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1. 发明授权

US08476260B2 Antitumor agent 有权
标题翻译：抗肿瘤剂
公开(公告)号：US08476260B2
公开(公告)日：2013-07-02
申请号：US12810564
申请日：2008-12-26
申请人： Shinji Miyoshi , Shinsuke Ooike , Kazunori Iwata , Hidemasa Hikawa , Kunio Sugahara
发明人： Shinji Miyoshi , Shinsuke Ooike , Kazunori Iwata , Hidemasa Hikawa , Kunio Sugahara
IPC分类号： A61P35/00 , A61P43/00 , A61K31/55 , A61K45/00 , C07D495/14
CPC分类号： A61K31/551 , C07D495/14
摘要： The present invention relates to a novel antitumor agent containing a compound that inhibits binding between acetylated histone and a bromodomain-containing protein, preferably a thienotriazolodiazepine compound represented by the following formula (I) wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof or a hydrate or solvate as an active ingredient.
摘要翻译：本发明涉及含有抑制乙酰化组蛋白与含溴结构域的蛋白质之间的结合的化合物的新型抗肿瘤剂，优选下述式（I）表示的噻吩并三氮唑并氮化合物，其中各符号如说明书中所定义，或药学上可接受的盐或水合物或溶剂化物作为活性成分。

2. 发明申请

US20100286127A1 ANTITUMOR AGENT 有权
标题翻译：抗菌剂
公开(公告)号：US20100286127A1
公开(公告)日：2010-11-11
申请号：US12810564
申请日：2008-12-26
申请人： Shinji Miyoshi , Shinsuke Ooike , Kazunori Iwata , Hidemasa Hikawa , Kunio Sugahara
发明人： Shinji Miyoshi , Shinsuke Ooike , Kazunori Iwata , Hidemasa Hikawa , Kunio Sugahara
IPC分类号： A61K31/551 , C07D495/14 , A61P35/00
CPC分类号： A61K31/551 , C07D495/14
摘要： The present invention relates to a novel antitumor agent containing a compound that inhibits binding between acetylated histone and a bromodomain-containing protein, preferably a thienotriazolodiazepine compound represented by the following formula (I) wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof or a hydrate or solvate as an active ingredient.
摘要翻译：本发明涉及含有抑制乙酰化组蛋白与含溴结构域的蛋白质之间的结合的化合物的新型抗肿瘤剂，优选下述式（I）表示的噻吩并三氮唑并氮化合物，其中各符号如说明书中所定义，或药学上可接受的盐或水合物或溶剂化物作为活性成分。

3. 发明授权

US5951787A Method of forming oxide-passivated film, ferrite system stainless steel, fluid feed system and fluid contact component 失效
标题翻译：形成氧化物钝化膜，铁氧体系不锈钢，流体进料系统和流体接触部件的方法
公开(公告)号：US5951787A
公开(公告)日：1999-09-14
申请号：US666312
申请日：1996-10-15
申请人： Tadahiro Ohmi , Shinji Miyoshi
发明人： Tadahiro Ohmi , Shinji Miyoshi
IPC分类号： C23C16/02 , C21D1/76 , C22C38/00 , C22C38/40 , C23C8/02 , C23C8/18 , C23C16/40 , C23C8/04
CPC分类号： C23C8/02 , C23C8/18
摘要： A passive film forming method enabling formation of a passivated-oxide film having a layer made of chromium oxide in its outermost surface without conducting composite electric polishing. Also disclosed is a ultra-high purity fluid feed system, processing apparatus, and a fluid contracting component, each of which is free of metal contamination and is excellent in the gas discharge characteristics, non-catalytic characteristics and corrosion resistance. The surface of the ferrite-based stainless steel containing Mn by not more than 0.03 wt %, Cu by not more than 0.05 wt %, C by not more than 0.01 wt %, and Al by not more 0.01 wt % is electrolytically polished, then moisture is removed from the surface of the stainless steel by making the steel in an inert gas, then a passivated oxide film having a layer made of non-crystalline chromium oxide is formed on the outermost surface thereof by executing heat treatment in a temperature range of 300.degree. C. to 600.degree. C. in a mixture gas atmosphere of inert gas and 500 ppb to 2% H.sub.2 O gas.
摘要翻译： PCT No.PCT / JP94 / 02255 Sec。 371日期1996年10月15日 102（e）日期1996年10月15日PCT 1994年12月27日PCT PCT。出版物WO95 / 18247 日期：1995年7月6日在无需进行复合电抛光的情况下，能够在其最表面形成具有由氧化铬构成的层的钝化氧化膜的钝化膜形成方法。还公开了一种超高纯度流体供给系统，处理装置和流体收缩部件，其各自没有金属污染，并且气体排放特性，非催化特性和耐腐蚀性优异。电解抛光含Mn不大于0.03重量％，不大于0.05重量％，不大于0.01重量％，不超过0.01重量％的Al和不超过0.01重量％的铁素体不锈钢的表面，然后通过将钢制成惰性气体而从不锈钢的表面除去水分，然后通过在其最外表面上形成具有由非结晶性氧化铬制成的层的钝化氧化物膜，在其最外表面上进行热处理，在惰性气体和500ppb至2％H 2 O气体的混合气体气氛中在300℃至600℃。

