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1. 发明授权

US06287853B1 Accessory factory function for interferon gamma and its receptor 失效
标题翻译：干扰素γ及其受体的附件因子功能
公开(公告)号：US06287853B1
公开(公告)日：2001-09-11
申请号：US08871572
申请日：1997-06-09
申请人： Sidney Pestka , Serguei Kotenko , Jaemog Soh , Robert J. Donnelly , Thomas M. Mariano , Jeffry R. Cook , Stuart Emanuel , Barbara Schwartz
发明人： Sidney Pestka , Serguei Kotenko , Jaemog Soh , Robert J. Donnelly , Thomas M. Mariano , Jeffry R. Cook , Stuart Emanuel , Barbara Schwartz
IPC分类号： C12N1563
CPC分类号： C07K14/705 , C07K14/7156
摘要： This invention relates (a) to a 540 kb YAC which encodes the necessary species-specific factor(s) and is able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens; (b) to the construction of a plasmid to integrate the selective marker for antibiotic G418 resistance into YACs and to delete some of the human DNA fragments from YACs in order to facilitate the manipulation of human genomic DNA in yeast artificial chromosome (YAC) clones; (c) to two fragmentation vectors, pSE1 and pSE2, which contain a neomycin resistance and URA3 gene, developed for targeting yeast artificial chromosomes (YACs) containing human genomic DNA; (d) to a chromosomal fragmentation procedure employed to produce a deletion set of yeast artificial chromosomes (YACs) from a parental YAC (GART D142H8) known to map to Chromosome 21q and to encode the human interferon-gamma receptor (Hu-IFN-gamma R) accessory factor gene as well as the phosphoribosylglycinamide formyltranisferase (GART) gene; and (e) to the isolation of cDNA clones that encode the necessary species-specific factor and that are able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens.
摘要翻译：本发明涉及（a）编码所需物种特异性因子的540kb YAC，并且能够代替人染色体21重建Hu-IFN-γ受体介导的I类HLA抗原的诱导; （b）构建质粒，将抗生素G418抗性的选择性标记整合到YAC中，并从YAC中删除一些人DNA片段，以便于酵母人造染色体（YAC）克隆中人基因组DNA的操作; （c）包含含有新霉素抗性和URA3基因的两个片段化载体pSE1和pSE2，用于靶向含有人基因组DNA的酵母人造染色体（YAC）; （d）涉及从已知映射到染色体21q并编码人干扰素-γ受体（Hu-IFN-γ）的亲本YAC（GART D142H8）产生一组缺失的酵母人造染色体（YAC）的染色体片段化方法 R）辅助因子基因以及磷酸核糖基甘氨酰甲酰甲酰氨基转移酶（GART）基因; 和（e）分离编码必需物种特异性因子的cDNA克隆，并能够代替人染色体21重建Hu-IFN-γ受体介导的I类HLA抗原的诱导。

2. 发明授权

US4936134A Rivet-setting tools and gripping jaws therefor 失效
标题翻译：铆钉固定工具和夹爪
公开(公告)号：US4936134A
公开(公告)日：1990-06-26
申请号：US392627
申请日：1989-08-11
申请人： Robert J. Donnelly
发明人： Robert J. Donnelly
IPC分类号： B21J15/04 , B21J15/38
CPC分类号： B21J15/043 , B21J15/386 , Y10T29/53757
摘要： A rivet-setting tool for pull-to-set blind rivets having mandrel-gripping jaws in which the teeth are widely-spaced at a level of only 8-15 teeth per inch; preferably the teeth in each jaw have non-uniform spacing, the spacing between some pairs of teeth being at least twice the spacing of the pairs of teeth in the same jaw; preferably, also, each tooth in one jaw is located directly opposite a tooth in the other jaw.
摘要翻译：一种用于拉拔式盲铆钉的铆钉固定工具，其具有心轴夹持爪，其中齿以每英寸仅8-15齿的水平宽间隔; 优选地，每个钳口中的齿具有不均匀的间隔，一对齿之间的间隔至少是同一颚中的成对齿的间距的两倍; 优选地，一个钳口中的每个齿都位于与另一个钳口中的牙齿正好相对的位置。

3. 发明申请

US20100137187A1 Glutamate-Enhanced Cell-Penetrating Peptides and Methods of Using Same 有权
标题翻译：谷氨酸增强细胞穿透肽及其使用方法
公开(公告)号：US20100137187A1
公开(公告)日：2010-06-03
申请号：US12617525
申请日：2009-11-12
申请人： Beverly E. Barton , H. Dan Lewis , Robert J. Donnelly , Ali Husain , Dimitrios Barlos , Sheraz Riaz
发明人： Beverly E. Barton , H. Dan Lewis , Robert J. Donnelly , Ali Husain , Dimitrios Barlos , Sheraz Riaz
IPC分类号： A61K38/00 , C07K2/00 , C12N5/02 , A61P35/04
CPC分类号： A61K47/645 , A61K47/62
摘要： Disclosed herein are novel glutamate-enhanced cell-penetrating peptides (CPPs) for use as delivery vehicles to mediate intracellular uptake of therapeutic payloads and methods of using the same.
摘要翻译：本文公开了用作介导细胞内摄取治疗有效载荷的递送载体的新型谷氨酸增强细胞穿透肽（CPP）及其使用方法。

