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1. 发明授权

US07713485B2 Microfluidics switch with moving planes 有权
标题翻译：微流体开关与移动平面
公开(公告)号：US07713485B2
公开(公告)日：2010-05-11
申请号：US10390669
申请日：2003-03-19
申请人： Shaw-Hwa Parng , Mei-Ya Wang , Hung-Jen Yang
发明人： Shaw-Hwa Parng , Mei-Ya Wang , Hung-Jen Yang
IPC分类号： B01L3/00
CPC分类号： F16K99/0011 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/165 , B01L2400/0622 , B01L2400/065 , F16K99/0001 , F16K99/0013 , F16K99/0028 , F16K2099/008
摘要： A microfluidics switch with moving planes has a first substrate with some holes and a second substrate with some micro-channels. Herein, the relative planes of both substrates are covered by a hydrophobic material. Therefore, while the substrates are neighboring and relatively moving, the overlap relation between the holes and the micro-channels are varied and a switch function is provided. Further, by using the hydrophobic material, while the distance between substrates is smaller than the height of drop of each liquid inputted into the holes, the fluids can not fluid between the planes and then different micro-channels are isolated from each other.
摘要翻译：具有移动平面的微流体开关具有具有一些孔的第一衬底和具有一些微通道的第二衬底。这里，两个基板的相对平面被疏水材料覆盖。因此，当基板相邻且相对移动时，孔和微通道之间的重叠关系发生变化，并提供开关功能。此外，通过使用疏水性材料，当基板之间的距离小于输入到孔中的每种液体的下落高度时，流体在平面之间不能流体化，因此不同的微通道彼此隔离。

2. 发明申请

US20110053202A1 ANALYTICAL SYSTEM, ANALYTICAL METHOD AND FLOW-PATH STRUCTURE 有权
标题翻译：分析系统，分析方法和流程结构
公开(公告)号：US20110053202A1
公开(公告)日：2011-03-03
申请号：US12634362
申请日：2009-12-09
申请人： Shaw-Hwa Parng , Chung-Hsien Tsai , Fu-Chun Huang , Chih-Wen Yang
发明人： Shaw-Hwa Parng , Chung-Hsien Tsai , Fu-Chun Huang , Chih-Wen Yang
IPC分类号： C12Q1/02 , G01N33/50 , G01N21/07 , B04B5/00 , C12M1/00 , G01N35/00 , C12Q1/00
CPC分类号： G01N33/5302 , B01L3/502746 , B01L3/502761 , B01L2200/0605 , B01L2200/0684 , B01L2200/143 , B01L2300/044 , B01L2300/0803 , B01L2300/087 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0605 , G01N2035/00495 , Y10T436/111666
摘要： An analytical system for performing centrifugal analysis on a working fluid with different components includes a uniform-dividing unit with a reduced cross section to divide the working fluid, a separating unit connected to the uniform-dividing unit, and a detecting unit. The detecting unit includes a detection compartment and a constant-quantity region connected to the separating unit through a separation channel. When rotating the uniform-dividing unit, the working fluid located at the uniform-dividing unit is transmitted to and separated by the separating unit, thereby causing one component of the working fluid to be separated from the other component and transmitted to the detection compartment through the constant-quantity region. With constant-quantity region, the detection compartment can be prevented from flushing by the excess of the separated component, and thus yield of product detection can be increased and different assays detection is carried out with a small sample volume at the same time.
摘要翻译：用于对具有不同部件的工作流体进行离心分析的分析系统包括具有减小的横截面以分割工作流体的均匀分割单元，连接到均匀分割单元的分离单元和检测单元。检测单元包括通过分离通道连接到分离单元的检测室和恒定量区域。当均匀分割单元旋转时，位于均匀分割单元处的工作流体被分离单元传递并分离，从而使工作流体的一个分量与另一个分量分离并传递到检测室恒定量区域。使用恒定量区域，可以防止检测室被分离成分过量的冲洗，从而可以提高产品检测的产率，同时以小的样品体积进行不同的检测检测。

