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1. 发明授权

US06316628B1 L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound and process for preparing the same 失效
标题翻译：反式 - （ - ） - 4-（4-氟苯基）-3-羟甲基哌啶化合物的L-酒石酸盐及其制备方法
公开(公告)号：US06316628B1
公开(公告)日：2001-11-13
申请号：US09342149
申请日：1999-06-29
申请人： Shigeya Yamazaki , Taro Ishibashi , Yoshihiro Kawada , Hiroyuki Yumoto , Taichi Yoshikawa , Masami Igi
发明人： Shigeya Yamazaki , Taro Ishibashi , Yoshihiro Kawada , Hiroyuki Yumoto , Taichi Yoshikawa , Masami Igi
IPC分类号： C07D21122
CPC分类号： C07D211/22
摘要： An L-tartrate of a trans-(−)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound, represented by the formula (I): wherein R1 is hydrogen atom, a substituted or unsubstituted, linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group having 7 to 12 carbon atoms. The L-tartrate of trans-(−)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine compound can be suitably used as an intermediate for pharmaceuticals such as paroxetine which is useful, for example, as an antidepressant.
摘要翻译：由式（I）表示的反 - （ - ） - 4-（4-氟苯基）-3-羟甲基哌啶化合物的L-酒石酸盐：其中R1是氢原子，取代或未取代的直链或支链烷基，其具有 1至6个碳原子，或具有7至12个碳原子的芳烷基。反式 - （ - ） - 4-（4-氟苯基）-3-羟甲基哌啶化合物的L-酒石酸盐可以适当地用作药物例如帕罗西汀的中间体，其可用作例如抗抑郁药。

2. 发明授权

US07329318B2 Methods of crystal precipitation 失效
标题翻译：晶体析出方法
公开(公告)号：US07329318B2
公开(公告)日：2008-02-12
申请号：US10527317
申请日：2003-09-17
申请人： Shigeya Yamazaki , Taichi Yoshikawa
发明人： Shigeya Yamazaki , Taichi Yoshikawa
IPC分类号： C30B7/04
CPC分类号： C07D263/58 , C07D405/12
摘要： Crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out by adding water to a solution or suspension comprising paroxetine hydrochloride and a polar organic solvent which contains no water or at most 60% by weight of water to adjust the water content to at least 70% by weight when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in a water-containing polar organic solvent. Crystals of paroxetine hydrochloride ½-hydrate being not colored in pink can be allowed to separate out in the presence of hydrogen chloride when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in water or a water-containing polar organic solvent.
摘要翻译：通过向包含盐酸帕罗西汀和不含水或至多60重量％水的极性有机溶剂的溶液或悬浮液中加入水分离使水分含量达到至少70，允许盐酸帕罗西汀水合物晶体分离出来使盐酸帕罗西汀1/2水合物的晶体在含水极性有机溶剂中分离出来时的重量％。当盐酸帕罗西汀1/2水合物的结晶在水或含水极性有机溶剂中分离出来时，盐酸帕罗西汀晶体可以在氯化氢存在下将不着色的粉红色半水合物分离出来。

3. 发明申请

US20060041138A1 Process for producing paroxetine hydrochloride hydrate 审中-公开
标题翻译：盐酸帕罗西汀水合物的制备方法
公开(公告)号：US20060041138A1
公开(公告)日：2006-02-23
申请号：US10527337
申请日：2003-09-17
申请人： Shigeya Yamazaki , Taichi Yoshikawa
发明人： Shigeya Yamazaki , Taichi Yoshikawa
IPC分类号： C07D407/02
CPC分类号： C07D405/12
摘要： A process for preparing a paroxetine hydrochloride hydrate, comprising reacting (3S, 4R)-1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-[(3,4-methylene-dioxy)phenoxymethyl]piperidine with hydrogen chloride in the presence of water, and allowing crystals to separate out from the resulting reaction mixture in the presence of water.
摘要翻译：一种制备盐酸帕罗西汀水合物的方法，包括使（3S，4R）-1-叔丁氧基羰基-4-（4-氟苯基）-3 - [（3,4-亚甲基 - 二氧基）苯氧基甲基]哌啶与氯化氢反应水的存在，并允许晶体在水存在下从所得反应混合物中分离出来。

