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1. 发明申请

US20090076032A1 Derivatives of 18Beta-Glycyrrhetinic Acid 审中-公开
标题翻译： 18β-甘草次酸的衍生物
公开(公告)号：US20090076032A1
公开(公告)日：2009-03-19
申请号：US12207899
申请日：2008-09-10
申请人： Simon Ward , Alice Macgowan , Stanley Roberts , Jenny Littlechild , Kirsty Line , Ed Irving , Sam Donnelly
发明人： Simon Ward , Alice Macgowan , Stanley Roberts , Jenny Littlechild , Kirsty Line , Ed Irving , Sam Donnelly
IPC分类号： A61K31/4965 , C07C69/757 , A61K31/215 , C07C69/76 , C07D241/24 , C07C69/73
CPC分类号： C07J63/008
摘要： The present invention relates to novel derivatives of 18β-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are pharmaceutical compositions comprising the derivatives of the present invention and medical uses of the derivatives, including their use in inhibiting enzymes such as retinol dehydrogenases. The present invention also relates to methods of treating diseases, such as hyperproliferative diseases, neoplasms, cancers and photoageing.
摘要翻译：本发明涉及18beta-glycyrryrinic acid的新衍生物和合成衍生物的方法。还包括在本发明范围内的药物组合物是包含本发明衍生物和衍生物的医学用途的药物组合物，包括它们在抑制酶如视黄醇脱氢酶中的用途。本发明还涉及治疗疾病如过度增殖性疾病，肿瘤，癌症和光老化的方法。

2. 发明申请

US20130028986A1 Pharmaceutical Compositions 审中-公开
公开(公告)号：US20130028986A1
公开(公告)日：2013-01-31
申请号：US13568234
申请日：2012-08-07
申请人： Simon Ward , Alice MacGowan , Michael J. Cork , Jonathan Hadgraft , Majella Lane , Adrian Davis , Richard Guy
发明人： Simon Ward , Alice MacGowan , Michael J. Cork , Jonathan Hadgraft , Majella Lane , Adrian Davis , Richard Guy
IPC分类号： A61K33/30 , A61K31/315 , A61P17/00
CPC分类号： A61K33/30 , A61K31/315 , A61K33/00
摘要： A composition comprising a pharmaceutically acceptable group (2, 4, 12, 13 or 14) metal compound for the treatment of a dermatological condition involving an abnormal decrease in the cell-to-cell adhesion between epithelial cells in the epidermal barrier.

3. 发明申请

US20090123549A1 Pharmaceutical Compositions 审中-公开
标题翻译：药物组合物
公开(公告)号：US20090123549A1
公开(公告)日：2009-05-14
申请号：US12063990
申请日：2006-08-21
申请人： Simon Ward , Alice MacGowan , Michael J. Cork , Jonathan Hadgraft , Majella Lane , Adrian Davis , Richard Guy
发明人： Simon Ward , Alice MacGowan , Michael J. Cork , Jonathan Hadgraft , Majella Lane , Adrian Davis , Richard Guy
IPC分类号： A61K9/14 , A61K33/30
CPC分类号： A61K33/30 , A61K31/315 , A61K33/00
摘要： A composition comprising a pharmaceutically acceptable group (2, 4, 12, 13 or 14) metal compound for the treatment of a dermatological condition involving an abnormal decrease in the cell-to-cell adhesion between epithelial cells in the epidermal barrier.
摘要翻译：一种组合物，其包含药学上可接受的基团（2,4，12,13或14）金属化合物，用于治疗涉及表皮屏障中的上皮细胞之间的细胞间细胞粘附异常降低的皮肤病学病症。

