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1. 发明授权

US5939404A Cancer metastasis inhibitor containing a streptococcus agalactiae Ia type or Ib type surface polysaccharide as a main ingredient 失效
标题翻译：含有无乳链球菌Ia型或Ib型表面多糖作为主要成分的癌症转移抑制剂
公开(公告)号：US5939404A
公开(公告)日：1999-08-17
申请号：US894461
申请日：1997-08-19
申请人： Shinji Iijima , Katsuhide Miyake , Shin Yamamoto , Yasuko Yoshida , Mitsuo Kawase
发明人： Shinji Iijima , Katsuhide Miyake , Shin Yamamoto , Yasuko Yoshida , Mitsuo Kawase
IPC分类号： A61K31/715 , A61K35/74 , C12P19/04 , A61K39/09 , C08B37/00
CPC分类号： C12P19/04 , A61K31/715
摘要： The present invention relates to the technology for inhibiting the cancer metastasis, and is aimed at the provision of a pharmaceutical composition for effectively inhibiting the metastasis of the cancer. A cancer metastasis inhibitor according to the present invention is characterized by containing a sugar chain separated from a surface of a Streptococcus agalactiae Ia type or Ib type as a main ingredient. Since the surface sugar chains of the Streptococcus agalactiae Ia type or Ib type have structures similar to surface sugar chains of the cancer cells, the former surface sugar chains adhere to E-selectin appearing in an intravascular endothelial cell, competitively inhibit the adhesion between intravascular endothelial cells and the cancer cells, and effectively prevent of the metastasis of the cancer, when the sugar chains exist in blood of a patient.
摘要翻译： PCT No.PCT / JP95 / 02735 Sec。 371日期1997年8月19日 102（e）日期1997年8月19日PCT 1995年12月27日PCT PCT。公开号WO97 / 24130 日期：1997年7月10日本发明涉及抑制癌症转移的技术，其目的在于提供有效抑制癌症转移的药物组合物。根据本发明的癌症转移抑制剂的特征在于含有从无乳链球菌Ia型或Ib型表面分离的糖链作为主要成分。由于无乳链球菌Ia型或Ib型的表面糖链具有类似于癌细胞的表面糖链的结构，所以前表面糖链粘附在出现在血管内内皮细胞中的E-选择素，竞争性地抑制血管内皮细胞细胞和癌细胞，并且当糖链存在于患者的血液中时，有效地预防癌症的转移。

2. 发明授权

US06828128B2 &bgr;1,3-galactosyltransferase and DNA encoding the same 失效
标题翻译： β1,3-半乳糖基转移酶和编码相同的DNA
公开(公告)号：US06828128B2
公开(公告)日：2004-12-07
申请号：US09900038
申请日：2001-07-09
申请人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
发明人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
IPC分类号： C12P1918
CPC分类号： C12P19/26 , C12N9/1051 , C12Y204/01062
摘要： The present invention provides a protein having a &bgr;1,3-galactosyltransferase activity derived from a microorganism; a DNA encoding the protein; a recombinant DNA containing the DNA and a vector; a transformant obtained by introducing the recombinant DNA into a host cell; a method for producing a protein having a &bgr;1,3-galactosyltransferase activity using the transformant; and a method for producing a galactose-containing carbohydrate using the transformant.
摘要翻译：本发明提供一种具有衍生自微生物的β1,3-半乳糖基转移酶活性的蛋白质; 编码蛋白质的DNA; 含有DNA和载体的重组DNA; 通过将重组DNA导入宿主细胞获得的转化体; 使用该转化体生产具有β1,3-半乳糖基转移酶活性的蛋白质的方法; 以及使用该转化体生产含半乳糖的碳水化合物的方法。

3. 发明申请

US20050064559A1 Beta1,3-galactosyltransferase and DNA encoding the same 失效
标题翻译： β1,3-半乳糖基转移酶和编码相同的DNA
公开(公告)号：US20050064559A1
公开(公告)日：2005-03-24
申请号：US10865873
申请日：2004-06-14
申请人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
发明人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12N9/38 , C12P19/26 , C12P19/28 , C12R1/19 , C12R1/46 , C07H21/04 , C08B37/00 , C12N15/74
CPC分类号： C12P19/26 , C12N9/1051 , C12Y204/01062
摘要： The present invention provides a protein having a β1,3-galactosyltransferase activity derived from a microorganism; a DNA encoding the protein; a recombinant DNA containing the DNA and a vector; a transformant obtained by introducing the recombinant DNA into a host cell; a method for producing a protein having a β1,3-galactosyltransferase activity using the transformant; and a method for producing a galactose-containing carbohydrate using the transformant.
摘要翻译：本发明提供一种具有衍生自微生物的β1,3-半乳糖基转移酶活性的蛋白质; 编码蛋白质的DNA; 含有DNA和载体的重组DNA; 通过将重组DNA导入宿主细胞获得的转化体; 使用该转化体生产具有β1,3-半乳糖基转移酶活性的蛋白质的方法; 以及使用该转化体生产含半乳糖的碳水化合物的方法。

