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1. 发明授权

US5648496A Process for producing aminonitropyridines 失效
标题翻译：制备氨基硝基吡啶的方法
公开(公告)号：US5648496A
公开(公告)日：1997-07-15
申请号：US623039
申请日：1996-03-28
申请人： Shinzo Seko , Kunihito Miyake
发明人： Shinzo Seko , Kunihito Miyake
IPC分类号： C07D213/73 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/38 , C07D215/42 , C07D215/60 , C07D471/04 , C07D491/04
CPC分类号： C07D213/73 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/38 , C07D215/42 , C07D215/60 , C07D471/04 , C07D491/04
摘要： A process for producing an aminonitropyridine represented by the general formula [1], which comprises reacting a nitropyridine represented by the general formula [2] (wherein X.sup.1, X.sup.2 and X.sup.3 indicate a hydrogen atom, a halogen atom, a nitro group, a cyano group, an aryl group, an aromatic heterocycle or an alkyl group, etc.; Y is an oxygen atom; and n is 0 or 1) with an O-substituted hydroxylamine represented by the general formula [3] (wherein R.sup.4 is a hydrogen atom, an alkyl group, a cycloalkyl group or an aralkyl group; and R.sup.5 is an alkyl group or an aralkyl group) or a salt thereof in the presence of a base and a metal catalyst. ##STR1##
摘要翻译：一种制备由通式[1]表示的氨基硝基吡啶的方法，其包括使由通式[2]表示的硝基吡啶与其反应（其中X 1，X 2和X 3表示氢原子，卤素原子，硝基，氰基基团，芳基，芳族杂环或烷基等; Y是氧原子; n是0或1）与通式[3]表示的O-取代羟胺（其中R 4是氢原子，烷基，环烷基或芳烷基; R 5为烷基或芳烷基）或其盐在碱和金属催化剂存在下反应。

2. 发明申请

US20110054185A1 PROCESS FOR PRODUCING THIAZOLE COMPOUND 有权
标题翻译：生产噻唑化合物的方法
公开(公告)号：US20110054185A1
公开(公告)日：2011-03-03
申请号：US11918004
申请日：2006-04-05
申请人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
发明人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
IPC分类号： C07D277/28
CPC分类号： C07D277/32 , C07D277/28 , C07D417/14
摘要： A process for producing a thiazole compound of the formula (3): wherein X1 is a hydrogen atom or a halogen atom, which comprises reacting a compound of the formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of the formula (2): wherein X1 is as defined above, and reacting the resulting hexahydrotriazine compound with hydroxylamine under acidic conditions. According to this process, the thiazole compound of the formula (3) can be industrially advantageously produced using inexpensive ammonia with suppressing the formation of a byproduct of the formula (4): wherein X1 is as defined above.
摘要翻译：一种制备式（3）的噻唑化合物的方法：其中X 1是氢原子或卤素原子，其包括使式（1）的化合物：其中X 1如上所定义，X 2表示卤素原子与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X1如上定义，并在酸性条件下使所得六氢三嗪化合物与羟胺反应。根据该方法，式（3）的噻唑化合物可以在工业上有利地使用廉价的氨制备，抑制式（4）的副产物的形成：其中X1如上所定义。

