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1. 发明授权

US3943134A Process for preparing acetonin 失效
标题翻译：制备乙酰丙酮的方法
公开(公告)号：US3943134A
公开(公告)日：1976-03-09
申请号：US515815
申请日：1974-10-18
申请人： Shigeo Kajiyama , Takamitsu Kobayashi , Keiro Yoshizue
发明人： Shigeo Kajiyama , Takamitsu Kobayashi , Keiro Yoshizue
IPC分类号： C07D239/06 , C07D239/04
CPC分类号： C07D239/06
摘要： 2,2,4,4,6-Pentamethyl-2,3,4,5-tetrahydropyrimidine, called acetonin, is prepared by reacting acetone with ammonia in the presence of an ammonium halide catalyst and in the presence of from 0.01 to 0.5 mole % (based on acetone) of a promoter selected from the group consisting of: bromine; iodine; iodine trichloride; alkali metal iodides; lithium rhodanide, bromide, nitrate and cyanide; ammonium iodide, rhodanide, bromide, nitrate and sulfide; ammonium salts of carboxylic acids and of sulfonic acids; salts of nitrogen-containing organic bases with carboxylic acids and with sulfonic acids; aliphatic amine hydroiodides; carboxylic acids; and sulfonic acids.
摘要翻译： 2,2,4,4,6-五甲基-2,3,4,5-四氢嘧啶，称为乙炔二酮，是通过丙酮与氨在卤化铵催化剂存在下反应制备的，并且在0.01至0.5摩尔％（基于丙酮）的促进剂，其选自：溴; 碘; 三氯化碘; 碱金属碘化物; 硫氰酸锂，溴化物，硝酸根和氰化物; 碘化铵，硫化铑，溴化物，硝酸盐和硫化物; 羧酸和磺酸的铵盐; 含氮有机碱与羧酸和磺酸的盐; 脂肪胺氢碘酸盐; 羧酸; 和磺酸。

2. 发明申请

US20090030006A1 SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE 有权
标题翻译： SPIROKETAL衍生物及其作为糖尿病药物的用途
公开(公告)号：US20090030006A1
公开(公告)日：2009-01-29
申请号：US11815074
申请日：2006-01-27
申请人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
发明人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
IPC分类号： A61K31/352 , A61P3/10 , C07D493/10 , A61K31/381 , A61K31/4433 , A61K31/498 , A61K31/404 , A61K31/4155 , C07D495/20 , C07D491/20
CPC分类号： C07D311/96 , C07D491/153 , C07D493/10 , C07H19/01
摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
摘要翻译：本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ -O）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

3. 发明授权

US08207134B2 Fused ring spiroketal derivative and use thereof as anti-diabetic drug 失效
标题翻译：稠环螺旋酮衍生物及其作为抗糖尿病药物的用途
公开(公告)号：US08207134B2
公开(公告)日：2012-06-26
申请号：US12375378
申请日：2007-07-27
申请人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
发明人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
IPC分类号： A01N43/04 , A61K31/70 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07H19/01
摘要： Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(═O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
摘要翻译：提供由式（I）表示的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，可被取代的C 1-6烷基，可被取代的C 7-14芳烷基和-C（= O）Rx; n表示选自1和2的整数; 并且环Ar选自由下式（a）至（f）表示的基团。或其前药或其药学上可接受的盐，以及药物和含有这种化合物或其前药的药物组合物或其药学上可接受的盐。

4. 发明申请

US20100286423A1 NICKEL-CONTAINING FILM-FORMING MATERIAL AND PROCESS FOR PRODUCING NICKEL-CONTAINING FILM 审中-公开
标题翻译：含镍的成膜材料和生产含镍薄膜的方法
公开(公告)号：US20100286423A1
公开(公告)日：2010-11-11
申请号：US12810257
申请日：2008-12-16
申请人： Toshitaka Hiro , Takamitsu Kobayashi
发明人： Toshitaka Hiro , Takamitsu Kobayashi
IPC分类号： C07F17/00 , C23C16/00
CPC分类号： C23C16/42 , C07F17/02 , H01L21/28061 , H01L21/28518 , H01L21/2855
摘要： A nickel-containing film-forming material including a compound represented by a structure of the following formula (1). In the formula (1), R1 and R2 are each independently a hydrogen atom or a group represented by a structure of the following formula (2), a and b are each an integer of 0 to 4, and a and b satisfy the condition of 0
摘要翻译：一种含镍成膜材料，其包含由下式（1）的结构表示的化合物。在式（1）中，R 1和R 2各自独立地为氢原子或由下式（2）的结构表示的基团，a和b各自为0〜4的整数，a和b满足条件的0

