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1. 发明授权

US08772277B2 Nitrogen-containing heterocyclic compound 有权
标题翻译：含氮杂环化合物
公开(公告)号：US08772277B2
公开(公告)日：2014-07-08
申请号：US13566091
申请日：2012-08-03
申请人： Shigemitsu Matsumoto , Koji Ono , Yusuke Tominari , Taisuke Katoh , Kazuhiro Miwa , Atsushi Hasuoka , Shinichi Imamura
发明人： Shigemitsu Matsumoto , Koji Ono , Yusuke Tominari , Taisuke Katoh , Kazuhiro Miwa , Atsushi Hasuoka , Shinichi Imamura
IPC分类号： A61K31/00 , C07D401/00
CPC分类号： C07D417/14 , C07D417/06 , C07D451/02
摘要： The present invention provides a novel compound having a superior activity as an ERR-α modulator and useful as an agent for the prophylaxis or treatment of ERR-α associated diseases.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供作为ERR-α调节剂具有优异活性的新型化合物，可用作预防或治疗ERR-α相关疾病的药剂。本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

2. 发明申请

US20130072467A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 有权
标题翻译：含氮的杂环化合物
公开(公告)号：US20130072467A1
公开(公告)日：2013-03-21
申请号：US13566091
申请日：2012-08-03
申请人： Shigemitsu MATSUMOTO , Koji Ono , Yusuke Tominari , Taisuke Katoh , Kazuhiro Miwa , Atsushi Hasuoka , Shinichi Imamura
发明人： Shigemitsu MATSUMOTO , Koji Ono , Yusuke Tominari , Taisuke Katoh , Kazuhiro Miwa , Atsushi Hasuoka , Shinichi Imamura
IPC分类号： C07D417/14 , A61K31/519 , C07D417/06 , C07D513/04 , A61K31/429
CPC分类号： C07D417/14 , C07D417/06 , C07D451/02
摘要： The present invention provides a novel compound having a superior activity as an ERR-α modulator and useful as an agent for the prophylaxis or treatment of ERR-α associated diseases.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供作为ERR-α调节剂具有优异活性的新型化合物，可用作预防或治疗ERR-α相关疾病的药剂。本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

3. 发明申请

US20130040951A9 PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER 审中-公开
标题翻译：癌症的预防或治疗药物
公开(公告)号：US20130040951A9
公开(公告)日：2013-02-14
申请号：US13388795
申请日：2010-08-04
申请人： Atsushi Hasuoka , Koji Ono , Masanori Kawasaki
发明人： Atsushi Hasuoka , Koji Ono , Masanori Kawasaki
IPC分类号： A61K31/5377 , C07D233/96 , C07D417/12 , C07D405/06 , A61P35/00 , A61K31/426 , A61K31/4166 , A61K31/4439 , A61K31/497 , A61K31/454 , C07D277/54 , C07D401/06
CPC分类号： C07D233/96 , A61K31/4166 , A61K31/426 , A61K31/427 , C07D277/20 , C07D277/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D417/12
摘要： A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has a superior activity as an estrogen-related receptor-α modulator, and is useful as a prophylactic or therapeutic agent for cancer.
摘要翻译：由式（I）表示的化合物：其中各符号如说明书所述，或其盐作为雌激素相关受体-α调节剂具有优异的活性，可用作癌症的预防或治疗剂。