4. 发明申请

US20060048696A1 Methods of crystal precipitation 失效
标题翻译：晶体析出方法
公开(公告)号：US20060048696A1
公开(公告)日：2006-03-09
申请号：US10527317
申请日：2003-09-17
申请人： Shigeya Yamazaki , Taichi Yoshikawa
发明人： Shigeya Yamazaki , Taichi Yoshikawa
IPC分类号： H01L21/322 , C30B15/14
CPC分类号： C07D263/58 , C07D405/12
摘要： Crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out by adding water to a solution or suspension comprising paroxetine hydrochloride and a polar organic solvent which contains no water or at most 60% by weight of water to adjust the water content to at least 70% by weight when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in a water-containing polar organic solvent. Crystals of paroxetine hydrochloride ½-hydrate being not colored in pink can be allowed to separate out in the presence of hydrogen chloride when crystals of paroxetine hydrochloride ½-hydrate are allowed to separate out in water or a water-containing polar organic solvent.
摘要翻译：通过向包含盐酸帕罗西汀和不含水或至多60重量％水的极性有机溶剂的溶液或悬浮液中加入水分离使水分含量达到至少70，允许盐酸帕罗西汀水合物晶体分离出来使盐酸帕罗西汀1/2水合物的晶体在含水极性有机溶剂中分离出来时的重量％。当盐酸帕罗西汀1/2水合物的结晶在水或含水极性有机溶剂中分离出来时，盐酸帕罗西汀晶体可以在氯化氢存在下将不着色的粉红色半水合物分离出来。

5. 发明申请

US20100186721A1 VARIABLE STROKE CHARACTERISTIC ENGINE 有权
标题翻译：可变式特征发动机
公开(公告)号：US20100186721A1
公开(公告)日：2010-07-29
申请号：US12439779
申请日：2007-09-04
申请人： Akinori Maezuru , Shigekazu Tanaka , Taichi Yoshikawa
发明人： Akinori Maezuru , Shigekazu Tanaka , Taichi Yoshikawa
IPC分类号： F02B75/04 , F02B75/32 , F02D15/02 , F01B31/14 , F01B9/04
CPC分类号： F02D15/02 , F01L1/185 , F01L1/20 , F01L2001/0537 , F01L2105/00 , F02B75/048 , F02B75/20 , F02B2075/1816
摘要： A variable stroke characteristic engine is provided in which a piston (11) and a crankshaft (30) are linked to a control shaft (65) via a variable stroke link mechanism (LV), and the variable stroke link mechanism (LV) is operated by an actuator (AC) that drives the control shaft (65) to thus make the stroke travel of the piston (11) variable, wherein a housing (HU) of the hydraulic actuator (AC) for operating the variable stroke link mechanism (LV) is provided in a bearing member (54) of a lower block (41) supporting the crankshaft (30), and the housing (HU) is thus made small, thereby suppressing any increase in the dimensions of the engine. Furthermore, a hydraulic switching valve unit (92) for controlling operation of the hydraulic actuator (AC) is directly mounted on the housing (HU), thereby enhancing the responsiveness of the hydraulic actuator (AC).
摘要翻译：提供了一种可变冲程特征引擎，其中活塞（11）和曲轴（30）经由可变行程连杆机构（LV）连接到控制轴（65），并且可变行程连杆机构（LV）被操作通过驱动控制轴（65）从而使活塞（11）的冲程行程变化的致动器（AC），其中用于操作可变冲程连杆机构（LV）的液压致动器（AC）的壳体（HU））设置在支撑曲轴（30）的下部块（41）的支承构件（54）中，并且壳体（HU）因此变小，从而抑制发动机的尺寸的任何增加。此外，用于控制液压致动器（AC）的操作的液压切换阀单元（92）直接安装在壳体（HU）上，从而提高液压致动器（AC）的响应性。

