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1. 发明申请

US20050065231A1 Inorganic antimicrobial agent, antimicrobial molded resin articles using the same and process for the production thereof 审中-公开
标题翻译：无机抗菌剂，使用其的抗微生物成型树脂制品及其生产方法
公开(公告)号：US20050065231A1
公开(公告)日：2005-03-24
申请号：US10492604
申请日：2002-10-15
申请人： Yuki Sasaki , Yasuo Matsumura , Takayoshi Aoki , Etsuo Tominaga , Shuji Sakuma , Tomoki Saito
发明人： Yuki Sasaki , Yasuo Matsumura , Takayoshi Aoki , Etsuo Tominaga , Shuji Sakuma , Tomoki Saito
IPC分类号： A01N59/16 , C08K5/00 , D01F1/10 , C08K3/00
CPC分类号： D01F1/103 , A01N59/16 , C08K5/0008 , A01N25/34 , A01N25/10 , A01N2300/00 , C08L59/00
摘要： The present invention relates to an inorganic antibacterial agent comprising a thermoplastic resin and inorganic antibacterial particles dispersed in the resin, and a shape factor SF2 defined by the following formula: SF2=100πL2/(4A) (Wherein L represents a perimeter of a plane image of a particle which is obtained from observation of a slice for inorganic antibacterial agent using a transmission electron microscope, and A represents the area of the plane image.) is not more than 200, and the existing ratio defined by the following formula: Existing ratio (%)=100×(number of inorganic antibacterial particles having SF2 of not more than 200)/(number of particles used for calculation of SF2) is not less than 80%. According to the present invention, when the inorganic antibacterial agent is dispersed in the antibacterial molded resin product, the dispersion of inorganic antibacterial agent is improved since inorganic antibacterial particles are dispersed in the thermoplastic resin. Moreover, inorganic antibacterial particles are dispersed homogeneously in the base resin since the occurrence of agglomeration and localization are well prevented in the thermoplastic resin.
摘要翻译：本发明涉及包含分散在树脂中的热塑性树脂和无机抗菌颗粒的无机抗菌剂和由下式定义的形状因子SF2：SF2 = 100piL2 /（4A）（其中L表示使用透射电子显微镜从无机抗菌剂的切片观察得到的粒子的平面图像，A表示平面图像的面积）不大于200，并且由下式定义的现有比例：现有比例（％）= 100×（SF2为200以下的无机抗菌颗粒数）/（SF2的计算用颗粒数）不小于80％。根据本发明，当无机抗菌剂分散在抗菌树脂制品中时，由于无机抗菌颗粒分散在热塑性树脂中，无机抗菌剂的分散性得到改善。此外，无机抗菌颗粒均匀地分散在基础树脂中，因为在热塑性树脂中很好地防止了聚集和定位的发生。

2. 发明授权

US07250453B2 Anti-bacterial composite particles and anti-bacterial resin composition 有权
标题翻译：抗菌复合颗粒和抗菌树脂组成
公开(公告)号：US07250453B2
公开(公告)日：2007-07-31
申请号：US10492352
申请日：2002-10-10
申请人： Shuji Sakuma , Tomoki Saito , Yuki Sasaki , Yasuo Matsumura , Etsuo Tominaga , Takayoshi Aoki
发明人： Shuji Sakuma , Tomoki Saito , Yuki Sasaki , Yasuo Matsumura , Etsuo Tominaga , Takayoshi Aoki
IPC分类号： C09D5/16
CPC分类号： C08K9/02 , A01N59/16 , A01N59/20 , D01F1/103 , A01N2300/00
摘要： Anti-bacterial composite particles which comprise a polymer base material comprising a thermal melting polymer, such as a polyolefine, exhibiting good dispersibility in a basic material resin and having a lower molecular weight or a lower softening point than that of the basic material resin, and inorganic fine particles comprising a metal having anti-bacterial activity carried thereon. An antibacterial resin composition can be prepared by melting and kneading a synthetic resin composition as the basic material resin together with the anti-bacterial composite particles and forming by known molding methods such as extrusion molding and injection molding, and can be used for producing various synthetic resin moldings which have an inorganic anti-bacterial agent uniformly dispersed in a synthetic resin composition and thus exhibits good anti-bacterial effect.
摘要翻译：包含聚合物基材的抗细菌复合颗粒包括在碱性材料树脂中表现出良好分散性并且具有比基本材料树脂低的分子量或更低的软化点的热熔性聚合物如聚烯烃，以及包含其上承载有抗菌活性的金属的无机细颗粒。可以通过将合成树脂组合物作为基础材料树脂与抗菌复合颗粒一起熔融捏合并通过已知的模塑方法如挤压成型和注塑成型来制备抗菌树脂组合物，并且可以用于生产各种合成具有均匀分散在合成树脂组合物中的无机抗菌剂并因此表现出良好的抗菌作用的树脂模制品。

