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    • 8. 发明专利
    • Serine protease inhibitor
    • 丝氨酸蛋白酶抑制剂
    • JP2004269382A
    • 2004-09-30
    • JP2003059658
    • 2003-03-06
    • Shiseido Co Ltd株式会社資生堂
    • HIBINO TOSHIHIKOUMISHIO KENICHI
    • A61K8/96A61K8/00A61K8/97A61K36/18A61K36/73A61P17/00A61P17/06A61P17/16A61P43/00A61Q19/00A61K35/78A61K7/00A61K7/48
    • PROBLEM TO BE SOLVED: To provide an external preparation for skin, which has a serine protease activity-inhibiting action and has effects for improving and preventing skin diseases, such as contact dermatitis, psoriasis, pemphigus vulgaris, congenital vulgaris, and skin roughening and chapped skin caused by dryness, cleansers, and the like, at whose diseased sites the changes in the activity of trypsin or plasmin are recognized. SOLUTION: This serine protease activity inhibitor is characterized by comprising one or more plants selected from Potentilla tormentilla Schrk (Rosaceae), Paeonia suffruticosa Andrews (Poeonia montan Sims) (Paeoniaceae), Crataegus cuneata Siebold et Zuccarini (Rosaceae), Eugenia aromatica OK, Myrcia sphaerocarpaDC, Arbutus meniezesii Pursh, and Arctostaphylos patula Greene or the solvent extracts of the plants. An external preparation for chapped skin contains the serine protease activity inhibitor. COPYRIGHT: (C)2004,JPO&NCIPI
    • 要解决的问题:提供具有丝氨酸蛋白酶活性抑制作用的皮肤外用制剂,并且具有改善和预防皮肤疾病如接触性皮炎,牛皮癣,寻常型天疱疮,先天性寻常型和皮肤的作用 由干燥,清洁剂等造成的粗糙和破裂的皮肤,在其病变部位识别胰蛋白酶或纤溶酶活性的变化。 该丝氨酸蛋白酶活性抑制剂的特征在于包含一种或多种选自Potentilla tormentilla Schrk(蔷薇科),Paeonia suffruticosa Andrews(Poeonia montan Sims)(Paeoniaceae),Crataegus cuneata Siebold et Zuccarini(Rosaceae),Eugenia aromatica OK,Myrcia sphaerocarpaDC,杨梅黄单胞菌和Arctostaphylos patula Greene或植物的溶剂提取物。 用于破裂皮肤的外用制剂含有丝氨酸蛋白酶活性抑制剂。 版权所有(C)2004,JPO&NCIPI