4. 发明授权

US5305602A Device for catching and removing particulates for a diesel engine 失效
标题翻译：用于捕获和除去柴油发动机的颗粒物的装置
公开(公告)号：US5305602A
公开(公告)日：1994-04-26
申请号：US924882
申请日：1992-08-06
申请人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
发明人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
IPC分类号： F01N3/02 , F01N3/023 , F01N3/027 , F01N3/032 , F01N9/00 , F02B3/06 , F01N3/10
CPC分类号： F01N3/0233 , F01N3/023 , F01N3/027 , F01N3/032 , F01N9/002 , F01N2900/0421 , F02B3/06 , Y02T10/47 , Y10S55/30
摘要： A device for removing for particulates a diesel engine having a filter arranged in the flow of the exhaust gas, a heater for heating the filter, and an air pump or obtaining a flow of air for incineration of the particulates trapped by the filter when it is clogged. The amount of the air for the incineration of the filter is calculated in accordance with the amount of the particulates remaining in the filter at the peripheral zone thereof just after the preceding incineration cycle.
摘要翻译：一种用于除去颗粒物的装置，具有布置在废气流中的过滤器的柴油发动机，用于加热过滤器的加热器和空气泵，或者当空气泵被吸收时，获得用于焚化被过滤器捕获的微粒的空气流堵塞用于焚烧过滤器的空气量根据刚刚在焚化循环之后的周边区域处的过滤器中残留的微粒的量来计算。

5. 发明授权

US09371964B2 High pressure gas tank and manufacturing method of high pressure gas tank 有权
标题翻译：高压气罐及高压气罐制造方法
公开(公告)号：US09371964B2
公开(公告)日：2016-06-21
申请号：US14128840
申请日：2012-06-28
申请人： Shinji Miyoshi , Kentaroh Hioki
发明人： Shinji Miyoshi , Kentaroh Hioki
IPC分类号： F17C1/16 , F17C1/06 , B29C70/32 , B29C70/08
CPC分类号： F17C1/16 , B29C70/086 , B29C70/32 , F17C1/06 , F17C2203/0604 , F17C2203/0607 , F17C2203/0624 , F17C2203/066 , F17C2203/0663 , F17C2209/2154
摘要： This high pressure gas tank is a tank in which a fiber-reinforced resin layer is formed around an outer periphery of a tank liner by fibers impregnated with thermosetting resin being wound around the outer periphery of the tank liner. The fiber-reinforced resin layer includes an inside layer formed on the tank liner side, and an outside layer formed on an outer periphery of the inside layer. The inside layer is formed as a dense layer, while the outside layer is formed as a layer that is less dense than the inside layer by forming a larger number of airspaces in the outside layer than there are in the inside layer.
摘要翻译：该高压气罐是槽，其中纤维强化树脂层通过卷绕在罐衬套的外周上的热固性树脂浸渍的纤维强化树脂层围绕罐衬套的外周形成。纤维增强树脂层包括形成在罐衬里侧的内层和形成在内层的外周上的外层。内层形成为致密层，而通过在外层中形成比内层更外层的空气层，外层形成为比内层更不致密的层。