4. 发明授权

US07238100B2 β1,3-galactosyltransferase and DNA encoding the same 失效
标题翻译： β1,3-半乳糖基转移酶和编码相同的DNA
公开(公告)号：US07238100B2
公开(公告)日：2007-07-03
申请号：US10865873
申请日：2004-06-14
申请人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
发明人： Katsuhide Miyake , Masaki Watanabe , Shinji Iijima
IPC分类号： C07H21/04 , C12P9/18 , C12N9/10 , C12N1/21 , C12N15/63
CPC分类号： C12P19/26 , C12N9/1051 , C12Y204/01062
摘要： The present invention provides a protein having a β1,3-galactosyltransferase activity derived from a microorganism; a DNA encoding the protein; a recombinant DNA containing the DNA and a vector; a transformant obtained by introducing the recombinant DNA into a host cell; a method for producing a protein having a β1,3-galactosyltransferase activity using the transformant; and a method for producing a galactose-containing carbohydrate using the transformant.
摘要翻译：本发明提供一种具有衍生自微生物的β1,3-半乳糖基转移酶活性的蛋白质; 编码蛋白质的DNA; 含有DNA和载体的重组DNA; 通过将重组DNA导入宿主细胞获得的转化体; 使用该转化体生产具有β1,3-半乳糖基转移酶活性的蛋白质的方法; 以及使用该转化体生产含半乳糖的碳水化合物的方法。

5. 发明授权

US5449625A Optical fiber based fluorescent immunoassay apparatus 失效
标题翻译：基于光纤的荧光免疫测定仪
公开(公告)号：US5449625A
公开(公告)日：1995-09-12
申请号：US98394
申请日：1993-08-16
申请人： Takeshi Kobayashi , Shinji Iijima , Yasunori Sakai , Ken-ichi Shimada
发明人： Takeshi Kobayashi , Shinji Iijima , Yasunori Sakai , Ken-ichi Shimada
IPC分类号： G01N21/64 , G01N33/53 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54366 , G01N33/5302 , G01N33/582 , Y10S435/968 , Y10S435/969 , Y10S436/80 , Y10S436/807
摘要： The present invention relates to an apparatus for performing a fluoroimmunoassay, the apparatus comprising an excitation light source, a fluorescence detector, an optical fiber for an excitation light from the excitation light source to which an antigen or antibody is bound, and a spectroscope, in which the mentioned antigen or antibody is bound to an outgoing end surface of the optical fiber for the excitation light. In the apparatus the spectroscope is constructed so that it introduces the excitation light emitted from the excitation light source to a incident end surface of the optical fiber for the excitation light and introduces a fluorescence emitted from a fluorescence-labeled antibody or antigen which forms an immunological complex with the antigen or antibody to the fluorescence detector. In the apparatus the outgoing end surface of the optical fiber for the excitation light has a transmittance for the excitation light from the excitation light source. The invention also relates to a sensing chip which is used in the apparatus for performing a fluoroimmunoassay therewith.
摘要翻译： PCT No.PCT / JP92 / 01652 Sec。 371日期：1993年8月16日 102（e）日期1993年8月16日PCT提交1992年12月17日PCT公布。公开号WO93 / 13418 日期：1993年7月8日。本发明涉及一种用于进行荧光免疫测定的装置，该装置包括激发光源，荧光检测器，用于来自激发光源的激发光的光纤，抗原或抗体所述抗原或抗体结合到所述光纤的出射端表面用于激发光。在该装置中，分光镜被构造成使得从激发光源发射的激发光引入用于激发光的光纤的入射端面，并引入从形成免疫学的荧光标记的抗体或抗原发射的荧光与荧光检测器的抗原或抗体复合。在该装置中，用于激发光的光纤的出射端面对于来自激发光源的激发光具有透射率。本发明还涉及用于与其进行荧光免疫测定的装置中的感测芯片。