4. 发明申请

US20120196864A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER 审中-公开
标题翻译：癌症的预防或治疗药物
公开(公告)号：US20120196864A1
公开(公告)日：2012-08-02
申请号：US13388795
申请日：2010-08-04
申请人： Atsushi Hasuoka , Koji Ono , Masanori Kawasaki
发明人： Atsushi Hasuoka , Koji Ono , Masanori Kawasaki
IPC分类号： A61K31/5377 , C07D233/96 , C07D417/12 , C07D405/06 , A61P35/00 , A61K31/426 , A61K31/4166 , A61K31/4439 , A61K31/497 , A61K31/454 , C07D277/54 , C07D401/06
CPC分类号： C07D233/96 , A61K31/4166 , A61K31/426 , A61K31/427 , C07D277/20 , C07D277/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D417/12
摘要： A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has a superior activity as an estrogen-related receptor-α modulator, and is useful as a prophylactic or therapeutic agent for cancer.
摘要翻译：由式（I）表示的化合物：其中各符号如说明书所述，或其盐作为雌激素相关受体-α调节剂具有优异的活性，可用作癌症的预防或治疗剂。

5. 发明授权

US08013008B2 Cyclic amine compound 有权
标题翻译：环胺化合物
公开(公告)号：US08013008B2
公开(公告)日：2011-09-06
申请号：US12516733
申请日：2007-11-29
申请人： Atsushi Hasuoka , Satoshi Yamamoto
发明人： Atsushi Hasuoka , Satoshi Yamamoto
IPC分类号： A61K31/402 , C07D207/12
CPC分类号： C07D207/12
摘要： A compound represented by the formula (I) each symbol of which is defined in the specification, or a salt thereof which has a superior androgen receptor regulating activity.
摘要翻译：由式（I）表示的化合物，其各符号在说明书中定义，或其盐具有优越的雄激素受体调节活性。

6. 发明申请

US20110098336A1 PYRROLIDIN-2-ONE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR 有权
标题翻译：吡咯烷-2-酮衍生物作为雄激素受体调节剂
公开(公告)号：US20110098336A1
公开(公告)日：2011-04-28
申请号：US12672516
申请日：2008-08-06
申请人： Atsushi Hasuoka
发明人： Atsushi Hasuoka
IPC分类号： A61K31/4015 , C07D207/273 , A61P13/08 , A61P15/12 , A61P19/10
CPC分类号： C07D207/273 , C07D209/54
摘要： A compound represented by the formula (I) according to claim 1 or a salt thereof has a superior androgen receptor modulating action.
摘要翻译：由权利要求1所述的式（I）表示的化合物或其盐具有优异的雄激素受体调节作用。

7. 发明申请

US20080139639A1 Proton Pump Inhibitors 有权
标题翻译：质子泵抑制剂
公开(公告)号：US20080139639A1
公开(公告)日：2008-06-12
申请号：US11664346
申请日：2005-09-30
申请人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
发明人： Masahiro Kajino , Atsushi Hasuoka , Naoki Tarui , Terufumi Takagi
IPC分类号： A61K31/40 , C07D207/48 , A61P1/04
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/41 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D207/335 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.
摘要翻译：一种质子泵抑制剂，其含有式（I）表示的化合物，其中X和Y相同或不同，并且各自是主链中具有1至20个碳原子的键或间隔基，R 1 >是任选取代的烃基或任选取代的杂环基，R 2，R 3和R 4相同或不同，并且各自任选取代的苯并[b]噻吩基，任选取代的呋喃基，任意取代的吡啶基，任意取代的吡唑基，任意取代的嘧啶基，酰基，卤素原子，氰基或硝基，R 5和R 6相同或不同，各自为氢原子或任选地取代烃基，其具有优异的质子泵作用，并显示出抗溃疡活性等转化为体内的质子泵抑制剂或其盐。或其前药。

