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1. 发明授权

US4492703A 4-(2-Substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters active on blood circulation 失效
标题翻译：对血液循环有活性的4-（2-取代苯基）-1,4-二氢吡啶-3,5-二羧酸酯
公开(公告)号：US4492703A
公开(公告)日：1985-01-08
申请号：US468819
申请日：1983-02-22
申请人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Stanislav Kazda
发明人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Stanislav Kazda
IPC分类号： A61K31/435 , A61K31/4427 , A61K31/4433 , A61K31/455 , A61P1/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/28 , C07D211/90 , C07D401/06 , C07D401/12 , C07D409/06 , C07D409/12 , C07D211/82
CPC分类号： C07D401/12 , C07D211/90 , C07D409/12
摘要： 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals,R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S or SO, andB is a direct bond or alkylene,or pharmaceutically acceptable addition salts thereof exhibit hypotensive, vasodilating and coronary activities.
摘要翻译：其中R 1，R 4，R 5，R 6和Y是氢或各种有机基团的式“IMAGE”的1,4-二氢吡啶类，R 2和R 3是各种有机基团，是苯基，萘基或各种杂环基，X 是直接键合O，S或SO，B是直接键或亚烷基，或其药学上可接受的加成盐表现出降血压，血管扩张和冠状动脉。

2. 发明授权

US4532248A Method of combatting coronary and vascular diseases 失效
标题翻译：打击冠心病和血管疾病的方法
公开(公告)号：US4532248A
公开(公告)日：1985-07-30
申请号：US398034
申请日：1982-07-14
申请人： Gerhard Franckowiak , Horst Boshagen , Friedrich Bossert , Siegfried Goldmann , Horst Meyer , Egbert Wehinger , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Robertson Towart
发明人： Gerhard Franckowiak , Horst Boshagen , Friedrich Bossert , Siegfried Goldmann , Horst Meyer , Egbert Wehinger , Jurgen Stoltefuss , Matthias Schramm , Gunter Thomas , Robertson Towart
IPC分类号： A61K31/435 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/455 , A61K31/47 , A61K31/495 , A61K31/535 , A61P3/00 , A61P3/08 , A61P7/10 , A61P9/02 , A61P9/04 , A61P29/00 , C07D211/00 , C07D211/82 , C07D211/84 , C07D211/90 , C07D213/00 , C07D221/00 , C07D307/00 , C07D311/00 , C07D333/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D491/10 , C07D491/107 , C07D498/04 , A61K31/44
CPC分类号： C07D401/04 , C07D211/84 , C07D211/90 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/10
摘要： 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.
摘要翻译：其中n为0,1或2，且R1至R7可以具有多种含义，其具有各向异性作用，并且其中许多是新的，可用于增加其中n为0,1或2的1,4-二氢吡啶 Ca ++进入细胞，特别是与冠状动脉和血管疾病的对抗，粘膜中的高血压肿胀和血糖升高或不正确的盐和液体平衡的疾病。

3. 发明授权

US4895855A Mixture of different dihydropyridines 失效
标题翻译：不同二氢吡啶的混合物
公开(公告)号：US4895855A
公开(公告)日：1990-01-23
申请号：US806160
申请日：1985-12-06
申请人： Siegfried Goldmann , Horst Boshagen , Friedrich Bossert , Gerhard Franckowiak , Horst Meyer , Jurgen Stoltefuss , Rainer Gross , Matthias Schramm , Gunter Thomas
发明人： Siegfried Goldmann , Horst Boshagen , Friedrich Bossert , Gerhard Franckowiak , Horst Meyer , Jurgen Stoltefuss , Rainer Gross , Matthias Schramm , Gunter Thomas
IPC分类号： C07D211/90 , A61K31/435 , A61K31/44 , A61K31/455 , A61P9/08 , A61P9/10 , A61P43/00 , C07D491/044 , C07D491/048 , C07D495/04
CPC分类号： A61K31/44
摘要： A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinforcing.
摘要翻译：有效治疗循环障碍的组合物包含（I）和（II）的混合物，其中变量可以有不同的会议。我是变力和II是血管舒张，但是组合中的成分预计是对抗性的，它们是加强的。

