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1. 发明授权

US6034231A Human CNP gene and precursor protein 失效
标题翻译：人CNP基因和前体蛋白
公开(公告)号：US6034231A
公开(公告)日：2000-03-07
申请号：US765830
申请日：1991-09-26
申请人： Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi , Hisayuki Matsuo , Kenji Kanagawa , Naoto Minamino
发明人： Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi , Hisayuki Matsuo , Kenji Kanagawa , Naoto Minamino
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/10 , C07K14/00 , C07K14/575 , C07K14/58 , C12N15/16 , C07H17/00
CPC分类号： C07K14/58 , A61K38/00
摘要： The gene of a human CNP (human C-type natriuretic peptide), as well as the hCNP precursor protein that is encoded by said gene. The hCNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - Met Ser Gly Leu Gly Cys. The hCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
摘要翻译：人CNP（人C型利钠肽）的基因以及由所述基因编码的hCNP前体蛋白。 hCNP前体由以下氨基酸序列表示。 - Met His Leu Ser Gln Leu Leu Ala Cys Ala - - Leu Leu Leu Leu Leu Leu Leu Ser Leu Arg Pro - - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - - Met Ser Gly Leu Gly Cys。 - hCNP前体及其衍生物是新颖的，具有钠尿和降血压活性。

2. 发明授权

US6020168A Porcine CNP gene and precursor protein 失效
标题翻译：猪CNP基因和前体蛋白
公开(公告)号：US6020168A
公开(公告)日：2000-02-01
申请号：US728220
申请日：1991-07-12
申请人： Hisayuki Matsuo , Kenji Kangawa , Naoto Minamino , Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi
发明人： Hisayuki Matsuo , Kenji Kangawa , Naoto Minamino , Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi
IPC分类号： C12N15/09 , A61K38/00 , C07H21/04 , C07K14/575 , C07K14/58 , C12N15/16 , C12P21/02 , C12R1/19 , C12P21/06 , C07H17/00 , C07K14/00
CPC分类号： C07K14/58 , A61K38/00
摘要： The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser These derivatives are novel and have natriuretic and hypotensive activities.
摘要翻译：公开了源自CNP（C型利尿钠肽）的基因和cDNA，以及源自CNP前体蛋白及其衍生物的衍生物。程序衍生物CNP前体由以下氨基酸序列表示： - Met His Leu Ser Gln Leu Leu Ala Cys Ala - - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - - Met Ser Gly Leu Gly Cys。 - 这些衍生物是新颖的，具有钠尿和降血压活性。

3. 发明授权

US5118615A Peptide and gene coding for same 失效
标题翻译：肽和基因编码相同
公开(公告)号：US5118615A
公开(公告)日：1992-06-02
申请号：US023818
申请日：1987-03-09
申请人： Hisayuki Matsuo , Kenji Kangawa , Yujiro Hayashi , Shinzo Oikawa , Takehiro Oshima , Shoji Tanaka , Hiroshi Nakazato , Yasunori Tawaragi
发明人： Hisayuki Matsuo , Kenji Kangawa , Yujiro Hayashi , Shinzo Oikawa , Takehiro Oshima , Shoji Tanaka , Hiroshi Nakazato , Yasunori Tawaragi
IPC分类号： A61K38/00 , C07K14/58 , C12N15/12 , C12N15/70
CPC分类号： C07K14/58 , C12N15/70 , A61K38/00 , Y10S514/869
摘要： Disclosed is a DNA fragment comprising a base sequence coding for a peptide occurring in human atrium cordis and having diuretic action or a precursor of the peptide, plasmids containing the DNA fragment, microorganisms transformed with the plasmid, and a process for production of the peptide using the transformant.Also disclosed is a new peptide consisting of 126 amino acids occurring in human atrium cordis and a precursor thereof. The peptide has notable diuretic action and hypotensive or antihypertensive actions.
摘要翻译：公开了一种DNA片段，其包含编码人心房中出现的具有利尿作用或肽前体的肽的碱基序列，含有该DNA片段的质粒，用质粒转化的微生物，以及使用转化子。还公开了由人心房中出现的126个氨基酸及其前体组成的新肽。肽具有显着的利尿作用和降血压或降压作用。

4. 发明授权

US06245887B1 Recombinant C-terminal &agr;-amidating enzyme 失效
标题翻译：重组C-末端α-酰胺化酶
公开(公告)号：US06245887B1
公开(公告)日：2001-06-12
申请号：US07509583
申请日：1990-04-16
申请人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
发明人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
IPC分类号： C07K1446
CPC分类号： C12N9/0071 , C12Y114/17003
摘要： A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.
摘要翻译：通过重组DNA技术产生非洲爪蟾的C-末端α-酰胺化酶及其前体; 编码酶或其前体的DNA; 含有DNA的质粒; 用质粒转化的宿主生物; 使用转化体生产酶的方法; 以及使用该酶制备C末端α-酰胺化肽的方法。