4. 发明申请

US20050107410A1 Compound possessing affinity at 5ht1-type receptors and use thereof in therapy of cns disorders 审中-公开
标题翻译：在5ht1型受体具有亲和力的化合物及其在治疗cns病症中的用途
公开(公告)号：US20050107410A1
公开(公告)日：2005-05-19
申请号：US10503833
申请日：2003-02-17
申请人： Paul Smith , Kevin Thewlis , Antonio Vong , Simon Ward
发明人： Paul Smith , Kevin Thewlis , Antonio Vong , Simon Ward
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/551 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P15/00 , A61P15/06 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P29/00 , A61P43/00 , C07D215/20 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D41/02 , C07D43/02
CPC分类号： C07D401/12 , C07D215/20 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH2 or oxygen and is a single bond; or X is nitrogen, Y is CH2 and is a single bond; is halogen, hydroxy, cyano, C1-6alkyl, haloC1-6alkyl or C1-6alkoxy; a is 0, 1, 2, 3 or 4; R2 and R3, together with the nitrogen atom to which they are attached, form a nitro group or an optionally substituted 3 to 7 membered heterocyclic group, or R2 and R3 are independently hydrogen, aroyl, C1-6alkyl, C1-6alkanoyl, fluoroC1-6alkanoyl, C1-6alkylsulfonyl, fluoroC1-6alkylsulfonyl, carbamoyl, C1-6alkylcarbamoyl, arylC1-6alkyl or a group CO(CH2)bNR4R5 wherein b is 1, 2, 3 or 4; and R4 and R5 are independently hydrogen or C1-6alkyl, or R4 and R5, together with the nitrogen atom to they are attached, form part of an optionally substituted 3 to 7 membered heterocyclic group. Methods of preparing the compounds and uses of the compounds in therapy, in particular for CNS disorders such as depression and anxiety, are also disclosed.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐：其中：A为任选取代的苯基，萘基，吲哚基，喹啉基，喹唑啉基，吲唑基，异喹啉基或苯并呋喃基; X是碳，Y是CH并且是双键; 或X是CH，Y是CH 2或氧并且是单键; 或X是氮，Y是CH 2，并且是单键; 是卤素，羟基，氰基，C 1-6烷基，卤代C 1-6烷基或C 1-6烷氧基; a是0，1，2，3或4; R2和R3与它们所连接的氮原子一起形成硝基或任选取代的3至7元杂环基，或R 2和R 3独立地是氢，芳酰基，C 1-6 烷基，C 1-6烷酰基，氟代C 1-6烷酰基，C 1-6烷基磺酰基，氟代C 1-6烷基，烷基磺酰基，氨基甲酰基，C 1-6烷基氨基甲酰基，芳基C 1-6 - 烷基或基团CO（CH 2）2 bRR 4 R 5，其中b 是1，2，3或4; 并且R 4和R 5独立地为氢或C 1-6烷基，或者R 4和R 5与它们连接的氮原子一起形成任选取代的3至7元杂环基的一部分。还公开了制备化合物的方法和化合物在治疗中的用途，特别是CNS障碍如抑郁和焦虑。

5. 发明申请

US20070270471A1 Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine 审中-公开
公开(公告)号：US20070270471A1
公开(公告)日：2007-11-22
申请号：US11573366
申请日：2005-08-05
申请人： Kevin Thewlis , Simon Ward
发明人： Kevin Thewlis , Simon Ward
IPC分类号： A61K31/40 , A61K31/4439 , A61P25/18 , C07D207/14 , C07D401/10
CPC分类号： C07D207/14 , C07D403/10 , C07D409/10
摘要： This case discloses compounds of formula (I) wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; B is —N(R4)— or —O—; A and D, which may be the same or different, are —C(R5)2—; each R2, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; n is 0, 1 or 2; R3 is C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro, amino, —(CH2)pNR3aSO2R3b, —(CH2)pNR3a(C═O)R3b, —(CH2)pNR3a(C═O)N(R3c)2, —(CH2)p(C═O)R3d, —(CH2)pSO2R3e, phenyl or heterocyclyl, wherein when R3 is phenyl or heterocyclyl, it is optionally substituted by one or more groups independently selected from: C1-6alkyl, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro, amino, —(CH2)pNR3aSO2R3b, —(CH2)pNR3a(C═O)R3b, —(CH2)pNR3a(C═O)N(R3c)2, —(CH2)p(C═O)R3d and —(CH2)pSO2R3e; where R3a and each R3c, which may be the same or different, is hydrogen or C1-6alkyl; R3b and R3e are C1-6alkyl or haloC1-6alkyl; R3d is C1-6alkyl, C1-4alkoxy or haloC1-6alkyl; or R3a and R3b, or R3a and R3c, together with the interconnecting atoms, may form a 5- or 6-membered ring; and p is 0, 1, or 2; R4 is carbocyclyl or carbocyclylC1-4alkyl, wherein the carbocyclyl group of either is optionally substituted by one or more groups independently selected from C1-6alkyl and halogen; or R4 is hydrogen, C1-6alkyl, haloC1-6alkyl, C1-6alkylcarbonyl, C1-6alkylsulfonyl or C1-6alkylaminocarbonyl; each R5, which may be the same or different, is hydrogen, C1-6alkyl or halogen; and R6 is hydrogen or fluorine.

