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1. 发明授权

US06960686B2 Preparation and purification of antiviral disulfonic acid disodium salt 失效
公开(公告)号：US06960686B2
公开(公告)日：2005-11-01
申请号：US10946842
申请日：2004-09-22
申请人： Silvio Iera , Christopher A. Demerson , Jacqueline F. Lunetta , Maria Papamichelakis , Michael F. MacEwan , Wayne G. McMahon , John R. Potoski , Arthur G. Mohan , Antonia Nikitenko
发明人： Silvio Iera , Christopher A. Demerson , Jacqueline F. Lunetta , Maria Papamichelakis , Michael F. MacEwan , Wayne G. McMahon , John R. Potoski , Arthur G. Mohan , Antonia Nikitenko
IPC分类号： C07C303/38 , C07C303/40 , C07C311/19 , C07C311/42 , C07D251/50 , C07D251/70 , C07C303/00 , A61K31/18
CPC分类号： C07C303/38 , C07C303/40 , C07D251/50 , C07D251/70 , C07C311/19 , C07C311/42
摘要： The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.

2. 发明授权

US06806366B2 Preparation and purification of antiviral disulfonic acid disodium salt 失效
标题翻译：抗病毒二磺酸二钠盐的制备与纯化
公开(公告)号：US06806366B2
公开(公告)日：2004-10-19
申请号：US10066356
申请日：2002-01-31
申请人： Silvio Iera , Christopher A. Demerson , Jacqueline F. Lunetta , Maria Papamichelakis , Michael F. MacEwan , Wayne G. McMahon , John R. Potoski , Arthur G. Mohan
发明人： Silvio Iera , Christopher A. Demerson , Jacqueline F. Lunetta , Maria Papamichelakis , Michael F. MacEwan , Wayne G. McMahon , John R. Potoski , Arthur G. Mohan
IPC分类号： C07D40312
CPC分类号： C07C303/38 , C07C303/40 , C07D251/50 , C07D251/70 , C07C311/19 , C07C311/42
摘要： The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
摘要翻译：本发明提供了用于制备抗病毒化合物4'，4-双 - {4,6-双 - [3-（双 - 氨基甲酰基 - 甲基-1-氨磺酰基） - 苯基氨基] - [ 3,5]三嗪-2-基氨基} - 联苯-2,2'-二磺酸及其药学上可接受的盐。

3. 发明授权

US5342944A Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones 失效
标题翻译：制备2-烷基-3,5,6,7-或8-取代-4（3H） - 喹唑啉酮的方法
公开(公告)号：US5342944A
公开(公告)日：1994-08-30
申请号：US092850
申请日：1993-07-19
申请人： Arthur G. Mohan , Joseph D'Antuono, III
发明人： Arthur G. Mohan , Joseph D'Antuono, III
IPC分类号： C07D239/90 , C07D239/91
CPC分类号： C07D239/90
摘要： A novel process for producing 2-alkyl-3,5,6,7 or 8-substituted-4 (3H)-quinazolinones of the formula: ##STR1## where R, R.sup.1 and R.sup.2 are defined in the specification by reacting the appropriately N-acyl substituted aminobenzoic acids with ethylchloroformate followed by further reaction with ammonia or a primary amine.
摘要翻译：通过使适当的N-酰基取代的氨基苯甲酸与氯甲酸乙酯反应，然后与氨进一步反应，制备下式的2-烷基-3,5,6,7或8-取代-4（3H） - 喹唑啉酮的新方法：或伯胺。

4. 发明授权

US5981721A Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof 失效
标题翻译：聚烯烃大环内酯席夫碱，其烷基酯及其多烯大环内酯烷基酯盐的制备方法
公开(公告)号：US5981721A
公开(公告)日：1999-11-09
申请号：US955414
申请日：1997-10-23
申请人： Arthur G. Mohan
发明人： Arthur G. Mohan
IPC分类号： C07H17/08 , C07H17/04 , A61K31/70
CPC分类号： C07H17/08
摘要： Processes for the preparation of high purity alkyl esters of polyene macrolide antibiotics are disclosed. The processes involve treating an amphoteric polyene macrolide antibiotic with an aldehyde to yield the corresponding Schiff base which is soluble in the reaction medium. The solution is then treated with an alkylating agent in the presence of a hindered tertiary amine as acid acceptor to yield the alkyl ester of the polyene macrolide antibiotic in the form of its Schiff base derivative. Contacting this derivative with water converts the Schiff base derivative to the desired alkyl ester of the polyene macrolide antibiotic which is recovered from the reaction medium.
摘要翻译：公开了制备多烯大环内酯类抗生素高纯度烷基酯的方法。该方法包括用醛处理两性多烯大环内酯类抗生素以产生可溶于反应介质的相应席夫碱。然后在受阻的叔胺作为酸受体的存在下用烷基化剂处理溶液，得到其席夫碱衍生物形式的多烯大环内酯类抗生素的烷基酯。将该衍生物与水接触将希夫碱衍生物转化为从反应介质中回收的所需的多烯大环内酯抗生素烷基酯。

