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1. 发明授权

US06298910B1 Aluminum-made heat exchanger with brazed joint portion 失效
标题翻译：具有钎焊接头部分的铝制热交换器
公开(公告)号：US06298910B1
公开(公告)日：2001-10-09
申请号：US09668935
申请日：2000-09-25
申请人： Shuji Komoda , Hisashi Nakashima , Shinichi Hamada
发明人： Shuji Komoda , Hisashi Nakashima , Shinichi Hamada
IPC分类号： F28F1906
CPC分类号： F28F19/06 , B23K1/0012 , B23K2101/14 , B23K2103/10 , F16N39/02 , F28D9/0043 , F28D2021/0089 , F28F21/084 , F28F21/089 , F28F2275/04
摘要： A heat exchanger has a core portion composed of several pairs of first and second plates laminated with and brazed to one another. Each of the first and second plates is composed a core member, a brazing filler layer formed on a surface of the core member, and a sacrifice layer formed on the other surface of the core member. For instance, to form a pair of the first and second plates, the first plate is formed with a convex portion with an opening portion, and a burring portion of the second plate is inserted into the opening portion and is plastically deformed such that the sacrifice layer of the second plate closely contacts the brazing filler metal layer of the first plate. Then the first and the second plates are brazed together.
摘要翻译：热交换器具有由几对彼此层叠并钎焊的多对第一和第二板组成的芯部分。第一板和第二板中的每一个由芯构件，形成在芯构件的表面上的钎料层构成，牺牲层形成在芯构件的另一个表面上。例如，为了形成一对第一板和第二板，第一板形成有具有开口部的凸部，第二板的翻边部插入开口部，并且塑性变形，使得牺牲第二板的层紧密接触第一板的钎料层。然后将第一和第二板钎焊在一起。

2. 发明授权

US6082439A Heat exchanger assembled without brazing in which adhesive is used to seal a combined portion and a core plate 失效
标题翻译：热交换器组装而不用钎焊，其中使用粘合剂来密封组合部分和芯板
公开(公告)号：US6082439A
公开(公告)日：2000-07-04
申请号：US978461
申请日：1997-11-26
申请人： Seiichi Kato , Hisashi Nakashima , Sumio Susa
发明人： Seiichi Kato , Hisashi Nakashima , Sumio Susa
IPC分类号： F28F9/02 , F28F9/16 , F28F7/00
CPC分类号： F28F9/0226 , F28F9/162 , F28F2225/08 , Y10S165/906
摘要： In a mechanically assembled type heat exchanger, in which an end portion of an oval tube is inserted into a barring hole of a core plate and expanded to be press fit to the core plate. Then adhesive is potted on the core plate for sealing the press fit portion in the end of the tube. A reinforcing member is formed around the barring hole for increasing the rigidity of the core plate so as to improve the durability of sealing.
摘要翻译：在机械组装式热交换器中，将椭圆管的端部插入到芯板的加压孔中并膨胀以与芯板压配合。然后将粘合剂封装在芯板上，用于密封管末端的压配合部分。形成围绕加压构件的加强构件，以提高芯板的刚性，从而提高密封的耐久性。

3. 发明授权

US6053629A Vibration generating device 失效
标题翻译：振动发生装置
公开(公告)号：US6053629A
公开(公告)日：2000-04-25
申请号：US170203
申请日：1998-10-13
申请人： Hisashi Nakashima
发明人： Hisashi Nakashima
IPC分类号： B06B1/18 , E02F3/40 , E02F9/22 , F15B13/04 , B01F11/00
CPC分类号： E02F9/221 , F15B13/0406
摘要： A vibration generating device is provided. Where a bucket link is replaced by the vibration generating device, the vibration generating device is connected to a main operating valve by conduits. Since both flow rate control valve and fluid motor are housed within a casing, a high pressure conduit for connecting the vibration generating device and main operating valve is not necessitated, thereby making the structure compact, and making the working of conduit arrangement easy and improve reliability. The center axial line of the cylinder chamber, rotary axial line of the valve element of the rotary valve and center axial line of the valve element of the flow rate valve are made parallel to one another so that these cylinder chamber, rotary valve and flow rate control valve are arranged in a superposing fashion, thereby making the entire vibration generating device compact.
摘要翻译：提供振动产生装置。在通过振动发生装置代替铲斗连杆的情况下，振动产生装置通过导管连接到主操作阀。由于流量控制阀和流体马达两者都容纳在壳体内，所以不需要用于连接振动产生装置和主操作阀的高压导管，从而使结构紧凑，并且使导管布置的工作容易并且提高可靠性。气缸室的中心轴线，旋转阀的阀元件的旋转轴线和流量阀的阀元件的中心轴线彼此平行，使得这些气缸室，旋转阀和流量控制阀以重叠的方式布置，从而使整个振动产生装置紧凑。

