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1. 发明申请

US20140162936A1 NEW CHYMASE BINDING COMPOUNDS AND MEDICAL USES THEREOF 有权
标题翻译：新型化合物结合物及其医疗用途
公开(公告)号：US20140162936A1
公开(公告)日：2014-06-12
申请号：US14119002
申请日：2012-04-24
申请人： Simon Brack , Sarah Batey , Dragan Grabulovski , Julian Bertschinger , Daniel Schlatter , Jörg Benz , David Banner , Michael Hennig
发明人： Simon Brack , Sarah Batey , Dragan Grabulovski , Julian Bertschinger , Daniel Schlatter , Jörg Benz , David Banner , Michael Hennig
IPC分类号： C12N9/12 , G01N33/573
CPC分类号： C12N9/12 , C07K14/4703 , C12N9/1205 , G01N33/573
摘要： The present invention relates to a polypeptide binding to a chymase (EC 3, 4, 21,39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)A(X2)(X3)(X4)(X5) (X6)LSFHKGEKFQIL(X7 (X8)(X9)(X10) (X11)(X12)G(X13)(X14)WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is R, N, Q, E, K, H, S, T, C, or D; (X2) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I; (X3) is R, T, H, N, K, S, C, N or Q; (X4) is S, W, T, C, N, Q, For Y; (X5) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W; (X6) is D, Q, H, E, S, T, C, N, R or K; (X7) is D, N, R, E, Q, S, T, C, K or D; (X8) is M, W, G, F, A, S, T, C, S, N, Q, Y, V, L, I or P; (X9) is T, H, S, D, C, N, Q, R, K, E or absent; (X10) is V, T, Q, G, A, L, I, P, S, C, M, N or absent; (X11) is P, A, D, G, K, V, L, I, E, R, M, H or absent; (X12) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D; (X13) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X14) is W, Y, L, G, A, V, I, P, M, or F; (b) an amino acid sequence which is at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X14).
摘要翻译：本发明涉及与胃促胰酶（EC3,4,21,39）结合的多肽，其中所述多肽包含选自以下的氨基酸序列或由以下组成：（a）GVTLFVALYDY（X1）A（X2 ）（X4）（X5）（X6）（X6）LSFHKGEKFQIL（X7（X8）（X9）（X10）（X11）（X12）G（X13）（X14）WEARSLTTGETGYIPSNYVAPVDSIQ（SEQ ID NO：1））是R，N，Q，E，K，H，S，T，C或D;（X2）是E，T，D，Q，L，P，A，S，C，M，N，E （X 4）为S，W，T，C，N，Q，Y为Y; （X5）是T，H，L，F，C，S，M，N，Q，R，K，G，A，V，I，P，Y或W;（X6） E，S，T，C，N，R或K;（X7）为D，N，R，E，Q，S，T，C，K或D;（X8）为M，W，G， A，S，T，C，S，N，Q，Y，V，L，I或P;（X9）是T，H，S，D，C，N，Q，R，K，E或不存在; （X10）是V，T，Q，G，A，L，I，P，S，C，M，N或不存在;（X11）是P，A，D，G，K，V，L， E，R，M，H或不存在;（X12）为N，V，P，I，E，T，S，A，G，L，C，M，Q或D;（X13） T，P，G，A，V，L，I，S，C，M，N或Q，（X14）是W，Y，L，G， A，V，I，P，M或F; （b）与（a）的氨基酸序列至少85％相同的氨基酸序列，其中所述身份确定不包括氨基酸位置（X1）至（X14）。

2. 发明授权

US09085760B2 Chymase binding compounds and medical uses thereof 有权
标题翻译：糜酶结合化合物及其医疗用途
公开(公告)号：US09085760B2
公开(公告)日：2015-07-21
申请号：US14119002
申请日：2012-04-24
申请人： Simon Brack , Sarah Batey , Dragan Grabulovski , Julian Bertschinger , Daniel Schlatter , Jörg Benz , David Banner , Michael Hennig
发明人： Simon Brack , Sarah Batey , Dragan Grabulovski , Julian Bertschinger , Daniel Schlatter , Jörg Benz , David Banner , Michael Hennig
IPC分类号： A61K38/16 , C07K14/00 , C12N9/12 , C07K14/47 , G01N33/573
CPC分类号： C12N9/12 , C07K14/4703 , C12N9/1205 , G01N33/573
摘要： The present invention relates to a polypeptide binding to a chymase (EC 3.4.21.39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X1)A(X2)(X3)(X4)(X5)(X6)LSFHKGEKFQIL(X7)(X8)(X9)(X10) (X11)(X12)G(X13)(X14)WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X1) is R, N, Q, E, K, H, S, T, C, or D; (X2) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I; (X3) is R, T, H, N, K, S, C, N or Q; (X4) is S, W, T, C, N, Q, F or Y; (X5) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W; (X6) is D, Q, H, E, S, T, C, N, R or K; (X7) is D, N, R, E, Q, S, T, C, K or D; (X8) is M, W, G, F, A, T, C, S, N, Q, Y, V, L, I or P; (X9) is T, H, S, D, C, N, Q, R, K, E or absent; (X10) is V, T, Q, G, A, L, I, P, S, C, M, N or absent; (X11) is P, A, D, G, K, V, L, I, E, R, M, H or absent; (X12) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D; (X13) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X14) is W, Y, L, G, A, V, I, P, M, or F; (b) an amino acid sequence which is at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X1) to (X14).
摘要翻译：本发明涉及结合糜酶的多肽（EC 3.4.21.39），其中所述多肽包含选自以下的氨基酸序列或由以下组成：（a）GVTLFVALYDY（X1）A（X2）（X3）（X4）（X5）（X6）（X9）（X8）（X9）（X10）（X11）（X12）G（X13）（X14）WEARSLTGG ，N，Q，E，K，H，S，T，C或D; （X2）是E，T，D，Q，L，P，A，S，C，M，N，E，G，A，V或I; （X3）为R，T，H，N，K，S，C，N或Q; （X4）为S，W，T，C，N，Q，F或Y; （X5）是T，H，L，F，C，S，M，N，Q，R，K，G，A，V，I，P，Y或W; （X6）为D，Q，H，E，S，T，C，N，R或K; （X7）为D，N，R，E，Q，S，T，C，K或D; （X8）为M，W，G，F，A，T，C，S，N，Q，Y，V，L，I或P; （X9）为T，H，S，D，C，N，Q，R，K，E或不存在; （X10）为V，T，Q，G，A，L，I，P，S，C，M，N或不存在; （X11）为P，A，D，G，K，V，L，I，E，R，M，H或不存在; （X12）为N，V，P，I，E，T，S，A，G，L，C，M，Q或D; （X13）是D，E，T，P，G，A，V，L，I，S，C，M，N或Q，（X14）是W，Y，L，G，A，V，I ，P，M或F; （b）与（a）的氨基酸序列至少85％相同的氨基酸序列，其中所述身份确定不包括氨基酸位置（X1）至（X14）。

