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1. 发明申请

US20050256848A1 System and method for user rank search 审中-公开
标题翻译：用户等级搜索的系统和方法
公开(公告)号：US20050256848A1
公开(公告)日：2005-11-17
申请号：US10844996
申请日：2004-05-13
申请人： Sherman Alpert , Thomas Cofino , John Karat , John Vergo , Catherine Wolf
发明人： Sherman Alpert , Thomas Cofino , John Karat , John Vergo , Catherine Wolf
IPC分类号： G06F7/00
CPC分类号： G06F16/9535
摘要： A method and apparatus are disclosed for ranking the results of a document search by identifying a prior, similar search and assigning a weight to each document based on whether the document was selected by a user of the prior search. The assigned weights are utilized to rank the documents identified by the document search in order of their relevance to the search terms. The search terms of the document search and information describing the selections made by a user of the document search are then stored to facilitate the assignment of weights to documents in future searches. According to another aspect of the invention, the weight assigned to a document is correlated to a degree of closeness of search terms of a prior search and search terms of a new document search. For example, a degree of closeness measurement is defined that correlates to a number of synonyms common between the search terms of a prior search and the search terms of a new document search.
摘要翻译：公开了一种方法和装置，用于通过基于先前搜索的用户是否选择了文档，通过识别先前的类似搜索和向每个文档分配权重来对文档搜索的结果进行排名。分配的权重用于按照与搜索项的相关性的顺序对由文档搜索确定的文档进行排名。然后存储文档搜索的搜索条件和描述用户对文档搜索进行的选择的信息，以便于将来的搜索中的文档的权重分配。根据本发明的另一方面，分配给文档的权重与新文档搜索的先前搜索和搜索项的搜索项的接近程度相关。例如，一定程度的亲密度测量被定义为与先前搜索的搜索词与新文档搜索的搜索词之间共同的多少同义词相关。

2. 发明申请

US20050177555A1 System and method for providing information on a set of search returned documents 审中-公开
标题翻译：用于提供一组搜索返回文档的信息的系统和方法
公开(公告)号：US20050177555A1
公开(公告)日：2005-08-11
申请号：US10776734
申请日：2004-02-11
申请人： Sherman Alpert , Yurdaer Doganata , Lev Kozakov , John Vergo , Catherine Wolf
发明人： Sherman Alpert , Yurdaer Doganata , Lev Kozakov , John Vergo , Catherine Wolf
IPC分类号： G06F17/30
CPC分类号： G06F16/353
摘要： A system and method for organizing document search results include identifying words having an association with search query terms. Features of the words are categorized in relation to the search query terms. The results of the document search are presented in at least one category in accordance with the features.
摘要翻译：用于组织文档搜索结果的系统和方法包括识别具有与搜索查询术语相关联的单词。这些词的特征与搜索查询词有关。文档搜索的结果根据特征呈现在至少一个类别中。

3. 发明申请

US20050074890A1 Electrophoretic in situ tissue staining 审中-公开
标题翻译：电泳原位组织染色
公开(公告)号：US20050074890A1
公开(公告)日：2005-04-07
申请号：US10848775
申请日：2004-05-18
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： A61N1/30 , A61N1/32 , G01N1/30 , G01N31/22 , G01N33/53 , G01N33/567
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

4. 发明授权

US07618807B2 Apparatus for electrophoretic in situ tissue staining 有权
标题翻译：电泳原位组织染色装置
公开(公告)号：US07618807B2
公开(公告)日：2009-11-17
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42 , C12M3/00
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

5. 发明授权

US06933117B2 Reagents and methods for automated hybridization 有权
标题翻译：用于自动化杂交的试剂和方法
公开(公告)号：US06933117B2
公开(公告)日：2005-08-23
申请号：US10136714
申请日：2002-04-30
申请人： Catherine Wolf , Hiroaki Nitta , Thomas Grogan , Jacques Cavadenti , Lidija Pestic-Dragovich , Anthony Hartman , Angela Sattler , Jennifer Wong
发明人： Catherine Wolf , Hiroaki Nitta , Thomas Grogan , Jacques Cavadenti , Lidija Pestic-Dragovich , Anthony Hartman , Angela Sattler , Jennifer Wong
IPC分类号： G01N33/53 , C07H21/02 , C07H21/04 , C12N1/08 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N37/00
CPC分类号： C12Q1/6837 , C12Q1/6832 , C12Q1/6841 , C12Q2527/137 , C12Q2527/125
摘要： The invention provides novel reagents, reagent kits, and methods for automated hybridization. More particularly, the invention provides reagents, reagent kits, and methods for automated in situ hybridization and automated hybridization on a microarray. The use of automated instruments for in situ hybridization and microarray hybridization dramatically reduces the amount of labor and time involved and also facilitates standardization of protocols and consistency between results.
摘要翻译：本发明提供了用于自动化杂交的新型试剂，试剂盒和方法。更具体地，本发明提供用于微阵列自动原位杂交和自动杂交的试剂，试剂盒和方法。使用自动化仪器进行原位杂交和微阵列杂交显着减少了劳动和时间，并促进了协议的标准化和结果之间的一致性。

