专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080085893A1 MATRIX METALLOPROTEASE INHIBITORS 审中-公开
标题翻译： MATRIX METALLOPROTEASE抑制剂
公开(公告)号：US20080085893A1
公开(公告)日：2008-04-10
申请号：US11859910
申请日：2007-09-24
申请人： Shyh-Ming YANG , Bingbing Wang , Robert Scannevin , Kenneth Rhodes , Bharat Lagu , Lawrence Wilson , Prabha Karnachi , William Murray
发明人： Shyh-Ming YANG , Bingbing Wang , Robert Scannevin , Kenneth Rhodes , Bharat Lagu , Lawrence Wilson , Prabha Karnachi , William Murray
IPC分类号： A61K31/18 , A61K31/351 , A61K31/381 , A61K31/404 , A61K31/4166 , A61K31/4409 , A61K31/4412 , A61K31/45 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P25/00 , A61P35/00 , C07C311/08 , C07D209/08 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/64 , C07D217/04 , C07D233/02 , C07D241/04 , C07D279/12 , C07D295/15 , C07D333/24 , C07D413/02 , C12N9/99
CPC分类号： C07D295/15 , C07C307/10 , C07C311/08 , C07C311/13 , C07C311/21 , C07C323/49 , C07C2601/08 , C07D207/08 , C07D207/14 , C07D209/08 , C07D209/16 , C07D209/44 , C07D211/14 , C07D211/46 , C07D211/52 , C07D211/62 , C07D213/34 , C07D213/38 , C07D213/643 , C07D217/04 , C07D233/72 , C07D241/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D295/26 , C07D309/06 , C07D333/20
摘要： The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating disorders related to matrix metalloproteases. More particularly, the compounds of the present invention are useful for treating stroke.
摘要翻译：本发明涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7在本说明书中定义。另外，本发明涉及治疗与基质金属蛋白酶相关的疾病的方法。更具体地，本发明的化合物可用于治疗中风。

2. 发明申请

US20080103129A1 HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS 失效
标题翻译：杂环衍生的金属蛋白酶抑制剂
公开(公告)号：US20080103129A1
公开(公告)日：2008-05-01
申请号：US11858972
申请日：2007-09-21
申请人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
发明人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61P35/00 , A61P25/00 , C07D403/02 , C07D223/02
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译：本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。本发明还提供了使用本发明的药物组合物的治疗和预防方法。

3. 发明申请

US20100279986A1 HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：杂环衍生的金属蛋白酶抑制剂
公开(公告)号：US20100279986A1
公开(公告)日：2010-11-04
申请号：US12834283
申请日：2010-07-12
申请人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
发明人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61K31/635 , A61K31/4412 , A61K31/5377 , A61K31/45 , A61K31/4436 , A61K31/551 , A61K31/541 , A61P9/00 , A61P9/14 , A61P35/00 , A61P29/00 , A61P25/00 , A61P25/28 , A61P25/14 , A61P19/02 , A61P1/04
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译：本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。本发明还提供了使用本发明的药物组合物的治疗和预防方法。

4. 发明授权

US07803793B2 Heterocyclic derived metalloprotease inhibitors 失效
标题翻译：杂环衍生金属蛋白酶抑制剂
公开(公告)号：US07803793B2
公开(公告)日：2010-09-28
申请号：US11858972
申请日：2007-09-21
申请人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
发明人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
IPC分类号： C07D225/02 , C07D401/06 , C07D401/12 , C07D409/12 , A61K31/55
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译：本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。本发明还提供了使用本发明的药物组合物的治疗和预防方法。

5. 发明申请

US20120302573A1 METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION 审中-公开
标题翻译：抑制PRO基质金属蛋白酶活化的方法
公开(公告)号：US20120302573A1
公开(公告)日：2012-11-29
申请号：US13479421
申请日：2012-05-24
申请人： Paul Francis JACKSON , Carl Manthey , Kenneth Rhodes , Robert Scannevin , Kristi Anne Leonard , Joseph Kent Barbay , Matthew Todd , Barry A. Springer
发明人： Paul Francis JACKSON , Carl Manthey , Kenneth Rhodes , Robert Scannevin , Kristi Anne Leonard , Joseph Kent Barbay , Matthew Todd , Barry A. Springer
IPC分类号： C12N9/99 , A61K31/4439 , A61K31/497 , A61K31/437 , A61K31/519 , A61K31/444 , A61K31/4985 , A61P35/00 , A61P19/02 , A61P9/00 , A61P1/04 , A61P9/12 , A61P11/00 , A61P1/00 , A61P1/02 , A61P17/02 , A61P25/06 , A61K31/427
CPC分类号： A61K31/519 , A61K31/427 , A61K31/454 , A61K31/4985
摘要： This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.
摘要翻译：本发明涉及用于预防，治疗或改善MMP9和/或MMP13介导的综合征，障碍或疾病的方法，包括向有需要的受试者施用有效量的本说明书实施例部分列出的化合物或形式，组合物或药物。治疗和/或预防的疾病包括类风湿性关节炎。