3. 发明授权

US09034301B2 Remineralization promoter and composition for oral cavity 有权
标题翻译：再矿化促进剂和口腔成分
公开(公告)号：US09034301B2
公开(公告)日：2015-05-19
申请号：US12594230
申请日：2008-04-08
申请人： Shuji Sakuma , Tsutomu Ishizaki , Tadayoshi Arakawa
发明人： Shuji Sakuma , Tsutomu Ishizaki , Tadayoshi Arakawa
IPC分类号： A61Q11/00 , A61K8/24 , A61K33/42 , A61K8/55 , A61K33/24 , C01B25/32
CPC分类号： A61K8/24 , A61K8/55 , A61K33/24 , A61Q11/00 , C01B25/322
摘要： It is intended to provide a remineralization promoter for tooth enamel and a composition for an oral cavity, which can highly effectively promote the remineralization of tooth enamel and strongly inhibit dental caries. The remineralization promoter for tooth enamel and the composition for an oral cavity are characterized by containing amorphous hydroxyapatite and/or amorphized hydroxyapatite showing two peaks at 2θ=31 to 35° in X-ray diffraction. The amorphized hydroxyapatite is obtained by reacting calcium salt with phosphate in an aqueous solution and drying the reaction solution at a temperature of 10 to 70° C.
摘要翻译：旨在提供用于牙釉质的再矿化促进剂和用于口腔的组合物，其可以高度有效地促进牙釉质的再矿化并且强烈抑制龋齿。用于牙釉质的再矿化促进剂和口腔组合物的特征在于含有无定形羟基磷灰石和/或非晶化羟基磷灰石，其在2θ处显示两个峰;在X射线衍射中为31至35°。无定形羟基磷灰石是通过在水溶液中使钙盐与磷酸盐反应得到的，并在10-70℃的温度下干燥反应溶液。

4. 发明授权

US09023398B2 Method for improving the aqueous solubility of poorly-soluble substances 有权
标题翻译：改善难溶性物质的水溶性的方法
公开(公告)号：US09023398B2
公开(公告)日：2015-05-05
申请号：US13497637
申请日：2010-09-10
申请人： Shuji Sakuma , Keiichiro Kikukawa , Ryosuke Miyasaka
发明人： Shuji Sakuma , Keiichiro Kikukawa , Ryosuke Miyasaka
IPC分类号： A61K9/14 , A01N25/26 , A61K47/02 , A23L1/00 , A01N25/08 , A23L1/03 , A61K9/50
CPC分类号： A61K9/143 , A01N25/08 , A01N25/26 , A23L29/015 , A23P20/10 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K47/02 , A01N25/30 , A01N47/30
摘要： Provided is a method for increasing the solubility of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, without using large amounts of additives. This is a method for improving aqueous solubility, which comprises coating the surface of the particle of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, with microparticles of a calcium compound such as calcium phosphate or calcium carbonate.
摘要翻译：本发明提供了在不使用大量添加剂的情况下，增加药物，兽药，准药，化妆品，食品，农药等中使用的难溶性物质的溶解性的方法。这是提高水溶性的方法，其包括将用于药物产品，兽药，准药，化妆品，食品，农药等的难溶性物质的颗粒表面涂覆在其中，钙化合物如磷酸钙或碳酸钙的微粒。