3. 发明授权

US06945285B2 Apparatus and method for collecting fluid fractions 失效
$Apparatus and method for collecting fluid fractions$
标题翻译：用于收集流体分数的装置和方法
公开(公告)号：US06945285B2
公开(公告)日：2005-09-20
申请号：US10437073
申请日：2003-05-14
申请人： Jhy-Wen Wu , Nan-Kuang Yao , Yuan-Fong Kao , Tim-Kuei Shia , Shaw-Hwa Parng
发明人： Jhy-Wen Wu , Nan-Kuang Yao , Yuan-Fong Kao , Tim-Kuei Shia , Shaw-Hwa Parng
IPC分类号： G01N1/18 , G01N30/84 , G01N35/10 , B67C3/00
CPC分类号： G01N1/18 , G01N30/84 , G01N2030/8411 , G01N2035/1037
摘要： An apparatus and a method for collecting fluid fractions. The present apparatus includes an inlet, a channel, a plurality of collectors, and an outlet. The inlet communicates with the collectors and the outlet through the channel. The collectors are disposed between the inlet and the outlet. The method for collecting the fluid fractions comprises two steps. First step, injecting the fluid in to the inlet for guiding the fluid to the outlet along the channel, wherein the fluid fills the collectors one by one due to the capillary attraction when passing through the collectors, and flows to the outlet after the collectors having been filled. Second step, injecting pressurized gas into the channel to drain the fluid fractions from fill the collectors respectively to a plurality of corresponding containers.
摘要翻译：用于收集流体分数的装置和方法。本装置包括入口，通道，多个收集器和出口。入口通过通道与收集器和出口连通。收集器设置在入口和出口之间。收集流体馏分的方法包括两个步骤。第一步，将流体注入到入口中，以将流体沿着通道引导到出口，其中当流体通过收集器时，流体由于毛细管吸引而逐个填充收集器，并且在收集器具有已经填满第二步骤，将加压气体注入通道以将流体部分从收集器填充到多个对应的容器中。

4. 发明申请

US20070080976A1 Biochip with microchannels 失效
标题翻译：带微通道的生物芯片
公开(公告)号：US20070080976A1
公开(公告)日：2007-04-12
申请号：US11270142
申请日：2005-11-08
申请人： Shaw-Hwa Parng
发明人： Shaw-Hwa Parng
IPC分类号： G01D15/16
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/0858 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/084
摘要： A biochip with multiple microchannels is provided. Due to the sloped microchannels, the fluids in the microchannels flow at substantially the same rate, thus facilitating cellular experiments of potential medicaments. Since the flow resistance of the sloped microchannels changes gradually, the fluids can flow in the microchannels without retention and the reagents react consistently with the cells in the microchannels. Hence, the cellular reaction time for the reagents in the microchannels can be correctly determined. Moreover, the biochip of this invention further includes at least one multi-splitter to control the influx or efflux of the fluids.
摘要翻译：提供了具有多个微通道的生物芯片。由于倾斜的微通道，微通道中的流体以基本相同的速率流动，因此有助于潜在药物的细胞实验。由于倾斜的微通道的流动阻力逐渐变化，流体可以在微通道内流动而不会保留，并且试剂与微通道中的电池一致。因此，可以正确地确定微通道中的试剂的细胞反应时间。此外，本发明的生物芯片还包括至少一个多分流器以控制流体的流入或流出。

5. 发明申请

US20060188403A1 Microfluidic chip 失效
公开(公告)号：US20060188403A1
公开(公告)日：2006-08-24
申请号：US11151443
申请日：2005-06-14
申请人： Shaw-Hwa Parng , Tung-Ming Yu
发明人： Shaw-Hwa Parng , Tung-Ming Yu
IPC分类号： G01N33/00
CPC分类号： G01N27/44704 , B01L3/502707 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/1827
摘要： A microfluidic chip on a transparent substrate includes microchannels, and an electric layer having a heater and a sensor layout on the microchannel nearby and aside for supplying heat source and sensing the temperature individually. The sensor is close to the microchannel for controlling the temperature accurately. Hence, the microfluidic chip can measure the temperature precisely without using an isolation layer and lower energy consumptions and reduce production costs.