6. 发明授权

US08015955B2 Variable stroke 有权
标题翻译：可变行程特征引擎
公开(公告)号：US08015955B2
公开(公告)日：2011-09-13
申请号：US12439779
申请日：2007-09-04
申请人： Akinori Maezuru , Shigekazu Tanaka , Taichi Yoshikawa
发明人： Akinori Maezuru , Shigekazu Tanaka , Taichi Yoshikawa
IPC分类号： F02B75/04 , F02D15/02
CPC分类号： F02D15/02 , F01L1/185 , F01L1/20 , F01L2001/0537 , F01L2105/00 , F02B75/048 , F02B75/20 , F02B2075/1816
摘要： A variable stroke characteristic engine is provided in which a piston (11) and a crankshaft (30) are linked to a control shaft (65) via a variable stroke link mechanism (LV), and the variable stroke link mechanism (LV) is operated by an actuator (AC) that drives the control shaft (65) to thus make the stroke travel of the piston (11) variable, wherein a housing (HU) of the hydraulic actuator (AC) for operating the variable stroke link mechanism (LV) is provided in a bearing member (54) of a lower block (41) supporting the crankshaft (30), and the housing (HU) is thus made small, thereby suppressing any increase in the dimensions of the engine. Furthermore, a hydraulic switching valve unit (92) for controlling operation of the hydraulic actuator (AC) is directly mounted on the housing (HU), thereby enhancing the responsiveness of the hydraulic actuator (AC).
摘要翻译：提供了一种可变冲程特征引擎，其中活塞（11）和曲轴（30）经由可变行程连杆机构（LV）连接到控制轴（65），并且可变行程连杆机构（LV）被操作通过驱动控制轴（65）从而使活塞（11）的冲程行程变化的致动器（AC），其中用于操作可变冲程连杆机构（LV）的液压致动器（AC）的壳体（HU））设置在支撑曲轴（30）的下部块（41）的支承构件（54）中，并且壳体（HU）因此变小，从而抑制发动机的尺寸的任何增加。此外，用于控制液压致动器（AC）的操作的液压切换阀单元（92）直接安装在壳体（HU）上，从而提高液压致动器（AC）的响应性。

7. 发明申请

US20100192915A1 VARIABLE STROKE CHARACTERISTIC ENGINE 审中-公开
标题翻译：可变式特征发动机
公开(公告)号：US20100192915A1
公开(公告)日：2010-08-05
申请号：US12440136
申请日：2007-09-04
申请人： Shigekazu Tanaka , Koichi Eto , Akinori Maezuru , Jiro Fujimoto , Keiko Yoshida , Taichi Yoshikawa
发明人： Shigekazu Tanaka , Koichi Eto , Akinori Maezuru , Jiro Fujimoto , Keiko Yoshida , Taichi Yoshikawa
IPC分类号： F02B75/04
CPC分类号： F02B75/048
摘要： A variable stroke characteristic engine in which a piston (11) and a crankshaft (30) are linked to a control shaft (65) via a variable stroke link mechanism (LV), and the variable stroke link mechanism (LV) is operated by a hydraulic actuator (AC) that drives the control shaft (65) to thus make the stroke travel of the piston (11) variable, in which the hydraulic actuator (AC) is formed from a housing (HU), a cover member covering an aperture of the housing (HU), a vane case provided integrally within the housing (HU), and a vane shaft (66) housed within the vane case, and the vane shaft (66) is formed integrally with the control shaft (65). The number of components of the actuator (AC) can be decreased, and its ease of assembly can be improved.
摘要翻译：一种可变冲程特征引擎，其中活塞（11）和曲轴（30）经由可变冲程连杆机构（LV）连接到控制轴（65），并且可变冲程连杆机构（LV）由驱动控制轴（65）的液压致动器（AC），从而使得活塞（11）的行程行程可变，其中液压致动器（AC）由壳体（HU）形成，盖构件覆盖孔的壳体（HU），一体地设置在壳体（HU）内的叶片壳体和容纳在叶片壳体内的叶片轴（66），叶片轴（66）与控制轴（65）一体形成。可以减少致动器（AC）的部件的数量，并且可以提高其组装的容易性。