6. 发明授权

US5144798A Regenerative particulate trap system for emission control 失效
标题翻译：用于排放控制的再生颗粒捕集系统
公开(公告)号：US5144798A
公开(公告)日：1992-09-08
申请号：US792200
申请日：1991-11-13
申请人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
发明人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
IPC分类号： F01N3/02 , F01N3/027
CPC分类号： F01N3/027 , Y10S55/30
摘要： A particulate trap filter is provided with an electric heater for burning out particulates accumulated therein. The electric heater is provided as a wiring pattern such that a higher power efficiency is provided for the portion corresponding to the portion of the filter located away from the center of the filter and a relatively lower power efficiency is provided for the portion corresponding to the central portion of the filter.

7. 发明授权

US5597109A Welding method for forming chromium oxide passivated film at welded portion, welding apparatus, and process apparatus 失效
标题翻译：在焊接部分形成氧化铬钝化膜的焊接方法，焊接装置和处理装置
公开(公告)号：US5597109A
公开(公告)日：1997-01-28
申请号：US296542
申请日：1994-08-26
申请人： Tadahiro Ohmi , Shinji Miyoshi , Yasumitsu Mizuguchi
发明人： Tadahiro Ohmi , Shinji Miyoshi , Yasumitsu Mizuguchi
IPC分类号： B23K9/035 , B23K9/16 , B23K28/00 , B23K35/38 , C23C8/10 , C23C22/00 , B23K31/02
CPC分类号： B23K9/164 , B23K35/383 , C23C8/10 , B23K2201/06
摘要： The invention has as an object thereof to provide a welding method which is capable of forming an oxide passivated film, which is corrosion resistant, non-catalytic, and has an extremely small amount of released gasses, chiefly on the welded portion or in the vicinity thereof during the welding process. During the welding process, a gas in which 800 ppm.about.2.5% of moisture is contained in an inert gas is caused to flow, and a passivated film having chromium oxide as a chief component thereof is formed on the surface of the welded portion. The welding method comprises a welding process and a passivation process; in the passivation process, a gas in which 1000 ppm.about.2.5% of moisture is contained in an inert gas is employed. The apparatus is provided with a system for generating moisture, a system for supplying an inert gas or a mixed gas in which hydrogen is added to an inert gas as a back shield gas, a system for supplying a back shield gas comprising an inert gas containing moisture, and a mechanism for supplying these gasses to the portion to be welded via switching of both systems.
摘要翻译：本发明的目的在于提供一种焊接方法，其能够形成耐腐蚀，不催化，并且具有极少量的释放气体的氧化物钝化膜，主要在焊接部分或附近在焊接过程中。在焊接过程中，在惰性气体中含有800ppm的水分含量为2.5％的气体流动，在焊接部分的表面上形成具有氧化铬作为主要成分的钝化膜。焊接方法包括焊接工艺和钝化工艺; 在钝化过程中，采用在惰性气体中含有1000ppm的差异2.5％的气体的气体。该装置设置有用于产生水分的系统，用于供应惰性气体的系统或其中将氢气作为背面保护气体添加到惰性气体中的混合气体的系统，用于提供包含含有湿气，以及通过两个系统的切换将这些气体供给到待焊接部分的机构。

