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1. 发明授权

US08758841B2 Cheese capable of disinfecting Helicobacter pylori 有权
标题翻译：能够消毒幽门螺杆菌的奶酪
公开(公告)号：US08758841B2
公开(公告)日：2014-06-24
申请号：US10510497
申请日：2003-04-11
申请人： Shunji Hayashi , Shigeru Aizawa , Naoki Taketomo , Tadashi Nakatsubo , Noriaki Matsunaga , Katsunori Kimura
发明人： Shunji Hayashi , Shigeru Aizawa , Naoki Taketomo , Tadashi Nakatsubo , Noriaki Matsunaga , Katsunori Kimura
IPC分类号： A23C9/12
CPC分类号： A23C19/0323 , A23Y2220/37
摘要： Natural cheese which comprises a lactic acid bacterium belonging to Lactobacillus gasseri having a disinfection potency against Helicobacter pylori, and a method for producing the natural cheese.
摘要翻译：天然乳酪，其含有具有对幽门螺杆菌的消毒效力的属于加氏乳杆菌的乳酸菌，以及天然干酪的制造方法。

2. 发明申请

US20050163888A1 Cheese capable of disinfecting helicobacter pylori 有权
标题翻译：能够消毒幽门螺杆菌的奶酪
公开(公告)号：US20050163888A1
公开(公告)日：2005-07-28
申请号：US10510497
申请日：2003-04-11
申请人： Shunji Hayashi , Shigeru Aizawa , Naoki Taketomo , Tadashi Nakatsubo , Noriaki Matsunaga , Katsunori Kimura
发明人： Shunji Hayashi , Shigeru Aizawa , Naoki Taketomo , Tadashi Nakatsubo , Noriaki Matsunaga , Katsunori Kimura
IPC分类号： A23C19/032 , A23L1/30 , A61K35/74 , A61K38/00 , A61P1/04 , A61P31/04 , A23C9/12
CPC分类号： A23C19/0323 , A23Y2220/37
摘要： Natural cheese which comprises a lactic acid bacterium belonging to Lactobacillus gasseri having a disinfection potency against Helicobacter pylori, and a method for producing the natural cheese.
摘要翻译：天然乳酪，其含有具有对幽门螺杆菌的消毒效力的属于加氏乳杆菌的乳酸菌，以及天然干酪的制造方法。

3. 发明申请

US20080160565A1 Human Abo Blood Group-Binding Lactobacilli 有权
标题翻译：人类血型组合乳酸杆菌
公开(公告)号：US20080160565A1
公开(公告)日：2008-07-03
申请号：US11720462
申请日：2005-12-01
申请人： Tadao Saito , Yasushi Kawai , Hideaki Uchida , Katsunori Kimura , Kakuhei Isawa , Keisuke Furuichi
发明人： Tadao Saito , Yasushi Kawai , Hideaki Uchida , Katsunori Kimura , Kakuhei Isawa , Keisuke Furuichi
IPC分类号： C12N1/20 , C12Q1/02 , A23L2/52 , A23C9/123
CPC分类号： A23C9/1234 , A23Y2220/37 , C12Q1/04 , G01N33/54373 , G01N33/56911 , G01N33/80 , G01N2333/335
摘要： Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.
摘要翻译：使用表面等离子体共振光谱和人肠粘蛋白和血型抗原作为探针进行乳杆菌筛选方法。对上述筛选乳酸杆菌的方法设定选择标准的试验进行了适应性筛选的方法，发现与ABO血型相容的乳杆菌可以通过设定100RU作为判断细菌的标准进行筛选在某些条件下结合。使用238种乳酸杆菌菌株，进行上述筛选方法和测试来判断其与酸奶生产的相容性，最后特别发现与血型A，B和O相容的芽孢杆菌菌株。

4. 发明授权

US07153502B2 Food or drink product with a disinfection property of Helicobacter pylori 有权
标题翻译：具有幽门螺杆菌消毒性能的食品或饮品
公开(公告)号：US07153502B2
公开(公告)日：2006-12-26
申请号：US10366401
申请日：2003-02-14
申请人： Katsunori Kimura , Haruhisa Hirata , Yasuhiro Koga
发明人： Katsunori Kimura , Haruhisa Hirata , Yasuhiro Koga
IPC分类号： C12N1/20
CPC分类号： C12R1/225 , A23C9/1234 , A23L29/065 , A23L33/10 , A23V2002/00 , A23Y2220/37 , A61K35/747 , A23V2200/10 , A23V2250/206
摘要： A food or drink product with a disinfection property of Helicobacter pylori and/or a protection property against infection with H. pylori, comprising as the effective ingredient Lactobacillus gasseri OLL 2716 (FERM BP-6999) with a high disinfection potency of H. pylori. The food or drink product prepared by using the lactic acid bacterium, such as acid milk and the like, is suitable for long-term ingestion as a food or drink product with a disinfection property of H. pylori and/or a protection property against infection with H. pylori.
摘要翻译：具有幽门螺杆菌消毒特性的食品或饮料产品和/或针对幽门螺旋杆菌感染的保护性物质，其包含幽门螺杆菌消毒效力高的有效成分加氏乳杆菌OLL 2716（FERM BP-6999）。通过使用乳酸菌（如酸乳等）制备的食品或饮料，适合作为具有幽门螺杆菌消毒性能的食品或饮料产品和/或抗感染保护性物质的长期摄入与幽门螺杆菌。