8. 发明申请

US20100018504A1 VARIABLE STROKE ENGINE ASSEMBLY 失效
标题翻译：可变式发动机总成
公开(公告)号：US20100018504A1
公开(公告)日：2010-01-28
申请号：US12440125
申请日：2007-09-07
申请人： Shigekazu Tanaka , Akinori Maezuru , Taichi Yoshikawa , Keitaro Nakanishi
发明人： Shigekazu Tanaka , Akinori Maezuru , Taichi Yoshikawa , Keitaro Nakanishi
IPC分类号： F02B75/04
CPC分类号： F02D15/02 , F01L1/022 , F01L1/185 , F01L1/20 , F01L1/3442 , F01L2001/0537 , F01L2001/34426 , F01L2001/3443 , F01L2105/00 , F02B75/048
摘要： In a variable stroke engine assembly for a front engine, front wheel drive vehicle, an engine output shaft (OS), a variable stroke control mechanism (63, 65, CR), an actuator (AC) and a starter motor (SM) are laid out in a favorable manner so that the general outer profile of the engine assembly can be made free from excessive protrusions, an increase in the engine room space requirement is avoided, layout freedom can be enhanced, and the cooling performance for the actuator can be improved.
摘要翻译：在用于前发动机，前轮驱动车辆，发动机输出轴（OS），可变行程控制机构（63,65，CR），致动器（AC）和起动电动机（SM））的可变行程发动机组件中，以有利的方式布置，使得发动机组件的一般外轮廓可以避免过多的突起，从而避免了发动机室空间要求的增加，可以提高布局自由度，并且致动器的冷却性能可以是改进。

9. 发明授权

US08408171B2 Variable stroke engine assembly 失效
标题翻译：可变行程发动机总成
公开(公告)号：US08408171B2
公开(公告)日：2013-04-02
申请号：US12440125
申请日：2007-09-07
申请人： Shigekazu Tanaka , Akinori Maezuru , Taichi Yoshikawa , Keitaro Nakanishi
发明人： Shigekazu Tanaka , Akinori Maezuru , Taichi Yoshikawa , Keitaro Nakanishi
IPC分类号： F02D15/04
CPC分类号： F02D15/02 , F01L1/022 , F01L1/185 , F01L1/20 , F01L1/3442 , F01L2001/0537 , F01L2001/34426 , F01L2001/3443 , F01L2105/00 , F02B75/048
摘要： In a variable stroke engine assembly for a front engine, front wheel drive vehicle, an engine output shaft (OS), a variable stroke control mechanism (63, 65, CR), an actuator (AC) and a starter motor (SM) are laid out in a favorable manner so that the general outer profile of the engine assembly can be made free from excessive protrusions, an increase in the engine room space requirement is avoided, layout freedom can be enhanced, and the cooling performance for the actuator can be improved.
摘要翻译：在用于前发动机，前轮驱动车辆，发动机输出轴（OS），可变行程控制机构（63,65，CR），致动器（AC）和起动电动机（SM））的可变行程发动机组件中，以有利的方式布置，使得发动机组件的一般外轮廓可以避免过多的突起，从而避免了发动机室空间要求的增加，可以提高布局自由度，并且致动器的冷却性能可以是改进。

10. 发明申请

US20100006069A1 VARIABLE STROKE ENGINE 有权
标题翻译：可变式发动机
公开(公告)号：US20100006069A1
公开(公告)日：2010-01-14
申请号：US12441352
申请日：2007-09-07
申请人： Taichi Yoshikawa , Shigekazu Tanaka , Jiro Fujimoto , Keitaro Nakanishi , Noriaki Fujii , Akinori Maezuru
发明人： Taichi Yoshikawa , Shigekazu Tanaka , Jiro Fujimoto , Keitaro Nakanishi , Noriaki Fujii , Akinori Maezuru
IPC分类号： F02B75/04 , F02B75/32 , F02D15/02 , F01B9/04 , F01B31/14
CPC分类号： F02D15/02 , F02B75/048
摘要： In a variable stroke engine comprising a plurality of links (60, 61) connecting a piston (11) with a crankshaft (30), a control member (65) disposed on an engine main body so as to be moveable in two directions over a prescribed range relative to the engine main body, a control link (63) connecting one of the plurality of links with the control member and an actuator (AC) for displacing the control member, the actuator comprises a ratchet mechanism that utilizes a force transmitted from the piston to the control member as an actuating force for the control member. By providing a spring member (73, SP, 121) that applies a biasing force to the control member, an appropriate actuating force can be applied to the control member in either direction.
摘要翻译：在包括将活塞（11）与曲轴（30）连接的多个连杆（60,61）的变速冲程发动机中，设置在发动机主体上的控制构件（65）能够沿着两个方向在一个相对于发动机主体的规定范围，将多个连杆中的一个与控制构件连接的控制连杆（63）和用于使控制构件移位的致动器（AC），致动器包括棘轮机构，其利用从活塞到控制构件作为控制构件的致动力。通过提供向控制构件施加偏压力的弹簧构件（73，SP，121），可以在任一方向上向控制构件施加适当的致动力。

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