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1. 发明申请

US20070111998A1 Novel heterocyclic compounds as pSTAT3/IL-6 inhibitors 失效
标题翻译：新型杂环化合物作为pSTAT3 / IL-6抑制剂
公开(公告)号：US20070111998A1
公开(公告)日：2007-05-17
申请号：US11546299
申请日：2006-10-12
申请人： Siripragada Rao , Akella Satya Srinivas , Shikha Rani , Gaddam Reddy , Sriram Rajagopal , Uma Ramachandran , Duddu Sharada , Rajagopalan Nirmala , Velaiah Sivasudar , Lakshmanan Manikandan , Ramachandran Balaji
发明人： Siripragada Rao , Akella Satya Srinivas , Shikha Rani , Gaddam Reddy , Sriram Rajagopal , Uma Ramachandran , Duddu Sharada , Rajagopalan Nirmala , Velaiah Sivasudar , Lakshmanan Manikandan , Ramachandran Balaji
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/416 , A61K31/403 , C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D209/88 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
摘要翻译：本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物，它们的代谢物和前药。本发明更具体地提供了通式（I）的新型杂环化合物。还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物，如上所述。

2. 发明授权

US07786142B2 Heterocyclic compounds as pSTAT3/IL-6 inhibitors 失效
标题翻译：杂环化合物作为pSTAT3 / IL-6抑制剂
公开(公告)号：US07786142B2
公开(公告)日：2010-08-31
申请号：US11546299
申请日：2006-10-12
申请人： Siripragada Mahender Rao , Akella Satya Surya Visweswara Srinvas , Shikha Rani , Gaddam Om Reddy , Sriram Rajagopal , Uma Ramachandran , Duddu Savaraiah Sharada , Rajagopalan Nirmala , Velaiah Sivasudar , Lakshmanan Manikandan , Ramachandran Balaji
发明人： Siripragada Mahender Rao , Akella Satya Surya Visweswara Srinvas , Shikha Rani , Gaddam Om Reddy , Sriram Rajagopal , Uma Ramachandran , Duddu Savaraiah Sharada , Rajagopalan Nirmala , Velaiah Sivasudar , Lakshmanan Manikandan , Ramachandran Balaji
IPC分类号： A61K31/4468 , A61K31/403 , C07D405/14 , C07D209/88
CPC分类号： C07D209/88 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above
摘要翻译：本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物，它们的代谢物和前药。本发明更具体地提供了通式（I）的新型杂环化合物。还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物，如上所述

3. 发明申请

US20100329998A1 NOVEL HETEROCYCLES 有权
标题翻译：新型杂环
公开(公告)号：US20100329998A1
公开(公告)日：2010-12-30
申请号：US12863796
申请日：2009-01-30
申请人： Visweswara Akella Satya Surya Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Thirunavukkarasu Sappanimuthu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narasimhan , Sathya Narayana Thara , Sriram Rajagopal , Om Gaddam , Nishikanth Reddy Gaddam , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran , Gopalan Balasubramanian , Narayanan Surendran , Shridhar Narayanan , Lolaknath Santosh Vishwakarma , Sanjeev Saxena
发明人： Visweswara Akella Satya Surya Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Thirunavukkarasu Sappanimuthu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narasimhan , Sathya Narayana Thara , Sriram Rajagopal , Om Gaddam , Nishikanth Reddy Gaddam , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran , Gopalan Balasubramanian , Narayanan Surendran , Shridhar Narayanan , Lolaknath Santosh Vishwakarma , Sanjeev Saxena
IPC分类号： A61K9/12 , A61K31/505 , C07D239/02 , C07D401/14 , A61K31/506 , A61K31/497 , C07D417/04 , C07D403/04 , C07D413/12 , A61K31/5377 , A61K31/54 , A61P37/00 , A61P29/00 , A61P19/02 , A61P19/10 , A61P35/02 , A61P35/04 , A61P9/00 , A61P1/00 , A61P11/00
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 动脉粥样硬化癌症; 恶病质缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症败血症败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

4. 发明授权

US08420653B2 Pyrimidine compounds and their uses 有权
标题翻译：嘧啶化合物及其用途
公开(公告)号：US08420653B2
公开(公告)日：2013-04-16
申请号：US12863796
申请日：2009-01-30
申请人： Visweswara Akella Satya Surya Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Thirunavukkarasu Sappanimuthu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narasimhan , Sathya Narayana Thara , Sriram Rajagopal , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran , Gopalan Balasubramanian , Narayanan Surendran , Shridhar Narayanan , Lolaknath Santosh Vishwakarma , Sanjeev Saxena , Nishikanth Reddy Gaddam
发明人： Visweswara Akella Satya Surya Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Thirunavukkarasu Sappanimuthu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narasimhan , Sathya Narayana Thara , Sriram Rajagopal , Om Reddy Gaddam , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran , Gopalan Balasubramanian , Narayanan Surendran , Shridhar Narayanan , Lolaknath Santosh Vishwakarma , Sanjeev Saxena
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 动脉粥样硬化癌症; 恶病质缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症败血症败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