6. 发明申请

US20070214511A1 Transgenic Bird And Method Of Constructing The Same 审中-公开
标题翻译：转基因鸟及其构建方法
公开(公告)号：US20070214511A1
公开(公告)日：2007-09-13
申请号：US10585693
申请日：2004-11-05
申请人： Takashi Yamashita , Takuya Shindo , Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
发明人： Takashi Yamashita , Takuya Shindo , Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
IPC分类号： A01K67/027 , C12N15/89 , C12N5/16 , C12P21/00 , C12Q1/68
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01
摘要： The present invention provides a G1 transgenic bird or an offspring thereof by: incubating a fertilized avian egg, microinjecting, into the early embryo thereof at a stage except for and after the blastodermic stage just after egg laying, a replication-deficient retroviral vector coding for a useful protein, allowing the egg to hatch out to thereby obtain a G0 transgenic chimeric bird, and mating the G0 transgenic chimeric bird with another G0 transgenic chimeric bird or an offspring thereof or with a wild-type bird. The present invention is a G1 transgenic bird or an offspring thereof by: incubating a fertilized avian egg, microinjecting, into the early embryo thereof at a stage except for and after the blastodermic stage just after egg laying, a replication-deficient retroviral vector coding for a useful protein, allowing the egg to hatch out to thereby obtain a G0 transgenic chimeric bird, and mating the G0 transgenic chimeric bird with another G0 transgenic chimeric bird or an offspring thereof or with a wild-type bird.
摘要翻译：本发明通过以下方式提供G1转基因鸟或其后代：在产卵后的胚根期以外的阶段将受精禽卵孵育至其早期胚胎，将其编码为复制缺陷型逆转录病毒载体一种有用的蛋白质，允许卵孵出，从而获得G0转基因嵌合鸟，并将G0转基因嵌合鸟与另一种G0转基因嵌合鸟或其后代或野生型鸟交配。本发明是一种G1转基因鸟或其后代，其特征在于：在产卵后的胚根期以外的阶段将受精禽卵孵化至其早期胚胎，将其编码为复制缺陷型逆转录病毒载体一种有用的蛋白质，允许卵孵出，从而获得G0转基因嵌合鸟，并将G0转基因嵌合鸟与另一种G0转基因嵌合鸟或其后代或野生型鸟交配。

7. 发明申请

US20060259997A1 Method of constructing transgenic bird using lentivirus vector and transgenic bird obtained thereby 审中-公开
标题翻译：使用慢病毒载体和由此获得的转基因鸟构建转基因鸟的方法
公开(公告)号：US20060259997A1
公开(公告)日：2006-11-16
申请号：US10569268
申请日：2004-08-27
申请人： Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
发明人： Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
IPC分类号： A01K67/027 , C12N5/06 , C12N15/867
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/30 , C12N15/86 , C12N2740/15043 , C12N2740/15045
摘要： The present invention provides a lentivirus vector which comprises a coat protein containing VSV-G; a recombinant bird host which is constructed by infecting a bird host with the lentivirus vector; a method of constructing the same; a transgenic chimeric bird which is constructed by infection with the lentivirus vector and offspring thereof. The present invention also provides a method of constructing a G0 transgenic chimeric bird and offspring thereof which comprises infecting fertilized bird egg early embryos with a lentivirus vector comprising a coat protein containing VSV-G, and incubating the embryos; and a G0 transgenic chimeric bird and offspring thereof which is constructed by the method mentioned above. The present invention provides a transgenic bird which is constructed by infecting a bird early embryos with a lentivirus vector comprising a coat protein pseudotyped with VSV-G.
摘要翻译：本发明提供一种慢病毒载体，其包含含有VSV-G的外壳蛋白; 通过用慢病毒载体感染鸟类宿主构建的重组禽类宿主; 一种构建它的方法; 通过感染慢病毒载体及其后代构建的转基因嵌合鸟。本发明还提供了构建G0转基因嵌合鸟及其后代的方法，其包括用含有VSV-G的外壳蛋白的慢病毒载体感染受精鸟卵早期胚胎，并培养胚胎; 和通过上述方法构建的G0转基因嵌合鸟及其后代。本发明提供一种转基因鸟，其通过用包含用VSV-G假型包被的蛋白质的慢病毒载体感染鸟类早期胚胎而构建。