8. 发明授权

US5458673A Exhaust gas particulate purifying process for internal combustion engine 失效
标题翻译：内燃机废气颗粒净化工艺
公开(公告)号：US5458673A
公开(公告)日：1995-10-17
申请号：US157474
申请日：1993-11-26
申请人： Akikazu Kojima , Mitsuo Inagaki , Shinji Miyoshi , Fumiaki Arikawa , Takayuki Takeuchi
发明人： Akikazu Kojima , Mitsuo Inagaki , Shinji Miyoshi , Fumiaki Arikawa , Takayuki Takeuchi
IPC分类号： B01D46/24 , B01D46/48 , F01N3/023 , F01N3/027 , F01N3/031 , F01N3/32 , F01N9/00 , F01N13/04 , B01D29/66
CPC分类号： F01N9/002 , F01N13/011 , F01N3/0233 , F01N3/027 , F01N3/031 , F01N2240/36 , F01N3/32 , Y02T10/47 , Y10S55/30
摘要： For regenerating an exhaust gas particulate collecting filter, there is provided an exhaust gas particulate purifying process in which damage to the filter caused by a thermal action can be prevented and further electric power can be saved when an electric current supply to an electric heater attached to the filter is controlled. In the filter container (4), an electric heater (21) is provided on an end surface of the filter on an upstream side with respect to a regenerating gas flow, or provided at a position close to the end surface. Also, a temperature sensor (22) for measuring a temperature of the filter is provided inside the filter or at a position close to an end surface of the filter opposite to the aforementioned end surface. Further, there is provided a first controller (13) for determining an appropriate current amount to be supplied to the electric heater and also for determined an electric power reducing pattern used in the case of stoppage of power supply, in accordance With the filter preheating temperature immediately before the start of regeneration detected by the temperature sensor (22). A second controller ( 17) controls a current amount supplied to the electric heater (21) in accordance with a command given by the first controller (13).
摘要翻译：为了再生废气微粒收集过滤器，提供了一种废气微粒净化过程，其中可以防止由热作用引起的过滤器损坏，并且当向连接到过滤器被控制。在过滤器容器（4）中，电动加热器（21）相对于再生气体流在上游侧设置在过滤器的端面上，或设置在靠近端面的位置。此外，用于测量过滤器的温度的温度传感器（22）设置在过滤器的内部或靠近与前述端面相反的过滤器端面的位置处。此外，提供了一种第一控制器（13），用于根据过滤器预热温度来确定要供应到电加热器的适当电流量，并且还确定在停止供电的情况下使用的减电模式在由温度传感器（22）检测到的再生开始之前。第二控制器（17）根据第一控制器（13）给出的命令来控制提供给电加热器（21）的电流量。

9. 发明授权

US5171335A Filter for collecting fine particles in exhaust gas 失效
标题翻译：用于在排气中收集精细颗粒的过滤器
公开(公告)号：US5171335A
公开(公告)日：1992-12-15
申请号：US773527
申请日：1991-10-09
申请人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
发明人： Akikazu Kojima , Shinji Miyoshi , Mitsuo Inagaki
IPC分类号： F01N3/02 , F01N3/021 , F01N3/022 , F01N3/025 , F01N3/027
CPC分类号： F01N3/025 , F01N3/0211 , F01N3/0222 , F01N3/027 , F01N2330/06 , Y10S55/10 , Y10S55/30
摘要： A filter for collecting fine particles in exhaust gas is equipped with: a multitude of cells bordering on each other and allowing exhaust gas to flow therethrough; cell partitions separating these multitude of cells from each other and having a multitude of pores through which the multitude of cells communicate with each other; and stop sections provided in the end portions of the multitude of cells so as to cause the exhaust gas introduced into each of the cells at one end thereof to flow into the adjacent cells through the pores of the cell partitions and be discharged at the other end of the cell. These stop sections are so arranged that the amount of exhaust gas entering the cells at the central region of one of the end portions is smaller than that at the peripheral region of the same. With this construction, the amount of fine particles accumulated in the peripheral filter region is relatively large, and that in the central filter region is relatively small. Thus, an increase in temperature occurs in the peripheral filter region, whereas it is suppressed in the central filter region, so that the difference in temperature between the two regions is kept at a low level, thereby effectively protecting the filter from damage.

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