5. 发明授权

US4074046A Process for azoles (ring closure of nitro compounds) 失效
标题翻译：唑类化合物（硝基化合物闭环）
公开(公告)号：US4074046A
公开(公告)日：1978-02-14
申请号：US731978
申请日：1976-10-14
申请人： Arthur G. Mohan
发明人： Arthur G. Mohan
IPC分类号： C07D235/08 , C07D263/56 , C07D263/57 , C07D263/58 , C07D277/66 , C07D277/68 , C07D413/06 , C07D263/54 , C07D277/60
CPC分类号： C07D263/56 , C07D235/08 , C07D263/57 , C07D263/58 , C07D277/66 , C07D277/68
摘要： Process for preparing known classes of 2-substituted azoles (I) and N-acylazolinones (II) by reacting carbon monoxide at elevated temperature and pressure in the presence of a cocatalyst composition, of which 5% palladium on carbon with a Lewis acid such as ferric chloride is representative, with a nitrogenous compound (III): ##STR1## to form the products (usually in admixture): ##STR2## where R is alkyl, alkenyl, aralkyl, aryl, styrl or ##STR3## R.sub.1 and R.sub.2 are hydrogen, alkyl, alkoxy, aryl, halo or, when taken together on adjacent carbon atoms, -CH.dbd.CH-CH.dbd.CH-; R.sub.4 may be alkyl, alkenyl, aralkyl, aryl, styryl, ##STR4## X is oxygen, sulfur or imino, Y is alkylene, alkenylene or arylene; and Z is nitro, azo or azoxy.
摘要翻译：在助催化剂组合物存在下，通过使一氧化碳在升高的温度和压力下反应制备已知类型的2-取代的吡咯（I）和N-酰基氮杂酮（II）的方法，其中5％钯碳与路易斯酸如氯化铁是代表性的，含氮化合物（III）：形成产物（通常为混合物）：其中R是烷基，烯基，芳烷基，芳基，苯乙烯或者R 1和R 2是氢，烷基，烷氧基，芳基，卤素或当在相邻碳原子上一起时，-CH = CH-CH = CH-; R 4可以是烷基，烯基，芳烷基，芳基，苯乙烯基，X是氧，硫或亚氨基，Y是亚烷基，亚烯基或亚芳基; Z为硝基，偶氮或氧杂环丁烷。

6. 发明授权

US4366079A Sulfonated rubrene and aqueous chemiluminescent compositions containing the same 失效
标题翻译：磺化红荧烯和含有它们的含水化学发光组合物
公开(公告)号：US4366079A
公开(公告)日：1982-12-28
申请号：US238340
申请日：1981-02-26
申请人： Michael M. Rauhut , Arthur G. Mohan
发明人： Michael M. Rauhut , Arthur G. Mohan
IPC分类号： C09K11/06 , C07C67/00 , C07C301/00 , C07C309/28 , C07D295/13 , C09B3/78 , C09K11/07 , C09K11/14
CPC分类号： C07D295/13 , C09B3/78 , C09K11/07
摘要： Water-soluble sulfonated rubrenes are used as fluorescer components in water-soluble chemiluminescent mixtures and particularly in combination with a water-soluble amide of oxalic acid which reacts with hydrogen peroxide to produce chemiluminescence.
摘要翻译：在水溶性化学发光混合物中使用水溶性磺化的红荧烷作为荧光剂成分，特别是与草酸的水溶性酰胺组合，与过氧化氢反应产生化学发光。

7. 发明授权

US4308395A Processes for preparing 3,5,6-trichlorosalicylic acid and esters thereof 失效
标题翻译：制备3,5,6-三氯水杨酸及其酯的方法
公开(公告)号：US4308395A
公开(公告)日：1981-12-29
申请号：US167570
申请日：1980-07-11
申请人： Robert J. Manfre , Arthur G. Mohan , Michael M. Rauhut
发明人： Robert J. Manfre , Arthur G. Mohan , Michael M. Rauhut
IPC分类号： C07C69/88 , C07C69/76 , C07C65/00
CPC分类号： C07C69/88
摘要： An improved single-pot process for synthesis of 3,5,6-trichlorosalicylic acid and esters thereof is described. Salicylic acid is chlorinated first in concentrated sulfuric acid and then with iodine catalyst to make the trichlorosalicylic acid which is extracted and then reacted with an alcohol to make the ester.
摘要翻译：描述了用于合成3,5,6-三氯水杨酸及其酯的改进的单锅法。水杨酸首先在浓硫酸中氯化，然后用碘催化剂氯化，得到提取的三氯水杨酸，然后与醇反应制得酯。