4. 发明申请

US20100022572A1 NOVEL SPIRO COMPOUND AND MEDICINE COMPRISING THE SAME 审中-公开
标题翻译：新型SPIRO化合物和包括其的药物
公开(公告)号：US20100022572A1
公开(公告)日：2010-01-28
申请号：US12504075
申请日：2009-07-16
申请人： Hisashi Nakashima , Takahisa Ogamino , Takaaki Araki , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya , Kimiyuki Shibuya
发明人： Hisashi Nakashima , Takahisa Ogamino , Takaaki Araki , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya , Kimiyuki Shibuya
IPC分类号： A61K31/438 , C07D221/20 , A61P3/00 , A61P3/04 , A61P9/12
CPC分类号： A61K31/438 , C07D221/20 , C07D471/10
摘要： It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome.A spiro compound represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译：提供可用于预防和/或治疗糖尿病，胰岛素抵抗，糖尿病并发症，肥胖症，血脂异常，高血压，脂肪肝或代谢综合征的新型化合物。由以下通式（1）表示的螺环化合物或其盐或其溶剂化物。

5. 发明授权

US06478079B1 Plate-fin type heat exchanger and method for manufacturing the same 失效
标题翻译：板翅式热交换器及其制造方法
公开(公告)号：US06478079B1
公开(公告)日：2002-11-12
申请号：US09375984
申请日：1999-08-16
申请人： Seiichi Kato , Hisashi Nakashima , Akio Ueda , Masakazu Hyodo , Fumio Moriyama
发明人： Seiichi Kato , Hisashi Nakashima , Akio Ueda , Masakazu Hyodo , Fumio Moriyama
IPC分类号： F28D104
CPC分类号： F28F1/32
摘要： A recess portion for setting an attachment position is formed in each plate fin at positions adjacent to both longitudinal ends of the plate fins on both upstream and downstream ends in an air flowing direction. Therefore, air passing through the plate fins is disturbed by a standing wall portion of the recess portion around the longitudinal ends of the plate fins. Thus, it can prevent a thermal boundary layer from being expanded in a heat exchanger having the plate fin, and heat-transmission efficiency can be improved in the heat exchanger. As a result, an entire area of the plate fin can be effectively used, thereby improving heat-exchanging capacity of the heat exchanger.
摘要翻译：用于设定安装位置的凹部在空气流动方向上在上游和下游端的板翅片的两个纵向端部相邻的位置处形成在每个板翅片中。因此，通过板翅片的空气被围绕板翅片的纵向端部的凹部的立壁部分所扰乱。因此，能够防止热边界层在具有板翅片的热交换器中膨胀，并且能够提高热交换器的传热效率。结果，可以有效地使用板翅的整个区域，从而提高热交换器的热交换能力。

6. 发明授权

US08236789B2 1-adamantyl azetidin-2-one derivatives and drugs containing same 有权
标题翻译： 1-金刚烷基氮杂环丁烷-2-酮衍生物和含有它们的药物
公开(公告)号：US08236789B2
公开(公告)日：2012-08-07
申请号：US12550206
申请日：2009-08-28
申请人： Hisashi Nakashima , Takahiro Mori , Ryoko Mori, legal representative , Takaaki Araki , Takahisa Ogamino , Kazutoyo Abe , Tadaaki Ohgiya
发明人： Hisashi Nakashima , Takahiro Mori , Takaaki Araki , Takahisa Ogamino , Kazutoyo Abe , Tadaaki Ohgiya
IPC分类号： C07D205/08 , C07D227/087 , A61K31/397 , A61K31/4427 , A61K31/443 , A61K31/4725 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/06
CPC分类号： C07D205/08 , A61K31/397 , C07D401/04 , C07D401/08 , C07D405/04
摘要： It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate. [wherein A ring represents C6-10 aryl group, 5- to 14-membered heteroaryl group, R1 is a hydrogen atom, halogen atom, C1-6 alkoxycarbonyl group, hydroxyl group, carboxyl group or carbamoyl group; R2 and R3 are the same or different and are a C1-6 alkyl group; R4, R5, and R6 are same or different, and are a hydrogen atom, halogen atom, C1-6 alkyl group, C1-6 alkoxy group, C6-10 aryl group, or R4 and R5, or R5 and R6 may together form a C1-3 alkylenedioxy group, R7 and R8 are the same of different and represent a hydrogen atom or C1-6 alkyl group, or may together form a C3-6 cyclic hydrocarbon group, n represents an integer of 0 or 1].
摘要翻译：提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1，特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征的疾病的新型化合物。它是由以下通式（1）表示的1-金刚烷基氮杂环丁-2-酮衍生物或其盐或其溶剂合物。 [其中A环表示C6-10芳基，5〜14元杂芳基，R1表示氢原子，卤素原子，C1-6烷氧基羰基，羟基，羧基或氨基甲酰基。 R2和R3相同或不同，为C1-6烷基; R 4，R 5和R 6相同或不同，为氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 6-10芳基或R 4和R 5，或者R 5和R 6可以一起形成 C 1-3亚烷基二氧基，R 7和R 8相同，表示氢原子或C 1-6烷基，或一起形成C 3-6环烃基，n表示0或1的整数]。

