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1. 发明授权

US4169157A Therapeutic preparations for peptic ulcers comprising aliphatic ketone derivative 失效
标题翻译：包含脂肪族酮衍生物的消化性溃疡的治疗剂
公开(公告)号：US4169157A
公开(公告)日：1979-09-25
申请号：US908634
申请日：1978-05-23
申请人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiharu Ohgoh , Manabu Murakami
发明人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiharu Ohgoh , Manabu Murakami
IPC分类号： A61K31/12 , A61P1/04 , C07C45/00 , C07C45/62 , C07C45/67 , C07C45/68 , C07C49/04 , C07C49/203 , C07C67/00 , A61K31/11
CPC分类号： A61K31/12 , C07C45/62 , C07C45/676
摘要： A therapeutic preparation having excellent effect for peptic ulcers with low toxicity which comprises aliphatic ketone derivative of the general formula: ##STR1## wherein represents a saturated or unsaturated bond, R.sub.1 is hydrogen or a lower alkyl group, R.sub.2 is hydrogen atom, a lower alkyl group or a lower alkylcarbonyl group, R.sub.3 is an aliphatic hydrocarbon group of the general formula: ##STR2## WHEREIN L, M AND N ARE 0 OR 1, PROVIDED THAT L+M+N.gtoreq.2; AND A, B, C, D, E AND F ARE HYDROGEN ATOM, OR THEY MAY FORM A BOND OF A--B, C--D OR E--F, PROVIDED THAT IF THE BOND IS A SATURATED BOND, THE A, B, C, D, E AND F REPRESENT ALL HYDROGEN ATOM.
摘要翻译：一种具有低毒性的消化性溃疡具有优异效果的治疗剂，其包含以下通式的脂肪族酮衍生物：其中表示饱和或不饱和键，R 1为氢或低级烷基，R 2为氢原子，低级烷基基团或低级烷基羰基，R 3是以下通式的脂族烃基：其中L，M和N为0或1，提供L + M + N> / = 2; A，B，C，D，E和F是氢原子，或者他们可以形成AB，CD或EF的债券，如果债券是饱和债券，A，B，C，D，E和代表所有氢原子。

2. 发明授权

US4199587A Method of treating hypertension with polyprenyl alcohol ester 失效
标题翻译：用聚丙烯醇酯治疗高血压的方法
公开(公告)号：US4199587A
公开(公告)日：1980-04-22
申请号：US11234
申请日：1979-02-12
申请人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiji Igarashi , Yoshikage Nakajima
发明人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiji Igarashi , Yoshikage Nakajima
IPC分类号： C07C29/40 , C07C29/42 , C07C33/02 , C07C33/048 , C07D213/80 , A61K31/22 , A61K31/235 , A61K31/455
CPC分类号： C07D213/80 , C07C29/40 , C07C29/42 , C07C33/02 , C07C33/048
摘要： This invention relates to a hypertension treating agent comprising an ester of a polyprenyl alcohol of the general formula: ##STR1## wherein n represents an integer of 7-10 and R' is a saturated or unsaturated aliphatic hydrocarbon group of 1-17 carbon atoms; cyclohexyl group; unsubstituted phenyl group or phenyl group substituted with a halogen atom or a lower alkoxy group; (halogen atom-substituted phenoxy)-lower alkyl group; or pyridyl group.
摘要翻译：本发明涉及包含以下通式的聚异戊醇的酯的高血压治疗剂：其中n表示7-10的整数，R'是1-17个碳原子的饱和或不饱和脂族烃基; 环己基未取代的苯基或被卤素原子或低级烷氧基取代的苯基; （卤素原子取代的苯氧基） - 低级烷基; 或吡啶基。