5. 发明申请

US20080207606A1 Novel heterocycles 有权
标题翻译：新的杂环
公开(公告)号：US20080207606A1
公开(公告)日：2008-08-28
申请号：US12068668
申请日：2008-02-08
申请人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran
发明人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran
IPC分类号： A61K31/541 , C07D239/24 , A61K31/505 , A61K31/496 , A61P37/00 , A61P35/00 , A61P19/02 , A61P29/00 , C07D295/00 , A61K31/5377
CPC分类号： C07D213/30 , C07D239/30 , C07D239/32 , C07D239/34 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 动脉粥样硬化癌症; 恶病质缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症败血症败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

6. 发明授权

US07863446B2 Heterocycles 有权
标题翻译：杂环
公开(公告)号：US07863446B2
公开(公告)日：2011-01-04
申请号：US12068668
申请日：2008-02-08
申请人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran
发明人： Akella Satya Surya Visweswara Srinivas , Ravikumar Tadiparthi , Ganapavarapu Veera Raghava Sharma , Sappanimuthu Thirunavukkarasu , Durairaj Peter Bhakiaraj , Virendra Kachhadia , Kilambi Narsimhan , Sathya Narayana Thara , Sriram Rajagopal , Gaddam Om Reddy , Sukunath Narayanan , Venkatesan Parameswaran , Venkatesan Janarthanam , Maruthikumar Narayanam , Sathyanarayana Gadde , Uma Ramachandran
IPC分类号： C07D239/24 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/505 , A61K31/506 , A61P11/06 , A61P17/04 , A61P19/02 , A61P1/00 , A61P25/00
CPC分类号： C07D213/30 , C07D239/30 , C07D239/32 , C07D239/34 , C07D239/42 , C07D239/52 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 动脉粥样硬化癌症; 恶病质缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症脓毒症败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

7. 发明申请

US20080221103A1 New heterocyclic compounds 审中-公开
标题翻译：新杂环化合物
公开(公告)号：US20080221103A1
公开(公告)日：2008-09-11
申请号：US12073635
申请日：2008-03-07
申请人： Ganapavarapu V.R. Sharma , Gaddam O. Reddy , Sriram Rajagopal , Uma Ramachandran , Sukunath Narayanan , Nagalakshmi Pichika , Venkatesh Nemmara Viswanathan , Lavanya Andiappan , Saravanan Thirunavukkarasu
发明人： Ganapavarapu V.R. Sharma , Gaddam O. Reddy , Sriram Rajagopal , Uma Ramachandran , Sukunath Narayanan , Nagalakshmi Pichika , Venkatesh Nemmara Viswanathan , Lavanya Andiappan , Saravanan Thirunavukkarasu
IPC分类号： A61K31/5377 , C07D239/24 , C07D413/14 , A61K31/435 , A61P37/06
CPC分类号： C07D239/24 , C07D413/14
摘要： Provided herein are heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as described herein. Further described herein in particular are heterocyclic compounds of the formula (I) for treating various diseases. and disorders by administering in a patient one or more TNF-α, Thromboxane synthase, 5-LOX, and PDE4 inhibitors. In particular described herein are methods for treating immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection and diseases mediated by HIV-1; HIV-2; HIV-3; cytomegalovirus (CMV); influenza; adenovirus; the herpes viruses (including HSV-1, HSV-2) and herpes zoster viruses in a mammal comprising administering an effective amount of a compound of formula (I).
摘要翻译：本文提供了通式（I）的杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药，其中R 1， R 2，R 3，R 4和R 5如本文所述。本文进一步描述的是用于治疗各种疾病的式（I）的杂环化合物。以及通过在患者中施用一种或多种TNF-α，血栓烷合成酶，5-LOX和PDE4抑制剂的障碍。本文特别描述的是用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症多发性骨髓瘤葡萄膜炎急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎类风湿性脊柱炎; 痛风性关节炎炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏反应接触性皮炎; 肌肉退化; 恶病质哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症脓毒症败血性休克中毒性休克综合征; 发热和由于HIV-1介导的感染和疾病引起的肌痛; HIV-2; HIV-3; 巨细胞病毒（CMV）; 流感; 腺病毒哺乳动物中的疱疹病毒（包括HSV-1，HSV-2）和带状疱疹病毒，包括施用有效量的式（I）化合物。