4. 发明授权

US4540684A 3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity 失效
标题翻译：具有正性肌力活性的3-硝基-5-酰胺-1,4-二氢吡啶
公开(公告)号：US4540684A
公开(公告)日：1985-09-10
申请号：US612093
申请日：1984-05-18
申请人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
发明人： Jurgen Stoltefuss , Gerhard Franckowiak , Horst Boshagen , Siegfried Goldmann , Matthias Schramm , Gunter Thomas , Rainer Gross
IPC分类号： A61K31/455 , A61P3/08 , A61P9/02 , A61P9/04 , C07D211/90 , C07D211/98 , A61K31/70 , C07D405/12
CPC分类号： C07D211/90
摘要： A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, andR.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.sub.1 -C.sub.8 -alkyl chain to the amide nitrogen atomor a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.
摘要翻译：其中R和R 1各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 12 - 烷氧基，C 1 -C 4卤代烷氧基，卤素，硝基，三氟甲基， X是氧或硫，R4和R5各自独立地是氢，C1-C4-烷基，C1-C6-烷氧基，卤素，三氟甲基，氨基或硝基，R2和R3各自独立地是氢，C1-C10 - 烷基，C 2 -C 10 - 烯基或C 3 -C 10 - 炔基，其任选被卤素，羟基，C 1 -C 4 - 烷氧基，氨基，单 - 和二-C 1 -C 4 - 烷基氨基，C 1 -C 6 - 和/或硝基，C3至C6元环烷基，任选被C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，卤素，氨基和/或硝基取代的苯基，或苯基-C 1 -C 3 - 烷基或通过C1-C8烷基链任选与酰胺氮原子键合的碳水化合物基团或其药学上可接受的酸加成盐，其改善心脏的收缩力，使血压升高 ure，降低血糖，减少粘膜肿胀，影响患者的盐和液体平衡。

5. 发明授权

US4822798A Circulation-active 4-phenyl-6-substituted dihydropyrimidines 失效
标题翻译：循环活性4-苯基-6-取代二氢嘧啶
公开(公告)号：US4822798A
公开(公告)日：1989-04-18
申请号：US526931
申请日：1983-08-26
申请人： Jurgen Stoltefuss , Horst Boshagen , Matthias Schramm , Gunter Thomas
发明人： Jurgen Stoltefuss , Horst Boshagen , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/505 , A61P9/00 , A61P9/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07D239/20
CPC分类号： C07D239/20
摘要： Circulatory system-active novel dihydropyrimidines of the formula ##STR1## in which R.sup.1 and R.sup.6 are diverse organic radicals, and pharmacologically acceptable addition salts thereof.
摘要翻译：其中R1和R6是不同的有机基团的式“IMAGE”的循环系统活性新型二氢嘧啶及其药理学上可接受的加成盐。

6. 发明授权

US4772612A Circulation-active 1,4-dihydropyridines 失效
标题翻译：循环活性1,4-二氢吡啶类
公开(公告)号：US4772612A
公开(公告)日：1988-09-20
申请号：US870042
申请日：1986-06-03
申请人： Siegfried Goldmann , Jurgen Stoltefuss , Gerhard Franckowiak , Rainer Gross , Matthias Schramm , Gunter Thomas
发明人： Siegfried Goldmann , Jurgen Stoltefuss , Gerhard Franckowiak , Rainer Gross , Matthias Schramm , Gunter Thomas
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/455 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , C07D211/90 , C07D333/00 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/04 , C07D491/048
CPC分类号： C07D409/12 , C07D211/90 , C07D491/04
摘要： Novel circulation active dihydropyridines of the formula ##STR1## in which X is CO, SO.sub.2 or CONH,R.sup.4 is H, OH, alkyl, halogen, acyloxy, alkoxyalkoxy, aralkyloxy, or together with R.sup.5 forms a heterocyclic ring, andthe other radicals are conventional in the dihydropyridine art,and pharmaceutically acceptable salts thereof.
摘要翻译：其中X为CO，SO 2或CONH，R 4为H，OH，烷基，卤素，酰氧基，烷氧基烷氧基，芳烷氧基或与R 5一起形成杂环的新型循环活性二氢吡啶类化合物，其中X为CO，SO2或CONH，在二氢吡啶领域中是常规的，及其药学上可接受的盐。

