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1. 发明申请

US20110236996A1 METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 有权
标题翻译：人体体液中CYSTATIN C的测定方法
公开(公告)号：US20110236996A1
公开(公告)日：2011-09-29
申请号：US13132790
申请日：2009-12-03
申请人： Shinya Nakayama , Hiroshi Takahashi , Yasushi Nakamura , Tomo Shimizu
发明人： Shinya Nakayama , Hiroshi Takahashi , Yasushi Nakamura , Tomo Shimizu
IPC分类号： G01N33/68
CPC分类号： G01N33/543 , G01N33/6893 , G01N2333/8139
摘要： There is provided a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity and is easily automatable at low cost as compared with conventional assay methods that use large amounts of polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor agglutinability.Disclosed is an assay method specific to cystatin C in a human body fluid, which is a particle-enhanced immunoassay method utilizes a combination of antibody-coated particles in which some insoluble carrier particles are coated with anti-human cystatin C monoclonal antibodies of one type which have high affinity and in which some other insoluble carrier particles are coated with anti-human cystatin C monoclonal antibodies of one type which recognize an epitope different from that of the monoclonal antibody of the first-mentioned type and which have relatively low affinity, wherein the binding amount of the anti-human cystatin C monoclonal antibodies relative to the total weight of the particles being coated with the corresponding antibodies is less than 5% by weight.
摘要翻译：与使用大量具有低特异性的多克隆抗体或具有高特异性的单克隆抗体的常规测定方法相比，提供了人体液中半胱氨酸蛋白酶抑制剂C的微粒增强免疫测定方法，其具有更高的特异性并且可以以低成本容易地自动化特异性但具有差的凝集性。本发明公开了一种人体液中半胱氨酸蛋白酶抑制剂C特异性检测方法，其是使用抗体包被的颗粒的组合，其中一些不溶性载体颗粒被一种类型的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体包被，其具有高亲和力，并且其中一些其它不溶性载体颗粒被一种类型的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体包被，所述抗人半胱氨酸蛋白酶抑制剂C单克隆抗体识别与第一类型的单克隆抗体的表位不同并具有相对低亲和力的表位，其中抗人半胱氨酸蛋白酶抑制剂C单克隆抗体相对于被相应抗体包被的颗粒的总重量的结合量小于5重量％。

2. 发明授权

US08802446B2 Method for measuring cystatin C in human body fluid 有权
标题翻译：人体液体中半胱氨酸蛋白酶抑制剂C的测定方法
公开(公告)号：US08802446B2
公开(公告)日：2014-08-12
申请号：US13132790
申请日：2009-12-03
申请人： Shinya Nakayama , Hiroshi Takahashi , Yasushi Nakamura , Tomo Shimizu
发明人： Shinya Nakayama , Hiroshi Takahashi , Yasushi Nakamura , Tomo Shimizu
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N33/6893 , G01N2333/8139
摘要： Provided is a method and reagent for measuring cystatin C in a human body fluid, by contacting a human body fluid with (a) first insoluble carrier particles coated with a first anti-human cystatin C monoclonal antibody and (b) second insoluble carrier particles coated with a second anti-human cystatin C monoclonal antibody, where the first anti-human cystatin C monoclonal antibody has an affinity for cystatin C that is higher than the second anti-human cystatin C monoclonal antibody, the second anti-human cystatin C monoclonal antibody recognizes an epitope of cystatin C that is different from the epitope recognized by the first anti-human cystatin C monoclonal antibody, and the first and second insoluble carrier particles are coated with from 1% to less than 4% by weight of the anti-human cystatin C monoclonal antibodies.
摘要翻译：本发明提供一种通过使人体液与（a）涂覆有第一抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的第一不溶性载体颗粒和（b）涂覆有第一抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的第二不溶性载体颗粒接触来测量人体液体中的半胱氨酸蛋白酶抑制剂C的方法和试剂使用第二抗人半胱氨酸蛋白酶抑制剂C单克隆抗体，其中第一抗人半胱氨酸蛋白酶抑制剂C单克隆抗体对半胱氨酸蛋白酶抑制剂C具有高于第二抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的亲和力，第二抗人半胱氨酸蛋白酶抑制剂C单克隆抗体识别与由第一抗人半胱氨酸蛋白酶抑制剂C单克隆抗体识别的表位不同的半胱氨酸蛋白酶抑制剂C的表位，并且第一和第二不溶性载体颗粒涂覆有1％至小于4重量％的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体。