3. 发明授权

US07745669B2 Process for production of alcohol compound 有权
标题翻译：醇化合物生产工艺
公开(公告)号：US07745669B2
公开(公告)日：2010-06-29
申请号：US12307223
申请日：2007-07-03
申请人： Toru Sakamoto , Shinzo Seko
发明人： Toru Sakamoto , Shinzo Seko
IPC分类号： C07C33/46 , C07C33/28
CPC分类号： C07C41/16 , C07C319/20 , C07C323/20 , C07C43/23
摘要： A process for the production of an alcohol compound represented by the formula (3): wherein X1, X2, X3, X4, Z, R and n are as defined below, comprising reacting a phenol represented by the formula (1): wherein X1, X2, X3 and X4 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 3 carbon atoms; Z represents an oxygen atom or a sulfur atom; and R represents an alkyl group, an alkenyl group, an alkynyl group, or an aralkyl group which may be substituted by a halogen atom, with a haloalcohol represented by the formula (2): wherein Y represents a chlorine atom or a bromine atom; and n represents an integer of 2 or 3, in a biphase system composed of a water-immiscible organic solvent and an aqueous alkali metal hydroxide solution in the presence of a phase-transfer catalyst.
摘要翻译：一种制备由式（3）表示的醇化合物的方法：其中X1，X2，X3，X4，Z，R和n如下所定义，包括使由式（1）表示的苯酚：其中X1 ，X 2，X 3和X 4独立地表示氢原子，卤素原子或碳原子数1〜3的烷基。 Z表示氧原子或硫原子; 和R表示可以被卤素原子取代的烷基，烯基，炔基或芳烷基与式（2）表示的卤代醇：其中Y表示氯原子或溴原子; 在相转移催化剂存在下，在由水不混溶的有机溶剂和碱金属氢氧化物水溶液组成的双相体系中，n表示2或3的整数。

4. 发明授权

US07439357B2 Process for preparing thiazole by aminomethylation 有权
标题翻译：通过氨基甲基化制备噻唑的方法
公开(公告)号：US07439357B2
公开(公告)日：2008-10-21
申请号：US11629754
申请日：2005-06-10
申请人： Naoyuki Takano , Shinzo Seko , Kazuyuki Tanaka
发明人： Naoyuki Takano , Shinzo Seko , Kazuyuki Tanaka
IPC分类号： C07D251/04 , C07D277/28
CPC分类号： C07D277/28
摘要： A process for preparing a thiazole compound of formula (3): wherein X1 represents a hydrogen atom or a halogen atom comprising reacting a compound of formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of formula (2): wherein X1 is as defined above, and hydrolyzing the compound of formula (2).
摘要翻译：制备式（3）的噻唑化合物的方法：其中X 1表示氢原子或卤素原子，包括使式（1）化合物：其中X 1〜 >如上所定义，X 2表示卤素原子，与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X 1如上定义，并水解式（2）的化合物。

5. 发明授权

US5597940A Process for producing .beta.-nitroenamine 失效
公开(公告)号：US5597940A
公开(公告)日：1997-01-28
申请号：US401928
申请日：1995-03-09
申请人： Shinzo Seko
发明人： Shinzo Seko
IPC分类号： C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C217/60 , C07C239/20 , C07C209/60 , C07C253/30
CPC分类号： C07C217/60 , C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C239/20 , C07C2101/16
摘要： Disclosed is a process for producing .beta.-nitroenamine represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and independently indicate a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group which may be optionally substituted with at least one group selected from the group consisting of a halogen atom, a lower alkoxy group, an aryloxy group, a hydroxyl group or an aryl group, or an aryl group which may be optionally substituted with a halogen atom, a lower alkyl group, a lower alkoxy group, an aryl group, an aryloxy group, a nitro group, a cyano group, an acylamino group, a di-lower alkylamino group, an arylamino group, a hydroxyl group, an arylsulfonyl group, a mercapto group, a lower alkylthio group or an arylthio group, R.sub.1 and R.sub.2 may bond together to form a cycloalkyl or bicycloalkyl and R.sub.3 is a hydrogen atom, a lower alkyl group, a cycloalkyl group or an aralkyl group; and an intermediate for producing the .beta.-nitroenamine.

