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1. 发明申请

US20080274110A1 Cell Death-Inducing Agents 审中-公开
标题翻译：细胞死亡诱导剂
公开(公告)号：US20080274110A1
公开(公告)日：2008-11-06
申请号：US11547747
申请日：2004-04-09
申请人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
发明人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
IPC分类号： A61K39/395 , C07K16/00 , A61P35/04 , C12N5/02
CPC分类号： C07K16/2833 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73
摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. As a result, the 2D7 antibody was found to recognize HLA class IA. In addition, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
摘要翻译：为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。结果发现2D7抗体识别HLA类别IA。此外，本发明人检查了2D7抗体是否具有细胞死亡诱导活性。当2D7抗体与另一种抗体交联时，观察到细胞核碎裂，表明诱导细胞死亡。此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使没有添加另一种抗体。这些结果表明HLA识别抗体的小体抗体可以用作细胞死亡诱导剂。

2. 发明申请

US20060275301A1 Cell death-inducing agent 失效
标题翻译：细胞死亡诱导剂
公开(公告)号：US20060275301A1
公开(公告)日：2006-12-07
申请号：US10530696
申请日：2003-10-10
申请人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
发明人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
摘要翻译：为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。结果表明，2D7抗原是HLA I类分子。基于该发现，本发明人检查了2D7抗体是否具有细胞死亡诱导活性。当2D7抗体与另一种抗体交联时，观察到细胞核碎裂，表明诱导细胞死亡。此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使没有添加另一种抗体。这些结果表明HLA识别抗体的小体抗体可以用作细胞死亡诱导剂。

3. 发明授权

US08158385B2 Cell death-inducing agent 失效
标题翻译：细胞死亡诱导剂
公开(公告)号：US08158385B2
公开(公告)日：2012-04-17
申请号：US10530696
申请日：2003-10-10
申请人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
发明人： Shuji Ozaki , Masahiro Abe , Masayuki Tsuchiya , Naoki Kimura , Shigeto Kawai
IPC分类号： C12P21/04 , C12P21/08
CPC分类号： C07K16/2833 , A61K2039/505 , C07K14/70539 , C07K2317/34 , C07K2317/565 , C07K2317/626 , C07K2317/73
摘要： To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
摘要翻译：为了鉴定2D7抗体的抗原，本发明人克隆了2D7抗原。结果表明，2D7抗原是HLA I类分子。基于该发现，本发明人检查了2D7抗体是否具有细胞死亡诱导活性。当2D7抗体与另一种抗体交联时，观察到细胞核碎裂，表明诱导细胞死亡。此外，发现2D7抗体的双抗体具有非常强的细胞死亡诱导活性，即使没有添加另一种抗体。这些结果表明HLA识别抗体的小体抗体可以用作细胞死亡诱导剂。

4. 发明申请

US20100092461A1 Remedy For Chemotherapy-Resistant Cancer Containing HLA Class I-Recognizing Antibody as the Active Ingredient and Use of the Same 审中-公开
标题翻译：包含HLA I类识别抗体作为其有效成分和使用的抗化学药物治疗的补救措施
公开(公告)号：US20100092461A1
公开(公告)日：2010-04-15
申请号：US12530670
申请日：2008-03-12
申请人： Toshio Matsumoto , Shuji Ozaki , Masahiro Abe
发明人： Toshio Matsumoto , Shuji Ozaki , Masahiro Abe
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2833 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/622 , C07K2317/626 , C07K2317/73 , A61K2300/00
摘要： The present invention describes therapeutic agents for chemotherapeutic agent-resistant cancers that include an HLA class I-recognizing antibody as an active ingredient. A further objective of the present invention is to provide methods for treating chemotherapeutic agent-resistant cancers that include the step of administering an HLA class I-recognizing antibody to a subject. It is herein demonstrated that cytotoxic activity due to C3B3 diabody is induced at a lower concentration in chemotherapeutic agent-resistant hematological tumor cell lines having high MDR1 and HLA class IA protein expression, than in their parent cell lines. It was also found that when the chemotherapeutic agent-resistant hematological tumor cell line is pretreated with a C3B3 diabody, cell injury associated with sole use of chemotherapeutic agent is enhanced and the amount of pharmaceutical agents taken up into cells are increased. More specifically, it was discovered that the C3B3 diabody exhibits anti-tumor activity on MDR1-expressing tumor cells having high HLA class I expression, and thereby is effective in overcoming drug resistance.
摘要翻译：本发明描述了包含HLA I类识别抗体作为活性成分的化学治疗剂抗性癌症的治疗剂。本发明的另一个目的是提供用于治疗耐化学药物的癌症的方法，其包括向受试者施用HLA I类识别抗体的步骤。在本文中证明，在具有高MDR1和HLA类别IA蛋白表达的化学治疗剂抗性血液肿瘤细胞系中，比在其亲本细胞系中，以较低浓度诱导由C3B3双抗体引起的细胞毒性活性。还发现当化学治疗剂抗性血液肿瘤细胞系用C3B3双抗体预处理时，与单独使用化学治疗剂相关的细胞损伤增强，并且吸收到细胞中的药剂的量增加。更具体地，发现C3B3双抗体对具有高HLA I类表达的MDR1表达的肿瘤细胞表现出抗肿瘤活性，从而有效克服耐药性。