3. 发明授权

US4175139A Hypertension treating agent containing polyprenyl alcohol 失效
标题翻译：含有聚丙烯醇的高血压治疗剂
公开(公告)号：US4175139A
公开(公告)日：1979-11-20
申请号：US931687
申请日：1978-08-07
申请人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiji Igarashi , Yoshikage Nakajima
发明人： Shizumasa Kijima , Isao Yamatsu , Yuichi Inai , Toshiji Igarashi , Yoshikage Nakajima
IPC分类号： C07C29/40 , C07C29/42 , C07C33/02 , C07C33/048 , C07D213/80 , A61K31/45
CPC分类号： C07D213/80 , C07C29/40 , C07C29/42 , C07C33/02 , C07C33/048
摘要： This invention relates to a hypertension treating agent comprising a polyprenyl alcohol or an ester thereof of the general formula: ##STR1## wherein n represents an integer of 7-10 and A represents a group of the general formula: ##STR2## in which a and b each represent hydrogen or they may form a bond, or ##STR3## in which R represents hydrogen or --COR', R' being a saturated or unsaturated aliphatic hydrocarbon group of 1-17 carbon atoms; cyclohexyl group; unsubstituted phenyl group or phenyl group substituted with a halogen atom or a lower alkoxy group; (halogen atom-substituted phenoxy)-lower alkyl group; or pyridyl group.
摘要翻译：本发明涉及包含以下通式的聚丙烯醇或其酯的高血压治疗剂：其中n表示7-10的整数，A表示以下通式的基团：（a）在其中a和b各自表示氢或它们可以形成键，或者其中R表示氢或-COR'，R'是1-17个碳原子的饱和或不饱和脂族烃基的图像（b）环己基未取代的苯基或被卤素原子或低级烷氧基取代的苯基; （卤素原子取代的苯氧基） - 低级烷基; 或吡啶基。

4. 发明授权

US4062879A Process for synthesis of coenzyme Q compounds 失效
标题翻译：合成辅酶Q化合物的方法
公开(公告)号：US4062879A
公开(公告)日：1977-12-13
申请号：US725447
申请日：1976-09-22
申请人： Shizumasa Kijima , Isao Yamatsu , Norio Minami , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatsu , Norio Minami , Yuichi Inai
IPC分类号： C07C45/00 , C07C46/06 , C07C50/28 , C07C67/00 , C07F5/04 , C07C49/73
CPC分类号： C07F5/04 , C07C46/06 , C07C50/28
摘要： A process for synthesizing 2,3-dimethoxy-5-methyl-6-substituted-1,4-benzoquinones having the formula: ##STR1## wherein R is ##STR2## in which n is an integer of 0 to 9, and A and B are hydrogens or taken together form a valence bond,In which 2-methyl-4,5,6-trimethoxyphenol is reacted with boric acid or a reactive derivative thereof to obtain a 2-methyl-4,5,6-trimethoxyphenol ester of boric acid, reacting the resulting ester with an n-prenol or iso-prenol having the formula: ##STR3## wherein R is as defined above, OR A REACTIVE DERIVATIVE OF SAID N- OR ISO-PRENOL, IN THE PRESENCE OF A SILICA-ALUMINA COMPOUND, TO OBTAIN A 2-METHYL-3-SUBSTITUTED-4,5,6-TRIMETHOXYPHENOL ESTER OF BORIC ACID, AND HYDROLYZING THE THUS-OBTAINED ESTER AND TREATING THE RESULTING 2-METHYL-3-SUBSTITUTED 4,5,6-TRIMETHOXYPHENOL HAVING THE FORMULA: ##STR4## wherein R is as defined above, with an oxidant.
摘要翻译：具有下式的合成2,3-二甲氧基-5-甲基-6-取代-1,4-苯醌的方法：其中R是，其中n是0-9的整数，A和 B是氢或一起形成价键，其中2-甲基-4,5,6-三甲氧基苯酚与硼酸或其反应性衍生物反应，得到2-甲基-4,5,6-三甲氧基苯酚酯硼酸，用具有本公式的N-丙烯酸酯或ISO-PRENOL反应所述酯类：其中R如上所定义，或者是在SILICA存在下的反应性衍生物，氧化铝化合物，得到2-甲基-3-取代的4,5,6-三甲氧基苯甲酸酯，并将所得的酯水解并处理结晶的2-甲基-3-取代的4,5,6- 具有公式的三甲苯酚：其中R如上所定义，其中R 1与氧化剂一起形成。