8. 发明授权

US08338462B2 1-heterocyclylsulfonyl, 3-aminomethyl, 5- (hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors 有权
标题翻译： 1-杂环基磺酰基，3-氨基甲基，5-（杂）芳基取代的1 H-吡咯衍生物作为酸分泌抑制剂
公开(公告)号：US08338462B2
公开(公告)日：2012-12-25
申请号：US13156226
申请日：2011-06-08
申请人： Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
发明人： Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
IPC分类号： C07D401/02 , A61K31/444
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/12 , C07D487/04
摘要： The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.
摘要翻译：本发明提供具有优异的酸分泌抑制作用并显示出抗溃疡活性等的化合物。本发明提供由式（I）表示的化合物，其中R 1是任选与苯环或杂环稠合的含氮单环杂环基，任选地与苯环或杂环稠合的含氮单环杂环基具有取代基，R 2为任选取代的C 6-14芳基，任选取代的噻吩基或任选取代的吡啶基，R 3和R 4各自为氢原子，或者R 3和R 4中的一个为氢原子，另一个是任选取代的低级烷基小时，酰基，卤素原子，氰基或硝基，R 5是烷基或其盐。

9. 发明申请

US20110144161A1 1-HETEROCYCLYLSULFONYL, 2-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS 有权
标题翻译：作为酸分泌抑制剂的1-杂环甲硅烷基，2-氨基乙基，5-（异丁基）芳基取代的1-H-吡咯烷酮衍生物
公开(公告)号：US20110144161A1
公开(公告)日：2011-06-16
申请号：US13037690
申请日：2011-03-01
申请人： Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
发明人： Masahiro Kajino , Atsushi Hasuoka , Haruyuki Nishida
IPC分类号： A61K31/444 , A61K31/4439 , C07D401/14 , C07D401/02 , A61P35/00 , A61P1/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/12 , C07D487/04
摘要： The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.
摘要翻译：本发明提供具有优异的酸分泌抑制作用并显示出抗溃疡活性等的化合物。本发明提供由式（I）表示的化合物，其中R 1是任选与苯环或杂环稠合的含氮单环杂环基，任选地与苯环或杂环稠合的含氮单环杂环基具有取代基，R 2为任选取代的C 6-14芳基，任选取代的噻吩基或任选取代的吡啶基，R 3和R 4各自为氢原子，或者R 3和R 4中的一个为氢原子，另一个是任选取代的低级烷基，酰基，卤素原子，氰基或硝基，R 5是烷基或其盐。

10. 发明授权

US07834051B2 Cyclic amine compounds 有权
标题翻译：环胺化合物
公开(公告)号：US07834051B2
公开(公告)日：2010-11-16
申请号：US12221739
申请日：2008-08-06
申请人： Atsushi Hasuoka
发明人： Atsushi Hasuoka
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D207/273 , C07D209/54
摘要： The present invention relates to pharmaceutical agents which are agents for the prophylaxis or treatment of hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis; the pharmaceutical agents frailty suppressants, muscle strength enhancers, muscle increasing agents, cachexia suppressants, body weight decrease suppressants, agents for the prophylaxis or treatment of prostate hypertrophy, amyotrophy or muscle loss caused by a disease or an agent for reducing the prostate weight.The present invention also relates to methods for the prophylaxis or treatment of hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis in a mammal, which comprises administering an effective amount of the pharmaceutical agents of the present invention or a prodrug thereof; use of the pharmaceutical agents of the present invention or a prodrug thereof for the production of an agent for the prophylaxis or treatment of hypogonadism, male climacteric disorder, frailty, cachexia or osteoporosis; and the like.
摘要翻译：本发明涉及作为预防或治疗性腺机能减退，男性更年期障碍，虚弱，恶病质或骨质疏松症的药剂的药剂; 药剂脆弱抑制剂，肌肉力量增强剂，肌肉增加剂，恶病质抑制剂，体重减轻抑制剂，用于预防或治疗前列腺肥大的药剂，由疾病引起的肌萎缩或肌肉损失或用于减少前列腺重量的药剂。本发明还涉及用于预防或治疗性腺机能减退，男性更年期病症，虚弱，恶病质或骨质疏松症的哺乳动物的方法，其包括施用有效量的本发明的药物或其前药; 使用本发明的药物或其前药用于制备用于预防或治疗性腺机能减退，男性更年期障碍，虚弱，恶病质或骨质疏松症的药剂; 等等。

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