Tang Ho , Geetha Ghai , Shengmin Sang , Jin-Woo Jhoo , Mou-Tuan Huang , Robert Rosen , Slavik Dushenkov
发明人： Chi-Tang Ho , Geetha Ghai , Shengmin Sang , Jin-Woo Jhoo , Mou-Tuan Huang , Robert Rosen , Slavik Dushenkov
IPC分类号： A61K31/44 , A61K31/40 , A61K31/381 , C07D333/24 , C07C69/76 , C07C69/88
CPC分类号： C07C69/017 , C07C49/747 , C07C49/753 , C07C59/90 , C07C62/38 , C07C69/738 , C07C69/757 , C07C2601/14 , C07C2602/12 , C07D311/58 , C07D311/62
摘要： The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.

9. 发明授权

US5876484A Method for removing soluble metals from an aqueous phase 失效
标题翻译：从水相中除去可溶性金属的方法
公开(公告)号：US5876484A
公开(公告)日：1999-03-02
申请号：US443154
申请日：1995-05-17
申请人： Ilya Raskin , Slavik Dushenkov , Yoram Kapulnik , Nanda P. B. A. Kumar
发明人： Ilya Raskin , Slavik Dushenkov , Yoram Kapulnik , Nanda P. B. A. Kumar
IPC分类号： C02F3/32 , C22B3/18
CPC分类号： C02F3/327 , Y02W10/18
摘要： A process for the removal of metal ions from solution and means for effecting such removal are described. The process is based on the hydroponic growth of sunflowers, terrestrial turfgrasses and/or members of the family Brassicaceae in solutions containing one or more metal ions. Metal ions can be efficiently removed from solutions by passing these solutions through the root biomass of these terrestrial plants. Receptacles containing the plants are also part of the invention.
摘要翻译：描述了从溶液中除去金属离子的过程以及用于实现这种去除的手段。该方法基于在含有一种或多种金属离子的溶液中向日葵，陆地草坪草和/或十字花科植物的成员的水培生长。通过使这些溶液通过这些陆生植物的根生物量，可以有效地从溶液中除去金属离子。含有植物的插座也是本发明的一部分。

10. 发明授权

US07288680B2 Benzotropolone derivatives and modulation of inflammatory response 失效
标题翻译： Benzotropolone衍生物和炎症反应调节
公开(公告)号：US07288680B2
公开(公告)日：2007-10-30
申请号：US11473821
申请日：2006-06-23
申请人： Chi-Tang Ho , Geetha Ghai , Shengmin Sang , Jin-Woo Jhoo , Mou-Tuan Huang , Robert T. Rosen , Slavik Dushenkov
发明人： Chi-Tang Ho , Geetha Ghai , Shengmin Sang , Jin-Woo Jhoo , Mou-Tuan Huang , Robert T. Rosen , Slavik Dushenkov
IPC分类号： C07C45/00 , C07C49/115 , C07D311/78 , C07D315/00 , A61K31/00
CPC分类号： C07C69/017 , C07C49/747 , C07C49/753 , C07C59/90 , C07C62/38 , C07C69/738 , C07C69/757 , C07C2601/14 , C07C2602/12 , C07D311/58 , C07D311/62
摘要： The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.
摘要翻译：本发明提供由通式表示的新颖的苯佐洛尔酮衍生物：包括新鲸蜡状酯B和EGCGCa。本发明的苯佐洛尔酮衍生物是有效的抗氧化剂和抗炎剂。本发明还提供以高产率合成苯佐洛尔隆化合物的新方法以及使用含有苯佐龙酮的化合物治疗炎性病症的方法。

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