6. 发明申请

US20150315267A1 A METHOD OF REDUCING BRAIN AMYLOID PLAQUES USING ANTI-AB ANTIBODIES 审中-公开
标题翻译：一种减少使用抗AB抗体的脑亚麻酸溶液的方法
公开(公告)号：US20150315267A1
公开(公告)日：2015-11-05
申请号：US14650200
申请日：2013-12-06
申请人： Thierry BUSSIERE , Paul H. WEINREB , Thomas ENGBER , Kenneth RHODES , Joseph ARNDT , Fang QIAN , Robert W. DUNSTAN , Shailendra PATEL , BIOGEN IDEC INTERNATIONAL NEUROSCIENCE GMBH , Neurimmune Holding AG
发明人： Thierry Bussiere , Paul H. Weinreb , Thomas Engber , Kenneth Rhodes , Joseph Arndt , Fang Qian , Robert W. Dunstan , Shailendra Patel , Jan Grimm , Marcel Maier
IPC分类号： C07K16/18 , A61K51/10
CPC分类号： C07K16/18 , A61K51/1018 , A61K51/1093 , A61K2039/505 , A61K2039/545 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： This disclosure relates to the use of anti-Aβ antibody or antigen-binding fragment thereof to reduce brain amyloid plaques, or minimizes the occurrence of microhemorrhage during chronic dosing of an anti-Aβ antibody or antigen-binding fragment thereof. For example, the disclosure relates to the method of reducing brain amyloid plaques, comprising administering to a subject an anti-Aβ antibody or antigen-binding fragment thereof that binds to the same epitope as BIIB037 antibody, wherein the administration can reduce amyloid plaques in brain without affecting vascular amyloid, and wherein BIIB037 antibody binds to an epitope comprising amino acids 3-6 of Aβ.
摘要翻译：本公开涉及抗A＆bgr的用途; 抗体或其抗原结合片段以减少脑淀粉样蛋白斑块，或者在慢性给药抗A药物期间最小化微出血的发生; 抗体或其抗原结合片段。例如，本公开涉及减少脑淀粉样蛋白斑块的方法，包括向受试者施用抗Aβ抗体; 抗体或抗原结合片段，其结合与BIIB037抗体相同的表位，其中所述施用可以减少脑中的淀粉样蛋白斑，而不影响血管淀粉样蛋白，并且其中BIIB037抗体结合包含A＆bgr的氨基酸3-6的表位。

7. 发明授权

US06689581B1 Potassium channel interactors and uses therefor 有权
标题翻译：钾通道相互作用及其用途
公开(公告)号：US06689581B1
公开(公告)日：2004-02-10
申请号：US09350614
申请日：1999-07-09
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： C12N1512
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。还提供了利用本发明组合物的诊断方法。

8. 发明授权

US06361971B1 Nucleic acid molecules encoding potassium channel interactors and uses therefor 有权
标题翻译：编码钾通道相互作用的核酸分子及其用途
公开(公告)号：US06361971B1
公开(公告)日：2002-03-26
申请号：US09399913
申请日：1999-09-21
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： C12N1512
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。还提供了利用本发明组合物的诊断方法。

9. 发明授权

US07115381B1 Methods for treating cardiovascular disorders 失效
标题翻译：治疗心血管疾病的方法
公开(公告)号：US07115381B1
公开(公告)日：2006-10-03
申请号：US09400492
申请日：1999-09-21
申请人： Kenneth Rhodes , Wenqian An
发明人： Kenneth Rhodes , Wenqian An
IPC分类号： C12N15/12 , C12N15/63 , C12N15/00 , G01N33/566 , G01N33/53
CPC分类号： G01N33/6872 , G01N2500/00 , G01N2800/32
摘要： The invention provides methods for identifying compounds suitable for treating a cardiovascular disorder, as well as methods for treating a cardiovascular disorder. The invention also provides methods for determining if a subject is at risk for a cardiovascular disorder.
摘要翻译：本发明提供了鉴定适用于治疗心血管疾病的化合物的方法，以及治疗心血管疾病的方法。本发明还提供了确定受试者是否处于心血管疾病风险的方法。

10. 发明授权

US06369197B1 Potassium channel interactors and uses therefor 有权
标题翻译：钾通道相互作用及其用途
公开(公告)号：US06369197B1
公开(公告)日：2002-04-09
申请号：US09298731
申请日：1999-04-23
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。还提供了利用本发明组合物的诊断方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式