7. 发明申请

US20100144694A1 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME 有权
标题翻译： 1,2-DIAZETIDIN-3-ONE衍生物和含有其的药物
公开(公告)号：US20100144694A1
公开(公告)日：2010-06-10
申请号：US12607650
申请日：2009-10-28
申请人： Hisashi Nakashima , Takaaki Araki , Takahisa Ogamino , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya
发明人： Hisashi Nakashima , Takaaki Araki , Takahisa Ogamino , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya
IPC分类号： A61K31/397 , C07D229/00 , A61P3/04 , A61P3/10
CPC分类号： C07D229/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04
摘要： [Object]It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).[Means to Solve the Object]A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译：提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1（特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征）的疾病的新化合物。。解决对象的方法由下述通式（1）表示的1,2-二氮杂环丁-3-酮衍生物或其盐或其溶剂化物。

8. 发明申请

US20090289136A1 LID MEMBER 审中-公开
标题翻译： LID会员
公开(公告)号：US20090289136A1
公开(公告)日：2009-11-26
申请号：US12307728
申请日：2007-07-04
申请人： Tetsuo Ishikawa , Toshio Hiranuma , Hisashi Nakashima
发明人： Tetsuo Ishikawa , Toshio Hiranuma , Hisashi Nakashima
IPC分类号： B02C23/00
CPC分类号： E03C1/2665 , B02C18/24 , B02C2018/147
摘要： To provide a lid body for a disposer apparatus which can keep inside of the disposer apparatus clean with ease. A washing-agent-reception portion is provided on a side of a rear surface of the lid body and at an inside of the body portion. The washing-agent-reception portion receives a washing agent package. When changing over drive of the disposer apparatus to a crushing operation for crushing garbage, water supply into the inside of the hopper starts concurrently with the crushing of the garbage by the crushing unit. Water to be supplied is supplied to the inside of the hopper through the lid body as a pathway thereof. At this time, the water passing through the lid body is supplied to the inside of the hopper as washing liquid with it dissolving washing agent. When driving the crushing unit, washing of the inside of the hopper is executed by the washing liquid concurrently with the crushing operation, which keeps the inside of the hopper clean.
摘要翻译：为了提供能够容易地保持处理器内部清洁的处理器装置的盖体。洗涤剂接收部设置在盖体的后表面侧和身体部分的内侧。洗衣剂接收部接收清洗剂包装。当将处理器装置的驱动转换为用于破碎垃圾的破碎操作时，供给到料斗内部的供水与粉碎单元对垃圾的破碎同时开始。供给的水通过盖体作为其通路供给到料斗的内部。此时，通过盖体的水以溶解洗涤剂的洗涤液体供给到料斗的内部。当驱动破碎装置时，与破碎操作同时地通过洗涤液进行料斗的内部洗涤，保持料斗内部的清洁。

9. 发明授权

US06427769B2 Heat exchanger having tube joined to core plate and method of manufacturing the same 失效
标题翻译：具有与芯板连接的管的热交换器及其制造方法
公开(公告)号：US06427769B2
公开(公告)日：2002-08-06
申请号：US09326223
申请日：1999-06-03
申请人： Kouji Horie , Seiichi Kato , Hisashi Nakashima
发明人： Kouji Horie , Seiichi Kato , Hisashi Nakashima
IPC分类号： F28F904
CPC分类号： F28F9/162 , Y10T29/49373
摘要： A heat exchanger has a tank for accommodating a heat medium therein and a tube connected to the tank through a core plate. Specifically, an end portion of the tube is inserted into a connection hole of the core plate and is mechanically joined thereto. A joined portion of the tube and the core plate is covered with adhesive through a wettability improving film for improving wettability of the adhesive to the joined portion. As a result, a sealing property between the tube and the core plate is easily and stably improved by the adhesive.
摘要翻译：热交换器具有用于容纳热介质的罐和通过芯板连接到罐的管。具体地，将管的端部插入到芯板的连接孔中并与其机械连接。管和芯板的接合部分通过润湿性改进膜用粘合剂覆盖，用于改善粘合剂对接合部分的润湿性。结果，通过粘合剂容易且稳定地改善管与芯板之间的密封性。

10. 发明授权

US08252781B2 1,2-diazetidin-3-one derivatives and drugs containing same 有权
标题翻译： 1,2-二氮杂环丁烷-3-酮衍生物和含有它们的药物
公开(公告)号：US08252781B2
公开(公告)日：2012-08-28
申请号：US12607650
申请日：2009-10-28
申请人： Hisashi Nakashima , Takaaki Araki , Takahisa Ogamino , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya
发明人： Hisashi Nakashima , Takaaki Araki , Takahisa Ogamino , Noriaki Gomi , Yasushi Kaneko , Kazutoyo Abe , Tadaaki Ohgiya
IPC分类号： C07D229/00 , C07D409/04 , C07D405/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , A61K31/397 , A61K31/4427 , A61K31/498 , A61P9/12 , A61P3/10 , A61P3/04 , A61P3/06
CPC分类号： C07D229/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04
摘要： [Object]It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).[Means to Solve the Object]A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译：提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1（特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征）的疾病的新化合物。。解决对象的方法由下述通式（1）表示的1,2-二氮杂环丁-3-酮衍生物或其盐或其溶剂化物。

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