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1. 发明授权

US06849736B2 Crystalline forms of valacyclovir hydrochloride 失效
标题翻译：盐酸伐昔洛韦的结晶形式
公开(公告)号：US06849736B2
公开(公告)日：2005-02-01
申请号：US10236729
申请日：2002-09-06
申请人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Yu Etinger , Michael Yuzefovich , Gennady A. Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Yu Etinger , Michael Yuzefovich , Gennady A. Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： C07D473/18 , A61K31/522 , A61P31/12 , A61P43/00 , C07D473/00
CPC分类号： C07D473/00 , A61K31/522 , C07D473/18
摘要： Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
摘要翻译：提供了盐酸伐昔洛韦的新型多晶型物和假多晶型物，以及含有它们的药物组合物。还提供了制备新型多晶型物和假多晶型物的方法，其包括盐酸伐昔洛韦一水合物和盐酸伐昔洛韦二水合物。

2. 发明申请

US20050043329A1 Crystalline forms of valacyclovir hydrochloride 审中-公开
标题翻译：盐酸伐昔洛韦的结晶形式
公开(公告)号：US20050043329A1
公开(公告)日：2005-02-24
申请号：US10791451
申请日：2004-03-01
申请人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： A61K31/522 , C07D473/00 , C07D473/18
CPC分类号： A61K31/522 , C07D473/00 , C07D473/18
摘要： Provided are novel crystalline forms of valacyclovir hydrochloride, in particular a novel hydrated form of valacyclovir hydrochloride having about 6% to about 10% by weight water. Also provided are methods for making the novel crystalline forms.
摘要翻译：提供盐酸伐昔洛韦的新型结晶形式，特别是具有约6％至约10％重量水的新型水合形式的盐酸伐昔洛韦。还提供了制备新型结晶形式的方法。

3. 发明申请

US20050187229A1 Crystalline forms of valacyclovir hydrochloride 审中-公开
公开(公告)号：US20050187229A1
公开(公告)日：2005-08-25
申请号：US11042526
申请日：2005-01-25
申请人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Shlomit Wizel , Judith Aronhime , Valerie Niddam-Hildesheim , Ben-Zion Dolitzky , Marina Etinger , Michael Yuzefovich , Gennady Nisnevich , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： C07D473/18 , A61K31/522 , A61P31/12 , A61P43/00 , C07D473/00 , C07D473/10
CPC分类号： C07D473/00 , A61K31/522 , C07D473/18
摘要： Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.

4. 发明授权

US06849737B2 Synthesis and purification of valacyclovir 失效
标题翻译：伐昔洛韦的合成和纯化
公开(公告)号：US06849737B2
公开(公告)日：2005-02-01
申请号：US10293347
申请日：2002-11-13
申请人： Marina Yu Etinger , Lev M. Yudovich , Michael Yuzefovich , Gennady A. Nisnevich , Ben Zion Dolitzky , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Marina Yu Etinger , Lev M. Yudovich , Michael Yuzefovich , Gennady A. Nisnevich , Ben Zion Dolitzky , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： C07D473/18 , A61K20060101 , A61K31/522 , A61P31/22 , C07B51/00 , C07D473/00
CPC分类号： C07D473/00
摘要： The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
摘要翻译：本发明涉及被保护的伐昔洛韦，N-叔丁氧基羰基-L-缬氨酸2 - [（2-氨基-1,6-二氢-6-氧-9H-嘌呤-9-基）甲氧基]乙酯和制作方法本发明还涉及制备伐昔洛韦的方法，其包括以下步骤：使用偶联剂将选自N-丁氧基羰基缬氨酸和N-甲酰基缬氨酸的胺保护的缬氨酸与阿昔洛韦偶联以形成受保护的伐昔洛韦，并将受保护的伐昔洛韦脱保护伐昔洛韦或其药学上可接受的盐。本发明还涉及纯形式的伐昔洛韦，制备纯伐昔洛韦的方法，以及含有纯伐昔洛韦的组合物。

5. 发明申请

US20050130993A1 Synthesis and purification of valacyclovir 审中-公开
公开(公告)号：US20050130993A1
公开(公告)日：2005-06-16
申请号：US11042538
申请日：2005-01-25
申请人： Marina Etinger , Lev Yudovich , Michael Yuzefovich , Gennady Nisnevich , Ben Dolitzky , Boris Pertsikov , Boris Tishin , Dina Blasberger
发明人： Marina Etinger , Lev Yudovich , Michael Yuzefovich , Gennady Nisnevich , Ben Dolitzky , Boris Pertsikov , Boris Tishin , Dina Blasberger
IPC分类号： C07D473/18 , A61K20060101 , A61K31/522 , A61P31/22 , C07B51/00 , C07D473/00 , C07D473/12
CPC分类号： C07D473/00
摘要： The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.

6. 发明授权

US09049311B2 Automated voice call transcription and data record integration 有权
标题翻译：自动语音通话转录和数据记录集成
公开(公告)号：US09049311B2
公开(公告)日：2015-06-02
申请号：US13969000
申请日：2013-08-16
申请人： Michael Yuzefovich
发明人： Michael Yuzefovich
IPC分类号： H04M1/64 , H04M15/00
CPC分类号： H04M15/41 , H04M15/68
摘要： An application may provide a communication session platform for a first participant to communicate to a second recipient in a service provider capacity. For instance a doctor, lawyer or other service provider may initiate a call application on a their user device and the device may transmit a communication session request to another user device of a patient or client, via the call application. The application may also provide transmitting a consent request to the client user device requesting consent to a term described by a pre-recorded content segment and receiving a confirmation message from the client user device agreeing to the consent request, and bridging the communication session between the client user device and the service provide user device.
摘要翻译：应用可以提供用于第一参与者的通信会话平台以服务提供商能力与第二接收者进行通信。例如，医生，律师或其他服务提供商可以在其用户设备上发起呼叫应用，并且设备可以经由呼叫应用向患者或客户端的另一用户设备发送通信会话请求。该应用还可以向客户端用户设备发送同意请求，请求同意由预先记录的内容段描述的术语，并从客户端用户设备接收同意请求的确认消息，以及桥接通信会话客户端用户设备和服务提供用户设备。

7. 发明申请

US20140050307A1 AUTOMATED VOICE CALL TRANSCRIPTION AND DATA RECORD INTEGRATION 审中-公开
标题翻译：自动语音电话转录和数据记录集成
公开(公告)号：US20140050307A1
公开(公告)日：2014-02-20
申请号：US13969000
申请日：2013-08-16
申请人： Michael Yuzefovich
发明人： Michael Yuzefovich
IPC分类号： H04M15/00
CPC分类号： H04M15/41 , H04M15/68
摘要： An application may provide a communication session platform for a first participant to communicate to a second recipient in a service provider capacity. For instance a doctor, lawyer or other service provider may initiate a call application on a their user device and the device may transmit a communication session request to another user device of a patient or client, via the call application. The application may also provide transmitting a consent request to the client user device requesting consent to a term described by a pre-recorded content segment and receiving a confirmation message from the client user device agreeing to the consent request, and bridging the communication session between the client user device and the service provide user device.
摘要翻译：应用可以提供用于第一参与者的通信会话平台以服务提供商能力与第二接收者进行通信。例如，医生，律师或其他服务提供商可以在其用户设备上发起呼叫应用，并且设备可以经由呼叫应用向患者或客户端的另一用户设备发送通信会话请求。该应用还可以向客户端用户设备发送同意请求，请求同意由预先记录的内容段描述的术语，并从客户端用户设备接收同意请求的确认消息，以及桥接通信会话客户端用户设备和服务提供用户设备。

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