5. 发明授权

US06738272B2 Charge pump rush current limiting circuit 有权
标题翻译：电荷泵冲击电流限流电路
公开(公告)号：US06738272B2
公开(公告)日：2004-05-18
申请号：US10124354
申请日：2002-04-16
申请人： Junko Yamanaka , Toshiki Ishii , Katsunori Kimura
发明人： Junko Yamanaka , Toshiki Ishii , Katsunori Kimura
IPC分类号： H02M318
CPC分类号： H02M3/07 , Y10S323/908
摘要： In a charge pump circuit, a constant current circuit is disposed between an input power supply and an output capacitor, when a power supply is started to turn on, the operation of the charge pump circuit is stopped, and the output capacitor is charged up to a given voltage by the constant current circuit, and thereafter the normal operation of the charge pump is started to limit the rush current. When the power supply is started, the operation is conducted by an oscillator circuit having a small duty ratio, and thereafter the control is replaced by the PFM control having the normal duty ratio, to thereby reduce the rush current as compared with that of the conventional PFM control. When the power supply is started, a pre-driver including a current limiting element is used to drive a driver, resulting in such an advantage that the rush current is reduced as compared with that driven by the conventional pre-driver.
摘要翻译：在电荷泵电路中，在输入电源和输出电容器之间设置恒流电路，当电源开始接通时，电荷泵电路的动作停止，输出电容充电至通过恒流电路的给定电压，然后开始电荷泵的正常操作以限制冲击电流。当电源启动时，通过占空比小的振荡电路进行动作，之后用具有正常占空比的PFM控制代替控制，从而与现有技术相比减小了冲击电流 PFM控制。当电源启动时，使用包括限流元件的预驱动器来驱动驱动器，从而产生与传统的前驱动器驱动相比冲击电流降低的优点。

6. 发明授权

US08465933B2 Method for screening human ABO blood group-binding lactobacilli 有权
标题翻译：筛选人ABO血型结合乳杆菌的方法
公开(公告)号：US08465933B2
公开(公告)日：2013-06-18
申请号：US12987518
申请日：2011-01-10
申请人： Tadao Saito , Yasushi Kawai , Hideaki Uchida , Katsunori Kimura , Kakuhei Isawa , Keisuke Furuichi
发明人： Tadao Saito , Yasushi Kawai , Hideaki Uchida , Katsunori Kimura , Kakuhei Isawa , Keisuke Furuichi
IPC分类号： G01N33/53
CPC分类号： A23C9/1234 , A23Y2220/37 , C12Q1/04 , G01N33/54373 , G01N33/56911 , G01N33/80 , G01N2333/335
摘要： Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238 lactobacillus strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discover bacillus strains compatible with blood groups A, B, and O.
摘要翻译：使用表面等离子体共振光谱和人肠粘蛋白和血型抗原作为探针进行乳杆菌筛选方法。对上述筛选乳酸杆菌的方法设定选择标准的试验进行了适应性筛选的方法，发现与ABO血型相容的乳杆菌可以通过设定100RU作为判断细菌的标准进行筛选在某些条件下结合。使用238种乳酸杆菌菌株，进行上述筛选方法和测试来判断其与酸奶生产的相容性，最后特别发现与血型A，B和O相容的芽孢杆菌菌株。

7. 发明授权

US07289308B2 Overcurrent protection circuit 有权
标题翻译：过流保护电路
公开(公告)号：US07289308B2
公开(公告)日：2007-10-30
申请号：US10996746
申请日：2004-11-24
申请人： Katsunori Kimura
发明人： Katsunori Kimura
IPC分类号： H02H3/08
CPC分类号： G05F1/5735
摘要： An overcurrent protection circuit has an output voltage detection resistor for detecting an output voltage. A foldback overcurrent protection circuit detects an output current flowing through an output transistor and controls the output current flowing through the output transistor in accordance with the detected output current. A first logic generating circuit receives an overcurrent detection signal from the foldback overcurrent protection circuit corresponding to the detected output current. A second logic generating circuit receives a detection signal from the output voltage detection resistor corresponding to a decrease in the detected output voltage. An AND circuit receives and processes an overcurrent delay signal generated by the first logic generating circuit and a voltage detection signal generated by the second logic generating circuit. A negative voltage generating circuit receives an output from the AND circuit and outputs a negative voltage to the foldback overcurrent protection circuit to control the output current flowing through the output transistor.
摘要翻译：过电流保护电路具有检测输出电压的输出电压检测电阻。折返过电流保护电路检测流过输出晶体管的输出电流，并根据检测到的输出电流控制流过输出晶体管的输出电流。第一逻辑发生电路从对应于检测到的输出电流的折返过电流保护电路接收过电流检测信号。第二逻辑发生电路从输出电压检测电阻接收检测信号，该检测信号对应于检测到的输出电压的降低。 AND电路接收并处理由第一逻辑发生电路产生的过电流延迟信号和由第二逻辑发生电路产生的电压检测信号。负电压发生电路接收AND电路的输出，向折返过电流保护电路输出负电压，以控制流过输出晶体管的输出电流。