6. 发明申请

US20080020450A1 Apparatus for Electrophoretic In Situ Tissue Staining 有权
标题翻译：电泳原位组织染色装置
公开(公告)号：US20080020450A1
公开(公告)日：2008-01-24
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42
CPC分类号： G01N31/22 , A61N1/30 , A61N1/325 , G01N1/30
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译：本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。本发明还涉及用于执行该方法的装置。

7. 发明申请

US20060041436A1 System, method, service method, and program product for managing entitlement with identity and privacy applications for electronic commerce 有权
公开(公告)号：US20060041436A1
公开(公告)日：2006-02-23
申请号：US10919845
申请日：2004-08-17
申请人： Carolyn Brodie , Maroun Touma , Charles Tresser , Catherine Wolf , Joel Wolf
发明人： Carolyn Brodie , Maroun Touma , Charles Tresser , Catherine Wolf , Joel Wolf
IPC分类号： G06Q99/00
CPC分类号： G06Q10/10
摘要： A system, method, service method, and program product for defining and/or managing entitlements and/or authentication entitlements to resources in a computer networking environment is disclosed. Upon receiving one or more dynamic events, the invention verifies one or more users (a selected user) has (entitlement) attributes that satisfy one or more access criteria to access one or more resources. The invention then permits and/or provides access to one or more resources for the selected user over one or more networks without revealing the identity of the selected user to the resource provider.

8. 发明授权

US06656685B2 Hybridization buffers using low molecular weight dextran sulfate and methods for their use 失效
标题翻译：使用低分子量硫酸葡聚糖的杂交缓冲液及其使用方法
公开(公告)号：US06656685B2
公开(公告)日：2003-12-02
申请号：US09772123
申请日：2001-01-29
申请人： Joseph Utermohlen , Catherine Wolf , Kimberly Christensen
发明人： Joseph Utermohlen , Catherine Wolf , Kimberly Christensen
IPC分类号： C12Q168
CPC分类号： C12Q1/6832 , C12Q2527/125
摘要： The invention is directed to an improvement in automated tissue staining system having evaporation inhibitor liquid covering the polynucleotide hybridization buffer-covered tissue on a slide, wherein the improvement comprises a polynucleotide hybridization buffer for in situ hybridization comprising a low molecular weight dextran sulfate having a molecular weight range from about 8,000 to about 16,000.
摘要翻译：本发明涉及自动化组织染色系统的改进，其具有覆盖载玻片上的多核苷酸杂交缓冲液覆盖的组织的蒸发抑制剂液体，其中改进包括用于原位杂交的多核苷酸杂交缓冲液，其包含具有分子重量范围从约8,000至约16,000。

9. 发明授权

US07410753B2 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 有权
标题翻译：从生物样品和细胞调节中去除嵌入介质在自动染色仪器上
公开(公告)号：US07410753B2
公开(公告)日：2008-08-12
申请号：US10394996
申请日：2003-03-21
申请人： Keri Hopkins , Alexis Pusch , Catherine Wolf , Anthony Hartman , James Pettay , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
发明人： Keri Hopkins , Alexis Pusch , Catherine Wolf , Anthony Hartman , James Pettay , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
IPC分类号： A01N1/00 , G01N33/00
CPC分类号： G01N1/36 , G01N1/30 , Y10T436/21 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents comprise components optimized to facilitate removal or etching of the embedding media from the biological sample. The present invention also provides reagents for use in an automated environment for cell conditioning biological samples wherein the cells are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents comprise components optimized to facilitate molecular access to cells and cell constituents within the biological sample.
摘要翻译：本发明提供用于在自动化环境中用于通过在组织化学或细胞化学程序中暴露待染色的生物样品而不依赖有机溶剂来去除或蚀刻包埋介质的试剂。试剂包括优化以有助于从生物样品中去除或蚀刻嵌入介质的组分。本发明还提供用于细胞调节生物样品的自动化环境中的试剂，其中细胞易于被试剂分子进入用于组织化学和细胞化学染色程序。试剂包含优化的促进分子进入生物样品中的细胞和细胞组分的组分。

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