6. 发明授权

US08304558B2 Method for producing thiazole compound 有权
标题翻译：噻唑化合物的制备方法
公开(公告)号：US08304558B2
公开(公告)日：2012-11-06
申请号：US12087587
申请日：2007-01-11
申请人： Naoyuki Takano , Morio Yamamoto , Shinzo Seko
发明人： Naoyuki Takano , Morio Yamamoto , Shinzo Seko
IPC分类号： C07D277/20
CPC分类号： C07D277/32
摘要： Disclosed is a simple and advantageous method for producing a thiazole compound, which method is suitable for commercial-scale implementation. In this method, a thiazole compound is produced by a reaction between 2-halogeno-allylisothiocyanate and sulfuryl chloride generating a large amount of heat, while suppressing decrease in the yield of the thiazole compound. Specifically disclosed is a method for producing 2-chloro-5-chloromethylthiazole represented by the formula (1): This method is characterized in that sulfuryl chloride is added to and reacted with 2-halogeno-allylisothiocyanate represented by the formula (2): wherein Hal represents chlorine or bromine, while blowing a gas inactive to the reaction into the reaction liquid.
摘要翻译：本发明公开了一种生产噻唑化合物的简便有效的方法，该方法适用于商业规模的实施。在该方法中，噻唑化合物通过2-卤代烯丙基异硫氰酸酯与磺酰氯的反应而产生，产生大量的热量，同时抑制噻唑化合物的产率降低。具体公开的是式（1）表示的2-氯-5-氯甲基噻唑的制造方法：该方法的特征在于，向式（2）表示的2-卤代烯丙基异硫氰酸酯中加入磺酰氯，并与式 Hal代表氯或溴，同时向反应液中吹入无反应的气体。

7. 发明授权

US07977490B2 Process for producing thiazole compound 有权
标题翻译：制备噻唑化合物的方法
公开(公告)号：US07977490B2
公开(公告)日：2011-07-12
申请号：US11918004
申请日：2006-04-05
申请人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
发明人： Kazuyuki Tanaka , Naoyuki Takano , Shinzo Seko
IPC分类号： C07D277/28
CPC分类号： C07D277/32 , C07D277/28 , C07D417/14
摘要： A process for producing a thiazole compound of the formula (3): wherein X1 is a hydrogen atom or a halogen atom, which comprises reacting a compound of the formula (1): wherein X1 is as defined above, and X2 represents a halogen atom, with ammonia and formaldehyde to obtain a hexahydrotriazine compound of the formula (2): wherein X1 is as defined above, and reacting the resulting hexahydrotriazine compound with hydroxylamine under acidic conditions. According to this process, the thiazole compound of the formula (3) can be industrially advantageously produced using inexpensive ammonia with suppressing the formation of a byproduct of the formula (4): wherein X1 is as defined above.
摘要翻译：一种制备式（3）的噻唑化合物的方法：其中X 1是氢原子或卤素原子，其包括使式（1）的化合物：其中X 1如上所定义，X 2表示卤素原子与氨和甲醛反应，得到式（2）的六氢三嗪化合物：其中X1如上定义，并在酸性条件下使所得六氢三嗪化合物与羟胺反应。根据该方法，式（3）的噻唑化合物可以在工业上有利地使用廉价的氨制备，抑制式（4）的副产物的形成：其中X1如上所定义。

8. 发明授权

US07652170B2 Method for producing primary amine compound 有权
标题翻译：伯胺化合物的制备方法
公开(公告)号：US07652170B2
公开(公告)日：2010-01-26
申请号：US12097974
申请日：2006-12-25
申请人： Hiroshi Souda , Naoyuki Takano , Shinzo Seko
发明人： Hiroshi Souda , Naoyuki Takano , Shinzo Seko
IPC分类号： C07C209/08
CPC分类号： C07C209/62 , C07C209/08 , C07C211/21 , C07C211/28
摘要： Disclosed is a method for producing a primary amine compound represented by the formula (2) below, which is characterized in that a halogen compound represented by the formula (1) below, ammonia and formaldehyde are reacted with each other, and then the thus-obtained reaction product is [1] brought into contact with an aqueous solution of an acid or [2] reacted with a hydroxylamine under acidic conditions. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product. (1) (In the formula, R1 and R2 independently represent a hydrogen atom, a C1-C5 alkyl group which may be substituted by a halogen atom or the like, a C1-C5 alkoxy group which may be substituted by a halogen atom, a cyano group, a C2-C11 alkenyl group or a phenyl group or the like; R3 represents a hydrogen atom, a linear or branched C1-C5 alkyl group or a cyano group; and X represents a halogen atom.) (2) (In the formula, R1, R2 and R3 are as defined above.)
摘要翻译：公开了下述式（2）表示的伯胺化合物的制造方法，其特征在于，将下式（1）表示的卤素化合物与氨和甲醛反应，得到的反应产物[1]在酸性条件下与酸的水溶液或[2]与羟胺反应。通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。（1）（式中，R 1和R 2各自独立地表示氢原子，可被卤素原子等取代的C1〜C5烷基，可被卤素原子取代的C1〜C5烷氧基，氰基，C 2 -C 11烯基或苯基等; R 3表示氢原子，直链或支链C 1 -C 5烷基或氰基; X表示卤素原子）（2）（在式中，R 1，R 2和R 3如上所定义。）