8. 发明申请

US20050157437A1 Overcurrent protection circuit 有权
标题翻译：过流保护电路
公开(公告)号：US20050157437A1
公开(公告)日：2005-07-21
申请号：US10996746
申请日：2004-11-24
申请人： Katsunori Kimura
发明人： Katsunori Kimura
IPC分类号： G05F1/56 , G05F1/573 , H02H7/00
CPC分类号： G05F1/5735
摘要： An overcurrent protection circuit for a voltage regulator constituted by a depletion mode output transistor includes a foldback overcurrent protection circuit 9, an output voltage detection resistor 5, a first logic generating circuit 6 which receives an overcurrent detection signal 11 from the foldback overcurrent protection circuit 8 as its input, a second logic generating circuit 7 which receives a detection signal 13 from the output voltage detection resistor 5 representing decrease of the output voltage as its input, a negative voltage generating circuit 9, and an AND circuit 10.
摘要翻译：由耗尽型输出晶体管构成的电压调节器的过电流保护电路包括折返过电流保护电路9，输出电压检测电阻5，第一逻辑发生电路6，其从折返过电流保护电路8接收过电流检测信号11 作为其输入，第二逻辑生成电路7从输出电压检测电阻器5接收检测信号13，表示输出电压作为其输入的减小，负电压产生电路9和AND电路10。

9. 发明授权

US6108888A Method for making a lid with a spout and a mold structure therefor 失效
标题翻译：用于制造具有喷口的盖子和其模具结构的方法
公开(公告)号：US6108888A
公开(公告)日：2000-08-29
申请号：US114824
申请日：1998-07-14
申请人： Katsunori Kimura
发明人： Katsunori Kimura
IPC分类号： B29C45/26 , B29C45/14 , B29C65/08 , B29D99/00 , B65D43/06 , B65D47/06 , B65D47/10 , B65D47/36 , B23Q17/00 , B29C13/00
CPC分类号： B29C45/14336 , B65D47/063 , B65D47/103 , B29C65/08 , B29C65/8246 , B29C65/8253 , B29C66/53247 , B29L2031/565 , Y10T29/49764
摘要： A method for making a lid with a spout is disclosed. The spout is affixed in an opening of the lid by injection molding the lid about the spout while the spout is held in place in the injection mold. The steps of molding the lid and affixing the spout to the lid are performed at the same time without the detriments of conventional ultrasonic welding. Preferably, a core insertion member is used in a movable base mold and a cavity insertion member is used in a fixed base mold to hold the spout in place and to mold the lid thereabout.
摘要翻译：公开了一种用喷嘴制作盖子的方法。喷嘴通过在盖子周围注射成型而固定在盖的开口中，同时喷嘴保持在注射模具中的适当位置。同时进行成型盖子并将喷嘴固定到盖子上的步骤，而不会损害常规的超声波焊接。优选地，在可移动基座模具中使用芯插入构件，并且在固定基座模具中使用空腔插入构件以将喷口保持在适当位置并在其周围模制盖子。

10. 发明授权

US09314041B2 Immune function modulating agents 有权
标题翻译：免疫功能调节剂
公开(公告)号：US09314041B2
公开(公告)日：2016-04-19
申请号：US11817617
申请日：2006-02-23
申请人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
发明人： Toshihiro Sashihara , Makoto Yamaguchi , Yoshitaka Nakamura , Shuji Ikegami , Seiko Narushima , Katsunori Kimura , Shinya Nagafuchi , Masaki Terahara
IPC分类号： C12N1/20 , A23C19/032 , A23C9/123 , A23L1/30 , A61K35/747 , C12R1/225
CPC分类号： A23C19/0323 , A23C9/1234 , A23L33/135 , A61K35/747 , C12R1/225
摘要： A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces. The probiotic lactobacillus was selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.
摘要翻译：从人类成年粪便独立分离的乳杆菌属的乳杆菌中发现益生菌乳杆菌。选自其他细菌菌株的益生菌乳杆菌：（1）对胃酸/胆汁酸具有高度抗性; （2）对小鼠来源的脾细胞的IL-12产生促进活性高，Th1 / Th2平衡提高效果好; （3）具有抑制通过向BALB / c小鼠腹膜内给予卵白蛋白诱导的抗原特异性IgE产生的高能力; （4）通过口服给C57BL / 6N小鼠口服给予抗原而诱导抗原特异性IgE产生的能力较强; （5）具有高自然杀伤细胞活化能力; （6）对来自用卵白蛋白免疫的小鼠脾细胞和肠系膜淋巴结细胞具有高IL-12产生促进活性和高Th1 / Th2平衡改善效果; 和（7）具有高的抑制由雪松花粉提取的抗原诱导的嗜酸性粒细胞增多的能力。这一发现导致了本发明的完成。

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