3. 发明申请

US20140080143A1 PSA ASSAY AND REAGENT THEREFOR 审中-公开
标题翻译： PSA测定及其试剂
公开(公告)号：US20140080143A1
公开(公告)日：2014-03-20
申请号：US14008441
申请日：2012-03-28
申请人： Yuki Takahashi , Tomo Shimizu , Yasushi Nakamura , Shinya Nakayama , Shinichiro Kitahara
发明人： Yuki Takahashi , Tomo Shimizu , Yasushi Nakamura , Shinya Nakayama , Shinichiro Kitahara
IPC分类号： G01N33/573
CPC分类号： G01N33/543 , G01N33/573 , G01N33/57434 , G01N33/577 , G01N2333/96433
摘要： Provided is a method for the simple and highly accurate assay of PSA by a one-step reaction that does not use carriers having different average grain sizes. Also provided is a reagent therefor. The PSA assay method comprises sensitizing insoluble carriers having the same average grain size within a range of greater than 0.20 μm but 0.40 μm or less using two types of anti-PSA monoclonal antibodies having different epitopes that are anti-PSA monoclonal antibodies that will react with both free PSA and PSA-ACT, which is a complex of free PSA and α1-antichymotrypsin, and bringing the carriers into contact with a sample in the presence of an aggregation promoter.
摘要翻译：提供了通过不使用具有不同平均粒径的载体的一步反应简单且高度精确地测定PSA的方法。还提供了一种试剂。 PSA测定方法包括使用具有不同表位的两种类型的抗PSA单克隆抗体对具有相同平均粒径的不溶性载体敏感，所述抗原单克隆抗体是抗PSA单克隆抗体，其将与游离PSA和PSA-ACT两者均为游离PSA和α1-抗胰凝乳蛋白酶的复合物，并使载体在聚集促进剂存在下与样品接触。

4. 发明申请

US20110165701A1 MONOCLONAL ANTIBODY AND IMMUNOASSAY USING THE SAME 审中-公开
标题翻译：使用单克隆抗体和免疫球蛋白
公开(公告)号：US20110165701A1
公开(公告)日：2011-07-07
申请号：US13061849
申请日：2009-09-03
申请人： Yuki Takahashi , Tomo Shimizu , Hiroshi Takahashi , Yasushi Nakamura
发明人： Yuki Takahashi , Tomo Shimizu , Hiroshi Takahashi , Yasushi Nakamura
IPC分类号： G01N33/53 , C07K16/42 , C07K16/00 , C12N5/16 , C12P21/08
CPC分类号： G01N33/545 , C07K16/4283 , G01N33/541 , G01N33/54393 , G01N33/6854
摘要： An objective of the present invention is to provide an anti-human IgM monoclonal antibody that is capable of reacting specifically with human IgM and inducing immunoagglutination based on an antigen-antibody reaction with human IgM in solution, and an immunoassay using the said monoclonal antibody. Another objective of the present invention is to provide an agent for suppressing non-specific reactions caused by human IgM that could not be prevented by conventional methods, and an immunoassay in which non-specific reactions caused by human IgM are suppressed.By selecting a monoclonal antibody that reacts with human IgM on the basis of evaluation of reactivity with human IgM in solution, a novel monoclonal antibody capable of agglutinating human IgM by itself and performing a practical immunoagglutination assay has been obtained, and the objectives above have been thus achieved.
摘要翻译：本发明的目的是提供能够与人IgM特异性反应并基于与溶液中的人IgM的抗原抗体反应诱导免疫凝集的抗人IgM单克隆抗体，以及使用所述单克隆抗体的免疫测定。本发明的另一个目的是提供一种用于抑制由人IgM引起的非特异性反应的试剂，其不能通过常规方法进行抑制，并且抑制由人IgM引起的非特异性反应的免疫测定。通过选择基于与溶液中的人IgM的反应性的评价与人IgM反应的单克隆抗体，获得能够自身凝集人IgM并进行实际的免疫凝集试验的新型单克隆抗体，并且已经得到上述目的从而实现。