7. 发明授权

US5432282A Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine derivatives 失效
标题翻译： 1,4-二氢-2-氨基-3-羧基-5-氰基 - 吡啶衍生物的制备方法
公开(公告)号：US5432282A
公开(公告)日：1995-07-11
申请号：US298013
申请日：1994-08-30
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/445 , A61K31/4709 , A61P9/00 , A61P9/04 , C07D20060101 , C07D211/90 , C07D215/12 , C07D215/14 , C07D215/48 , C07D261/06 , C07D261/08 , C07D401/04 , C07D409/04 , C07D409/12 , C07D409/14 , C07D211/84
CPC分类号： C07D401/04 , C07D215/14
摘要： The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译：本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。

8. 发明授权

US5254692A 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines 失效
标题翻译： 2,6-二烷基-4-（苯并噻唑基或苯并恶唑-7-基）-1,4-二氢吡啶
公开(公告)号：US5254692A
公开(公告)日：1993-10-19
申请号：US961289
申请日：1992-10-15
申请人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
发明人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
IPC分类号： C07D263/56 , C07D263/57 , C07D277/66 , C07D413/04 , C07D417/04 , C07D491/04 , C07D277/64
CPC分类号： C07D263/57 , C07D277/66 , C07D413/04 , C07D417/04 , C07D491/04
摘要： 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## and R.sup.4 represents hydrogen, orand physiologically acceptable salts thereof.
摘要翻译：表现出具有大量中性血管行为的正性肌力作用的2,6-二烷基-4-（苯并噻唑基或苯并恶唑-7-基）-1,4-二氢吡啶，其中R1和R5是相同或不同，代表具有至多8个碳原子的直链或支链烷基，R2代表硝基或氰基，或R1和R2一起形成下式的内酯环R3表示下式的基团：图像> ，R4代表氢或其生理上可接受的盐。

9. 发明授权

US5204472A Quinoline and isoquinoline intermediates 失效
标题翻译：喹啉和异喹啉中间体
公开(公告)号：US5204472A
公开(公告)日：1993-04-20
申请号：US807523
申请日：1991-12-13
申请人： Jurgen Stoltefuss , Horst Boshagen , Siegfried Goldmann , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
发明人： Jurgen Stoltefuss , Horst Boshagen , Siegfried Goldmann , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
IPC分类号： C07D211/90 , C07D215/14 , C07D217/04 , C07D401/04 , C07D409/04 , C07D409/14 , C07D491/04
CPC分类号： C07D401/04 , C07D211/90 , C07D215/14 , C07D217/04 , C07D409/04 , C07D409/14 , C07D491/04
摘要： Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## in which R.sup.6 -denotes hydrogen, halogen or straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms,R.sup.7 denotes aryl, thienyl or pyridyl, andR.sup.4 represents hydrogen, or optionally substituted alkyl, alkenyl, alkadienyl or alkynyl,and their physiologically acceptable salts.
摘要翻译：式（I）的正性正向活性4-喹啉基 - 二氢吡啶，其中R 1和R 5相同或不同并且表示具有至多8个碳原子的直链或支链烷基，R 2表示硝基或氰基，或R 1和 R2一起形成下式的内酯环：R 3表示下式的基团：其中R 6表示氢，卤素或直链或支链烷基或烷氧基，每种情况都具有至8个碳原子，R7表示芳基，噻吩基或吡啶基，R4表示氢或任选取代的烷基，烯基，链二烯基或炔基，及其生理上可接受的盐。

10. 发明授权

US5225558A 2-amino-5-cyano-1,4-dihydropyridines, and their use in medicaments 失效
标题翻译： 2-氨基-5-氰基-1,4-二氢吡啶并在药物中的应用
公开(公告)号：US5225558A
公开(公告)日：1993-07-06
申请号：US886644
申请日：1992-05-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Horst Boshagen , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/445 , A61K31/4709 , A61P9/00 , A61P9/04 , C07D20060101 , C07D211/90 , C07D215/12 , C07D215/14 , C07D215/48 , C07D261/06 , C07D261/08 , C07D401/04 , C07D409/04 , C07D409/12 , C07D409/14
CPC分类号： C07D401/04 , C07D215/14
摘要： The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译：本发明涉及新的2-氨基-5-氰基-4-喹啉-1,4-二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。

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