5. 发明授权

US5821083A Recombinant C-terminal .alpha.-amidating enzyme 失效
标题翻译：重组C-末端α-酰胺化酶
公开(公告)号：US5821083A
公开(公告)日：1998-10-13
申请号：US759184
申请日：1996-12-04
申请人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
发明人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
IPC分类号： C12N1/21 , C12N9/02 , C12N15/12 , C12N15/55 , C12N15/52 , C12P21/00
CPC分类号： C12N9/0071 , C12Y114/17003
摘要： A C-terminal .alpha.-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal .alpha.-amidated peptide using the enzyme.
摘要翻译：通过重组DNA技术产生非洲爪蟾的C末端α-酰胺化酶及其前体; 编码酶或其前体的DNA; 含有DNA的质粒; 用质粒转化的宿主生物; 使用转化体生产酶的方法; 以及使用该酶生产C末端α-酰胺化肽的方法。

6. 发明授权

US06262232B1 Recombinant C-terminal &agr;-amidating enzyme 失效
公开(公告)号：US06262232B1
公开(公告)日：2001-07-17
申请号：US07219375
申请日：1988-07-15
申请人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
发明人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
IPC分类号： C07K1446
CPC分类号： C12N9/0071 , C12Y114/17003
摘要： A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.

7. 发明授权

US5434133A CNP analog peptides and their use 失效
标题翻译： CNP类似物及其用途
公开(公告)号：US5434133A
公开(公告)日：1995-07-18
申请号：US828450
申请日：1992-01-31
申请人： Shoji Tanaka , Yoshiharu Minamitake , Yasuo Kitajima , Mayumi Furuya , Hisayuki Matsuo
发明人： Shoji Tanaka , Yoshiharu Minamitake , Yasuo Kitajima , Mayumi Furuya , Hisayuki Matsuo
IPC分类号： A61K38/22 , A61K38/00 , A61P43/00 , C07K7/08 , C07K14/575 , C07K14/58 , C12N15/16 , C07K14/00 , A61K38/16 , A61K38/17 , C07K14/435
CPC分类号： C07K14/58 , A61K38/00 , Y02P20/55
摘要： Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly, H-Gly-Leu-Ser-Lys-Gly, H-ser, H-Ser-Ser, H-Arg-Ser-Ser, H-Arg-Arg-Ser-Ser, H-Leu-Arg-Arg-Ser-Ser, H-Ser-Leu-Arg-Arg-Ser-Ser;(B) represents H-Cys or Pmp;(C) represents Phe-, pCl-Phe, pF-Phe, pNO.sub.2 -Phe or Cha;(D) represents Ile, Val, Aib, tLeu, Gly or Leu;(E) represents Lys or Arg;(F) represents Ile, Leu or Met;(G) represents Ser or Ala;(H) represents Met or Gln;(I) represents --OH, -Asn-OH, -Asn-Ser-OH, -Asn-Ser-Phe-OH, -Asn-Ser-Phe-Arg-OH or -Asn-Ser-Phe-Arg-Tyr-OH; and the symbol " . . . " represents a disulfide bond;provided that 1) .alpha.-hANP, 2) .alpha.-hANP (7-28) and 3) CNP-22 are excluded from the scope of that general formula.Also disclosed are agents for suppressing the growth of vascular smooth muscle cells that contains those peptides as effective ingredients.
摘要翻译：由通式表示的新肽：其加成盐; 其中（A）表示H，H-Gly，H-Lys-Gly，H-Ser-Lys-Gly，H-Leu-Ser-Lys-Gly，H-Gly-Leu-Ser-Lys-Gly， Ser，H-Ser-Ser，H-Arg-Ser-Ser，H-Arg-Arg-Ser-Ser，H-Leu-Arg-Arg-Ser-Ser，H-Ser-Leu-Arg-Arg- 塞尔（B）代表H-Cys或Pmp; （C）表示Phe-，pCl-Phe，pF-Phe，pNO2-Phe或Cha; （D）代表Ile，Val，Aib，tLeu，Gly或Leu; （E）表示Lys或Arg; （F）表示Ile，Leu或Met; （G）表示Ser或Ala; （H）表示Met或Gln; （I）表示-OH，-Asn-OH，-Asn-Ser-OH，-Asn-Ser-Phe-OH，-Asn-Ser-Phe-Arg-OH或-Asn-Ser-Phe-Arg-Tyr- 哦; 符号“......”代表二硫键; 条件是1）α-hANP，2）α-hANP（7-28）和3）CNP-22被排除在该通式的范围之外。还公开了抑制含有那些肽作为有效成分的血管平滑肌细胞生长的药剂。

