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1. 发明授权

US07550598B2 Kinase inhibitors 失效
标题翻译：激酶抑制剂
公开(公告)号：US07550598B2
公开(公告)日：2009-06-23
申请号：US11208437
申请日：2005-08-18
申请人： Sheldon X. Cao , Anthony R. Gangloff , Bheema R. Paraselli , Jeffrey A. Stafford , Hasanthi P. Wijesekera
发明人： Sheldon X. Cao , Anthony R. Gangloff , Bheema R. Paraselli , Jeffrey A. Stafford , Hasanthi P. Wijesekera
IPC分类号： C07D215/38 , A61K38/40
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound of the formula: wherein R1, R2, R3, Q, U, V, W, X, and Y are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于包含下式化合物的激酶：其中R 1，R 2，R 3，Q，U，V，W，X和Y如本文所定义。

2. 发明授权

US07381825B2 Histone deacetylase inhibitors 失效
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US07381825B2
公开(公告)日：2008-06-03
申请号：US10803575
申请日：2004-03-17
申请人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
发明人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
IPC分类号： C07D401/04
CPC分类号： C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10
摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.
摘要翻译：可用于抑制组氨酸脱乙酰酶的化合物，其具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> ZQLM或ZLM <？in-line-formula description =“In-line 式“end =”tail“？>其中M是能够与脱乙酰酶催化部位和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。

3. 发明授权

US07375228B2 Histone deacetylase inhibitors 失效
公开(公告)号：US07375228B2
公开(公告)日：2008-05-20
申请号：US10803580
申请日：2004-03-17
申请人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
发明人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
IPC分类号： C07D401/04
CPC分类号： C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10
摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

4. 发明授权

US07169801B2 Histone deacetylase inhibitors 失效
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US07169801B2
公开(公告)日：2007-01-30
申请号：US10803344
申请日：2004-03-17
申请人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
发明人： Jerome C. Bressi , Jason W. Brown , Sheldon X. Cao , Anthony R. Gangloff , Andrew J. Jennings , Jeffrey A. Stafford , Phong H. Vu , Xiao-Yi Xiao
IPC分类号： A61K31/415 , A61K31/44 , C07D401/02 , C07D403/02
CPC分类号： C07D235/18 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/10
摘要： Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0–10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.
摘要翻译：可用于抑制组氨酸脱乙酰酶的化合物，其具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> ZQLM或ZLM <？in-line-formula description =“In-line 式“end =”tail“？>其中M是能够与脱乙酰酶催化部位和/或金属离子络合的取代基; L是在M取代基和化合物的其余部分之间分离0-10个原子之间的取代基; Z和Q如本文所定义。

5. 发明申请

US20110082111A1 POLO-LIKE KINASE INHIBITORS 失效
公开(公告)号：US20110082111A1
公开(公告)日：2011-04-07
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/675 , C07D487/04 , A61K31/551 , A61K31/397 , C07F9/165 , C07D487/14 , C07C229/34 , C07C229/22 , C07C69/74 , C07C69/75 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

6. 发明申请

US20090281092A1 POLO-LIKE KINASE INHIBITORS 失效
公开(公告)号：US20090281092A1
公开(公告)日：2009-11-12
申请号：US12237306
申请日：2008-09-24
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

7. 发明授权

US08008332B2 Substituted indazoles as glucokinase activators 失效
标题翻译：取代吲哚作为葡萄糖激酶活化剂
公开(公告)号：US08008332B2
公开(公告)日：2011-08-30
申请号：US11754205
申请日：2007-05-25
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , David J. Hosfield , Robert J. Skene , Jeffrey A. Stafford , Mingnam Tang
IPC分类号： A61K31/427 , A61K31/4402 , C07D231/56 , A61K31/4353 , A61K31/519 , A61K31/4995 , C07D487/04 , C07D471/04 , A61P3/10 , A61P9/00
CPC分类号： C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供了与己糖激酶一起使用的化合物，其包含：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

8. 发明授权

US07790734B2 Dipeptidyl peptidase inhibitors 有权
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US07790734B2
公开(公告)日：2010-09-07
申请号：US10934326
申请日：2004-09-02
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号： C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D401/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译：提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。

9. 发明申请

US20090291938A1 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激素抑制剂
公开(公告)号：US20090291938A1
公开(公告)日：2009-11-26
申请号：US12274213
申请日：2008-11-19
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物用于激酶：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

10. 发明授权

US07399884B2 Histone deacetylase inhibitors 失效
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US07399884B2
公开(公告)日：2008-07-15
申请号：US11557402
申请日：2006-11-07
申请人： Jerome C. Bressi , Sheldon X. Cao , Jeffrey A. Stafford , Phong H. Vu
发明人： Jerome C. Bressi , Sheldon X. Cao , Jeffrey A. Stafford , Phong H. Vu
IPC分类号： C07C259/04 , C07C229/34 , C07D231/16 , C07D239/22 , C07D241/36
CPC分类号： C07C259/06 , C07D231/16 , C07D239/38 , C07D241/44
摘要： Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen;R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl;M is a substituent capable of complexing with a protein metal ion; andL is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.
摘要翻译：提供组蛋白脱乙酰酶抑制剂及其用途，其具有以下通式：其中R 1，R 2，R 3和R 4， / SUB>各自独立地选自氢，取代或未取代的直链C 1-12烷基，C 2-12-12氨基烷基或C 1 -C 12烷基， 2-12个氧杂烷基，以及取代和未取代的3,4,5,6,7或8元环，条件是R 3和R 4 不是氢; R 5选自羰基，取代或未取代的C 1-3烷基，取代或未取代的C 1-3烷基，烷基-C（O），取代或未取代的-C（O）-C 1-3烷基和取代或未取代的-C（O）C（O）C 1-3烷基; M是能与蛋白质金属离子络合的取代基; L是包含连接M取代基与L取代基的α原子的3-12个原子的链的取代基。

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