6. 发明申请

US20070262772A1 Method and apparatus for correcting magnetic flux sensor signals 审中-公开
标题翻译：用于校正磁通量传感器信号的方法和装置
公开(公告)号：US20070262772A1
公开(公告)日：2007-11-15
申请号：US11430572
申请日：2006-05-09
申请人： John Rogers , Simon Ward
发明人： John Rogers , Simon Ward
IPC分类号： G01N27/82
CPC分类号： E21B17/006 , E21B47/0007 , E21B47/0008 , E21B47/08
摘要： Apparatus for detecting defects in an oilfield string at a well site as the string is pulled from the well include a plurality of magnetic flux sensors 12 circumferentially spaced about the string, and a plurality of stand-off sensors 14 circumferentially spaced about the string for determining changes in stand-off distance between one or more stand-off sensors and an external surface of the string. Computer 18 corrects signals from the plurality of magnetic flux sensors as a function of the detected stand-off distance.
摘要翻译：用于检测井的井场中的缺陷的设备，当从井中拉出绳索时，包括围绕绳索周向间隔开的多个磁通量传感器12和围绕该串的圆周间隔的多个支座传感器14，用于确定在一个或多个支架传感器和弦的外表面之间的间隔距离的变化。计算机18根据检测到的间隔距离校正来自多个磁通量传感器的信号。

7. 发明申请

US20060271299A1 Wellbore evaluation system and method 有权
标题翻译：井眼评估体系和方法
公开(公告)号：US20060271299A1
公开(公告)日：2006-11-30
申请号：US11430363
申请日：2006-05-09
申请人： Simon Ward , John Rogers
发明人： Simon Ward , John Rogers
IPC分类号： G01V9/00
CPC分类号： E21B47/022 , E21B43/127 , E21B47/0007 , E21B47/0008 , E21B47/082
摘要： A wellbore evaluation system evaluates mechanical wear and corrosion to components of a well system including a production tubing string positionable in a well and a sucker rod string movable within the production tubing string. A deviation sensor determines a deviation profile of the production tubing string in the well, and a rod sensor senses and measures wear and corrosion to the sucker rod string as it is removed from the well to determine a rod profile. A data acquisition computer is in communication with the sensors for computing and comparing the deviation profile and the rod profile as a function of depth in the well. A 3-dimensional image of wellbores, with isogram mapping, may be generated and examined over the internet.
摘要翻译：井眼评估系统评估对井系统的部件的机械磨损和腐蚀，包括可定位在井中的生产油管柱和可在生产油管柱内移动的抽油杆串。偏差传感器确定井中的生产油管柱的偏差轮廓，并且杆传感器感测并测量当抽油杆柱从井中移出以确定杆轮廓时对抽油杆柱的磨损和腐蚀。数据采集计算机与传感器通信，用于计算和比较作为井中深度的函数的偏差轮廓和杆轮廓。可以通过互联网生成和检查具有等位线映射的井筒的三维图像。