8. 发明授权

US5438148A Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(3,4-dihydroxyphenyl)-1-methylethyl]- 2 失效
标题翻译：合成方法[R-（R * - ，R * - ）] - 5-（3-氯苯基-3- [2-（3,4-二羟基苯基）-1-甲基乙基] -2-恶唑烷酮
公开(公告)号：US5438148A
公开(公告)日：1995-08-01
申请号：US309303
申请日：1994-09-20
申请人： Arthur G. Mohan , David M. Blum
发明人： Arthur G. Mohan , David M. Blum
IPC分类号： C07D263/20
CPC分类号： C07D263/20
摘要： The invention is the simultaneous addition of boron tribromide and a solution of [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-oxazolidinone in methylene chloride to methylene chloride while maintaining a constant ratio of 2.10:1.00 of boron tribromide to the substrate [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-oxazolidinone at a temperature of -5.degree. C. to 10.degree. C. gives [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-hydroxyoxyphenyl)-1-methylethyl]-2-oxazolidinone in an isolated yield of 86.7% and a purity of 98.7%.
摘要翻译：本发明同时加入三溴化硼和[R-（R *，R *）] - 5-（3-氯苯基-3- [2-（3,4-二甲氧基苯基）-1-甲基乙基] - 同时保持三溴化硼与底物的恒定比例为2.10：1.00 [R-（R *，R *）] -5-（3-氯苯基-3- [2-（3 ，4-二甲氧基苯基）-1-甲基乙基] -2-恶唑烷酮，得到[R-（R *，R *）] - 5-（3-氯苯基-3- [2-（3,4-羟基苯氧基苯基）-1-甲基乙基] -2-恶唑烷酮，分离收率86.7％，纯度98.7％。

9. 发明授权

US4379320A Chemical lighting device 失效
标题翻译：化学照明装置
公开(公告)号：US4379320A
公开(公告)日：1983-04-05
申请号：US235863
申请日：1981-02-19
申请人： Arthur G. Mohan , Michael M. Rauhut
发明人： Arthur G. Mohan , Michael M. Rauhut
IPC分类号： G09F13/20 , B43K29/10 , C09K11/07 , F21K2/06
CPC分类号： F21K2/06 , C09K11/07
摘要： In chemical light devices comprising a chemi-luminescent mixture with a first fluorescer contained in a transparent or translucent container, a second fluorescer is incorporated in the walls of the container to shift at least part of the emissions from the device from the shorter wavelength emission of the first fluorescer to a longer wavelength emission of the second fluorescer. The second fluorescer has an absorption spectrum substantially overlapping the emission spectrum of the first fluorescer. The shift is usually about 20 to 100 nanometers and may be as much as 200 nanometers.
摘要翻译：在包含含有透明或半透明容器中的第一荧光剂的化学发光混合物的化学光装置中，将第二荧光剂结合到容器的壁中，以将来自装置的至少部分发射从较短的波长发射第一荧光剂到第二荧光剂的较长波长发射。第二荧光剂具有与第一荧光剂的发射光谱基本重叠的吸收光谱。该移动通常为约20至100纳米，并且可以高达200纳米。

10. 发明授权

US4226738A N,N-Bis(trifluoromethylsulfonyl)oxamides and chemiluminescent compositions containing the same 失效
标题翻译： N，N-双（三氟甲基磺酰基）酰胺和含有它们的化学发光组合物
公开(公告)号：US4226738A
公开(公告)日：1980-10-07
申请号：US956567
申请日：1978-11-01
申请人： Michael M. Rauhut , Shin-Shyong Tseng , Arthur G. Mohan
发明人： Michael M. Rauhut , Shin-Shyong Tseng , Arthur G. Mohan
IPC分类号： C09K11/06 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/51 , C07D213/72 , C07D213/76 , C09K11/07 , C09K3/00
CPC分类号： C07D213/76 , C09K11/07
摘要： N,N'-bis(trifluoromethylsulfonyl)oxamides are described with a number of variations by substitution at the amido nitrogen atoms. These compounds when used in chemiluminescent formulations will furnish superior light intensity and quantum efficiency. Preparation of compounds and their use for chemiluminescence are described.
摘要翻译： N，N'-双（三氟甲基磺酰基）氧酰胺通过在酰氨基氮原子上的取代具有许多变化来描述。当这些化合物用于化学发光制剂时，将提供优异的光强度和量子效率。描述了化合物的制备及其用于化学发光的用途。

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