5. 发明申请

US20130004976A1 HUMAN INSULIN ASSAY AND ASSAY REAGENT 审中-公开
标题翻译：人胰岛素测定和测定试剂
公开(公告)号：US20130004976A1
公开(公告)日：2013-01-03
申请号：US13518788
申请日：2010-12-27
申请人： Tomo Shimizu , Junichi Kondou , Yasushi Nakamura , Mitsuaki Yamamoto
发明人： Tomo Shimizu , Junichi Kondou , Yasushi Nakamura , Mitsuaki Yamamoto
IPC分类号： G01N33/566 , G01N30/00 , C07K16/26 , G01N33/577
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/33 , C07K2317/34 , G01N2333/62
摘要： A problem of the present invention is to provide an antibody specific to human insulin and an assay and an assay reagent using the antibody capable of accurately assaying human insulin without being affected by porcine insulin. The present invention provides an assay and an assay reagent capable of specifically assaying human insulin by combining a monoclonal antibody specifically reactive with human insulin and nonreactive with porcine insulin and a different anti-human insulin antibody.
摘要翻译：本发明的一个问题是提供一种对人胰岛素有特异性的抗体以及使用能够精确测定人胰岛素而不受猪胰岛素影响的抗体的测定法和测定试剂。本发明提供能够通过将与胰岛素特异性反应的单克隆抗体与猪胰岛素和不同抗人胰岛素抗体反应的单克隆抗体结合来特异性测定人胰岛素的测定法和测定试剂。

6. 发明申请

US20110195438A1 INSULIN ASSAY 有权
标题翻译：胰岛素测定
公开(公告)号：US20110195438A1
公开(公告)日：2011-08-11
申请号：US13122930
申请日：2010-07-21
申请人： Junichi Kondou , Tomo Shimizu , Mitsuaki Yamamoto , Yasushi Nakamura
发明人： Junichi Kondou , Tomo Shimizu , Mitsuaki Yamamoto , Yasushi Nakamura
IPC分类号： G01N33/74 , C07K16/42
CPC分类号： G01N33/74 , C07K16/26 , G01N33/53 , G01N2333/62
摘要： The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.
摘要翻译：本发明提供一种胰岛素特异性测定法和能够使用具有与结合抗胰岛素抗体结合的胰岛素反应的性质而不与未与抗胰岛素抗体结合的胰岛素反应的抗体敏感且特异性地测定胰岛素的测定试剂，而不受胰岛素原和胰岛素类似物的影响。

7. 发明授权

US09476891B2 Insulin assay 有权
标题翻译：胰岛素分析
公开(公告)号：US09476891B2
公开(公告)日：2016-10-25
申请号：US13122930
申请日：2010-07-21
申请人： Junichi Kondou , Tomo Shimizu , Mitsuaki Yamamoto , Yasushi Nakamura
发明人： Junichi Kondou , Tomo Shimizu , Mitsuaki Yamamoto , Yasushi Nakamura
IPC分类号： G01N33/74 , C07K16/26 , G01N33/53
CPC分类号： G01N33/74 , C07K16/26 , G01N33/53 , G01N2333/62
摘要： The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.
摘要翻译：本发明提供一种胰岛素特异性测定法和能够使用具有与结合抗胰岛素抗体结合的胰岛素反应的性质而不与未与抗胰岛素抗体结合的胰岛素反应的抗体敏感且特异性地测定胰岛素的测定试剂，而不受胰岛素原和胰岛素类似物的影响。