5. 发明申请

US20120302775A1 PROCESS FOR PRODUCING EPOXY COMPOUNDS 有权
标题翻译：生产环氧化合物的方法
公开(公告)号：US20120302775A1
公开(公告)日：2012-11-29
申请号：US13515707
申请日：2010-12-17
申请人： Hiroshi Uchida , Takamitsu Kobayashi , Naoya Fukumoto
发明人： Hiroshi Uchida , Takamitsu Kobayashi , Naoya Fukumoto
IPC分类号： C07D301/12
CPC分类号： C07D301/12 , C07D303/28
摘要： To provide an efficient method of producing an epoxy compound comprising reacting hydrogen peroxide and acetonitrile with the carbon-carbon double bond of an organic compound having a carbon-carbon double bond. A method of producing an epoxy compound comprising epoxidizing the carbon-carbon double bond of an organic compound having a carbon-carbon double bond in the presence of acetonitrile by using hydrogen peroxide as an oxidizing agent, wherein the reaction proceeds while controlling the acetonitrile concentration in the reaction system in the range of 0.6-5 mol/L by using a solvent containing an alcohol.
摘要翻译：提供一种制备环氧化合物的有效方法，包括使过氧化氢和乙腈与具有碳 - 碳双键的有机化合物的碳 - 碳双键反应。一种环氧化合物的制造方法，其特征在于，在乙腈存在下，通过使用过氧化氢作为氧化剂，使具有碳 - 碳双键的有机化合物的碳 - 碳双键环氧化，其中反应进行同时控制乙腈浓度通过使用含有醇的溶剂，反应体系在0.6-5mol / L的范围内。

6. 发明申请

US20090028854A1 sc(Fv)2 SITE-DIRECTED MUTANT 审中-公开
标题翻译： sc（Fv）2 SITE-DIRECTED MUTANT
公开(公告)号：US20090028854A1
公开(公告)日：2009-01-29
申请号：US11916351
申请日：2006-06-09
申请人： Tomoyuki Igawa , Hiroyuki Tsunoda , Takamitsu Kobayashi , Shoujiro Kadono
发明人： Tomoyuki Igawa , Hiroyuki Tsunoda , Takamitsu Kobayashi , Shoujiro Kadono
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/00 , C07K2317/24 , C07K2317/56 , C07K2317/622
摘要： To solve the above-mentioned problems, the present inventors introduced site-specific mutations into sc(Fv)2 and examined the stabilizing effects on sc(Fv)2. As a result, they succeeded for the first time in significantly increasing the Tm value of sc(Fv)2 by amino acid substitutions. Furthermore, they discovered that sc(Fv)2 is stabilized by introducing site-specific mutations into sc(Fv)2.
摘要翻译：为了解决上述问题，本发明人将位点特异性突变引入sc（Fv）2，并检查了对sc（Fv）2的稳定效果。结果，它们首次成功地通过氨基酸取代显着增加sc（Fv）2的Tm值。此外，他们发现sc（Fv）2通过将位点特异性突变引入sc（Fv）2来稳定。