5. 发明授权

US4061660A Process for synthesis of coenzyme Q compounds 失效
标题翻译：合成辅酶Q化合物的方法
公开(公告)号：US4061660A
公开(公告)日：1977-12-06
申请号：US725510
申请日：1976-09-22
申请人： Shizumasa Kijima , Isao Yamatsu , Norio Minami , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatsu , Norio Minami , Yuichi Inai
IPC分类号： C07C45/00 , C07C46/06 , C07C50/28 , C07C67/00 , C07F5/04 , C07C49/73
CPC分类号： C07F5/04 , C07C46/06 , C07C50/28
摘要： A process for the synthesis of 2,3-dimethoxy-5-methyl-6-substituted-1,4-benzoquinones having the formula: ##STR1## wherein R is ##STR2## in which n is an integer of 0 to 9, and A and B are hydrogens or A--B is a direct valence bond between the carbon atoms to which they are attached,Characterized by reacting 2-methyl-4,5,6-trimethoxyphenol with an aryl boronic acid, a lower alkyl boronic acid or an acid anhydride thereof to obtain a 2-methyl-4,5,6-trimethoxyphenol ester of boric acid, reacting the resulting ester with an n-prenol or iso-prenol having the formula: ##STR3## wherein R is as defined above, OR A REACTIVE DERIVATIVE OF SAID N- OR ISO-PRENOL, IN THE PRESENCE OF A SILICA-ALUMINA COMPOUND, TO OBTAIN A 2-METHYL-3-SUBSTITUTED-4,5,6-TRIMETHOXYPHENOL ESTER OF BORIC ACID, AND HYDROLYZING THE THUS-OBTAINED ESTER AND TREATING THE RESULTING 2-METHYL-3-SUBSTITUTED-4,5,6-TRIMETHOXYPHENOL HAVING THE FORMULA: ##STR4## wherein R is as defined above, WITH AN OXIDIZING AGENT.
摘要翻译：一种用于合成具有下式的2,3-二甲氧基-5-甲基-6-取代-1,4-苯醌的方法，其中R是其中n是0-9的整数，以及 A和B是氢原子，或AB是它们所连接的碳原子之间的直接键合键，其特征在于通过使具有亚芳基酸的2-甲基-4,5,6-三甲氧基苯酚，低级碱金属硼酸或酸获得硼酸的2-甲基-4,5,6-三甲氧基苯酚的无水物，用具有下式的N-PRENOL或ISO-PRENOL反应结果的酯：其中R如上所定义，OR A 在二氧化硅铝化合物存在下，得到N-或ISO-PRENOL的反应性衍生物，得到2-甲基-3-取代的4,5,6-三甲氧基苯甲酸酯，并将所得的酯化和处理具有该化合物的结构式2-甲基-3-取代的4,5,6-三甲氧基苯酚：其中R如上定义，其中R是氧化剂。

6. 发明授权

US4039573A Process for preparation of 1,4-benzohydroquinone derivatives 失效
标题翻译： 1,4-苯并氢醌衍生物的制备方法
公开(公告)号：US4039573A
公开(公告)日：1977-08-02
申请号：US621084
申请日：1975-10-09
申请人： Shizumasa Kijima , Isao Yamatsu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatsu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
IPC分类号： C07C69/035 , B01J27/00 , B01J31/00 , C07C41/00 , C07C43/23 , C07C46/06 , C07C50/28 , C07C67/00 , C07C43/22 , C07C69/16
CPC分类号： C07C50/28 , C07C46/06
摘要： 2,3-DIMETHOXY-5-SUBSTITUTED-6-METHYL-1,4-BENZOHYDROQUINONE OR 1-MONOESTER THEREOF IS PREPARED BY REACTING 2,3-DIMETHOXY-6-METHYL-1,4-BENZOHYDROQUINONE OR 1-MONOACYLESTER THEREOF WITH PRENOL, ISOPRENOL OR DERIVATIVES THEREOF IN THE PRESENCE OF AN ACIDIC CATALYST FOR CONDENSATION WHICH IS ADSORBED ON AN ADSORBENT. This obtained compound is easily converted to quinone compounds which produces many clinical effects in medical and pharmaceutical uses.
摘要翻译： 2,3-二甲基-5-取代的6-甲基-1,4-苯并噻唑酮或其单 - 单体是通过用PRENOL反应2,3-二甲基-6-甲基-1,4-苯并噻唑酮或其单 - 单体等制备的。，其中存在酸性催化剂的异丙酚或其衍生物，用于在吸附剂上吸收的凝血剂。所得化合物容易转化为在医疗和药物用途中产生许多临床效果的醌化合物。

7. 发明授权

US5104996A Process for preparing 2,3,5-trimethylbenzoquinone 失效
标题翻译：制备2,3,5-三甲苯硼酸的方法
公开(公告)号：US5104996A
公开(公告)日：1992-04-14
申请号：US192661
申请日：1988-05-11
申请人： Noriyasu Hirose , Kimio Hamamura , Yuichi Inai , Kiiti Ema , Takashi Banba , Shizumasa Kijima
发明人： Noriyasu Hirose , Kimio Hamamura , Yuichi Inai , Kiiti Ema , Takashi Banba , Shizumasa Kijima
IPC分类号： B01J27/122 , C07B61/00 , C07C45/00 , C07C46/08 , C07C50/02 , C07C67/00
CPC分类号： C07C50/02 , C07C46/08
摘要： 2,3,5-trimethyl-benzoquinone is produced by oxidizing 2,3,6-trimethyl-phenol in the presence of a catalyst of cupric chloride and lithium chloride in a solvent mixture of an aromatic hydrocarbon and a lower aliphatic alcohol having 1 to 4 carbon atoms.