9. 发明授权

US06388124B2 Dihalo-compound and process for producing vitamin A derivative 失效
标题翻译：二卤化合物和生产维生素A衍生物的方法
公开(公告)号：US06388124B2
公开(公告)日：2002-05-14
申请号：US09769527
申请日：2001-01-26
申请人： Toshiya Takahashi , Shinzo Seko
发明人： Toshiya Takahashi , Shinzo Seko
IPC分类号： C07C6962
CPC分类号： C07C403/08 , C07B2200/09 , C07C69/63 , C07C403/12 , C07C403/22 , C07C2601/16 , Y02P20/55
摘要： There is disclosed a dihalo-compound of formula (1): wherein X1 and X2 represent different halogen atoms, R represents a hydrogen atom or a protective group for a hydroxyl group, and a process for producing vitamin A derivative via a sulfone derivative of formula (5): wherein Ar represents an optionally substituted aryl group, and R represents the same as defined above.
摘要翻译：公开了式（1）的二卤化合物：其中X1和X2表示不同的卤素原子，R表示氢原子或羟基的保护基，以及通过式（1）的砜衍生物生产维生素A衍生物的方法 5）：其中Ar表示任选取代的芳基，R表示与上述相同的含义。

10. 发明授权

US5639895A Process for producing .beta.-nitroenamine 失效
标题翻译：生产β-硝基苯胺的方法
公开(公告)号：US5639895A
公开(公告)日：1997-06-17
申请号：US713652
申请日：1996-09-13
申请人： Shinzo Seko
发明人： Shinzo Seko
IPC分类号： C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C217/60 , C07C239/20 , C07C307/02 , C07C45/65 , C07C47/21
CPC分类号： C07C217/60 , C07C209/00 , C07C211/24 , C07C211/29 , C07C215/52 , C07C239/20 , C07C2101/16
摘要： Disclosed is a process for producing .beta.-nitroenamine represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and independently indicate a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group which may be optionally substituted with at least one group selected from the group consisting of a halogen atom, a lower alkoxy group, an aryloxy group, a hydroxyl group or an aryl group, or an aryl group which may be optionally substituted with a halogen atom, a lower alkyl group, a lower alkoxy group, an aryl group, an aryloxy group, a nitro group, a cyano group, an acylamino group, a di-lower alkylamino group, an arylamino group, a hydroxyl group, an arylsulfonyl group, a mercapto group, a lower alkylthio group or an arylthio group, R.sub.1 and R.sub.2 may bond together to form a cycloalkyl or bicycloalkyl and R.sub.3 is a hydrogen atom, a lower alkyl group, a cycloalkyl group or an aralkyl group; and an intermediate for producing the .beta.-nitroenamine.
摘要翻译：公开了由式I表示的β-硝基苯胺的制备方法：其中R 1和R 2相同或不同，并且独立地表示氢原子或可以任选被至少一个基团取代的C 1 -C 10烷基选自卤素原子，低级烷氧基，芳氧基，羟基或芳基，或可以被卤素原子任选取代的芳基，低级烷基，低级烷氧基芳基，芳氧基，硝基，氰基，酰氨基，二低级烷基氨基，芳基氨基，羟基，芳基磺酰基，巯基，低级烷硫基或芳硫基，R1和R2可以键合在一起形成环烷基或双环烷基，R3是氢原子，低级烷基，环烷基或芳烷基; 和用于生产β-硝基苯胺的中间体。

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