6. 发明授权

US08512233B2 Curved laryngoscope and operation instrument assembly applying the same 有权
标题翻译：弯曲喉镜及其操作仪器组合应用
公开(公告)号：US08512233B2
公开(公告)日：2013-08-20
申请号：US12947776
申请日：2010-11-16
申请人： Yu-Jin Kao , Hong-Wen Chang , Chih-Wen Yang , Shaw-Hwa Parng , Tzu-Yu Hsiao
发明人： Yu-Jin Kao , Hong-Wen Chang , Chih-Wen Yang , Shaw-Hwa Parng , Tzu-Yu Hsiao
IPC分类号： A61B1/267
CPC分类号： A61B1/267 , A61B1/00154 , A61B1/018
摘要： A curved laryngoscope and an operation instrument assembly applying the same are provided, wherein the curved laryngoscope is provided with a guiding structure and a locating device. The guiding structure and the locating device can be individually or both adopted in the curved laryngoscope to assist various operation instruments in moving and being located reliably, and therefore improve the reliability, accuracy and facility in operation using the curved laryngoscope.
摘要翻译：提供弯曲喉镜和应用其的操作仪器组件，其中弯曲喉镜设置有引导结构和定位装置。引导结构和定位装置可以单独或两者采用弯曲喉镜，以协助各种操作仪器的移动和定位可靠，从而提高使用弯曲喉镜的可靠性，准确性和使用方便。

7. 发明申请

US20120029292A1 CURVED LARYNGOSCOPE AND OPERATION INSTRUMENT ASSEMBLY APPLYING THE SAME 有权
标题翻译：弯曲的喉镜和操作仪器组件适用于此
公开(公告)号：US20120029292A1
公开(公告)日：2012-02-02
申请号：US12947776
申请日：2010-11-16
申请人： Yu-Jin Kao , Hong-Wen Chang , Chih-Wen Yang , Shaw-Hwa Parng , Tzu-Yu Hsiao
发明人： Yu-Jin Kao , Hong-Wen Chang , Chih-Wen Yang , Shaw-Hwa Parng , Tzu-Yu Hsiao
IPC分类号： A61B1/267
CPC分类号： A61B1/267 , A61B1/00154 , A61B1/018
摘要： A curved laryngoscope and an operation instrument assembly applying the same are provided, wherein the curved laryngoscope is provided with a guiding structure and a locating device. The guiding structure and the locating device can be individually or both adopted in the curved laryngoscope to assist various operation instruments in moving and being located reliably, and therefore improve the reliability, accuracy and facility in operation using the curved laryngoscope.
摘要翻译：提供弯曲喉镜和应用其的操作仪器组件，其中弯曲喉镜设置有引导结构和定位装置。引导结构和定位装置可以单独或两者采用弯曲喉镜，以协助各种操作仪器的移动和定位可靠，从而提高使用弯曲喉镜的可靠性，准确性和使用方便。

8. 发明授权

US07585462B2 Biochip with microchannels 失效
标题翻译：带微通道的生物芯片
公开(公告)号：US07585462B2
公开(公告)日：2009-09-08
申请号：US11270142
申请日：2005-11-08
申请人： Shaw-Hwa Parng
发明人： Shaw-Hwa Parng
IPC分类号： G01N21/00
CPC分类号： B01L3/502746 , B01L2300/0816 , B01L2300/0858 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/084
摘要： A biochip with multiple microchannels is provided. Due to the sloped microchannels, the fluids in the microchannels flow at substantially the same rate, thus facilitating cellular experiments of potential medicaments. Since the flow resistance of the sloped microchannels changes gradually, the fluids can flow in the microchannels without retention and the reagents react consistently with the cells in the microchannels. Hence, the cellular reaction time for the reagents in the microchannels can be correctly determined. Moreover, the biochip of this invention further includes at least one multi-splitter to control the influx or efflux of the fluids.
摘要翻译：提供了具有多个微通道的生物芯片。由于倾斜的微通道，微通道中的流体以基本相同的速率流动，因此有助于潜在药物的细胞实验。由于倾斜的微通道的流动阻力逐渐变化，流体可以在微通道内流动而不会保留，并且试剂与微通道中的电池一致。因此，可以正确地确定微通道中的试剂的细胞反应时间。此外，本发明的生物芯片还包括至少一个多分流器以控制流体的流入或流出。