5. 发明申请

US20130172634A1 METHOD FOR PRODUCING ALCOHOL BY GUERBET REACTION 有权
标题翻译：通过反应生产醇的方法
公开(公告)号：US20130172634A1
公开(公告)日：2013-07-04
申请号：US13822047
申请日：2011-09-14
申请人： Tetsuya Yoshioka , Takashi Tsuchida , Jun Kubo , Shuji Sakuma
发明人： Tetsuya Yoshioka , Takashi Tsuchida , Jun Kubo , Shuji Sakuma
IPC分类号： C07C29/34
CPC分类号： C07C29/34 , B01J21/10 , B01J23/007 , B01J27/18 , B01J29/082 , B01J37/03 , C07C31/12 , C07C31/10 , C07C31/125
摘要： A method for increasing the yield of alcohols by a Guerbet reaction in a gas phase and reducing production cost is provided. A method for producing alcohols by a Guerbet reaction, wherein the reaction is performed in a gas phase and at a total pressure of less than 1 atm and preferably from 0.01 to 0.5 atm, using one or more raw material alcohols.
摘要翻译：提供了一种通过Guerbet反应在气相中提高醇的产率并降低生产成本的方法。通过Guerbet反应制备醇的方法，其中使用一种或多种原料醇在气相和小于1atm，优选0.01至0.5atm的总压下进行反应。

6. 发明申请

US20090136577A1 Intestinal Absorptive Anti-Tumor Agent 有权
标题翻译：肠吸收性抗肿瘤剂
公开(公告)号：US20090136577A1
公开(公告)日：2009-05-28
申请号：US11887710
申请日：2006-04-05
申请人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
发明人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
IPC分类号： A61K9/14
CPC分类号： A61K38/21 , A61K9/0019 , A61K9/143 , A61K9/1611 , A61K9/167 , A61K31/02 , A61K31/165 , A61K31/282 , A61K31/475 , A61K31/496 , A61K31/513 , A61K31/573 , A61K31/675 , A61K33/00 , A61K38/48
摘要： An objective of the present invention is to provide intestinal absorptive antitumor agents with an excellent intestinal absorptive effect by using injectable antitumor agents. In the intestinal absorptive pharmaceutical agents of the present invention, antitumor components that can be used only as injections are supported by hydroxyapatite particles.
摘要翻译：本发明的目的是通过使用可注射的抗肿瘤剂来提供具有优异肠吸收作用的肠吸收性抗肿瘤剂。在本发明的肠吸收药剂中，只能作为注射剂使用的抗肿瘤成分由羟基磷灰石颗粒负载。

7. 发明授权

US06323383B1 Synthesis method of chemical industrial raw material and high-octane fuel, and high-octane fuel composition 有权
标题翻译：化学工业原料和高辛烷值燃料的合成方法，高辛烷值燃料组成
公开(公告)号：US06323383B1
公开(公告)日：2001-11-27
申请号：US09601139
申请日：2000-09-27
申请人： Takashi Tsuchida , Kiminori Atsumi , Shuji Sakuma , Tomoyuki Inui
发明人： Takashi Tsuchida , Kiminori Atsumi , Shuji Sakuma , Tomoyuki Inui
IPC分类号： C01L118
CPC分类号： C10L1/023 , B01J27/1806 , C07C1/20 , C07C1/24 , C07C41/09 , C07C45/002 , C07C2527/167 , C10G3/45 , C10G3/49 , C10G2300/301 , C10G2400/02 , C10G2400/20 , Y02P20/52 , Y02P30/42 , C07C11/167 , C07C11/04 , C07C47/06 , C07C43/06
摘要： A process for the synthesis of chemical industrial feedstock and high-octane fuel, wherein calcium phosphate which is controlled in the molar Ca/P ratio and/or one which contains an activating metal (M) at a molar (Ca+M)/P ratio of 1 to 2 is used as the catalyst and ethanol is used as the feedstock.
摘要翻译：一种用于合成化学工业原料和高辛烷值燃料的方法，其中以摩尔Ca / P比控制磷酸钙和/或以摩尔浓度（Ca + M）/ P 使用1〜2的比例作为催化剂，使用乙醇作为原料。