8. 发明申请

US20090069313A1 Novel MAO-A inhibitors 审中-公开
标题翻译：新型MAO-A抑制剂
公开(公告)号：US20090069313A1
公开(公告)日：2009-03-12
申请号：US11896902
申请日：2007-09-06
申请人： Debendranath Dey , Gajendra Singh , Partha Neogi , Uma Ramachandran , Chithra Santhanagopalan
发明人： Debendranath Dey , Gajendra Singh , Partha Neogi , Uma Ramachandran , Chithra Santhanagopalan
IPC分类号： A61K31/5377 , C07D277/16 , A61K31/426 , C07D209/34 , A61P25/24 , A61P25/32 , A61P25/08 , A61P25/00 , A61P25/34 , A61P25/28 , A61K31/404 , C07D413/12 , A61K31/422
CPC分类号： C07D277/36 , C07D209/34 , C07D277/34 , C07D413/12 , C07D417/12
摘要： The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for prophylaxis and treatment of mental disorders such as depression, in a mammal, comprising administering an effective amount of a compound of formula (I). These compounds are also effective in treating a disease, condition or disorder such as weight loss, obesity, bulimia, depression, bipolar disorders, psychoses, schizophrenia, behaviors, alcoholism, tobacco abuse, memory loss, Alzheimer's disease, dementia of aging, seizure disorders, epilepsy, attention deficit disorder, and Parkinson's disease, which is modulated by a cannabinoid receptor antagonist.
摘要翻译：本发明提供了作为MAO-A抑制剂的式（I）化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药的新医学用途。还包括在哺乳动物中预防和治疗精神障碍如抑郁症的方法，包括施用有效量的式（I）化合物。这些化合物在治疗疾病，病症或病症如体重减轻，肥胖，贪食症，抑郁症，双相性精神障碍，精神病，精神分裂症，行为，酒精中毒，吸烟，记忆丧失，阿尔茨海默病，老年痴呆，癫痫发作障碍，癫痫，注意力缺陷障碍和由大麻素受体拮抗剂调节的帕金森病。

9. 发明申请

US20070256678A1 MULTI-SEAMED WARMING DEVICES WITH ADHESIVE DISPOSED THEREON AND METHODS OF WARMING 审中-公开
标题翻译：具有粘合剂处理的多层加热装置及其加热方法
公开(公告)号：US20070256678A1
公开(公告)日：2007-11-08
申请号：US11745838
申请日：2007-05-08
申请人： Daniel Yim , Uma Ramachandran
发明人： Daniel Yim , Uma Ramachandran
IPC分类号： A61F7/00
CPC分类号： A61F7/034 , A61F7/03 , A61F2007/0001 , A61F2007/0226 , A61F2007/023 , A61F2007/0258 , A61F2007/0268
摘要： Self-contained disposable single-use heat-generating apparatuses and methods for providing heat are disclosed that have adhesive formed on at least a portion thereof. One exemplary apparatus includes a heat-generating pack having a first bag layer defined by a first surface area bonded to a second bag layer defined by a second surface area and creating one or a multiple pouches therebetween. A heat-generating agent is disposed within the pouch(es) and adapted to consume air at a predetermined consumption rate in an exothermic reaction. At least a portion of one of the first surface area and the second surface area comprises an air permeable surface area having a predetermined airflow rate such that the heat-generating agent remains substantially evenly distributed within the pouches.
摘要翻译：公开了在其至少一部分上形成有粘合剂的独立的一次性一次性发热装置和用于提供热量的方法。一个示例性装置包括具有由第一表面区域限定的第一袋层的发热包装，该第一表面区域由第二表面区域限定的第二袋层结合并在其间形成一个或多个袋。发泡剂设置在袋内并适于在放热反应中以预定的消耗速率消耗空气。第一表面区域和第二表面区域中的一个的至少一部分包括具有预定气流速率的透气表面区域，使得发热剂基本均匀地分布在袋内。

10. 发明申请

US20070256679A1 WARMING DEVICES WITH ELASTIC DISPOSED THEREIN AND METHODS OF WARMING 审中-公开
标题翻译：具有弹性处理的加热装置和加热方法
公开(公告)号：US20070256679A1
公开(公告)日：2007-11-08
申请号：US11745850
申请日：2007-05-08
申请人： Daniel Yim , Uma Ramachandran
发明人： Daniel Yim , Uma Ramachandran
IPC分类号： A61F7/00
CPC分类号： A61F7/034 , A61F7/03 , A61F2007/0001 , A61F2007/0226 , A61F2007/023
摘要： Self-contained disposable single-use heat-generating apparatuses and methods for providing heat are disclosed that have elastic member formed on at least a portion thereof. One exemplary apparatus includes a heat-generating pack having a first bag layer defined by a first surface area bonded to a second bag layer defined by a second surface area and creating one or a multiple pouches therebetween, an elastic member being disposed between at least two pouches. A heat-generating agent is disposed within the pouch(es) and adapted to consume air at a predetermined consumption rate in an exothermic reaction. At least a portion of one of the first surface area and the second surface area comprises an air permeable surface area having a predetermined airflow rate such that the heat-generating agent remains substantially evenly distributed within the pouches.
摘要翻译：公开了在其至少一部分上形成有弹性构件的独立的一次性一次性发热装置和用于提供热量的方法。一个示例性的装置包括一个发热包，其具有第一袋层，该第一袋层由第一表面区域限定，第一表面区域与由第二表面区域限定的第二袋层结合，并在其间形成一个或多个袋，弹性构件设置在至少两个小袋子发泡剂设置在袋内并适于在放热反应中以预定的消耗速率消耗空气。第一表面区域和第二表面区域中的一个的至少一部分包括具有预定气流速率的透气表面区域，使得发热剂基本均匀地分布在袋内。

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