8. 发明授权

US08048918B2 Treatment of hyperproliferative diseases 失效
标题翻译：治疗过度增生性疾病
公开(公告)号：US08048918B2
公开(公告)日：2011-11-01
申请号：US10085239
申请日：2002-02-27
申请人： Simon Ward , Claes Bavik , Michael Cork , Rachid Tazi-Aahnini
发明人： Simon Ward , Claes Bavik , Michael Cork , Rachid Tazi-Aahnini
IPC分类号： A01N37/02 , A01N37/10 , A61K31/22 , A61K31/19
CPC分类号： C07K16/28 , A61K31/10 , A61K31/11 , A61K31/285 , A61K31/415 , A61K31/575 , A61K38/177 , A61K2039/505 , G01N33/566 , G01N2500/02
摘要： We describe methods and compositions for treating a patient suffering from a hyperproliferative disorder or photoageing. Our methods involve blocking the activity of a retinol binding protein receptor (RBPr) in cells of the patient, and/or administering to the patient an antagonist of a retinol binding protein receptor (RBPr) and/or lowering the endogenous level of retinoic acid (RA) in cells of said patient.
摘要翻译：我们描述了治疗患有过度增生性疾病或光老化的患者的方法和组合物。我们的方法包括阻断患者细胞中视黄醇结合蛋白受体（RBPr）的活性，和/或向患者施用视黄醇结合蛋白受体（RBPr）的拮抗剂和/或降低视黄酸的内源性水平 RA）在所述患者的细胞中。

9. 发明申请

US20090044134A1 DYNAMIC INTERFACES FOR PRODUCTIVITY APPLICATIONS 审中-公开
标题翻译：生产力应用的动态界面
公开(公告)号：US20090044134A1
公开(公告)日：2009-02-12
申请号：US12187014
申请日：2008-08-06
申请人： Richard Cave , Simon Ward
发明人： Richard Cave , Simon Ward
IPC分类号： G06F3/00
CPC分类号： G06F17/218 , G06F17/24
摘要： Systems, methods, and computer readable media for providing improved user interfaces for productivity applications are provided. In some embodiments, when a user inputs data into a document, the interface can determine what the format is for that data, such as a text format or an image format. The interface can then remove any presented icons, which can be in the form of a toolbar, not useful for the selected data format and provide icons that are useful for the selected data format. The icons provided can be a predetermined set of icons selected by the designer of the user interface or can be a custom set of icons preselected by a user of the interface.
摘要翻译：提供了用于为生产力应用提供改进的用户界面的系统，方法和计算机可读介质。在一些实施例中，当用户将数据输入到文档中时，接口可以确定该数据的格式，例如文本格式或图像格式。然后，该界面可以删除任何呈现的图标，其可以是工具栏的形式，对所选择的数据格式不是有用的，并且提供对所选数据格式有用的图标。所提供的图标可以是由用户界面的设计者选择的预定图标组，或者可以是由界面的用户预先选择的一组自定义图标。

10. 发明申请

US20070203218A1 Compounds Which Potentiate Glutamate Receptor And Uses Thereof In Medicine 失效
公开(公告)号：US20070203218A1
公开(公告)日：2007-08-30
申请号：US11573368
申请日：2005-08-05
申请人： Kevin Thewlis , Simon Ward
发明人： Kevin Thewlis , Simon Ward
IPC分类号： A61K31/4015 , A61K31/277 , A61K31/18
CPC分类号： C07D207/27 , C07C311/07 , C07C311/08 , C07C311/37 , C07C317/28 , C07C2602/08 , C07D275/02
摘要： This case discloses compounds of formula (I) wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; R2 and R3, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino; each R4, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; p is 0, 1 or 2; each R5, which may be the same or different, is C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro or amino; q is 0,1 or 2; R6 is −NR6aSO2R6b, —NR6aC(═O)R6b, —NR6a(C═O)N(R6c)2, —(C═O)R6d, —CH2NR6aSO2R6b, —CH2NR6aC(═O)R6b, CH2NR6a(C═O)N(R6c)2 or —CH2(C═O)R6d; where R6a and each R6c, which may be the same or different, is hydrogen or C1-6alkyl; R6b and R6d are C1-6alkyl or haloC1-6alkyl; or R6a and R6b, or R6a and R6c, together with the interconnecting atoms, may form a 5- or 6-membered ring; n is 1 or 2; and R7 and R8, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano or amino. It also discloses methods for preparing the compounds and their use in therapy such as treating schizophrenia.

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