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1. 发明授权

US08518984B2 Spiro-oxindole MDM2 antagonists 失效
公开(公告)号：US08518984B2
公开(公告)日：2013-08-27
申请号：US12945511
申请日：2010-11-12
申请人： Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
发明人： Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
IPC分类号： C07D487/10 , A61K31/4015
CPC分类号： C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D471/20 , C07D491/107 , C07D495/10 , C07F9/6561 , A61K2300/00
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

2. 发明申请

US20110112052A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS 失效
公开(公告)号：US20110112052A1
公开(公告)日：2011-05-12
申请号：US12945511
申请日：2010-11-12
申请人： Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
发明人： Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar Shangary , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
IPC分类号： C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61P1/00 , A61P35/04
CPC分类号： C07D487/10 , A61K31/407 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D471/20 , C07D491/107 , C07D495/10 , C07F9/6561 , A61K2300/00
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
摘要翻译：本文提供了药物化学领域中的化合物，组合物和方法。本文提供的化合物和组合物涉及作为p53和MDM2之间的相互作用的拮抗剂的螺 - 羟吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

3. 发明申请

US20120035457A1 ELECTROMAGNETIC SYSTEM AND METHOD 审中-公开
标题翻译：电磁系统与方法
公开(公告)号：US20120035457A1
公开(公告)日：2012-02-09
申请号：US13210293
申请日：2011-08-15
申请人： Vishwanath Subramaniam , Joseph West , Jennifer McFerran Brock , Emily Sequin , Duxin Sun , Peng Zou
发明人： Vishwanath Subramaniam , Joseph West , Jennifer McFerran Brock , Emily Sequin , Duxin Sun , Peng Zou
IPC分类号： A61B5/053 , A61B5/05 , A61N2/02
CPC分类号： A61B5/05 , A61B5/415 , A61B5/418
摘要： Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.
摘要翻译：健康和癌组织之间的电磁（EM）特性的差异允许检测动物组织中发生的异常状况，例如手术前癌症检测。通过使用时变EM场，在组织样品中产生电涡流，并使用相敏检测进行评估。在一些方面，接收器线圈中的电压和驱动器线圈中的电压之间的相移的变化提供了样品的EM性质的差异的直接和即时的指示。

4. 发明申请

US20140070846A1 Interface Circuitry For A Test Apparatus 有权
标题翻译：用于测试设备的接口电路
公开(公告)号：US20140070846A1
公开(公告)日：2014-03-13
申请号：US13613810
申请日：2012-09-13
申请人： Peng Zou , Fenardi Thenus , David J. Harriman
发明人： Peng Zou , Fenardi Thenus , David J. Harriman
IPC分类号： H03K19/0175
CPC分类号： G01R31/31924
摘要： In one embodiment, a test apparatus includes a field programmable gate array (FPGA) including a first transmitter to communicate first signals according to current mode logic (CML) signaling and a first receiver to receive second signals according to the CML signaling, and an interface circuit to couple the FPGA to a device that is to communicate according to voltage mode signaling. The interface circuit may adapt the first signals communicated by the first transmitter according to the CML signaling to voltage mode signaling signals for receipt by the device. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，测试装置包括现场可编程门阵列（FPGA），其包括根据当前模式逻辑（CML）信令来传送第一信号的第一发射机和根据CML信令接收第二信号的第一接收机，以及接口电路将FPGA耦合到根据电压模式信号进行通信的设备。接口电路可以将根据CML信令的由第一发射机传送的第一信号适配成电压模式信令信号，以供设备接收。描述和要求保护其他实施例。