5. 发明申请

US20090022687A1 Novel Pharmaceuticals That Use Anti-HLA Antibodies 审中-公开
标题翻译：使用抗HLA抗体的新型药物
公开(公告)号：US20090022687A1
公开(公告)日：2009-01-22
申请号：US11913229
申请日：2006-05-18
申请人： Toshio Matsumoto , Shuji Ozaki , Masahiro Abe
发明人： Toshio Matsumoto , Shuji Ozaki , Masahiro Abe
IPC分类号： A61K38/21
CPC分类号： C07K16/2833 , A61K38/212 , A61K38/217 , A61K39/3955 , C07K2317/73 , A61K2300/00
摘要： The present inventors tested the effects of interferons on the expression of HLA-A in cells and cell injury caused by anti-HLA class I antibodies, by using a 2D7-DB antibody as an anti-HLA class I antibody and the IM-9 cell line as the cells to be tested. As a result, the expression of HLA-A was demonstrated to be upregulated by IFNα or IFNγ, Furthermore, WST-8 assays were performed to examine the cell viability when an interferon and an anti-HLA class I antibody were used in combination. As a result, cell death activity was found to be increased by the combination of 2D7-DB and IFNα or IFNγ.
摘要翻译：本发明人通过使用2D7-DB抗体作为抗HLA I类抗体和IM-9细胞，测试了干扰素对细胞中HLA-A的表达和由抗HLA I类抗体引起的细胞损伤的影响线作为要测试的细胞。结果表明HLA-A的表达被IFNα或IFNγ上调。此外，当组合使用干扰素和抗HLA I类抗体时，进行WST-8测定以检查细胞活力。结果发现2D7-DB和IFNα或IFNgma的组合增加了细胞死亡活性。

6. 发明授权

US08744156B2 Photographic information processing apparatus and photographic information processing method 有权
标题翻译：摄影信息处理设备和摄影信息处理方法
公开(公告)号：US08744156B2
公开(公告)日：2014-06-03
申请号：US12764013
申请日：2010-04-20
申请人： Masahiro Abe
发明人： Masahiro Abe
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G16H40/63
摘要： A photographic information processing apparatus corrects photographic information based on temporarily determined photographic information relating to a photographing operation. The photographic information processing apparatus includes a photographic information correction determination unit determines whether correction of the photographic information is required based on an operation by an operator, an image data acquisition unit detects an X-ray having penetrated a body of a patient and acquires image data based on the detected X-ray, a photographic information correction unit corrects the temporarily determined photographic information based on patient information of the patient in a case where the correction of the photographic information is determined to be required, and an image data output unit outputs the image data after the correction of the temporarily determined photographic information is completed. The acquired image data is prevented from being output unless the temporarily determined photographic information is corrected.
摘要翻译：摄影信息处理设备基于与拍摄操作相关的临时确定的摄影信息来校正摄影信息。摄影信息处理设备包括摄影信息校正确定单元，基于操作者的操作来确定是否需要校正摄影信息，图像数据获取单元检测穿透患者身体的X射线并获取图像数据基于检测到的X射线，摄影信息校正单元在确定需要照相信息的校正的情况下，基于患者的患者信息来校正临时确定的摄影信息，并且图像数据输出单元输出完成临时确定的摄影信息的修正之后的图像数据。除非修正了临时确定的摄影信息，否则防止所获取的图像数据被输出。

7. 发明授权

US08665490B2 Information processing apparatus, display method therefor, and computer-readable storage medium 有权
标题翻译：信息处理装置，显示方法和计算机可读存储介质
公开(公告)号：US08665490B2
公开(公告)日：2014-03-04
申请号：US12563270
申请日：2009-09-21
申请人： Masahiro Abe
发明人： Masahiro Abe
IPC分类号： G06K15/00 , H04N1/60 , H04N5/262 , G06K9/20
CPC分类号： H04N1/3871 , H04N1/0044 , H04N1/00469 , H04N1/32133 , H04N2201/3225 , H04N2201/3271 , H04N2201/3273
摘要： An information processing apparatus sets, on an image to be printed, the print position of attribute information of the image. The information processing apparatus displays, on a display device, the print preview screen of the image to be printed in which an image forming the attribute information is arranged at the set print position. When a region corresponding to the attribute information on the print preview screen displayed on the display device is selected, the information processing apparatus enlarges and displays the attribute information.
摘要翻译：信息处理设备在要打印的图像上设置图像的属性信息的打印位置。信息处理设备在显示设备上显示要在其上形成属性信息的图像被布置在设置的打印位置的要打印的图像的打印预览屏幕。当选择与在显示装置上显示的打印预览画面上的属性信息对应的区域时，信息处理装置放大并显示属性信息。