7. 发明授权

US07014221B2 Joint for piping 失效
标题翻译：管接头
公开(公告)号：US07014221B2
公开(公告)日：2006-03-21
申请号：US10745052
申请日：2003-12-22
申请人： Kazuo Iwasaki , Takamitsu Kobayashi , Yusushi Tsuchiya , Yoshinori Ishii , Kazuya Suzuki , Nagahisa Amano
发明人： Kazuo Iwasaki , Takamitsu Kobayashi , Yusushi Tsuchiya , Yoshinori Ishii , Kazuya Suzuki , Nagahisa Amano
IPC分类号： F16L39/00
CPC分类号： F16L37/0987 , F16L37/0985
摘要： A joint for piping includes a pipe with an annular swelling wall and a connector body with a socket that includes locking pieces. The locking pieces hold the annular swelling wall when the pipe is inserted through the connector body to connector the pipe to the connector body. A projected member on the pipe fits in a recess on the connector body to prevent rotation between the pipe and the connector body.
摘要翻译：用于管道的接头包括具有环形膨胀壁的管道和具有包括锁定件的插座的连接器主体。当管道插入连接器主体以将管道连接到连接器主体时，锁定件保持环形膨胀壁。管上的突出部件装配在连接器主体上的凹部中，以防止管道和连接器主体之间的旋转。

8. 发明授权

US08993791B2 Process for producing epoxy compounds 有权
标题翻译：生产环氧化合物的方法
公开(公告)号：US08993791B2
公开(公告)日：2015-03-31
申请号：US13515707
申请日：2010-12-17
申请人： Hiroshi Uchida , Takamitsu Kobayashi , Naoya Fukumoto
发明人： Hiroshi Uchida , Takamitsu Kobayashi , Naoya Fukumoto
IPC分类号： C07D301/03 , C07D301/12 , C07D303/28
CPC分类号： C07D301/12 , C07D303/28
摘要： To provide an efficient method of producing an epoxy compound comprising reacting hydrogen peroxide and acetonitrile with the carbon-carbon double bond of an organic compound having a carbon-carbon double bond. A method of producing an epoxy compound comprising epoxidizing the carbon-carbon double bond of an organic compound having a carbon-carbon double bond in the presence of acetonitrile by using hydrogen peroxide as an oxidizing agent, wherein the reaction proceeds while controlling the acetonitrile concentration in the reaction system in the range of 0.6-5 mol/L by using a solvent containing an alcohol.
摘要翻译：提供一种制备环氧化合物的有效方法，包括使过氧化氢和乙腈与具有碳 - 碳双键的有机化合物的碳 - 碳双键反应。一种环氧化合物的制造方法，其特征在于，在乙腈存在下，通过使用过氧化氢作为氧化剂，使具有碳 - 碳双键的有机化合物的碳 - 碳双键环氧化，其中反应进行同时控制乙腈浓度通过使用含有醇的溶剂，反应体系在0.6-5mol / L的范围内。

9. 发明授权

US07767651B2 Spiroketal derivatives and use thereof as diabetic medicine 有权
标题翻译：螺缩酮衍生物及其作为糖尿病药物的用途
公开(公告)号：US07767651B2
公开(公告)日：2010-08-03
申请号：US11815074
申请日：2006-01-27
申请人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
发明人： Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D491/153 , C07D493/10 , C07H19/01
摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
摘要翻译：本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ ΟO）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

10. 发明申请

US20100234609A1 FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS ANTI-DIABETIC DRUG 失效
标题翻译：熔融环螺旋体衍生物及其作为抗糖尿病药物使用
公开(公告)号：US20100234609A1
公开(公告)日：2010-09-16
申请号：US12375378
申请日：2007-07-27
申请人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
发明人： Tsutomu Sato , Yoshihito Ohtake , Masahiro Nishimoto , Takashi Emura , Takamitsu Kobayashi , Marina Yamaguchi , Kyouko Takami
IPC分类号： C07D493/10 , C07D513/20 , C07D498/20 , C07D491/20 , C07F7/08 , C07D495/20
CPC分类号： C07H19/01
摘要： Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(═O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
摘要翻译：提供由式（I）表示的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，可被取代的C 1-6烷基，可被取代的C 7-14芳烷基和-C（= O）Rx; n表示选自1和2的整数; 并且环Ar选自由下式（a）至（f）表示的基团。或其前药或其药学上可接受的盐，以及药物和含有这种化合物或其前药的药物组合物或其药学上可接受的盐。

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