5. 发明授权

US08539781B2 Component for solar adsorption refrigeration system and method of making such component 有权
标题翻译：太阳能吸附制冷系统的组成部分及其制造方法
公开(公告)号：US08539781B2
公开(公告)日：2013-09-24
申请号：US12666208
申请日：2008-06-22
申请人： J. Donald Carruthers , Karl Boggs , Luping Wang , Shaun Wilson , Jose I. Arno , Paul J. Marganski , Steven M. Bilodeau , Peng Zou , Brian Bobita , Joseph D. Sweeney , Douglas Edwards
发明人： J. Donald Carruthers , Karl Boggs , Luping Wang , Shaun Wilson , Jose I. Arno , Paul J. Marganski , Steven M. Bilodeau , Peng Zou , Brian Bobita , Joseph D. Sweeney , Douglas Edwards
IPC分类号： F25B15/00
CPC分类号： B01J20/26 , B01J20/20 , B01J20/28054 , B01J20/28092 , B01J20/30 , B01J20/305 , B01J20/3078 , B01J2220/445 , C09K5/047 , F25B17/08 , F25B27/007 , F25B35/04 , F25B37/00 , F25B2500/01
摘要： An adsorption structure is described that includes at least one adsorbent member formed of an adsorbent material and at least one porous member provided in contact with a portion of the adsorbent member to allow gas to enter and exit the portion of the adsorbent member. Such adsorption structure is usefully employed in adsorbent-based refrigeration systems. A method also is described for producing an adsorbent material, in which a first polymeric material is provided having a first density and a second polymeric material is provided having a second density, in which the second polymeric material is in contact with the first polymeric material to form a structure. The structure is pyrolyzed to form a porous adsorbent material including a first region corresponding to the first polymeric material and a second region corresponding to the second polymeric material, in which at least one of the pore sizes and the pore distribution differs between the first region and the second region.
摘要翻译：描述了吸附结构，其包括由吸附剂材料形成的至少一个吸附构件和与吸附构件的一部分接触设置的至少一个多孔构件，以允许气体进入和离开吸附构件的该部分。这种吸附结构在吸附剂型制冷系统中有用。描述了一种用于生产吸附材料的方法，其中提供具有第一密度的第一聚合物材料和第二聚合物材料，其具有第二密度，其中第二聚合物材料与第一聚合物材料接触，形成一个结构。该结构被热解以形成多孔吸附剂材料，其包括对应于第一聚合物材料的第一区域和对应于第二聚合物材料的第二区域，其中孔径和孔分布中的至少一个在第一区域和第第二个地区。

6. 发明申请

US20110161683A1 APPARATUS FOR HIGH EFFICIENT REAL-TIME PLATFORM POWER MANAGEMENT ARCHITECTURE 有权
标题翻译：高效实时平台电源管理架构的设备
公开(公告)号：US20110161683A1
公开(公告)日：2011-06-30
申请号：US12724084
申请日：2010-03-15
申请人： Peng Zou , Joseph T. Dibene, II , Fernardi Thenus
发明人： Peng Zou , Joseph T. Dibene, II , Fernardi Thenus
IPC分类号： G06F1/26
CPC分类号： G06F1/3203 , G06F1/266 , G06F1/324 , G06F1/3287 , G06F1/3296 , Y02D10/126 , Y02D10/17 , Y02D10/171 , Y02D10/172
摘要： In some embodiments, the invention provides a higher efficiency, real-time platform power management architecture for computing platforms. A more direct power management architecture may be provided using integrated voltage regulators and in some embodiments, a direct power management interface (DPMI) as well. Integrated voltage regulators, such as in-silicon voltage regulators (ISVR) can be used to implement quicker, more highly responsive power state transitions.
摘要翻译：在一些实施例中，本发明为计算平台提供了更高效率的实时平台电源管理架构。可以使用集成稳压器提供更直接的功率管理架构，并且在一些实施例中也可以提供直接功率管理接口（DPMI）。集成稳压器，例如硅片内稳压器（ISVR）可用于实现更快，更高响应的功率状态转换。

7. 发明授权

US09038855B2 Fluid processing systems and methods 有权
标题翻译：流体处理系统和方法
公开(公告)号：US09038855B2
公开(公告)日：2015-05-26
申请号：US13375462
申请日：2010-06-08
申请人： Steven M. Lurcott , John E. Q. Hughes , Peter Wrschka , Thomas H. Baum , Donald D. Ware , Peng Zou
发明人： Steven M. Lurcott , John E. Q. Hughes , Peter Wrschka , Thomas H. Baum , Donald D. Ware , Peng Zou
IPC分类号： G01F11/00 , B01F15/02 , B01F3/08 , B67D7/02
CPC分类号： B01F15/0203 , B01F3/0861 , B01F15/0258 , B01F2003/0896 , B65B3/14 , B67D7/025 , B67D7/0261 , B67D7/0283 , B67D7/741
摘要： Systems and methods for delivering fluid-containing feed materials to process equipment are disclosed. A liner-based pressure dispensing vessel is subjected to filling by application of vacuum between the liner and overpack. Multiple feed material flow controllers of different calibrated flow ranges may be selectively operated in parallel for a single feed material. Feed material blending and testing for scale-up may be performed with feed materials supplied by multiple liner-based pressure dispensing containers. A gravimetric system may be used to determine concentration of at least one component of a multi-component solution or mixture.
摘要翻译：公开了用于将含流体的进料传送到加工设备的系统和方法。基于衬管的压力分配容器通过在衬套和外包装之间施加真空而进行填充。不同校准流量范围的多个进料流量控制器可以针对单个进料进行选择性并行操作。用于放大的进料混合和测试可以通过由多个基于衬管的压力分配容器供应的进料进行。重量分析系统可用于测定多组分溶液或混合物中至少一种组分的浓度。