9. 发明授权

US06843263B2 Partially closed microfluidic system and microfluidic driving method 失效
标题翻译：部分封闭的微流体系统和微流体驱动方法
公开(公告)号：US06843263B2
公开(公告)日：2005-01-18
申请号：US10177122
申请日：2002-06-24
申请人： Yuan-Fong Kuo , Nan-Kuang Yao , Jhy-Wen Wu , Tim Shia , Shaw-Hwa Parng
发明人： Yuan-Fong Kuo , Nan-Kuang Yao , Jhy-Wen Wu , Tim Shia , Shaw-Hwa Parng
IPC分类号： B01L3/00 , F04B43/02 , F04B43/04 , F17D1/18 , F15C1/04
CPC分类号： F04B43/02 , B01L3/5027 , F04B43/043 , Y10T137/0396 , Y10T137/2213 , Y10T137/2224
摘要： This specification disclosed a partially closed microfluidic system and a fluid driving method. The microfluidic system is comprised of a substrate with microfluidic elements and a thin film. A feature of this structure is that the thin film is elastic and deformable. It has a single opening corresponding to a vent hole on the substrate, thus forming a partially closed microfluidic system. The substrate is designed to have several positions for micro fluid elements and deformable chambers and uses micro channels to form a complete network. Since the thin film is elastic and deformable, one is able to impose a pressure on the thin film above the deformable chambers in this partially closed microfluidic system to drive the fluid into motion. Once the pressure is released, the fluid flows back to its original configuration.
摘要翻译：本说明书公开了部分封闭的微流体系统和流体驱动方法。微流体系统由具有微流体元件的基底和薄膜组成。该结构的特征在于薄膜是弹性的和可变形的。它具有对应于衬底上的通气孔的单个开口，从而形成部分闭合的微流体系统。基板被设计为具有用于微流体元件和可变形室的多个位置，并且使用微通道形成完整的网络。由于薄膜是弹性和可变形的，因此能够在该部分封闭的微流体系统中的可变形室上方的薄膜上施加压力，以驱动流体运动。一旦压力释放，流体就会流回原来的状态。

10. 发明授权

US08216516B2 Analytical system, analytical method and flow-path structure 有权
标题翻译：分析系统，分析方法和流路结构
公开(公告)号：US08216516B2
公开(公告)日：2012-07-10
申请号：US12634362
申请日：2009-12-09
申请人： Shaw-Hwa Parng , Chung-Hsien Tsai , Fu-Chun Huang , Chih-Wen Yang
发明人： Shaw-Hwa Parng , Chung-Hsien Tsai , Fu-Chun Huang , Chih-Wen Yang
IPC分类号： G01N33/00
CPC分类号： G01N33/5302 , B01L3/502746 , B01L3/502761 , B01L2200/0605 , B01L2200/0684 , B01L2200/143 , B01L2300/044 , B01L2300/0803 , B01L2300/087 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0605 , G01N2035/00495 , Y10T436/111666
摘要： An analytical system for performing centrifugal analysis on a working fluid with different components includes a uniform-dividing unit with a reduced cross section to divide the working fluid, a separating unit connected to the uniform-dividing unit, and a detecting unit. The detecting unit includes a detection compartment and a constant-quantity region connected to the separating unit through a separation channel. When rotating the uniform-dividing unit, the working fluid located at the uniform-dividing unit is transmitted to and separated by the separating unit, thereby causing one component of the working fluid to be separated from the other component and transmitted to the detection compartment through the constant-quantity region. With constant-quantity region, the detection compartment can be prevented from flushing by the excess of the separated component, and thus yield of product detection can be increased and different assays detection is carried out with a small sample volume at the same time.
摘要翻译：用于对具有不同部件的工作流体进行离心分析的分析系统包括具有减小的横截面以分割工作流体的均匀分割单元，连接到均匀分割单元的分离单元和检测单元。检测单元包括通过分离通道连接到分离单元的检测室和恒定量区域。当均匀分割单元旋转时，位于均匀分割单元处的工作流体被分离单元传递并分离，从而使工作流体的一个分量与另一个分量分离并传递到检测室恒定量区域。使用恒定量区域，可以防止检测室被分离成分过量的冲洗，从而可以提高产品检测的产率，同时以小的样品体积进行不同的检测检测。

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