8. 发明授权

US08436878B2 Image forming apparatus 有权
标题翻译：图像形成装置
公开(公告)号：US08436878B2
公开(公告)日：2013-05-07
申请号：US12702488
申请日：2010-02-09
申请人： Kazuhisa Yoneda , Hiroyuki Nagao , Hidenobu Mandai , Kazuhiro Matsuyama , Yasushi Nakamura , Yoshiya Kinoshita
发明人： Kazuhisa Yoneda , Hiroyuki Nagao , Hidenobu Mandai , Kazuhiro Matsuyama , Yasushi Nakamura , Yoshiya Kinoshita
IPC分类号： B41J2/415 , A62B7/08
CPC分类号： G03G21/206 , A61L9/22 , A61L2209/11 , G03G2221/1645
摘要： An image forming apparatus in one embodiment of the present invention is an image forming apparatus that includes a main body that performs processing to form an image on a recording paper, the image forming apparatus including, an ion generating section that is external to the main body, generates ions and emits those ions to the outside.
摘要翻译：本发明的一个实施例中的图像形成装置是一种图像形成装置，其包括执行在记录纸上形成图像的处理的主体，该图像形成装置包括：离子产生部，其在主体外部，产生离子并将这些离子发射到外部。

9. 发明授权

US07853192B2 Paper discharge structure and image forming apparatus using the same 有权
标题翻译：排纸结构及使用其的成像装置
公开(公告)号：US07853192B2
公开(公告)日：2010-12-14
申请号：US11785207
申请日：2007-04-16
申请人： Hiroyuki Nagao , Takashi Kikutani , Kazuhisa Yoneda , Yasushi Nakamura , Toshikazu Kitaura , Hidenobu Mandai
发明人： Hiroyuki Nagao , Takashi Kikutani , Kazuhisa Yoneda , Yasushi Nakamura , Toshikazu Kitaura , Hidenobu Mandai
IPC分类号： B65H29/22 , B65H31/02
CPC分类号： G03G15/6552
摘要： A paper discharge structure includes: a paper discharge roller for discharging paper with an image from a discharge port; a paper output tray located below the paper discharge roller for holding sheets of paper P discharged by the paper discharge roller; and a side-wall surface formed extending from the vicinity of the paper discharge roller to the vicinity of the paper output tray, is constructed such that the side-wall surface is formed with an inclined portion that extends from the lower part of the paper discharge roller to the vicinity of the paper output tray and is inclined with respect to the vertical direction.
摘要翻译：排纸结构包括：用于从排出口排出具有图像的纸张的排纸辊; 位于排纸辊下方的用于保持由排纸辊排出的纸张P的出纸盘; 并且从排纸辊附近形成到纸出纸盘附近的侧壁表面被构造成使得侧壁表面形成有从纸排出口的下部延伸的倾斜部分辊到出纸托盘附近并相对于垂直方向倾斜。

10. 发明申请

US20090291261A1 Glass Substrate Processing Method and Glass Component 有权
标题翻译：玻璃基板加工方法和玻璃成分
公开(公告)号：US20090291261A1
公开(公告)日：2009-11-26
申请号：US12091168
申请日：2006-11-22
申请人： Takeshi Hidaka , Yasushi Nakamura , Tomonori Imamura , Shinya Okamoto , Hirotaka Koyo , Yasuhiro Saito , Keiji Tsunetomo
发明人： Takeshi Hidaka , Yasushi Nakamura , Tomonori Imamura , Shinya Okamoto , Hirotaka Koyo , Yasuhiro Saito , Keiji Tsunetomo
IPC分类号： B32B3/02 , B44C1/22
CPC分类号： B28D1/00 , B23K26/0006 , B23K26/0624 , B23K26/355 , B23K26/40 , B23K2103/16 , B23K2103/50 , C03C15/00 , C03C23/0025 , C03C2217/77 , Y10T428/24479
摘要： A glass substrate processing method includes irradiating laser light L onto a glass substrate 1 such that the laser light L is focused within the glass substrate 1, thereby forming a high density area 3 that has a higher density than areas where the laser light L is not irradiated around the portion where the laser light L is focused; and performing chemical etching on the glass substrate 1 using an etching solution such that at least a portion of the high density area is allowed to remain, thereby forming a projection 2 on a surface 1a of the glass substrate 1.
摘要翻译：玻璃基板处理方法包括将激光L照射到玻璃基板1上，使得激光L聚焦在玻璃基板1内，从而形成具有比激光L不比区域高的密度的高密度区域3 照射在激光L聚焦的部分周围; 并使用蚀刻溶液对玻璃基板1进行化学蚀刻，使得能够保留高密度区域的至少一部分，从而在玻璃基板1的表面1a上形成突起2。

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