8. 发明授权

US5268286A Method for immobilizing biocatalyst in granular form with a photo-crosslinkable resin 失效
标题翻译：用光交联树脂固定颗粒状生物催化剂的方法
公开(公告)号：US5268286A
公开(公告)日：1993-12-07
申请号：US665360
申请日：1991-03-06
申请人： Takeshi Kobayashi , Shinji Iijima , Masamichi Kamihira , Mikiko Hata , Takamitsu Iida , Masahiro Sakamoto , Hiroshi Itoh , Naoki Isobe
发明人： Takeshi Kobayashi , Shinji Iijima , Masamichi Kamihira , Mikiko Hata , Takamitsu Iida , Masahiro Sakamoto , Hiroshi Itoh , Naoki Isobe
IPC分类号： C12N11/08 , C12N11/10 , C12N11/04 , C12N11/12
CPC分类号： C12N11/10 , C12N11/08
摘要： A biocatalyst is immobilized with a graft product of a polymer and saponified polyvinyl acetate containing a stilbazolium group as a photo-crosslinking group. The polymer is preferably gelatin, collagen, starch, cellulose, gum arabic, tragacanth gum, carrageenan, mannan, dextrin or alginic acid. The graft product is prepared by bonding the polymer to the polyvinyl acetate, either directly through functional groups of the polymer and polyvinyl acetate or through a crosslinking agent. The polymer provides affinity for the biocatalyst and by grafting the polymer to the saponified polyvinyl acetate, damage to cells upon immobilization is reduced. A liquid composition containing a biocatalyst and the graft product is added to an aqueous solution of an inorganic salt or an organic salt to form a granular gel and the gel is irradiated with actinic rays to cure the gel.
摘要翻译：生物催化剂用聚合物的接枝产物和含有咔唑基作为光交联基团的皂化聚乙酸乙烯酯固定化。聚合物优选为明胶，胶原，淀粉，纤维素，阿拉伯胶，黄蓍胶，角叉菜胶，甘露聚糖，糊精或海藻酸。通过将聚合物直接通过聚合物和聚乙酸乙烯酯的官能团或通过交联剂直接结合聚乙酸乙烯酯来制备接枝产物。聚合物对生物催化剂提供亲和性，并且通过将聚合物接枝到皂化的聚乙酸乙烯酯上，固定时对细胞的损伤降低。将含有生物催化剂和接枝产物的液体组合物加入到无机盐或有机盐的水溶液中以形成颗粒状凝胶，并用光化射线照射凝胶以固化凝胶。

9. 发明授权

US4751007A Method for filtering Bacillus subtilis 失效
标题翻译：枯草芽孢杆菌+ B的过滤方法
公开(公告)号：US4751007A
公开(公告)日：1988-06-14
申请号：US93649
申请日：1987-09-08
申请人： Takeshi Kobayashi , Shinji Iijima , Toshiro Minami , Shunji Yasuda , Yoshihisa Katoh
发明人： Takeshi Kobayashi , Shinji Iijima , Toshiro Minami , Shunji Yasuda , Yoshihisa Katoh
IPC分类号： C12N1/20 , B01D29/00 , B01D29/17 , B01D29/25 , B01D29/37 , B01D39/20 , C12R1/07 , B01D37/00
CPC分类号： B01D71/024 , B01D61/147 , B01D65/02 , B01D2311/16 , B01D2315/10 , B01D2321/04 , Y10S435/803
摘要： A method comprising passing a culture solution including Bacillus subtilis or gene-recombinated Bacillus thereof through a pipe-like ceramic filter at a flow rate of 2 m/sec or less, the ceramic filter having a filter layer at an inner cylindrical surface thereof, the filter layer being made of spherical particles, and a surface roughness (Rmax) of the inner surface of the ceramic filter being 10 microns or less.
摘要翻译：一种包括使包含枯草芽胞杆菌或其基因重组芽孢杆菌的培养液通过管状陶瓷过滤器，流速为2m / sec以下的方法，所述陶瓷过滤器在其内圆柱面具有过滤层，过滤层由球形颗粒制成，陶瓷过滤器的内表面的表面粗糙度（Rmax）为10微米或更小。

10. 发明申请

US20090064351A1 TRANSGENIC BIRD PRODUCING ERYTHROPOIETIN AND METHOD OF CONSTRUCTING THE SAME 审中-公开
标题翻译：产生抗坏血酸的转基因生物及其构建方法
公开(公告)号：US20090064351A1
公开(公告)日：2009-03-05
申请号：US11910327
申请日：2006-02-24
申请人： Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
发明人： Shinji Iijima , Masamichi Kamihira , Kenichi Nishijima
IPC分类号： C12P21/00 , A01K67/027 , C12N5/06 , C12N15/63
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C07K14/505 , C12N15/8509 , C12N15/86 , C12N2740/13043
摘要： The present invention has its object to provide a transgenic bird producing erythropoietin at high concentration levels as well as a method for constructing the same. The present invention provides a G0 transgenic chimera bird as obtained by incubating a fertilized avian egg, infecting the early embryo formed after egg laying, except for the blastoderm stage immediately following egg laying, with a replication-deficient retroviral vector containing a foreign erythropoietin gene and allowing the embryo to hatch.
摘要翻译：本发明的目的是提供一种以高浓度水平生产促红细胞生成素的转基因鸟以及其构建方法。本发明提供了一种G0转基因嵌合体鸟，其通过孵育受精禽卵，感染产卵后形成的早期胚胎，除了立即产卵后的胚盘期外，还含有含有外源促红细胞生成素基因的复制缺陷型逆转录病毒载体，允许胚胎孵化。

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