4. 发明授权

US4099169A Alarm device for detaining user 失效
标题翻译：用于拘留用户的报警装置
公开(公告)号：US4099169A
公开(公告)日：1978-07-04
申请号：US486475
申请日：1974-07-08
申请人： Robert J. Donnelly
发明人： Robert J. Donnelly
IPC分类号： G08B25/12 , G08B25/00
CPC分类号： G08B25/12
摘要： Provided is an alarm box in which the user is temporarily detained during the operation of the box. A handle switch is provided which, upon manual grasping causes the sending of a tamper signal. The handle is located on an alarm box housing. Cuffs are joined respectively to the alarm box housing (below the handle) and to a cover. The cover is pivotally joined to the housing for closing the cuffs upon the arm of the user. Within the cuffs are pressure sensitive switches that form a part of an electrical circuit. The closing of the handle switch and the cuff switch initiates the operation of a timing control. The timing control, in turn, activates a solenoid. A portion of the cover extends and is movable within the housing. That portion of the cover has a tear-shaped aperture which is engaged by the solenoid. The aperture is so disposed as to permit the inward (or toward the housing) movement of the cover but the combination with the solenoid's plunger, resist the removal of the cover. In this way, the user is held by the cuffs for a predetermined time. A local bell may be provided to indicate that the alarm box is properly operating. The closing of the buff switches and initiation of the timing control causes the sending of a primary signal or alarm.
摘要翻译：提供了一种报警箱，其中用户在盒的操作期间被暂时扣留。提供了一种手柄开关，其在手动抓取时导致发送篡改信号。手柄位于报警盒外壳上。袖口分别连接到报警箱壳体（手柄下方）和盖子。盖子枢转地连接到壳体，用于在使用者的手臂上封闭袖带。在袖口内是构成电路的一部分的压敏开关。手柄开关和袖带开关的关闭启动定时控制的操作。定时控制反过来激活螺线管。盖的一部分延伸并且可在壳体内移动。盖的该部分具有与螺线管接合的泪状孔。孔被设置成允许盖的向内（或朝向壳体）移动，但是与电磁阀的柱塞的组合抵抗盖的移除。以这种方式，使用者由袖口保持预定时间。可能会提供本地铃声来指示报警盒正常运行。关闭扬声器开关和启动定时控制会导致发出主信号或报警。

5. 发明授权

US08389481B2 Glutamate-enhanced cell-penetrating peptides and methods of using same 有权
标题翻译：谷氨酸增强细胞穿透肽及其使用方法
公开(公告)号：US08389481B2
公开(公告)日：2013-03-05
申请号：US12617525
申请日：2009-11-12
申请人： Beverly E. Barton , H. Dan Lewis , Robert J. Donnelly , Ali Husain , Dimitrios Barlos , Sheraz Riaz
发明人： Beverly E. Barton , H. Dan Lewis , Robert J. Donnelly , Ali Husain , Dimitrios Barlos , Sheraz Riaz
IPC分类号： A61K38/10 , A61K38/04 , C12N5/00 , C12N5/02 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K47/645 , A61K47/62
摘要： Disclosed herein are novel glutamate-enhanced cell-penetrating peptides (CPPs) for use as delivery vehicles to mediate intracellular uptake of therapeutic payloads and methods of using the same.
摘要翻译：本文公开了用作介导细胞内摄取治疗有效载荷的递送载体的新型谷氨酸增强细胞穿透肽（CPP）及其使用方法。

6. 发明授权

US06308841B1 Holder for taper's knives 失效
标题翻译：夹具用于锥形刀
公开(公告)号：US06308841B1
公开(公告)日：2001-10-30
申请号：US09651851
申请日：2000-08-31
申请人： Robert J. Donnelly
发明人： Robert J. Donnelly
IPC分类号： A47F500
CPC分类号： B25H3/04 , A47B55/02
摘要： A holder for taper's knives is an open grid structure defined by parallel pairs of spaced apart stringer pieces connected together with transverse joiner pieces. Pairs of stringers in an upper tier are aligned with associated pairs of stringers in a lower tier. Some of the stringer pieces sub-divide the slot courses defined by the spaces apart ones of stringers in each pair. Knives are inserted into the slots courses and hang down with a handle of the knife supported on top of the pair stringers. Support legs and carrying handles at opposite ends of the grid structure are constituted from others of the joiner pieces.
摘要翻译：锥形刀的保持器是由与横向接合件连接在一起的平行的间隔开的纵梁组成的开放格栅结构。上层的桁条对与较低层中相关的桁条对成对准。一些桁条部分划分由每对中的间隔开的桁条间隔定义的槽道。将刀插入插槽槽中，并用支撑在双绞线顶部的刀柄将其悬挂下来。格栅结构的两端的支撑腿和手柄由其他的连接件构成。

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