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    • 1. 发明申请
    • DEVICE AND METHOD FOR FOCUSING A BEAM OF LIGHT WITH REDUCED FOCAL PLANE DISTORTION
    • 用减轻焦点平面失真聚焦光束的装置和方法
    • US20120228802A1
    • 2012-09-13
    • US12669466
    • 2008-07-21
    • Shyi-Herng KanTseng-Ming HsiehJackie Y. Ying
    • Shyi-Herng KanTseng-Ming HsiehJackie Y. Ying
    • B29C35/08G02B27/30
    • B29C64/135
    • A system for focusing a light beam may be used for multi-photon stereolithography. It comprises a collimator or expander for adjusting the beam divergence and a scanner for directing the beam onto a focusing device to focus the beam to a focal point or beam waist and to scan the focused beam. A controller controls adjustment of the beam divergence so that the focal point or beam waist is scanned substantially in a plane. A light source may be provided to generate the light beam. The expander may comprise a diverging lens and a converging lens for expanding the beam to produce a collimated beam. The divergence of the collimated beam is dependent on the distance between the diverging lens and the converging lens, which may be adjusted to adjust the beam divergence. The focusing device may comprise a dry objective lens to focus the collimated beam onto the target material to induce multi-photon absorption in the target material at the beam waist of the focused beam.
    • 用于聚焦光束的系统可以用于多光子立体光刻。 它包括用于调整光束发散的准直器或扩展器和用于将光束引导到聚焦装置上以将光束聚焦到焦点或光束腰部并扫描聚焦光束的扫描器。 控制器控制光束发散的调节,使得焦点或光束腰部基本上在平面中扫描。 可以提供光源以产生光束。 扩展器可以包括发散透镜和用于展开光束以产生准直光束的会聚透镜。 准直光束的发散度取决于发散透镜和会聚透镜之间的距离,其可以被调整以调节光束发散。 聚焦装置可以包括干物镜,以将准直光束聚焦到目标材料上,以在聚焦光束的束腰处的目标材料中引起多光子吸收。
    • 3. 发明申请
    • TWO-PHOTON STEREOLITHOGRAPHY USING PHOTOCURABLE COMPOSITIONS
    • 使用光电组合物的双光子立体成像
    • US20120098164A1
    • 2012-04-26
    • US12669461
    • 2008-07-21
    • Shyi-Herng KanTseng-Ming HsiehJackie Y. Ying
    • Shyi-Herng KanTseng-Ming HsiehJackie Y. Ying
    • H01J37/30
    • B29C64/135
    • Two-photon stereolithography can be performed using a photocurable material comprising a poly(meth)acrylate having a (meth)acrylate functionality of at least 3 and a molecular weight (MW) of at least 650, a urethane(meth)acrylate having a (meth)acrylate functionality of 2 to 4 and a MW of 400 to 10,000, a di(meth)acrylate made from bisphenol A or bisphenol F; and a photoinitiator. A beam of light is focused to a focus region of the material to induce two-photon absorption in the focus region, and thus polymerization of the material in the focus region. The beam is scanned across said material according to a pre-selected pattern so that the beam is focused to different pre-selected regions, to induce polymerization of the material at the pre-selected regions.
    • 双光子立体光刻可以使用包含(甲基)丙烯酸酯官能度为至少3,分子量(MW)至少为650的聚(甲基)丙烯酸酯的光固化材料,具有( (甲基)丙烯酸酯官能度为2〜4,MW为400〜10,000,由双酚A或双酚F制成的二(甲基)丙烯酸酯; 和光引发剂。 光束被聚焦到材料的焦点区域,以在聚焦区域中引起双光子吸收,从而聚焦在聚焦区域中的材料。 根据预先选择的图案将光束扫描穿过所述材料,使得光束被聚焦到不同的预选区域,以在预选区域处诱导材料的聚合。
    • 4. 发明申请
    • Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement
    • 用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
    • US20070218544A1
    • 2007-09-20
    • US11375375
    • 2006-03-14
    • Jackie YingShyi-Herng KanJeremy Hock LohKarl SchumacherTseng-Ming Hsieh
    • Jackie YingShyi-Herng KanJeremy Hock LohKarl SchumacherTseng-Ming Hsieh
    • C12M1/34H01L21/00C12M3/00
    • A61L27/38A61L27/56B33Y80/00C12N5/0068C12N2533/30
    • The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
    • 本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置,更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。 在一些实施方案中,生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。 结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸,包括组织和器官的微结构和孔隙率。 在一些情况下,通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。 孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分(例如,分子和/或细胞)之间进行交换。 例如,孔可以允许在结构和其宿主环境之间传递分子,细胞迁移和/或结缔组织的产生。 本发明的结构可以植入哺乳动物,或者另外地和/或另外可以作为生物人造辅助装置离体使用。