3. 发明授权

US5986066A Biosensory layers 失效
标题翻译：生物传感层
公开(公告)号：US5986066A
公开(公告)日：1999-11-16
申请号：US878105
申请日：1997-06-18
申请人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
发明人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
IPC分类号： G01N33/53 , G01N33/543 , C07K16/00 , G01N33/547
CPC分类号： G01N33/5438 , G01N33/54353 , Y10S436/823 , Y10S436/828 , Y10S977/714 , Y10S977/795 , Y10S977/92
摘要： A biologically recognizing layer on a solid phase consisting of biologically recognizing molecules comprising regions which recognize a substance to be analyzed and regions which do not recognize a substance to be analyzed.The biologically recognizing molecules are aligned on a suitably modified surface by means of molecular regions which do not recognize the substance to be analyzed. The biologically recognizing molecules are cross-linked with the aligning surface and are consequently covalently altered. The molecular regions recognizing the substance to be analyzed are not altered by the covalent bonding and retain their bonding activity.The layer is produced in a novel two-stage method. In the first step, the biologically recognizing molecules, the aligning molecules and carrier molecules are adsorbed. In the second step, the molecules are covalently anchored by cross-linking. Cross-linking is brought about by photolytic activation of a water soluble reagent bonded to the carrier molecules.
摘要翻译：由包含识别待分析物质的区域和不能识别被分析物质的区域的生物识别分子组成的固相上的生物识别层。生物识别分子通过不识别待分析物质的分子区域在适当修饰的表面上排列。生物识别分子与对准表面交联并因此共价改变。识别待分析物质的分子区域不会因共价键而改变，并保持其结合活性。该层以新颖的两阶段方法生产。在第一步中，生物识别分子，对准分子和载体分子被吸附。在第二步中，分子通过交联共价锚定。交联是通过与载体分子结合的水溶性试剂的光解活化引起的。

4. 发明授权

US5646302A Heterotrifunctional compounds for photoaffinity labelling 失效
标题翻译：用于光亲和标记的异双官能化合物
公开(公告)号：US5646302A
公开(公告)日：1997-07-08
申请号：US085719
申请日：1993-06-30
申请人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
发明人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
IPC分类号： C07C247/16 , C07C247/18 , C07D207/40 , C07D207/416 , C07D213/18 , C07K1/113 , C07K14/00 , C07K16/00 , C07K19/00 , G01N33/532 , C07D207/452
CPC分类号： C07D207/416 , C07C247/18 , G01N33/532
摘要： The invention is concerned with novel heterotrifunctional compounds which contain a chemically reactive group R, a photochemically reactive group Ar--N.sup.3 and a reductively cleavable S--S(X.sub.2)-group. The chemically reactive group and the photochemically reactive group are separated by a spacer group which contains a disulfide group. The water-solubilizing groups are carboxylic acids and sulfonic acids or derivatives thereof which are attached either to the aromatic ring or to the spacer group between the aromatic ring and the cleavable SS group. The compounds facilitate a novel photoaffinity method for the labelling of biomolecules, whereby the labelled biomolecule preserves its water solubility and the labelling molecule preferably projects free into the solution after anchorage to the surface of the biomolecule.
摘要翻译：本发明涉及含有化学反应性基团R，光化学反应性基团Ar-N 3和还原性可切割的S-S（X 2） - 基团的新型异三官能化合物。化学反应性基团和光化学反应性基团被含有二硫基的间隔基隔开。水溶性基团是羧酸和磺酸或其衍生物，其连接到芳香环或芳族环和可切割SS基团之间的间隔基。该化合物促进用于标记生物分子的新型光亲和方法，由此标记的生物分子保持其水溶性，并且标记分子优选在锚定到生物分子的表面之后自由地投入溶液中。

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