8. 发明授权

US08409484B2 Method for producing a ceramic compact 有权
标题翻译：陶瓷压块的制造方法
公开(公告)号：US08409484B2
公开(公告)日：2013-04-02
申请号：US12637008
申请日：2009-12-14
申请人： Masahiko Namerikawa , Yukihisa Takeuchi , Shinsuke Yano , Kazuyoshi Shibata , Koji Ikeda , Masahiro Abe
发明人： Masahiko Namerikawa , Yukihisa Takeuchi , Shinsuke Yano , Kazuyoshi Shibata , Koji Ikeda , Masahiro Abe
IPC分类号： B29C39/10
CPC分类号： H05K3/207 , C04B35/6342 , C04B35/63448 , C04B35/6346 , C04B2235/6023 , H05K1/0306 , H05K3/4611 , H05K3/4629 , H05K2201/09118 , Y10T428/24851 , Y10T428/24917 , Y10T428/24926
摘要： A ceramic compact having a patterned conductor is obtained by coating the patterned conductor with a slurry and then by hardening the slurry. The slurry is prepared by mixing a thermosetting resin precursor, a ceramic powder, and a medium. In the ceramic compact, an isocyanate- or isothiocyanate-containing gelling agent and a hydroxyl-containing polymer are reacted and hardened to produce a thermosetting resin. The hydroxyl-containing polymer is preferably a butyral resin, an ethylcellulose-based resin, a polyethyleneglycol-based resin, or a polyether-based resin.
摘要翻译：具有图案化导体的陶瓷压块通过用浆料涂覆图案化的导体，然后通过硬化浆料而获得。通过混合热固性树脂前体，陶瓷粉末和介质来制备浆料。在陶瓷压块中，将含异氰酸酯或异硫氰酸酯的胶凝剂和含羟基的聚合物反应并硬化以制备热固性树脂。含羟基的聚合物优选为丁缩醛树脂，乙基纤维素系树脂，聚乙二醇类树脂或聚醚类树脂。

9. 发明申请

US20110051896A1 RADIOGRAPHIC IMAGING CONTROL APPARATUS AND METHOD 有权
标题翻译：放射成像控制装置和方法
公开(公告)号：US20110051896A1
公开(公告)日：2011-03-03
申请号：US12852392
申请日：2010-08-06
申请人： Masahiro Abe
发明人： Masahiro Abe
IPC分类号： H05G1/64
CPC分类号： A61B6/00 , A61B6/545 , A61B6/583
摘要： A radiographic imaging apparatus that is connectable to a plurality of radiation sensors includes an information acquisition unit configured to acquire information about a radiographing site and a radiographing posture of a subject based on an instruction from an operator, a sensor drive status management unit configured to manage drive statuses of the plurality of radiation sensors, and a sensor selection unit configured to select a radiation sensor to be used in performing radiographing from the plurality of radiation sensors based on the acquired information and drive statuses of the plurality of radiation sensors.
摘要翻译：可连接到多个辐射传感器的放射线照相成像装置包括：信息获取单元，被配置为基于来自操作者的指令来获取关于受检者的放射照片位置和放射照片姿势的信息;传感器驱动状态管理单元，被配置为管理多个辐射传感器的驱动状态，以及传感器选择单元，被配置为基于所获取的多个辐射传感器的信息和驱动状态来选择要用于从多个辐射传感器执行射线照相的辐射传感器。

10. 发明授权

US07726879B2 X-ray imaging apparatus, control method for x-ray imaging apparatus, program, and storage medium 有权
标题翻译： X射线成像装置，X射线成像装置的控制方法，程序和存储介质
公开(公告)号：US07726879B2
公开(公告)日：2010-06-01
申请号：US12247592
申请日：2008-10-08
申请人： Masahiro Abe , Tsukasa Sako , Yuichi Nishii , Hideto Shiozawa
发明人： Masahiro Abe , Tsukasa Sako , Yuichi Nishii , Hideto Shiozawa
IPC分类号： G01N23/04
CPC分类号： A61B6/08 , A61B6/4405 , A61B6/469
摘要： An X-ray imaging apparatus includes a visible light imaging unit which captures an image of a visual field region with visible light, an X-ray irradiation unit which irradiates X-rays, an X-ray imaging unit which receives the irradiated X-rays and acquires a radiograph based on the X-rays, and a detection unit which detects an irradiated region irradiated with the X-rays based on the acquired radiograph.
摘要翻译：一种X射线摄像装置，具备：以可见光捕获视场区域的图像的可见光摄像单元，照射X射线的X射线照射单元，接收X射线照射的X射线摄像单元并且基于X射线获取X射线照片;以及检测单元，其基于获取的射线照片检测用X射线照射的照射区域。

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