8. 发明授权

US08872546B2 Interface circuitry for a test apparatus 有权
标题翻译：用于测试设备的接口电路
公开(公告)号：US08872546B2
公开(公告)日：2014-10-28
申请号：US13613810
申请日：2012-09-13
申请人： Peng Zou , Fenardi Thenus , David J. Harriman
发明人： Peng Zou , Fenardi Thenus , David J. Harriman
IPC分类号： H03K19/0175
CPC分类号： G01R31/31924
摘要： In one embodiment, a test apparatus includes a field programmable gate array (FPGA) including a first transmitter to communicate first signals according to current mode logic (CML) signaling and a first receiver to receive second signals according to the CML signaling, and an interface circuit to couple the FPGA to a device that is to communicate according to voltage mode signaling. The interface circuit may adapt the first signals communicated by the first transmitter according to the CML signaling to voltage mode signaling signals for receipt by the device. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，测试装置包括现场可编程门阵列（FPGA），其包括根据当前模式逻辑（CML）信令来传送第一信号的第一发射机和根据CML信令接收第二信号的第一接收机，以及接口电路将FPGA耦合到根据电压模式信号进行通信的设备。接口电路可以将根据CML信令的由第一发射机传送的第一信号适配成电压模式信令信号，以供设备接收。描述和要求保护其他实施例。

9. 发明授权

US08856564B2 Method and apparatus for power profile shaping using time-interleaved voltage modulation 有权
标题翻译：使用时间交织电压调制的功率分布整形的方法和装置
公开(公告)号：US08856564B2
公开(公告)日：2014-10-07
申请号：US12641916
申请日：2009-12-18
申请人： Peng Zou , Joseph T Dibene, II , Fenardi Thenus
发明人： Peng Zou , Joseph T Dibene, II , Fenardi Thenus
IPC分类号： G06F1/32
CPC分类号： G06F1/3203
摘要： Embodiments of an apparatus, system and method are described for dynamically time-interleaving supply voltage modulation to shape a power profile. An apparatus may comprise, for example, a power management module to monitor power information received from a plurality of devices and send a power control signal including delay information to each device having power information that exceeds a power threshold, the delay information comprising information for time-interleaving power usage among the devices having power information that exceeds the power threshold. Other embodiments are described and claimed.
摘要翻译：描述了用于动态时间交织电源电压调制以形成功率分布的装置，系统和方法的实施例。装置可以包括例如电力管理模块，用于监视从多个设备接收的功率信息，并向包括超过功率阈值的功率信息的每个设备发送包括延迟信息的功率控制信号，延迟信息包括时间信息在具有超过功率阈值的功率信息的设备之间交换功率使用。描述和要求保护其他实施例。

10. 发明申请

US20120252195A1 ION IMPLANTATION SYSTEM AND METHOD 有权
标题翻译：离子植入系统和方法
公开(公告)号：US20120252195A1
公开(公告)日：2012-10-04
申请号：US13502855
申请日：2010-10-25
申请人： Edward E. Jones , Sharad N. Yedave , Ying Tang , Barry Lewis Chambers , Robert Kaim , Joseph D. Sweeney , Oleg Byl , Peng Zou
发明人： Edward E. Jones , Sharad N. Yedave , Ying Tang , Barry Lewis Chambers , Robert Kaim , Joseph D. Sweeney , Oleg Byl , Peng Zou
IPC分类号： H01L21/265 , C23C16/50
CPC分类号： H01L21/265 , C23C14/48 , C23C14/52 , H01J37/08 , H01J37/3171 , H01J37/32055 , H01J37/32412 , H01J37/32449 , H01J2237/006 , H01J2237/022
摘要： An ion implantation system and method, providing cooling of dopant gas in the dopant gas feed line, to combat heating and decomposition of the dopant gas by arc chamber heat generation, e.g., using boron source materials such as B2F4 or other alternatives to BF3. Various arc chamber thermal management arrangements are described, as well as modification of plasma properties, specific flow arrangements, cleaning processes, power management, eqillibrium shifting, optimization of extraction optics, detection of deposits in flow passages, and source life optimization, to achieve efficient operation of the ion implantation system.
摘要翻译：一种离子注入系统和方法，用于提供掺杂剂气体进料管线中的掺杂气体的冷却，以通过例如使用诸如B2F4的硼源材料或BF3的其他替代物来通过电弧室发热来防止掺杂气体的加热和分解。描述了各种电弧室热管理布置，以及等离子体性能，特定流量布置，清洁过程，功率管理，平衡偏移，提取光学优化，流路中沉积物的检测和源寿命优化等方面的改进，以实现高效率离子注入系统的操作。

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