8. 发明授权

US4468459A Process for the preparation of polyprenyl ketone derivatives 失效
标题翻译：聚丙烯酮衍生物的制备方法
公开(公告)号：US4468459A
公开(公告)日：1984-08-28
申请号：US446817
申请日：1982-12-03
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Isao Yamatsu , Kouichi Suzuki , Takeshi Suzuki , Toshihiko Nakamura
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Isao Yamatsu , Kouichi Suzuki , Takeshi Suzuki , Toshihiko Nakamura
IPC分类号： A61K31/12 , A61K31/19 , A61P35/00 , C07C45/00 , C07C49/24 , C07C49/258 , C07C51/00 , C07C59/76 , C07C67/00 , C12P7/26 , C12P7/40
CPC分类号： C12R1/365 , C07C49/24 , C07C49/258 , C07C59/76 , C12P7/26
摘要： Longer carbon chain polyprenyl ketone derivatives are prepared by cultivag Nocardia strain FERM-P No. 1609 in the presence of shorter carbon chain polyprenyl ketones.

9. 发明授权

US4456558A Polyprenyl ketone derivatives 失效
标题翻译：聚丙烯基酮衍生物
公开(公告)号：US4456558A
公开(公告)日：1984-06-26
申请号：US312068
申请日：1981-10-16
申请人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Isao Yamatsu , Kouichi Suzuki , Takeshi Suzuki , Toshihiko Nakamura
发明人： Akio Sato , Kenji Nakajima , Yoshimasa Takahara , Shizumasa Kijima , Isao Yamatsu , Kouichi Suzuki , Takeshi Suzuki , Toshihiko Nakamura
IPC分类号： A61K31/12 , A61K31/19 , A61P35/00 , C07C45/00 , C07C49/24 , C07C49/258 , C07C51/00 , C07C59/76 , C07C67/00 , C12P7/26 , C11C1/00
CPC分类号： C12R1/365 , C07C49/24 , C07C49/258 , C07C59/76 , C12P7/26
摘要： This invention relates to novel polyprenyl ketone derivatives having the eral formula: ##STR1## in which n is an integer of 1-5, and R represents a hydroxymethyl, formyl or carboxyl group, and a process for the preparation of the same.
摘要翻译：本发明涉及具有以下通式的新型聚异戊烯酮衍生物：其中n为1-5的整数，R为羟甲基，甲酰基或羧基，及其制备方法。

10. 发明授权

US4163864A Process for preparing 2-methyl-3-prenyl-4,5,6-trimethoxyphenol 失效
标题翻译： 2-甲基-3-异戊烯基-4,5,6-三甲氧基苯酚的制备方法
公开(公告)号：US4163864A
公开(公告)日：1979-08-07
申请号：US878470
申请日：1978-02-16
申请人： Eiichi Morita , Hirosaburo Ejiri , Keizo Takayanagi , Yukio Morita , Yasuhide Tanaka , Shizumasa Kijima , Kimio Hamamura , Isao Yamatsu
发明人： Eiichi Morita , Hirosaburo Ejiri , Keizo Takayanagi , Yukio Morita , Yasuhide Tanaka , Shizumasa Kijima , Kimio Hamamura , Isao Yamatsu
IPC分类号： A61K31/09 , A61P1/16 , A61P9/00 , A61P9/08 , A61P9/10 , B01J27/00 , C07B61/00 , C07C41/00 , C07C41/30 , C07C43/23 , C07C46/06 , C07C50/28 , C07C67/00
CPC分类号： C07C50/28 , C07C41/30 , C07C46/06
摘要： 2-METHYL-3-PRENYL-4,5,6-TRIMETHOXYPHENOL OF THE FORMULA: ##STR1## wherein R represents a group of the formula: ##STR2## WHEREIN N IS AN INTEGER OF 0 TO 9 AND A and B represent hydrogen atom or A--B may form a bond,Is prepared by reacting 6-methyl-2,3,4-trimethoxyphenol with a prenol or isoprenol substituted by the group R as defined above in the presence of a complex catalyst comprising Lewis acid and a silica-alumina compound.
摘要翻译： 2-甲基-3-丙烯基-4,5,6-三甲氧基苯酚：其中R表示下式的基团：其中N为0至9的整数，A和B表示氢原子或AB可以形成键，其是通过在包含路易斯酸和二氧化硅 - 氧化铝的复合催化剂存在下，如上定义的由如上定义的基团R取代的PRENOL或异丙苯反应6-甲基-2,3,4-三羟甲基酚制备的复合。

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