8. 发明授权

US06602681B1 Enzymatic production of a C-terminal &agr;-amidated peptide or protein 失效
标题翻译： C末端α-酰胺化肽或蛋白质的酶促产生
公开(公告)号：US06602681B1
公开(公告)日：2003-08-05
申请号：US08845381
申请日：1997-04-25
申请人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
发明人： Kazuhiro Ohsuye , Katsuhiko Kitano , Shoji Tanaka , Hisayuki Matsuo , Kensaku Mizuno
IPC分类号： C12P1206
CPC分类号： C12N9/0071 , C12Y114/17003
摘要： A C-terminal &agr;-amidating enzyme of Xenopus laevis and precursor thereof produced by a recombinant DNA technique; a DNA coding for the enzyme or precursor thereof; a plasmid containing the DNA; a host organism transformed with the plasmid; a process for production of the enzyme using the transformant; and a process for production of a C-terminal &agr;-amidated peptide using the enzyme.
摘要翻译：通过重组DNA技术产生非洲爪蟾的C-末端α-酰胺化酶及其前体; 编码酶或其前体的DNA; 含有DNA的质粒; 用质粒转化的宿主生物; 使用转化体生产酶的方法; 以及使用该酶制备C末端α-酰胺化肽的方法。

9. 发明授权

US09416434B2 High-toughness coating film and sliding member 有权
标题翻译：高韧性涂膜和滑动件
公开(公告)号：US09416434B2
公开(公告)日：2016-08-16
申请号：US14385183
申请日：2012-03-16
申请人： Kiyoyuki Kawai , Shoji Tanaka
发明人： Kiyoyuki Kawai , Shoji Tanaka
IPC分类号： C23C14/06 , C22C27/06 , F16J9/26 , C23C14/32
CPC分类号： C22C27/06 , C23C14/0641 , C23C14/32 , F16J9/26 , Y10T428/31678
摘要： Provided is a high-toughness coating film having excellent wear resistance, in particular, resistance to cracking and peeling. A high-toughness coating film (2) includes a composition containing a mixture of metallic chromium, in which nitrogen is dissolved, and Cr2N. A content of the nitrogen in the high-toughness coating film is 2.0 to 8.5 mass %, and IP, which is expressed by total of each diffraction peak intensity of Cr2N/(total of each diffraction peak intensity of metallic chromium+total of each diffraction peak intensity of Cr2N), is 3 to 40% when 2θ is in a range of 30° to 90°, where θ is an incident angle in X-ray diffraction of the high-toughness coating film.
摘要翻译：提供具有优异的耐磨性，特别是耐开裂和剥离的高韧性涂膜。高韧性涂膜（2）包括含有溶解有氮的金属铬与Cr 2 N的混合物的组合物。高韧性涂膜中的氮含量为2.0〜8.5质量％，IP由Cr 2 N的衍射峰强度的总和（各衍射峰强度的金属铬的总和+各衍射的总和）表示当2θ在30°至90°的范围内时，Cr为高于Cr 2 N的峰强度）为3〜40％，其中θ为高韧性涂膜的X射线衍射中的入射角。

10. 发明申请

US20120271830A1 DATA PROCESSING DEVICE 审中-公开
标题翻译：数据处理设备
公开(公告)号：US20120271830A1
公开(公告)日：2012-10-25
申请号：US13516438
申请日：2009-12-16
申请人： Tomohiro Shiino , Yoko Sano , Tsuyoshi Sempuku , Hideto Miyazaki , Kuniyo Ieda , Takashi Sadahiro , Shoji Tanaka
发明人： Tomohiro Shiino , Yoko Sano , Tsuyoshi Sempuku , Hideto Miyazaki , Kuniyo Ieda , Takashi Sadahiro , Shoji Tanaka
IPC分类号： G06F17/30
CPC分类号： G06F16/64 , G06F16/68
摘要： Disclosed is a data processing device including a data acquisition unit for acquiring data from a medium, an integrated database for integrating the data acquired by the data acquisition unit thereinto, a data analysis determination unit for analyzing the data integrated into the integrated database, a display control unit for creating an image of a side view of and an image of a bottom view of a solid expressing the data integrated into the integrated database on the basis of an analysis result acquired by the data analysis determination unit and the data, and a display unit for displaying the images created by the display control unit.
摘要翻译：公开了一种数据处理装置，包括：用于从介质获取数据的数据获取单元，用于将由数据获取单元获取的数据集成到其中的综合数据库，用于分析集成到集成数据库中的数据的数据分析确定单元，控制单元，用于基于由数据分析确定单元获取的分析结果和数据来创建表示集成到集成数据库中的数据的实体的侧视图和底视图的图像;以及显示器用于显示由显示控制单元创建的图像的单元。

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