8. 发明授权

US4691718A Toothbrush 失效
标题翻译：牙刷
公开(公告)号：US4691718A
公开(公告)日：1987-09-08
申请号：US846069
申请日：1986-03-31
申请人： Shuji Sakuma , Hirotaka Fujinawa
发明人： Shuji Sakuma , Hirotaka Fujinawa
IPC分类号： A61C15/00 , A46B15/00 , A61N1/30
CPC分类号： A61N1/303
摘要： A toothbrush includes a bristle portion having implanted bristles and molded from an ion eluting-type ceramic, a conductor extending into the interior of the bristle portion, and a battery to which the conductor is connected. An electric current flows from the user's hand toward the surface of the teeth through the user's body as the teeth are brushed, thereby causing calcium of fluorine ion, which elutes from the ceramic constituting the bristle portion, to be deposited onto and to penetrate the teeth and dental pulpa while tartar is removed from the surface of the teeth by electronic decomposition.
摘要翻译：牙刷包括具有植入的刷毛并由离子洗脱型陶瓷模制的刷毛部分，延伸到刷毛部分的内部的导体和连接导体的电池。当刷牙时，电流从使用者的手朝着使用者身体的牙齿表面流动，从而从构成刷毛部分的陶瓷洗脱出的氟离子钙被沉积到牙齿上并穿过牙齿和牙髓，而牙垢通过电子分解从牙齿表面除去。

9. 发明申请

US20100275509A1 METHOD FOR PRODUCING COMPOSITION USING ALCOHOL AS STARTING MATERIAL 有权
标题翻译：使用醇作为起始材料生产组合物的方法
公开(公告)号：US20100275509A1
公开(公告)日：2010-11-04
申请号：US12246386
申请日：2008-10-06
申请人： Shuji Sakuma , Takashi Tsuchida , Tetsuya Yoshioka
发明人： Shuji Sakuma , Takashi Tsuchida , Tetsuya Yoshioka
IPC分类号： C10L1/182
CPC分类号： C10G3/45 , B01J25/02 , B01J27/14 , B01J35/0006 , B01J35/1014 , C10G3/47 , C10G3/52 , C10G45/00 , C10G45/32 , C10G45/44 , C10G2400/02 , C10L1/02 , Y02P30/20
摘要： The present invention is to provide compositions comprising organic compounds useful as a chemical industrial material or a fuel composition with the use of an alcohol such as ethanol as a material. It is a method for producing compositions using alcohol as a starting material and comprising: allowing alcohol to contact with an alcohol conversion catalyst such as hydroxyapatite (first step) and conducting a hydrogenation reaction respectively for all reaction products consisting of a liquid phase including alcohols, water and hydrocarbons of 4-12 carbons and a gas phase which is light gas containing paraffins, alcohols and olefins; all liquid phase reaction products consisting of all reaction products from which light gas has been removed; a liquid phase dehydration reaction products consisting of all reaction products from which light gas, unreacted alcohol and product water have been removed; and light gas (second step).
摘要翻译：本发明提供包含可用作化学工业材料的有机化合物或使用醇如乙醇作为材料的燃料组合物的组合物。它是以醇为原料制备组合物的方法，其包括：使醇与醇转化催化剂如羟基磷灰石接触（第一步），并分别对由包括醇的液相组成的所有反应产物进行氢化反应， 4-12个碳原子的水和碳氢化合物，以及含有链烷烃，醇和烯烃的轻质气体的气相; 由所有反应产物组成的所有液相反应产物都被除去; 由除去轻质气体，未反应的醇和产物水的所有反应产物组成的液相脱水反应产物; 和轻气（第二步）。

10. 发明授权

US5528833A Scissors with ceramic coated replaceable cutting blades 失效
标题翻译：剪刀与陶瓷涂层可更换切割刀片
公开(公告)号：US5528833A
公开(公告)日：1996-06-25
申请号：US229537
申请日：1994-04-19
申请人： Shuji Sakuma
发明人： Shuji Sakuma
IPC分类号： B26B13/04
CPC分类号： B26B13/04
摘要： Scissors having a pair of blades that are pivotally connected to each other, each blade having a handle portion and a cutting portion detachably connected thereto. The cutting portion of each blade has a ceramic coating on a cutting edge thereof to increase its cutting life and to provide long lasting sharpness. Depending upon the component used in the coating process, the ceramic coating can be colored.
摘要翻译：剪刀具有彼此枢转地连接的一对叶片，每个叶片具有手柄部分和可拆卸地连接到其上的切割部分。每个叶片的切割部分在其切割边缘上具有陶瓷涂层以增加其切割寿命并提供持久的清晰度。根据涂覆过程中使用的组分，陶瓷涂层可以着色。

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